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BEGIN:VEVENT
DTSTAMP:20260507T163322Z
DTSTART;VALUE=DATE-TIME:20230510T131500
DTEND;VALUE=DATE-TIME:20230510T141500
SUMMARY:BMS Seminar: Preparing for a fresh start: Embryonic development o
 f the human germline\, Dr Wolfrum Gruhn\, Gurdon Institute\, University 
 of Cambridge
TZID:Europe/London
UID:20230510-8a17841a87bcdd590187dbe763b84980@warwick.ac.uk
CREATED:20230502T095947Z
DESCRIPTION:Abstract: Development of the germline is an integral part of 
 the animal life cycle\, culminating in the formation of gametes\, which 
 allow the transfer of genetic and epigenetic information to the next gen
 eration. In mammals\, the germline segregates from the somatic cell lina
 ges in early embryonic development and commences a process of epigenetic
  remodelling that paves the way for gametogenesis and embryonic developm
 ent in the following life cycle. Understanding human germline developmen
 t holds the key for improving treatments for infertility or germ cell ca
 ncer and will help to answer how environmental factors may influence epi
 genetic information transferred to the next generation. Here\, he will d
 iscuss our recent work analysing epigenetic changes during the establish
 ment and development of the human germline. Using a recently established
  stem cell model recapitulating linage segregation in the human embryo\,
  we find that morphogen-induced enhancer remodelling defines a window of
  opportunity for germline specification during gastrulation. Here\, the 
 combinatorial function of mesendoderm transcription factors and BMP-SMAD
  signalling activates a transcription factor circuitry establishing the 
 germ cell identity. Analysing epigenetic remodelling in first trimester 
 human embryonic germ cells\, we find a profound reduction of repressive 
 epigenetic marks at most somatic genes and transposable elements (TEs) w
 ithout transcriptional activation. Efficient maintenance of a heterochro
 matic state is limited to a subset of genomic loci\, such as evolutionar
 ily young TEs and some developmental genes. Accordingly\, transcriptiona
 l repression in the early human germline presents an exemplary balanced 
 system relying on local maintenance of heterochromatic features and a la
 ck of inductive cues. Biography: Dr Wolfram Gruhn is a postdoctoral rese
 arch associate in Professor Azim Surani’s research group at the Gurdon i
 nstitute in Cambridge. His research is focused on understanding the esta
 blishment and embryonic development of the mammalian germline. Here\, he
  is particularly interested in the transcription factor-mediated regulat
 ion of cis-regulatory elements and the impact of epigenetic remodelling 
 on transcription during human germ cell differentiation. To facilitate t
 he study of transcription factor and cis-regulatory element function\, D
 r. Gruhn has contributed to the improvement of techniques such as mammal
 ian DamID\, auxin-inducible degrons\, and CRISPR-mediated epigenome edit
 ing. His work has been supported by an EMBO long-term fellowship and the
  Eric Reid Fund for Methodology
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20230502T095947Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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