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BEGIN:VEVENT
DTSTAMP:20260611T073927Z
DTSTART;VALUE=DATE-TIME:20190528T130000
DTEND;VALUE=DATE-TIME:20190528T140000
SUMMARY:SLS/WMS Dev Biol and Stem Cell Seminar Series: Professor Enrique 
 Amaya\, Division of Cell Matrix Biology and Regenerative Medicine\, Univ
 ersity of Manchester
TZID:Europe/London
UID:20190528-8a17841b6abc34ad016ac4bffc171415@warwick.ac.uk
CREATED:20190517T074529Z
DESCRIPTION:Seminar: A conserved role for reactive oxygen species during 
 early embryonic development and appendage regeneration Abstract: Enrique
 ’s team are investigating the molecular & cellular mechanisms responsibl
 e for scar free wound healing & tissue regeneration in frog embryos & ta
 dpoles. They have shown that tadpole tail amputation induces a sustained
  production of reactive oxygen species (ROS)\, which is necessary for ta
 il regeneration. When ROS production following tail amputation is inhibi
 ted\, both cell proliferation & growth factor signaling fail to occur no
 rmally. Intriguingly\, the team have found that fertilization also induc
 es a dramatic increase in ROS production\, which is also sustained throu
 ghout early embryogenesis. Indeed\, if they inhibit or attenuate ROS pro
 duction following fertilization\, cell cycle progression & growth factor
  signaling are also inhibited or attenuated\, respectively. Thus\, they 
 have found many remarkable parallels in the induction\, maintenance & ro
 les for ROS during tissue regeneration and those following fertilization
  & during embryogenesis. Indeed\, both injury & fertilization seem to se
 t in motion a similar series of events\, & as such\, they have begun to 
 think of fertilization as an injury\, which induces development\, in muc
 h the same way that injury induces a regenerative response in post-embry
 onic stages. Thus\, Enrique postulates that a successful regenerative re
 sponse is dependent on a return to an embryonic-like state of cellular o
 xidation\, which facilitates cell cycle progression & growth factor sign
 aling.
LOCATION:GLT3\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_STEM
LAST-MODIFIED:20190517T074529Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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