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BEGIN:VEVENT
DTSTAMP:20260610T012045Z
DTSTART;VALUE=DATE-TIME:20190708T120000
DTEND;VALUE=DATE-TIME:20190708T130000
SUMMARY:WMS/SLS Micro Seminar: Targeting Host Immuno-Metabolic Circuits t
 o Design Host-Directed Therapies for TB\, Dr Amit Singhal\, Agency for S
 cience\, Technology and Research A*STAR\, Singapore
TZID:Europe/London
UID:20190708-8a17841b6b2d9d3c016b46088b2255b8@warwick.ac.uk
CREATED:20190702T075912Z
DESCRIPTION:Abstract: An effective host immune response is important to c
 ontrol Mycobacterium tuberculosis (Mtb) insult\, and to contain its late
 nt persistence. A new paradigm in TB treatment\, host-direct therapy (HD
 T)\, uses adjunctive drugs to harness intrinsic antimicrobial and immuno
 regulatory mechanisms for better treatment outcomes. Using chemical gene
 tics approach we have demonstrated that activating AMP-activated protein
  kinase (AMPK) and Sirtuin 1 (SIRT1)\, regulators of whole-body energy m
 etabolism\, by FDA approved drugs / supplements could control inflammati
 on and Mtb infection. This indicates a deep engagement of Mtb pathogenic
 ity with host’s immuno-metabolic machinery. We hypothesize that the func
 tional connections between immunity and pathways controlling metabolic s
 ignaling could be harnessed to advance the HDT pipeline\, leading to the
  development of clinically relevant anti-tuberculosis arsenal. We are ut
 ilizing preclinical and clinical models to further understand the molecu
 lar and cellular mechanisms of AMPK and SIRT1 activators. The data relat
 ed to this effort will be presented and discussed Biography: Dr. Amit Si
 nghal began his career in the field of infectious disease immunology as 
 a PhD fellow at All India institute of Medical Sciences\, New Delhi\, In
 dia. After doing postdoctoral stints at Institute Pasteur\, Brussels and
  Novartis Institute for Tropical Disease\, Singapore he joined Singapore
  Immunology Network in 2011 and started his independent group in 2014. H
 e is applying various basic and advanced omics approaches to understand 
 the mechanisms utilized by bacteria for evading host’s immuno-metabolic 
 signalling. The information gained from these experiments is being curre
 ntly exploited for designing clinically relevant host-directed therapies
 .
LOCATION:MBU (A151)\, Medical School Building
CATEGORIES:BiomedicalSciences,BMS_MI,Joint WMS/SLS Micro
LAST-MODIFIED:20190702T075912Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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