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BEGIN:VEVENT
DTSTAMP:20260509T201445Z
DTSTART;VALUE=DATE-TIME:20220323T130000
DTEND;VALUE=DATE-TIME:20220323T140000
SUMMARY:BMS Seminar: In toto analysis of myocyte fusion in the zebrafish 
 myotome reveals tissue scale processes regulating multinucleated skeleta
 l muscle formation\, Dr Timothy Saunders\, Division of Biomedical Scienc
 es\, WMS
TZID:Europe/London
UID:20220323-8a17841b7e6d30bd017e715f39c112be@warwick.ac.uk
CREATED:20220318T122737Z
DESCRIPTION:Abstract: Skeletal myogenesis is dynamic\, involving cell sha
 pe changes in concert with cell fusion and rearrangements. Yet\, the fin
 al muscle arrangement is highly robust with stereotypic pattern of stria
 ted fibres. Here\, we combined spatiotemporal live imaging with quantita
 tive analyses to dissect in toto fast-twitch myocyte fusion in zebrafish
  embryos. We found a strong mediolateral bias in fusion timing within ea
 ch somite. However\, at a cellular scale there was significant heterogen
 eity in cell shape at fusion and the relationship between initial positi
 on within the somite and fusion partner. We observed a close coordinatio
 n between slow muscle rearrangements and fast myocyte fusion. In mutants
  lacking slow fibres\, fusion is substantially noisier\, with reduced sp
 atiotemporal coordination. We propose a model where slow muscles ā€œguideā€
  fast myocytes by funnelling them closer together and thus enhancing fus
 ion rate. Finally\, we show that expression of myomaker \, which encodes
  a key fusogen\, is permissive but not instructive in determining where 
 and when fusion will occur. Our study establishes that cell fusion and r
 obust myotome formation depends on coordination between cell-specific fa
 ctors and interactions between different cell populations. Biography: Th
 ough originally trained as a theoretical physicist\, Dr Timothy Saunders
 \, Associate Professor\, now runs a developmental biology laboratory tha
 t focuses on deciphering the mechanisms by which organ shape emerges dur
 ing embryogenesis. His lab uses quantitative live imaging of Drosophila 
 and zebrafish combined with theoretical modelling to unravel how biochem
 ical and mechanical inputs drive organ morphogenesis. MS Teams link avai
 lable here
LOCATION:IBRB lecture theatre and via MS Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20220318T122737Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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