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BEGIN:VEVENT
DTSTAMP:20260513T015231Z
DTSTART;VALUE=DATE-TIME:20200205T130000
DTEND;VALUE=DATE-TIME:20200205T140000
SUMMARY:BMS Divisional Seminar by Professor Lawrence Young\, Dr Samuel De
 an\, Division of Biomedical Sciences\, ÌÇÐÄTV Medical School\, Universi
 ty of ÌÇÐÄTV
TZID:Europe/London
UID:20200205-8a17841b6f85aa19016fa3b46f625dee@warwick.ac.uk
CREATED:20200131T100849Z
DESCRIPTION:Professor Lawrence Young Dissecting the role of the tumour mi
 croenvironment in EBV-associated nasopharyngeal carcinoma Abstract: The 
 cancer mass represents a dynamic landscape where a heterogenous populati
 on of tumour cells interact with a variety of infiltrating host cells\, 
 extracellular matrix proteins and secreted factors. This tumour microenv
 ironment (TME) influences the development\, growth and spread of cancer 
 while also shaping therapeutic responses. Nasopharyngeal carcinoma (NPC)
  is an undifferentiated tumour with an extensive but ill-defined TME com
 prising infiltrating T cells\, NK cells\, macrophages and fibroblasts. T
 he precise role of the TME on the growth and invasiveness of NPC is unkn
 own but it is likely that these infiltrating cells provide an essential 
 support to the growth and survival of the tumour cells. The unique geogr
 aphic distribution of NPC in China and South-East Asia\, along with the 
 presence of latent Epstein-Barr virus (EBV) infection in every tumour ce
 ll\, provide insights into the aetiology of this particular malignancy. 
 The TME may support the maintenance of stable EBV infection in carcinoma
  cells and create an immune suppressive milieu that facilitates immune e
 vasion. Better definition of the TME in NPC and its relationship to EBV 
 infection will improve our understanding of NPC pathogenesis and support
  the development of novel therapeutic and preventative interventions. Dr
  Samuel Dean Flagellum composition and function in protozoan parasites A
 bstract - Trypanosomatids are microscopic vector-borne parasites that ca
 use wide-spread human and animal diseases. They currently infect ~17 mil
 lion people\, kill 80\,000 people annually and are a terrible agricultur
 al and economic burden upon developing counties. There is an urgent need
  for new therapies because no vaccines are available and existing drugs 
 are often ineffective and toxic. Central to their ability to spread and 
 cause disease is a protrusion of the surface called the flagellum. The f
 lagellum is essential for parasite movement and host-parasite interactio
 n\, and flagellum function is required for parasite virulence and transm
 ission. Flagella have three distinct domains defined by the arrangement 
 of their microtubules: the basal body that is embedded in the cytoplasm\
 , the axoneme that protrudes from the cell body\, and the transition zon
 e (TZ) that links the two. The axonemes of most motile flagella contain 
 a central pair (CP) of microtubules that extend from the TZ and are esse
 ntial for flagellum beating\; defects in the CP cause the human patholog
 ies hydrocephalus and primary ciliary dyskinesia. Further\, in recent ye
 ars the TZ has emerged as central to flagellum function and it is the lo
 cation of many of the proteins and complexes that are implicated in a cl
 ass of human genetic diseases called ‘ciliopathies’. My research has use
 d a novel proteomics method specifically designed to isolate insoluble c
 ytoskeletal structures for proteomics analysis. Using this methodology\,
  I determined the composition of the trypanosome TZ and discovered that 
 two of its proteins act as CP nucleating factors. My lab will focus on a
 ddressing the following questions: 1) How do trypanosome TZ proteins nuc
 leate the CP microtubules? 2) What is the role of the TZ in other flagel
 lum functions? 3) What is the role of the metazoan orthologs of trypanos
 ome TZ proteins in ciliary function and human disease?
LOCATION:GLT2\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20200131T100849Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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