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BEGIN:VEVENT
DTSTAMP:20260507T195845Z
DTSTART;VALUE=DATE-TIME:20230420T140000
DTEND;VALUE=DATE-TIME:20230420T150000
SUMMARY:BMS Special Seminar: Squeezing the eggs to grow : Mechano-regulat
 ion of mammalian follicle development\, Dr Chii Jou (Joe) Chan\, Mechano
 biology Institute and Department of Biological Sciences\, National Unive
 rsity of Singapore
TZID:Europe/London
UID:20230420-8a17841a86c5c3610186cb2294cd1964@warwick.ac.uk
CREATED:20230323T122535Z
DESCRIPTION:Abstract : The formation of functional eggs in the ovarian fo
 llicles is a critical process of early mammalian development. While gene
 tic studies have revealed key genes for oocyte functions\, the underlyin
 g mechanisms driving follicle growth remain enigmatic. Recent studies sh
 owed that follicle growth is sensitive to mechanical environment\, calli
 ng for a need to understand mechanical signalling within follicle. Here\
 , we investigate the mechanical functions of theca cells (TCs)\, which s
 it on a basement membrane encapsulating the follicles. Using live imagin
 g and ex vivo reconstitution\, we demonstrate that the TCs are highly co
 ntractile and generate compressive stress to modulate follicle growth. W
 e further found that the TCs are mechanosensitive to stretch and substra
 te stiffness\, suggesting that the basement membrane may in turn regulat
 e TC functions in vivo. We hypothesise that such mechanical feedback is 
 essential for regulating follicle growth and oocyte functions through me
 chanotransduction pathways. Our work has implications for future underst
 anding and treatment of ovarian disease and infertility. Biography: Trai
 ned in soft matter physics\, Joe carried out his PhD research with Joche
 n Guck at the University of Cambridge\, studying the mechanical and opti
 cal properties of cells and nuclei using novel biophotonic tools. He the
 n joined the lab of Takashi Hiiragi (EMBL Heidelberg) to study the roles
  of fluid pressure in regulating mouse blastocyst size and cell fate spe
 cification during early embryo development (Chan\, 2019\, Nature). Curre
 ntly at NUS\, his lab focuses on understanding how mechano-chemical sign
 alling regulate mammalian ovarian follicle growth during development and
  ageing. To address these questions\, the lab combines unique ex vivo re
 constitution with quantitative imaging\, biophysical\, molecular and com
 putational approaches to map out intra-follicular cellular dynamics and 
 mechanical interactions. Other research themes in his lab include the bi
 ophysical control of ovulation and the study of crosstalk between ovaria
 n macrophages and ECM in contributing to inflammation and fibrosis durin
 g ageing. He has recently been awarded the Singaporean Teaching and Acad
 emic Research Talent Inauguration Award (2022).
LOCATION:IBRB Lecture Theatre
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20230323T122535Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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