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BEGIN:VEVENT
DTSTAMP:20260510T050805Z
DTSTART;VALUE=DATE-TIME:20210721T130000
DTEND;VALUE=DATE-TIME:20210721T140000
SUMMARY:BMS Divisional Webinar: Recurrent miscarriage: concepts\, mechani
 sm of disease and new treatments\, Professor Jan Brosens\, Division of B
 iomedical Sciences\, ÌÇÐÄTV Medical School
TZID:Europe/London
UID:20210721-8a1785d77520fbbd01752268f3b20aa5@warwick.ac.uk
CREATED:20210716T132425Z
DESCRIPTION:Abstract: Human pregnancy is unusual as it involves genetical
 ly diverse embryos\, cyclical breakdown and regeneration of the uterine 
 mucosa (endometrium)\, and close integration of fetal and maternal cells
  at the uteroplacental interface. Not surprisingly\, pregnancy often fal
 ters in early gestation. This presentation describes the discovery of an
  implantation checkpoint designed to limit prolonged maternal investment
  in a failing pregnancy or low-fitness conceptus. Mechanistic studies\, 
 including culturing of human blastocysts in endometrial organoids/assemb
 loids\, demonstrate that implantation checkpoint failure presents the em
 bryo with an endometrium that is easy to invade but also vulnerable to b
 reakdown in early pregnancy. Further\, in contrast to the current clinic
 al paradigm\, implantation checkpoint failure provides a much more robus
 t explanation for the epidemiological characteristics of recurrent misca
 rriage. It also points towards a novel strategy for miscarriage preventi
 on\, first evaluated in a randomised placebo-controlled feasibility tria
 l at UHCW. Biography: Jan Brosens graduated from the KU Leuven\, Belgium
 \, in 1990 and pursued postgraduate training in Obstetrics and Gynaecolo
 gy in the United Kingdom. He became a Member of the Royal College of Obs
 tetricians and Gynaecologists in 1995 and a Fellow of the College in 200
 8. He obtained a Ph.D. from the University of London in 1999. He was awa
 rded a Wellcome Trust Clinical Scientist Fellowship in 1998. He joined I
 mperial College London\, first as Chair of Reproductive Sciences (2004) 
 and then as Chair of Reproductive Medicine (2008). In May 2011\, he was 
 appointed as Chair of Obstetrics and Gynaecology at the University of Wa
 rwick and Head of the Division of Reproductive Health. Currently\, Jan B
 rosens is a Wellcome Trust Investigator\, co-director of the Centre of E
 arly Life at the University of ÌÇÐÄTV\, and scientific director of Tomm
 y’s National Miscarriage Research Centre\, a partnership between Imperia
 l College London\, University of Birmingham\, University of ÌÇÐÄTV and 
 their affiliated national health service trusts.
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20210716T132425Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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