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BEGIN:VEVENT
DTSTAMP:20260507T205635Z
DTSTART;VALUE=DATE-TIME:20230208T130000
DTEND;VALUE=DATE-TIME:20230208T140000
SUMMARY:BMS Seminar: Mechanobiology of cell fate choice\, Dr Kevin Chalut
 \, Cambridge Institute of Science
TZID:Europe/London
UID:20230208-8a17841b852b439c0185376e3665290f@warwick.ac.uk
CREATED:20230124T122925Z
DESCRIPTION:Abstract. The role of extracellular matrix (ECM) mechanics in
  cell fate choice and regeneration has been largely overlooked\; however
 \, ECM mechanics plays a significant role in building and maintaining ti
 ssue. My lab is investigating the interplay between mechanics and signal
 ing in cell fate transitions in stem cells\, and is beginning to apply s
 ome of what we have learned to whole tissue. I will show how cell surfac
 e mechanics in particular impacts cell signalling that is instructive fo
 r cell fate choice\, both in stem cells and development. I will also pre
 sent an outlook suggesting how the interplay between mechanics and signa
 ling has significant impact on regeneration\, and what tools and concept
 s will be important for investigating that interplay. Biography: Kevin C
 halut is a physical biologist with a PhD in Physics from Duke University
 . He was a group leader at the Wellcome Trust-MRC Cambridge Stem Cell In
 stitute at the University of Cambridge for 10 years\, and now leads a la
 b at Altos Labs. His lab has worked to understand how the mechanical env
 ironment and mechanical properties of cells affects stem cell fate choic
 es across the lifespan\, and how the mechanical environment can lead to 
 loss of function in stem cells. His work focuses on using the tools and 
 concepts of physics to study cell fate choice and regeneration both in c
 ells and tissues. His lab primarily investigates how external and intern
 al mechanical inputs regulate fate decisions\, and exactly how cells pro
 cess information during that fate choice. The ultimate goal of his labor
 atory is to apply their physics-based techniques to understand how organ
 isms develop and maintain tissues\, and how to use stem cells for therap
 eutic use in extending healthy lifespan. Our primary objective is to bri
 ng together physics\, engineering and biology to better understand cell 
 fate choices\, and how to control stem cells to enhance tissue function.
 
LOCATION:GLT1\, WMS and via MS Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20230124T122925Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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