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BEGIN:VEVENT
DTSTAMP:20260507T081539Z
DTSTART;VALUE=DATE-TIME:20231017T131500
DTEND;VALUE=DATE-TIME:20231017T140000
SUMMARY:Host microbiome and disease seminar: Bacterial clade-specific ana
 lysis identifies distinct epithelial responses in inflammatory bowel dis
 ease\, Dr Edward Giles FRACP MBBS MRCPCH
TZID:Europe/London
UID:20231017-8a17841b8b14196e018b2941f1b41ac5@warwick.ac.uk
CREATED:20231013T133749Z
DESCRIPTION:Abstract: Abnormal immune responses to the resident gut micro
 biome can drive inflammatory bowel disease (IBD). We combined high-resol
 ution\, culture-based shotgun metagenomic sequencing and analysis with m
 atched host transcriptomics across three intestinal sites (terminal ileu
 m\, cecum\, rectum) from pediatric IBD patients and matched controls to 
 investigate this relationship. Combining our site-specific approach with
  bacterial culturing\, we establish a cohort-specific bacterial culture 
 collection\, comprising 6\,620 isolates (170 distinct species\, 32 putat
 ive novel)\, cultured from 286 mucosal biopsies. Phylogeny-based\, clade
 -specific metagenomic analysis identifies key\, functionally distinct En
 terococcus clades associated with either IBD or health. Strain-specific 
 in vitro validation demonstrates differences in cell cytotoxicity and in
 flammatory signaling in intestinal epithelial cells\, consistent with th
 e colonic mucosa-specific response measured in patients with IBD. This d
 emonstrates the importance of strain-specific phenotypes and considerati
 on of anatomical sites in exploring the dysregulated host-bacterial inte
 ractions in IBD. Biography: Ed Giles is a consultant paediatric gastroen
 terologist at Monash and the Royal Children’s Hospital in Melbourne and 
 lead for inflammatory bowel disease at Monash. Ed trained at the Univers
 ity of Melbourne and the Royal Children’s Hospital\, and several hospita
 ls in London. He received a PhD from the University of London in 2015. H
 e was a consultant at the Royal London Hospital and Barts Medical School
  until he returned to Melbourne in 2016. He is a research fellow at the 
 Hudson Institute of Medical Research and senior lecturer in the departme
 nt of paediatrics at Monash University. He has held a number of senior p
 ositions\, including past president of the Australasian Society of Paedi
 atric Gastroenterology\, Hepatology and Nutrition and foundation chair o
 f the Gastroenterological Society of Australia – Paediatric Network. His
  research interests are in host-microbiome interactions\, particularly i
 n IBD. He has projects developing novel biotherapeutics\, and collaborat
 ions in laboratory research for which he jointly holds several grants wo
 rth over AUD$9 million. He has published widely\, including in Science\,
  Science Translational Medicine and Nature Reviews Microbiology. He is a
 lso involved in clinical research and is PI on several industry clinical
  trials.
LOCATION:A039\, Medical School Building
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Microbiology and
  Infectious Disease seminar
LAST-MODIFIED:20231013T133749Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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