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BEGIN:VEVENT
DTSTAMP:20260614T013826Z
DTSTART;VALUE=DATE-TIME:20180117T130000
DTEND;VALUE=DATE-TIME:20180117T140000
SUMMARY:Seminar: The evolution of Enterohaemorrhagic Escherichia coli O15
 7: super-shedding from cattle and predicting the relative threat to huma
 n health\, Professor David Gally\, Professor of Microbial Genetics\, Ros
 lin Institute\, University of Edinburgh
TZID:Europe/London
UID:20180117-8a17841b5e514981015e57bd36f23c8a@warwick.ac.uk
CREATED:20170906T150931Z
DESCRIPTION:Abstract: My group studies the colonization of cattle by ente
 rohaemorrhagic Escherichia coli (EHEC) O157 strains and aims to understa
 nd the genetic factors that lead to effective transmission between anima
 ls and infection in humans. Specifically\, our recent work has applied w
 hole genome sequencing to define the subset of animal strains that are a
  zoonotic threat to human health. By analyzing the genome content of bot
 h human and cattle strains we aim to predict the strains more likely to 
 cause serious human disease and ongoing work is using machine-learning m
 ethods to acheive this. Variation and evolution of Shiga toxin (Stx)-enc
 oding bacteriophages are a primary research area coupled to how the prop
 hage state contributes to the overall biology of E. coli O157 in cattle 
 and humans\; this includes both their genetic payload\, including sRNAs\
 , and how their homologous sequences contribute to genome plasticity. Th
 e work is in partnership with researchers at the Universities of Glasgow
  and Edinburgh\; the Scottish E. coli Reference Laboratory (SERL)\; the 
 Moredun Research Institute (MRI)\; Scotlandā€™s Rural College (SRUC)\; Hea
 lth Protection Scotland (HPS)\; Public Health England (PHE) and the USDA
 . Biography: I hold a personal chair in Microbial Genetics at the Univer
 sity of Edinburgh and have been part of the Roslin Institute since 2011.
  I lead a BBSRC Institute Strategic Programme on the ā€˜Control of Infecti
 ous Diseasesā€™ in Livestock (2017-2022) at the Roslin Institute. My backg
 round is in Microbiology\, initially bacterial physiology for my PhD and
  first Post Doctoral position at the University of Michigan (cell wall a
 ssembly) but I then moved into gene regulation during a second Post Doct
 oral post in North Carolina and then returned to the UK supported by an 
 MRC Career Development Fellowship which was focused on the regulation of
  fimbrial adhesins in E. coli. I obtained a Lectureship in Bacteriology 
 at Edinburgh Vet School in 1998 which soon led to a DEFRA Veterinary Fel
 lowship on the biology of enterohaemorrhagic E. coli (EHEC) which has re
 mained the main research focus of my group for nearly twenty years.
LOCATION:MTC\, ĢĒŠÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20180105T103304Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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