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BEGIN:VEVENT
DTSTAMP:20260511T053728Z
DTSTART;VALUE=DATE-TIME:20210127T130000
DTEND;VALUE=DATE-TIME:20210127T140000
SUMMARY:BMS Divisional Webinar: Shaping embryonic tissues during early ze
 brafish development\, Dr Michael Smutny\, Assistant Professor\, Division
  of Biomedical Sciences\, ÌÇÐÄTV Medical School
TZID:Europe/London
UID:20210127-8a17841b7520fbc001752249ea150d12@warwick.ac.uk
CREATED:20210122T125853Z
DESCRIPTION:Abstract: Multicellular organisms are shaped through coordina
 tion of cellular machines that generate cell movement and shape and gene
 s that establish cell identities during development. Understanding how c
 omplex tissues are formed and patterned in the embryo by mechanisms that
  connect gene regulation\, cellular effectors and tissue-scale mechanics
  in a 3D environment remains a significant challenge. To address this\, 
 we investigate mechanisms that control cell and tissue morphogenesis and
  cell fate specification in forming tissues during gastrulation of early
  zebrafish embryos. We currently focus on two highly dynamic neighbourin
 g germ layers in the embryo and show that mechanical signalling can occu
 r across tissue boundaries influencing behaviour of cells in the adjacen
 t tissue layer. Using a combination of live cell imaging\, biophysical t
 ools\, and computational modelling\, we explore mechanisms of force gene
 ration\, transduction and integration on tissue-scale that drive morphog
 enetic events such as cell rearrangements and pattering in the neural pl
 ate and mesendoderm collective cell migration. Linking these mechanical 
 events to processes on gene expression level will provide a multimodal d
 ataset that enables integrated analysis of interrelated mechanisms at pl
 ay to mediate formation of early embryonic tissues.
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20210122T125853Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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