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BEGIN:VEVENT
DTSTAMP:20260506T213042Z
DTSTART;VALUE=DATE-TIME:20231003T120000
DTEND;VALUE=DATE-TIME:20231003T130000
SUMMARY:SLS and WMS Microbiology and Infectious Diseases Seminar: Simulta
 neous Growth and Sporulation Patterns Bacterial Biofilm Development\, Pr
 ofessor Joe Larkin\, Boston University
TZID:Europe/London
UID:20231003-8a17841a8a655fa0018a73f4c8214e56@warwick.ac.uk
CREATED:20230908T084216Z
DESCRIPTION:Abstract: When nutrients run out\, many bacteria form dormant
  spores that stop growth but can tolerate harsh environments. This starv
 ation response has often been interpreted as a bet hedging strategy in c
 ase conditions improve much later. However\, spores also contain a memor
 y of the conditions under which they sporulated. Spores formed in extrem
 ely nutrient poor environments may not germinate efficiently\, suggestin
 g that generating spores during periods of nutrient richness could actua
 lly be a beneficial strategy. One way to achieve this could be to form s
 pores in biofilms\, where high cell density can accelerate sporulation t
 hrough cell-to-cell quorum sensing signals. The soil bacterium Bacillus 
 subtilis is a model organism for both sporulation and biofilm formation\
 , but our understanding of spore formation in biofilms has been hindered
  by the fact few experiments have used strains proficient in both phenot
 ypes. Using wild strains lacking lab domestication mutations\, we find t
 hat in biofilm conditions\, sporulation can progress rapidly\, creating 
 colonies with high spore counts even early in growth. By integrating sep
 arate fluorescent reporters for vegetative cells and spores\, we find th
 at developing biofilms generate a distinctive pattern: an expanding ring
  of vegetative cells surrounds a spore-rich core. We compare time-lapse 
 data to predictions of a reaction-diffusion model of biofilm growth to s
 how that nutrient conditions and the timing of cell differentiation netw
 orks combine to pattern spores and cells during biofilm development\, cr
 eating a rich source of spores from nutritious conditions.
LOCATION:MRI\, SLS
URL:
ATTACH:
CATEGORIES:BiomedicalSciences,SLS/WMS Microbiology and Infectious Disease
  seminar
LAST-MODIFIED:20230908T084216Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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