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BEGIN:VEVENT
DTSTAMP:20260513T233631Z
DTSTART;VALUE=DATE-TIME:20190617T130000
DTEND;VALUE=DATE-TIME:20190617T140000
SUMMARY:CDB seminar: Mechanogenetics: Mechanobiology of membrane: from en
 docytosis to mechanosensitive\, Dr Allen Liu\, University of Michigan
TZID:Europe/London
UID:20190617-8a17841b6b2d9d3c016b45d2dca2546a@warwick.ac.uk
CREATED:20190617T092539Z
DESCRIPTION:Abstract: Biological membranes are involved in a large number
  of cellular processes including cell migration\, membrane trafficking\,
  and cell signaling. Significant amount of work have elucidated the mole
 cular machineries that regulate dynamic membrane-based processes. In par
 allel\, there are growing interests in recent years in trying to underst
 and how mechanical state of the cells are utilized as a regulatory input
  to control cellular processes. My lab is interested in studying the mec
 hanochemical responses of biological systems. In this talk\, I will pres
 ent two directions related to this theme. On the cellular level\, we hav
 e reconstituted the function of a bacterial mechanosensitive channel Msc
 L in mammalian cells. Using this system\, we investigated the role of ac
 tin cytoskeleton in mediating local membrane tension that activates MscL
 \, and whether MscL expression might influence 3D confined migration\, d
 uring which cells experience significant stress. On the synthetic level\
 , we are building artificial systems that can sense mechanical input and
  transduce a biochemical response. To this end\, we are attempting to bu
 ild artificial platelets that mimic the functionalities of natural plate
 lets. I will discuss several modular platforms that we have developed th
 at together will integrate into functional artificial cells. I term this
  ‘mechanogenetics’ – analogous to optogenetics\, where light is used to 
 control cells expressing light-sensitive ion channels – a new biological
  technique that may have broad applications in cell and synthetic biolog
 y. Biography: Allen Liu received a B.Sc. degree in Biochemistry (Honors)
  from the University of British Columbia\, Vancouver\, Canada\, in 2001.
  He obtained his Ph.D. in Biophysics in 2007 from the University of Cali
 fornia-Berkeley and received his post-doctoral training at The Scripps R
 esearch Institute-La Jolla. He started his group in 2012\, and he is cur
 rently an Associate Professor in the Department of Mechanical Engineerin
 g and Biomedical Engineering at the University of Michigan. His current 
 research interests lie in cellular mechanotransduction and uses tools fr
 om systems biology\, synthetic biology\, biophysics\, and microfluidics.
  He is a recipient of the NIH Director’s New Innovator Award\, a Young I
 nnovator by Cellular and Molecular Bioengineering (CMBE)\, a Rising Star
  from CMBE-BMES\, and Future of Biophysics Burroughs Wellcome Fund Sympo
 sium speaker. He is a recipient of the Endeavour Executive Fellowship (A
 ustralia) and the Alexander von Humboldt Fellowship for Experienced Rese
 archer (Germany).
LOCATION:MBU (A151)\, Medical School Building
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_CDB
LAST-MODIFIED:20190617T092539Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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