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BEGIN:VEVENT
DTSTAMP:20260509T201446Z
DTSTART;VALUE=DATE-TIME:20220202T130000
DTEND;VALUE=DATE-TIME:20220202T140000
SUMMARY:BMS Seminar: Endometrial hypoxia and menstruation\, Dr Jacqueline
  Maybin\, Senior Clinical Research Fellow and Honorary Consultant Gynaec
 ologist\, MRC Centre for Reproductive Health at University of Edinburgh
TZID:Europe/London
UID:20220202-8a17841b7e6d30bd017e90e226cb0846@warwick.ac.uk
CREATED:20220126T100257Z
DESCRIPTION:Abstract: Heavy menstrual bleeding (HMB) is a common and debi
 litating symptom but menstruation remains a taboo subject. Hence\, it is
  rarely discussed\, under-researched and sub-optimally managed. Many cur
 rently available medical treatments fail due to hormonal side effects an
 d/or lack of effectiveness. We study endometrial physiology and patholog
 y during menstrual breakdown and repair with the aim of developing bette
 r treatments for those suffering with HMB. Over 80 years ago it was prop
 osed that progesterone withdrawal caused intense vasoconstriction and tr
 ansient endometrial hypoxia that resulted in menstruation. Subsequent re
 search confirmed that inflammation initiates menstruation and disputed t
 he presence and role of hypoxia in endometrial physiology. By studying h
 uman tissue and a mouse model of “simulated menstruation” we have shown 
 that hypoxia is present in the menstrual endometrium. We also revealed t
 hat hypoxia is not necessary for endometrial breakdown at menstruation b
 ut is essential for timely repair of the denuded endometrial surface to 
 limit menstrual blood loss. This seminar will detail our work on the pre
 sence and role of hypoxia and hypoxia inducible factor (HIF\, the master
  regulator of the cellular response to hypoxia) in the human endometrium
  using in vivo MRI techniques alongside ex vivo studies. In addition\, t
 he effects of pharmacological and genetic inhibition of hypoxia pathways
  in our mouse model of simulated menstruation will be described. Finally
 \, evidence will be presented proposing HIF-1 stabilisers as a potential
  non-hormonal therapeutic strategy for women with HMB. Biography: I am a
  Senior Clinical Research Fellow at the MRC Centre for Reproductive Heal
 th at the University of Edinburgh and an Honorary NHS Consultant in Gyna
 ecology at the Royal Infirmary of Edinburgh. I run a specialist menstrua
 l disorders service and offer medical treatments as well as surgical int
 erventions\, ranging from minimally invasive hysteroscopy and laparoscop
 y to open abdominal procedures. My research aims to develop better preve
 ntative and therapeutic strategies for abnormal uterine bleeding\, a com
 mon and debilitating complaint. Specifically\, I hold a Wellcome Trust C
 linical Career Development Fellowship to investigate the role of hypoxia
  in menstrual physiology and pathology with the aim of developing more e
 ffective\, acceptable treatments for heavy menstrual bleeding. I also ha
 ve funding from the Royal Society of Edinburgh to examine the potential 
 link between Long COVID and menstrual disturbance. I sit on the Editoria
 l Board of Reproduction\, Frontiers in Reproductive Health (Gynaecology)
  and Physiological Reviews and am a member of the RCOG Blair Bell commit
 tee. MS Teams link available here
LOCATION:tba
CATEGORIES:BiomedicalSciences,DivisionalSeminars,CSRL
LAST-MODIFIED:20220126T100257Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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