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BEGIN:VEVENT
DTSTAMP:20260511T111508Z
DTSTART;VALUE=DATE-TIME:20201208T120000
DTEND;VALUE=DATE-TIME:20201208T130000
SUMMARY:SLS/WMS Micro Seminar Series: Evasion of nutritional immunity by 
 African Trypanosomes\, Dr Calvin Tiengwe\, Imperial College London
TZID:Europe/London
UID:20201208-8a1785d77618ef1e017623e952d32ec6@warwick.ac.uk
CREATED:20201202T144422Z
DESCRIPTION:Abstract: Iron is an essential regulatory signal for virulenc
 e factors in many pathogens. Its sequestration by host cells (nutritiona
 l immunity) is an elaborate strategy to limit pathogenesis. How invading
  pathogens evade host-mediated iron sequestration is widely studied but 
 the underlying mechanisms in African trypanosomes remain enigmatic. Tryp
 anosomes are deeply diverged eukaryotic parasites of humans and livestoc
 k. They invade the bloodstream and various tissues relying exclusively o
 n their hosts to satisfy their iron needs. In this talk\, I will present
  data demonstrating that iron regulatory mechanisms in trypanosomes appe
 ar to have diverged significantly from their hosts. I will demonstrate t
 hat multiple systems of iron import in trypanosomes promote survival in 
 both acute and chronic anaemic phases during an infection. Our overall g
 oal is to identify differences in iron-stress response pathways that can
  direct future drug design. Biography: Dr. Calvin Tiengwe is interested 
 in understanding the mechanisms that regulate cellular iron homeostasis 
 in Trypanosoma brucei\, a “neglected” pathogen that causes African sleep
 ing sickness in humans and a range of diseases in cattle\, other livesto
 ck. He did his Ph.D. in Molecular Parasitology at the University of Glas
 gow with Dr. Richard McCulloch and Prof. Dave Barry studying nuclear DNA
  replication in T. brucei. After his Ph.D.\, he did two consecutive post
 docs in the USA at Johns Hopkins Medical School (Paul Englund lab) and S
 tate University of New York at Buffalo (Jay Bangs lab). His current rese
 arch has the potential of solving an important\, long-standing fundament
 al question - are there alternative eukaryotic mechanisms for iron sensi
 ng and regulation of iron homeostasis in the African trypanosome\, T. br
 ucei? https://www.imperial.ac.uk/people/c.tiengwe
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_MI,Joint WMS/SLS Mic
 ro
LAST-MODIFIED:20201202T144422Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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