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BEGIN:VEVENT
DTSTAMP:20260511T112736Z
DTSTART;VALUE=DATE-TIME:20210310T130000
DTEND;VALUE=DATE-TIME:20210310T140000
SUMMARY:BMS Divisional Webinar: Illuminating bacterial transcription mech
 anisms by watching single-molecule movies\, Professor Achilles Kapanidis
 \, University of Oxford
TZID:Europe/London
UID:20210310-8a1785d77540ff4601754a0dbc5820a8@warwick.ac.uk
CREATED:20201116T091511Z
DESCRIPTION:Abstract: Recording movies of single fluorescent biological m
 olecules while in action offers unprecedented direct access to biologica
 lly important heterogeneity and dynamics\; this holds true for reactions
  involving purified biochemical components\, as well as for reactions in
 side the complex biological milieu of living cells. During the past few 
 years\, we have developed and used such methods (single-molecule FRET\, 
 super-resolution imaging\, and single-particle tracking) to answer long-
 standing questions in bacterial transcription and DNA repair. Here\, I w
 ill discuss examples of our in vitro work focusing on the discovery and 
 sequence-dependence of pausing during initial transcription\, and the el
 ucidation of the intricate sequence of conformational changes that allow
  RNA polymerase to open promoter DNA for transcription initiation. I wil
 l also discuss examples of our in vivo single-molecule work inside livin
 g bacteria\, including the exploration of the relation between chromosom
 e organization and gene expression. Finally\, I will discuss how the sam
 e methods can be used to detect bacterial pathogens and their antibiotic
  resistance. Our methods and biological observations are general and sho
 uld apply to many other biological systems and organisms. Biography: Ach
 illes Kapanidis studied Chemistry at the Aristotelian Univ of Thessaloni
 ki (Greece) and completed his PhD in Biological Chemistry at Rutgers Uni
 v (USA). After holding research scientist positions in single-molecule b
 iophysics at Berkeley and UCLA\, he became a senior lecturer at Oxford U
 niv in 2005\, and a Professor of Biological Physics in 2013\; Prof Kapan
 idis has also been an ERC grant holder and is currently a Wellcome Trust
  Investigator. Prof Kapanidis is currently leading a group of physical a
 nd biological scientists (the “Gene Machines” group) which studies micro
 bial biological machinery in gene expression\, maintenance\, and regulat
 ion\, with a focus on gene transcription and DNA repair. The main tool o
 f the group is single-molecule fluorescence microscopy coupled with adva
 nced image and time-series analysis\; the past few years\, his group has
  also been working on rapid and ultrasensitive detection of antibiotic r
 esistance and pathogenic viruses\, including influenza and coronaviruses
 . Prof Kapanidis has also been pursuing miniaturized single-molecule ima
 ging\, a project that culminated in the formation of the Oxford Nanoimag
 ing spin-out\, and for which he has won the 2019 BBSRC Innovator of the 
 Year award.
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20201116T091511Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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