BEGIN:VCALENDAR
PRODID:-//SiteBuilder 2//University of ÌÇÐÄTV ITS Web Team//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-TIMEZONE:Europe/London
X-LIC-LOCATION:Europe/London
BEGIN:VTIMEZONE
TZID:Europe/London
LAST-MODIFIED:20201010T011803Z
TZURL:http://tzurl.org/zoneinfo/Europe/London
X-LIC-LOCATION:Europe/London
X-PROLEPTIC-TZNAME:LMT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+000115
TZOFFSETTO:+0000
DTSTART:18471201T000000
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19160521T020000
RDATE:19170408T020000
RDATE:19180324T020000
RDATE:19190330T020000
RDATE:19200328T020000
RDATE:19210403T020000
RDATE:19220326T020000
RDATE:19230422T020000
RDATE:19240413T020000
RDATE:19270410T020000
RDATE:19300413T020000
RDATE:19330409T020000
RDATE:19340422T020000
RDATE:19350414T020000
RDATE:19380410T020000
RDATE:19390416T020000
RDATE:19400225T020000
RDATE:19460414T020000
RDATE:19470316T020000
RDATE:19480314T020000
RDATE:19490403T020000
RDATE:19530419T020000
RDATE:19540411T020000
RDATE:19570414T020000
RDATE:19600410T020000
RDATE:19680218T020000
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19161001T030000
RDATE:19170917T030000
RDATE:19180930T030000
RDATE:19190929T030000
RDATE:19201025T030000
RDATE:19211003T030000
RDATE:19221008T030000
RDATE:19391119T030000
RDATE:19471102T030000
RDATE:19481031T030000
RDATE:19491030T030000
RDATE:19711031T030000
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19230916T030000
RRULE:FREQ=YEARLY;UNTIL=19240921T020000Z;BYMONTH=9;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19250419T020000
RRULE:FREQ=YEARLY;UNTIL=19260418T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19251004T030000
RRULE:FREQ=YEARLY;UNTIL=19381002T020000Z;BYMONTH=10;BYMONTHDAY=2,3,4,5,6,
 7,8;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19280422T020000
RRULE:FREQ=YEARLY;UNTIL=19290421T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19310419T020000
RRULE:FREQ=YEARLY;UNTIL=19320417T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19360419T020000
RRULE:FREQ=YEARLY;UNTIL=19370418T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BDST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19410504T020000
RDATE:19450402T020000
RDATE:19470413T020000
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19410810T030000
RRULE:FREQ=YEARLY;UNTIL=19430815T010000Z;BYMONTH=8;BYMONTHDAY=9,10,11,12,
 13,14,15;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BDST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19420405T020000
RRULE:FREQ=YEARLY;UNTIL=19440402T010000Z;BYMONTH=4;BYMONTHDAY=2,3,4,5,6,7
 ,8;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19440917T030000
RDATE:19450715T030000
RDATE:19470810T030000
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19451007T030000
RRULE:FREQ=YEARLY;UNTIL=19461006T020000Z;BYMONTH=10;BYMONTHDAY=2,3,4,5,6,
 7,8;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19500416T020000
RRULE:FREQ=YEARLY;UNTIL=19520420T020000Z;BYMONTH=4;BYMONTHDAY=14,15,16,17
 ,18,19,20;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19501022T030000
RRULE:FREQ=YEARLY;UNTIL=19521026T020000Z;BYMONTH=10;BYMONTHDAY=21,22,23,2
 4,25,26,27;BYDAY=SU
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19531004T030000
RRULE:FREQ=YEARLY;UNTIL=19601002T020000Z;BYMONTH=10;BYMONTHDAY=2,3,4,5,6,
 7,8;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19550417T020000
RRULE:FREQ=YEARLY;UNTIL=19560422T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19580420T020000
RRULE:FREQ=YEARLY;UNTIL=19590419T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19610326T020000
RRULE:FREQ=YEARLY;UNTIL=19630331T020000Z;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19611029T030000
