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BEGIN:VEVENT
DTSTAMP:20260510T061047Z
DTSTART;VALUE=DATE-TIME:20210506T123000
DTEND;VALUE=DATE-TIME:20210506T133000
SUMMARY:BMS Divisional Webinar: The role of the gut microbiota in endomet
 riosis\, Dr Ramakrishna Kommagani\, Department of Obstetrics and Gynecol
 ogy\, Washington University School of Medicine
TZID:Europe/London
UID:20210506-8a1785d778f97ee601794089f57e6744@warwick.ac.uk
CREATED:20210506T071733Z
DESCRIPTION:Abstract: Endometriosis\, which causes pain in the pelvis and
  lower abdomen\, afflicts 1 in 10 women between 15 and 49 years of age i
 n the United States. Nearly half of these women experience chronic pelvi
 c pain\, and many find that available treatments (hormone therapy and su
 rgery) have negative side effects and do not prevent recurrences. A well
 -accepted theory is that endometriosis occurs when endometrial tissue en
 ters the peritoneal cavity via retrograde menstruation and implants onto
  pelvic organs and peritoneal surfaces. However\, whereas up to 90% of w
 omen experience retrograde menstruation\, only 10% of women develop endo
 metriosis\, suggesting that unknown factors contribute to development of
  endometriosis. Thus\, identifying such causal factors is essential to d
 evelop new tools to diagnose and treat this painful disease. Our recent 
 work found that whereas some gut bacteria promote endometriosis\, others
  protect against endometriosis by fermenting fiber to produce short chai
 n fatty acids (SCFAs). We found that altered gut microbiota promotes les
 ion growth and that gut-derived butyrate concentration is decreased in f
 eces from mice with endometriosis. Further\, we found that butyrate acts
  through both GPR signaling and HDAC inhibition to inhibit lesion growth
 . These findings are the first to provide evidence that a gut microbiota
 -derived metabolite protects against endometriosis. These results will e
 nable future studies aimed at developing diagnostic tests (e.g.\, fecal 
 n-butyrate concentration) and treatment strategies (e.g.\, n-butyrate an
 alogs or n-butyrate-producing probiotics) for endometriosis. Biography: 
 Dr. Rama Kommagani is an Assistant Professor in the Department of Obstet
 rics & Gynecology and a faculty member in the Center for Reproductive He
 alth Sciences at Washington University School Of medicine. Dr. Kommagani
  received B.S. and M.S. in Microbiology from Osmania University\, India 
 and Ph.D. in Biomedical Sciences from Wright State University\, Ohio. Su
 bsequently\, Dr. Kommagani conducted postdoctoral training in the labora
 tory of Dr. Bert O’Malley at Baylor College of Medicine\, where he inves
 tigated the cellular and molecular mechanisms of Steroid Receptors funct
 ion in normal endometrial functions. Dr. Kommagani was then a recruited 
 to Washington University where he is focusing on the molecular pathogene
 sis and translational aspects of gynaecological pathologies. Specificall
 y\, on the functional crosstalk between microbiome and inflammation with
  endometriosis. In 2015 Dr. Kommagani received the Early Investigators A
 ward from the Endocrine Society. He has published more than 40 peer-revi
 ewed manuscripts in high impact journals including Cell Metabolism\, PNA
 S\, eLife and Human reproduction. He is also a recipient of the NIH K99/
 R00 grant and served on several NIH study sections.
LOCATION:via MS Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20210506T071733Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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