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BEGIN:VEVENT
DTSTAMP:20260614T001600Z
DTSTART;VALUE=DATE-TIME:20180131T130000
DTEND;VALUE=DATE-TIME:20180131T140000
SUMMARY:Seminar by Professor Paul Thornalley and Dr Chrystala Constantini
 dou\, Division of Biomedical Sciences\, ÌÇÐÄTV Medical School
TZID:Europe/London
UID:20180131-8a17841b5e514981015e5bd11dcd65a0@warwick.ac.uk
CREATED:20170907T100944Z
DESCRIPTION:When the sweet turns nasty! Prerequisites\, mechanisms and ne
 w therapeutics for chronic vascular complications of diabetes Chronic va
 scular complications are the major cause of morbidity and premature mort
 ality in the diabetic patient population. These are: microvascular compl
 ications – nephropathy\, retinopathy and neuropathy\; and macrovascular 
 complications - coronary artery disease\, peripheral arterial disease an
 d stroke. Current treatment is ineffective and new options are limited. 
 For example\, on-treatment mortality of diabetic patients with nephropat
 hy is higher than for cancer and the last clinical trials leading to lic
 ensed new drugs for diabetic nephropathy reported 17 years ago. Dysregul
 ation and misuse of glucose in peripheral sites in hyperglycemia drives 
 the development of diabetic vascular complications. The seminar will add
 ress recent advances that have identified the key prerequisites for cell
  and tissue vulnerability to the chronic damaging effects of hyperglycem
 ia\, the mechanisms involved and a new approach to therapy in clinical e
 valuation – Glyoxalase 1 inducers. Flagella assembly and regulation in p
 olar bacteria Flagella are complex structures formed by up to 100 differ
 ent proteins. The assembly of the proteins follows a specific order\, be
 ginning from the inner end of the construction (cytoplasm and inner memb
 rane) and finishing at the outer end of the organelle outside the bacter
 ium. Flagella-gene expression is mediated in a hierarchical manner. Addi
 ng to the complexity are the diverse patterns and numbers of flagella di
 fferent bacterial species possess. For pathogenic bacteria such as Campy
 lobacter jejuni\, flagellar motility and chemotaxis play key roles in in
 testinal colonisation\, invasion of epithelial cells\, biofilm formation
  and protein secretion. A number of genes of unknown function have been 
 identified as crucial for the correct assembly of the flagellar structur
 es in C. jejuni and other polar bacteria. Studies on one such gene\, flh
 F\, have provided us with novel insights into the regulation of flagella
 r biogenesis.
LOCATION:MTC Lecture Theatre\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20180131T090700Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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