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BEGIN:VEVENT
DTSTAMP:20260610T084624Z
DTSTART;VALUE=DATE-TIME:20190213T130000
DTEND;VALUE=DATE-TIME:20190213T140000
SUMMARY:BMS Seminar: Immune recognition of the cell wall of a pathogenic 
 fungus\, Professor Neil Gow FRS\, Deputy Vice-Chancellor (Research and I
 mpact)\, University of Exeter
TZID:Europe/London
UID:20190213-8a17841b663f9e45016643875302249c@warwick.ac.uk
CREATED:20190213T094914Z
DESCRIPTION:Abstract: Immune surveillance and defence mechanisms is based
  on the recognition of a suite of molecules in the cell wall that are re
 cognised by pattern recognition receptors of the innate immune system. D
 ifferences in the cell wall composition of different fungi and or the sa
 me fungus organisms growing in different morphologies and in differing e
 nvironments generates a moving target for immune recognition. We have us
 ed a variety of microscopic\, genetic and immunological tools to generat
 e a new spatially accurate model of the cell wall and to explore how dyn
 amic changes in the wall influence immune surveillance. We show that imm
 une relevant epitopes can be diffuse or clustered\, superficial or burie
 d in the cell wall and they changed during batch culture and between yea
 st\, hypha and other cellular morphologies. The immune reactivity of dif
 ferent fungal cell surfaces was not necessarily related to the phylogene
 tic relationship between organisms\, or the relative virulence of differ
 ent strains. These experiments demonstrate that the fungal cell surface 
 is ordered\, complex and dynamically changing\, making immune recognitio
 n a challenging process requiring the concerted action of multiple recep
 tors operating singly and in combination.
LOCATION:MTC Lecture Theatre\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20190213T094914Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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