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BEGIN:VEVENT
DTSTAMP:20260509T133012Z
DTSTART;VALUE=DATE-TIME:20220504T140000
DTEND;VALUE=DATE-TIME:20220504T150000
SUMMARY:SLS/WMS Development Biology and Stem Cell Seminar :Developing a t
 ransient\, cell-free mRNA cardiac regenerative therapeutic\, Cathy Wilso
 n\, Group Leader\, Department of Pharmacology\, University of Cambridge
TZID:Europe/London
UID:20220504-8a17841a804667f901806bf835730431@warwick.ac.uk
CREATED:20220427T170110Z
DESCRIPTION:Abstract There are 23 million heart failure patients worldwid
 e\, which has an enormous socio-economic impact. The only effective trea
 tment for end-stage heart failure is heart transplantation\, and regener
 ation of the heart is one of the best potential alternative treatments. 
 Using a switchable mouse model of Myc and Cyclin T1 overexpression\, we 
 have demonstrated that increased levels of Cyclin T1 is sufficient to en
 able Myc driven transcription in adult hearts. Once transiently activate
 d\, Myc transcription leads to extensive cell-cycle entry through to cel
 l division and a large increase in cardiomyocyte number in vivo. Our dat
 a indicate that Cyclin T1 is the critically rate-limiting factor for Myc
  in adult mouse heart and their co-expression can switch heart into a re
 generative state. These results represent a significant milestone in the
  regenerative field and could be exploited therapeutically in the treatm
 ent of heart disease. As a first step towards translation\, we have deve
 loped a modified synthetic mRNA that expresses Myc and Cyclin T1 mRNA as
  a prototypical therapeutic agent. These results represent a major step 
 towards the development of a regenerative therapeutics based on stimulat
 ing cardiomyocyte proliferation in adults.
LOCATION:GLT2
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Dev Biol and Ste
 m Cell Seminar
LAST-MODIFIED:20220427T170110Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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