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BEGIN:VEVENT
DTSTAMP:20260510T105504Z
DTSTART;VALUE=DATE-TIME:20210302T120000
DTEND;VALUE=DATE-TIME:20210302T130000
SUMMARY:SLS/WMS Micro Webinar: Dr Joan Geoghegan\, Institute of Microbiol
 ogy and Infection\, University of Birmingham
TZID:Europe/London
UID:20210302-8a1785d7756ec68b01758d4bf4cc1d5e@warwick.ac.uk
CREATED:20210226T131902Z
DESCRIPTION:Abstract: Staphylococcus aureus colonises the skin of more th
 an 90% of individuals with the inflammatory skin disease atopic dermatit
 is (AD) and exacerbates the disease. Adhesion of S. aureus to corneocyte
 s in the stratum corneum is a key step during the initiation of colonisa
 tion and our research aims to uncover the bacterial and host factors con
 tributing to this process. Here we explore the adhesive events that medi
 ate bacterial adhesion to skin corneocytes. We identify bacterial cell w
 all-anchored proteins that promote adhesion to AD corneocytes and show t
 hat S. aureus exploits the aberrant display of the protein corneodesmosi
 n on the corneocyte surface to adhere strongly to the stratum corneum in
  AD. Biography: Joan Geoghegan is a Royal Society Wolfson Fellow and Sen
 ior Lecturer in Microbiology and Infection at the University of Birmingh
 am. Her research career has focused on understanding the molecular basis
  of colonisation and infection by Staphylococcus aureus. Her PhD trainin
 g at Trinity College Dublin with Tim Foster involved the biochemical and
  biophysical characterisation of staphylococcal fibrinogen-binding prote
 ins\, carrying out part of her thesis work in the laboratory of Magnus H
 öök (Texas A&M University). As a postdoctoral researcher at Trinity Coll
 ege Dublin\, Joan initiated early studies on the molecular basis of prot
 ein-mediated biofilm accumulation in S. aureus. In 2012 she established 
 her research group studying staphylococcal pathogenesis at Trinity Colle
 ge Dublin and in 2020 she was appointed to the Institute of Microbiology
  and Infection at the University of Birmingham. Joan’s current research 
 focuses on defining the bacterial factors that underlie the success of S
 . aureus as a human pathogen. She is interested in elucidating mechanism
 s used by the bacterium to interact with host proteins and cells and to 
 resist clearance by the immune system and interference from other microb
 es. A major aim of this work is to identify new targets for the treatmen
 t and prevention of bacterial infection. Joan was awarded the WH Pierce 
 Prize by the Society for Applied Microbiology in 2020.
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars,HealthGRP,Joint WMS/SLS 
 Micro
LAST-MODIFIED:20210226T131902Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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