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BEGIN:VEVENT
DTSTAMP:20260513T234536Z
DTSTART;VALUE=DATE-TIME:20191114T103000
DTEND;VALUE=DATE-TIME:20191114T113000
SUMMARY:BMS Seminar: Zebrafish Bucky Ball and Drosophila Oskar: Unrelated
  Proteins with Functional Conservation during Germline Development\, Dr 
 Roland Dosch\, Göttingen Graduate Centre for Neurosciences\, Biophysics 
 and Molecular Biosciences
TZID:Europe/London
UID:20191114-8a1785d76dde7e71016df3c5f37869e4@warwick.ac.uk
CREATED:20191023T105054Z
DESCRIPTION:Abstract: Reproduction is a fundamental principle of biologic
 al systems\, which is not found in chemistry or physics. The reproductiv
 e cells or primordial germ cells (PGCs) of many animal species are speci
 fied by a Ribonucleo-protein (RNP) granule termed germ plasm. So far\, o
 nly two proteins are known to act as germ plasm organizers: Bucky ball (
 Buc) in zebrafish and Oskar (Osk) in Drosophila. Both proteins recapitul
 ate germ plasm activities but seem to be unique to their animal groups. 
 We discovered that Osk and Buc show conserved activities during germ cel
 l specification. Overexpression of DrosophilaOsk in zebrafish induces ad
 ditional PGCs. Surprisingly\, Osk and Buc do not show homologous protein
  motifs that would explain their related function. Nonetheless\, we dete
 ct that Osk and Buc contain long amino acid stretches of intrinsically d
 isordered regions (IDRs). These IDRs rapidly change their sequence durin
 g evolution and hence\, might obscure biochemical interaction motifs con
 served between Osk and Buc. Indeed\, we discover that Buc binds to the k
 nown Oskar interactors Vasa protein and nanosmRNA providing a molecular 
 mechanism for their related function. These results identify a conserved
  core-complex in the germ plasm controlled by two proteins with unrelate
 d sequence but similar activities. More importantly\, Osk and Buc might 
 represent a first example of a widespread phenomenon. Additional protein
 -pairs might exist in genome databases\, which are currently listed as n
 ovel or species-specific\, but with similar function across distant spec
 ies. 1994-1999 PhD\, Deutsches Krebsforschungszentrum (DKFZ)\, Heidelber
 g\, Germany 1999-2003 Postdoc University of Pennsylvania\, Philadelphia\
 , USA 2004-2010 Junior group leader\, University of Geneva\, Switzerland
  2010-2018 Group leader at the Inst. of Developmental Biochemistry\, Geo
 rg August University\, Göttingen since 2018 Group leader at the Inst. of
  Human Genetics\, University Medical Center\, Göttingen
LOCATION:BSR3\, ÌÇÐÄTV Medical School Atrium (first floor)
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20191023T105054Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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