RRULE:FREQ=YEARLY;UNTIL=19671029T020000Z;BYMONTH=10;BYMONTHDAY=23,24,25,2
 6,27,28,29;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19640322T020000
RRULE:FREQ=YEARLY;UNTIL=19670319T020000Z;BYMONTH=3;BYMONTHDAY=19,20,21,22
 ,23,24,25;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:BST
TZOFFSETFROM:+0100
TZOFFSETTO:+0100
DTSTART:19681026T230000
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19720319T020000
RRULE:FREQ=YEARLY;UNTIL=19800316T020000Z;BYMONTH=3;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19721029T030000
RRULE:FREQ=YEARLY;UNTIL=19801026T020000Z;BYMONTH=10;BYMONTHDAY=23,24,25,2
 6,27,28,29;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19810329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19811025T020000
RRULE:FREQ=YEARLY;UNTIL=19891029T010000Z;BYMONTH=10;BYMONTHDAY=23,24,25,2
 6,27,28,29;BYDAY=SU
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19901028T020000
RRULE:FREQ=YEARLY;UNTIL=19951022T010000Z;BYMONTH=10;BYDAY=4SU
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
DTSTART:19960101T000000
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19961027T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260611T224106Z
DTSTART;VALUE=DATE-TIME:20190219T120000
DTEND;VALUE=DATE-TIME:20190219T130000
SUMMARY:WMS-SLS Micro Seminar: Epigenetic regulation of differentiation-d
 ependent HPV gene expression\, Dr Jo Parish\, Institute of Cancer and Ge
 nomic Sciences\, College of Medical & Dental Sciences\, University of Bi
 rmingham
TZID:Europe/London
UID:20190219-8a17841b65e801fc01660b141c363e9c@warwick.ac.uk
CREATED:20190213T153104Z
DESCRIPTION:Abstract: Oncogenic human papillomavirus (HPV) infection caus
 es cancers of the anogenital and oropharyngeal tracts. HPV targets the u
 ndifferentiated basal cells of the epithelium at these body sites and us
 es the cellular DNA replication machinery to support virus replication. 
 Viral gene expression in undifferentiated basal cells is attenuated\, pr
 esumably as part of an immune evasion strategy to ensure persistence of 
 infection. In normal\, uninfected epithelia upwards cellular migration i
 nduces differentiation and cell cycle exit. However\, in HPV-infected ce
 lls\, differentiation results in increased transcription of the viral on
 cogenes\, E6 and E7\, to prevent cell cycle exit and support amplificati
 on of the viral DNA. Using a physiological organotypic model of the comp
 lex HPV18 life cycle\, we have shown that the cellular transcriptional r
 egulators CTCF and YY1 are recruited to the HPV genome to coordinate the
  formation of an epigenetically repressed chromatin loop between the vir
 al transcriptional enhancer and the early gene region to attenuate early
  gene expression in undifferentiated cells. Cellular differentiation res
 ults in reduced YY1 protein expression and loss of recruitment to the vi
 ral genome causing loss of chromatin loop formation\, epigenetic de-repr
 ession of the viral genome\, and enhanced viral early gene expression. T
 he strict control of HPV gene expression combined with manipulation of t
 he host cell environment is vital for persistence of infection and compl
 etion of the virus life cycle. Disruption of HPV transcriptional control
  is also a key step in the development of cancer and we aim to determine
  the molecular basis for aberrant HPV oncogene expression and identify k
 ey events that drive carcinogenesis.
LOCATION:MBU (A151)\, Medical School Building\, Gibbet Hill Campus\, Univ
 ersity of ÌÇÐÄTV
CATEGORIES:BiomedicalSciences,HealthGRP,GRPEvents,BMS_MI,Joint WMS/SLS Mi
 cro
LAST-MODIFIED:20190213T153104Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
END:VCALENDAR