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BEGIN:VEVENT
DTSTAMP:20260509T143235Z
DTSTART;VALUE=DATE-TIME:20220419T160000
DTEND;VALUE=DATE-TIME:20220419T170000
SUMMARY:BMS Seminar: The mechano-responsive cell membrane and the regulat
 ion of integrin signalling\, Professor Satyajit Mayor\, National Centre 
 for Biological Sciences Bangalore
TZID:Europe/London
UID:20220419-8a1785d77faca581017ffe77b2956b7f@warwick.ac.uk
CREATED:20220406T104211Z
DESCRIPTION:Abstract: The surface of a eukaryotic cell interfaces with th
 e external milieu constantly decoding signals in the form of chemical an
 d physical cues\, interpreted primarily by membrane receptors. These rec
 eptors are embedded in a plasma membrane that is templated by an active 
 cortical actin meshwork. Active mechanics of actin filaments at the inne
 r leaflet of the membrane orchestrate nanoclusters of membrane proteins 
 and lipids. Nanoclusters of GPI-anchored proteins and glycolipids at the
  outer leaflet require long acyl chain containing moieties in each leafl
 et as well as cholesterol to link to the active cortical actin at the in
 ner leaflet. A combination of active contractile stresses and transbilay
 er coupling drive the creation of active emulsions\, mesoscale liquid or
 dered (lo) domains of GPI-anchored proteins and lipids. Force transducin
 g signalling receptors such as extra-cellular matrix ligand-activated in
 tegrin receptors orchestrates the creation of these membrane domains by 
 triggering the acto-myosin machinery and activating the mechano-transduc
 er\, Vinculin. This translates into a substrate encoded mechano-chemical
  signal in the form of a localised lo-domain. These domains serve to cru
 cial aspects of integrin receptor function\, including cell spreading\, 
 migration\, and sensing mechanical stiffness of the matrix. The active a
 ctin-membrane composite membrane therefore behaves as a mechano-responsi
 ve medium\, serving to integrate chemical and physical cues presented at
  the cell surface. Biography: Professor Satyajit Mayor is a distinguishe
 d cell biologist. He has worked on various aspects of trafficking of mol
 ecules into and out of cells. Particularly noteworthy is his study of GP
 I-linked proteins\, and the elucidation of nano-scale ‘rafts’ in cell me
 mbranes. His work has been recognised by several national and internatio
 nal awards\, such as the Shanti Swarup Bhatnagar Award and the Infosys P
 rize. He has also been elected Foreign Associate of the US National Acad
 emy of Sciences.
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20220406T104211Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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