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BEGIN:VEVENT
DTSTAMP:20260511T022235Z
DTSTART;VALUE=DATE-TIME:20210113T130000
DTEND;VALUE=DATE-TIME:20210113T140000
SUMMARY:BMS Divisional Webinar: Phage Ecology Informing Applied Developme
 nt\, Professor Martha Clokie\, Department of Genetics and Genome Biology
 \, University of Leicester
TZID:Europe/London
UID:20210113-8a17841b74f8c628017508d647371e81@warwick.ac.uk
CREATED:20210111T143440Z
DESCRIPTION:Abstract: My talk will cover how looking into the ecology of 
 dynamics between bacteriophages and bacteria can help us develop phages 
 for therapeutic application. In general there are two discreet communiti
 es of phage biologists\, those who isolate phages and try and use them t
 o treat plant\, animal and human diseases and those who try and understa
 nd the fundamental aspects of phage biology. My work is largely centred 
 in the middle of these extremes and I will share thoughts\, and insights
  from recent studies on how I think an ecological understanding of phage
 s may prevent us from ‘reinventing the wheel’\, each time we wish to tre
 at a different pathogen and allow us to identify commonalities between u
 nrelated phage groups. I will share recent data from my lab to support t
 hese ideas. Biography: I am a Professor of Microbiology at the Universit
 y of Leicester with 73 published papers on bacteriophages. I lead a grou
 p of 5 post-doctoral assistants and 5 PhD students working on different 
 aspects of the therapeutic development of phages that target human and a
 nimal pathogens. I have a good grounding in all aspects of phage therapy
  development – from unravelling fundamental biology to product developme
 nt\, and commercialisation. Three three patents have been filed from my 
 work. In brief these are: to protect a set of therapeutic Clostridium di
 fficile phages - granted in the US and Europe (Therapeutic Phages\; PCT/
 GB20 13759275.4\; and 14/423284)\; a Lyme disease phage-based diagnostic
  test (PCT/GB2017/053323)\, currently being commercially developed with 
 the R.E.D. laboratories\, a leading European diagnostic company\; and an
  animal Salmonella phage mix (Therapeutic Phages\; PCT/GB20 1815483.1). 
 I have edited four books on phages\, these have sold thousands of copies
  are the recognised authority on phage methods (and have also been trans
 lated to Chinese). I have consulted to many biotech companies. I am the 
 Editor in Chief for a newly to be launched journal PHAGE: therapy\, appl
 ications and research. I have been exposed to the practical use of phage
  in humans in Georgia and Russia and consulted with medical professional
 s to help design phage clinical trials to treat respiratory infections a
 nd diabetic foot ulcers respectively. Much of my work has focussed on de
 veloping phage products that target the anaerobic gut pathogen\, Clostri
 dium difficile. This led to a string of papers on the fundamental and ap
 plied aspects of the disease. I have a track record of translating funda
 mental science to applied settings evidenced by my work on Salmonella\, 
 that led to two recent three-year BBSRC (Biotechnology and Biological Sc
 iences Research Council) awards to design\, formulate and evaluate phage
  products for use in British and Thai livestock. I have had projects to 
 optimise phages production\, stability and spray drying. I worked with t
 he Department of Health and Wellcome Trust to inform debate and prioriti
 sation of alternative therapies to antibiotic/antimicrobial drugs (2016)
 \; served on FSA (Food Standards Agency) Committee to advise on phage re
 gulation in food (2016)\; Served on MRC funding committee for Antimicrob
 ial Resistance Cross-Council Initiative Theme 2 (2015/2016). My work has
  been the focus of recent phage documentaries on BBC world service and B
 loomsburg Press. I was also recently on BBC R4 Life Scientific (October 
 2019)\, a programme that showcases scientists and on iconic ‘Infinite Mo
 nkey Cage’\, a science comedy hosted by Brian Cox\, January 2018. I deve
 loped and regularly run a course to teach phage biology to African acade
 mics\, as part of a Gates funded ‘Phages for Global Health’ Yale-Leicest
 er collaboration. All of my applied work is routed in fundamental biolog
 y and my early phage research was focussed on understanding how ocean ba
 cteriophages controlled their marine bacterial hosts. My work paved the 
 way for a new research field which is still very much active\, that of d
 etermining complex ways that phages interact with their bacterial hosts.
 
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20210111T143440Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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