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BEGIN:VEVENT
DTSTAMP:20260512T014919Z
DTSTART;VALUE=DATE-TIME:20210204T123000
DTEND;VALUE=DATE-TIME:20210204T133000
SUMMARY:BMS Webinar: Chance of live birth – what is the importance of pre
 gnancy history and maternal age? Dr Astrid Marie Kolte\, Assistant Profe
 ssor\, University of Copenhagen
TZID:Europe/London
UID:20210204-8a17841b7715684b01774e93b0155bf5@warwick.ac.uk
CREATED:20210202T214151Z
DESCRIPTION:Background: Adverse prior pregnancy outcomes influences the c
 hance of live birth in the next pregnancy and increasing maternal age de
 creases chance of live birth. However\, no prior studies have taken each
  woman’s exact pregnancy history into account. Aims: 1) How does the seq
 uence of prior pregnancy events\, obstetric complications and maternal a
 ge affect chance of live birth in the next pregnancy\; 2) Are prior preg
 nancies predictive for the outcome? Materials and methods: Nationwide\, 
 registry-based cohort study of all women living in Denmark from 1977 to 
 2017 (n=1 285 230) with at least one pregnancy in either the Danish Medi
 cal Birth Registry or the Danish National Patient Registry (n= 2 722 441
  pregnancies). Data were analysed using logistic regression with a robus
 t covariance model to account for women with more than one pregnancy. Mo
 del discrimination and calibration were ascertained using 20% of the wom
 en in the cohort randomly selected as an internal validation set. Main r
 esults and the role of chance: Obstetric complications\, still birth\, e
 ctopic pregnancies and pregnancy losses had a negative effect on the cha
 nce of live birth in the next pregnancy. Consecutive\, identical pregnan
 cy outcomes (pregnancy losses\, live births or ectopic pregnancies) imme
 diately preceding the next pregnancy had a larger impact than the total 
 number of any outcome. Model discrimination was modest (C-index = 0.60\,
  positive predictive value = 0.45)\, but the models were well calibrated
 . Discussion: Prior pregnancy history has a significant impact on the ch
 ance of live birth in the next pregnancy. However\, the results emphasiz
 e that only taking age and number of losses into account does not predic
 t if a pregnancy will end as a live birth or not. A better understanding
  of biological determinants for pregnancy outcomes is urgently needed. F
 unding: The work was supported by the Novo Nordisk Foundation\, Ole Kirk
  Foundation and Rigshospitalet's Research Foundation. Biography: Dr Kolt
 e is a medical doctor from University of Copenhagen from 2009 and holds 
 a PhD from the same university from 2016. The title of the thesis was “R
 ecurrent Pregnancy Loss – a family affair | Studies of genetics\, epidem
 iology and evolution”. Since 2019 she has been an assistant professor at
  the Dept. Clinical Medicine\, University of Copenhagen. Currently\, she
  is an OBGYN resident at North Zealand Hospital. She has been involved i
 n research since the early 2000’s and she has worked extensively on diff
 erent aspects of pregnancy complications\, especially recurrent pregnanc
 y loss. She has published 32 peer-reviewed papers\, participated in the 
 ESHRE guideline on recurrent pregnancy loss from 2017 and have co-author
 ed several book chapters. Her scientific works include studies on evolut
 ion\, immunology\, mental health\, endocrinology and epidemiology.
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20210202T214151Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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