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BEGIN:VEVENT
DTSTAMP:20260507T022107Z
DTSTART;VALUE=DATE-TIME:20230808T160000
DTEND;VALUE=DATE-TIME:20230808T170000
SUMMARY:SLS and WMS Microbiology and Infectious Diseases Seminar: Bacteri
 al Cell Wall Architecture and Dynamics : A Matter of Life and Death\, Dr
  Simon Foster\, University of Sheffield
TZID:Europe/London
UID:20230808-8a17841b898c299e0189bf60eebe3321@warwick.ac.uk
CREATED:20230804T070908Z
DESCRIPTION:Abstract: The shape and integrity of bacteria are determined 
 by cell wall peptidoglycan\, a single macromolecule that surrounds the c
 ell. The synthesis of peptidoglycan is also the site of action of import
 ant antibiotics such as penicillin and vancomycin. Thus\, bacterial viab
 ility\, growth and division are dependent on the architecture and dynami
 cs of this essential polymer. We use a range of high-resolution microsco
 py approaches\, coupled with biochemical\, genetic and physiological app
 roaches to reveal peptidoglycan architecture\, and its dynamics\, using 
 the major human pathogen Staphylococcus aureus as our primary organism. 
 Atomic force microscopy has demonstrated a complex\, nanoscale peptidogl
 ycan architecture in diverse species\, which meets the challenges of mai
 ntaining viability and growth within their environmental niches\, by exp
 loiting the bioengineering versatility of the polymer. The application o
 f super-resolution fluorescence microscopy\, coupled with new chemical p
 robes has begun to reveal how the polymer is synthesized and hydrolysed 
 during growth and division. We have also used these approaches to determ
 ine the mode of action of antibiotics and molecular mechanisms of antimi
 crobial resistance. Followed by Pizza and Drinks Reception in the IBRB A
 trium.
LOCATION:IBRB Lecture Theatre
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Microbiology and
  Infectious Disease seminar
LAST-MODIFIED:20230804T070908Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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