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BEGIN:VEVENT
DTSTAMP:20260508T123616Z
DTSTART;VALUE=DATE-TIME:20221024T121500
DTEND;VALUE=DATE-TIME:20221024T131500
SUMMARY:BMS Special seminar: An integrated mechano-response mediated by A
 TR and ATM\, Professor Marco Foiani\, Professor of Molecular Biology\, D
 epartment of Oncology and Hematology-Oncology\, University of Milan
TZID:Europe/London
UID:20221024-8a17841b83cbb3fe0183ea8921d44bc0@warwick.ac.uk
CREATED:20221020T155022Z
DESCRIPTION:Abstract: ATM and ATR DNA damage response kinases contain ela
 stic domains. We previously showed that ATR also responds to nuclear mec
 hanical stress preventing nuclear envelope collapse and ruptures. We fou
 nd that also ATM is involved in the response to mechanical stress. Cytos
 keleton mediates ATM activation following cell deformation and ATM defic
 iency causes cell hyper-stiffness\, stress fiber accumulation and YAP nu
 clear enrichment. ATM locates to actin cytoskeleton and\, following cyto
 skeleton stress\, promotes recovery by modulating cytoskeleton and chrom
 atin. Our data contribute to explain some clinical features of A-T patie
 nts and pinpoint the existence of an integrated mechano-response in whic
 h ATM and ATR have distinct roles\, unrelated to their canonical DDR fun
 ctions. Biography: Professor Marco Foiani studied at the University of M
 ilan and moved to NIH-USA (1989-91) in the laboratory of dr. Alan Hinneb
 ush for his postdoctoral training. He continued his career at the Univer
 sity of Milan and\, since 2000 also at IFOM. Foiani has studied differen
 t cellular processes (translational\, chromosome replication\, DNA recom
 bination\, DNA repair\, DNA topology and nuclear envelope dynamics) and 
 regulatory pathways (translational control\, cell cycle\, checkpoint\, g
 ene gating) using a variety of approaches (biochemical\, genetic\, imagi
 ng\, genomic\, molecular biology). His major contributions are within th
 e fields of chromosome dynamics and genome integrity. His work has contr
 ibuted to elucidate the ATR and ATM-dependent checkpoint processes contr
 olling the interfaces between DNA replication\, recombination\, transcri
 ption and DNA topology and preventing abnormal chromosome transitions. I
 n recent years he has been studied the connections between cell metaboli
 sm and genome integrity pathways and between chromosome dynamics and mec
 hano-transduction circuits controlling cell and nuclear plasticity.
LOCATION:GLT2\, WMS
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20221020T155022Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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