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BEGIN:VEVENT
DTSTAMP:20260613T044945Z
DTSTART;VALUE=DATE-TIME:20180214T130000
DTEND;VALUE=DATE-TIME:20180214T140000
SUMMARY:Seminar: Mapping the distribution of synapses along dendritic tre
 es by Professor Juan Burrone\, Professor of Development Neurophysiology\
 , Department of Developmental Neurobiology\, King's College London
TZID:Europe/London
UID:20180214-8a17841b5e514981015e57be44953c91@warwick.ac.uk
CREATED:20170906T151040Z
DESCRIPTION:Abstract: Neurons in the brain have extensive dendritic arbou
 rs that receive both excitatory and inhibitory inputs all along it. The 
 transformation of all these inputs to an output in a single neuron occur
 s through the integration of synaptic events and the generation of an ac
 tion potential (or spike) at the axon. The contribution that a single sy
 napse makes to spike output will vary according to its strength and its 
 location on a neuronal arbour. Describing how synapses are distributed a
 cross a neuron is therefore crucial for understanding how neurons integr
 ate their synaptic inputs and how they function within a circuit. Provid
 ing such a description is a formidable challenge however- a single pyram
 idal neuron in the mammalian hippocampus\, for example\, can receive ten
 s of thousands of excitatory and inhibitory inputs. Here\, we employ mul
 tiple techniques (electrophysiology\, serial block face scanning electro
 n microscopy\, single and multi-photon microscopy) to begin to map the s
 tructure and function of synaptic inputs along the dendrites of pyramida
 l neurons in area CA1 of the hippocampus. We find that both the presynap
 tic and postsynaptic compartments of excitatory synapses are distributed
  in a distance-dependent manner along the basal dendrites of pyramidal c
 ells. This distribution has important consequences for how neurons integ
 rate inputs that arrive at different dendritic locations. In addition\, 
 we are now also employing new approaches to establish how GABAergic inhi
 bitory inputs are distributed along these same dendrites. Despite the fa
 ct that they are fewer in number\, GABAergic inhibition plays a central 
 role in shaping dendritic integration and neuronal output. Indeed\, the 
 balance between the overall levels of excitation and inhibition received
  by a given neuron in the cortex is tightly controlled\, a feature that 
 is thought to be crucial in maintaining the stability of cortical networ
 ks. We present data suggesting that the balance between excitation and i
 nhibition may extend to subcellular compartments\, allowing dendrites to
  integrate inputs locally and stably.
LOCATION:MTC\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20180124T151849Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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