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BEGIN:VEVENT
DTSTAMP:20260612T022539Z
DTSTART;VALUE=DATE-TIME:20181010T130000
DTEND;VALUE=DATE-TIME:20181010T140000
SUMMARY:BMS Seminar: Temporal regulation of genome replication\, Dr Conra
 d Nieduszynski\, Dunn School of Pathology\, University of Oxford
TZID:Europe/London
UID:20181010-8a1785d765e801f30165ed29ff8c62d1@warwick.ac.uk
CREATED:20181009T131600Z
DESCRIPTION:Abstract: Accurate and complete genome replication is essenti
 al for all life. A single DNA replication error in a single cell divisio
 n can give rise to genomic disorders\, including cancer. Our research ai
 ms to determine how cells faithfully complete genome replication before 
 cell division. DNA replication initiates at thousands of specific sites\
 , called DNA replication origins\, distributed throughout the genome. Fa
 ithful completion of genome replication requires sufficient\, appropriat
 ely distributed origins to be activated (‘fired’). We aim to discover ho
 w the cell regulates the ‘firing’ of these origins? I will present two u
 npublished stories from the lab. First\, in mammalian cells\, 3D genome 
 organisation is strongly predictive of replication timing. We have disru
 pted genome architecture\, via cohesin degradation\, and assessed the co
 nsequences for replication timing. In both asynchronous and synchronised
  cells we find that replication timing patterns do not depend upon intac
 t cohesin-mediated genome architecture. These surprising results suggest
  that cohesin-mediated genome architecture does not play a role in eithe
 r the establishment or maintenance of replication timing. Second\, we ha
 ve established single molecule methods for the study of DNA replication.
  Errors in DNA replication occur on single molecules in individual cells
 \; however these errors can be hidden from view in genomic approaches th
 at look at data from populations of several million cells. We have devel
 oped a sequencing method for the measurement of replication fork movemen
 t on single molecules. Using sequencing reads of 40-250 kb we have gener
 ate the first whole genome map of DNA replication dynamics at the single
 -molecule level. Our approach unmasks the heterogeneity of eukaryotic DN
 A replication - a critical step for investigating fork stalling and for 
 the genomic characterisation of mammalian replication initiation.
LOCATION:GLT3\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20181009T131600Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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