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BEGIN:VEVENT
DTSTAMP:20260510T172226Z
DTSTART;VALUE=DATE-TIME:20210422T123000
DTEND;VALUE=DATE-TIME:20210422T133000
SUMMARY:BMS Divisional Webinar: Endometriosis and its microenvironment\, 
 one cell at a time\, Dr Elise Courtois\, Associate Director\, The Jackso
 n Laboratory for Genomic Medicine in Farmington\, Conn.
TZID:Europe/London
UID:20210422-8a17841a785a72cd0178d52412921cb4@warwick.ac.uk
CREATED:20210415T104654Z
DESCRIPTION:Abstract: Endometrial lesions are highly complex tissues comp
 rised of cells of endometrial\, immune and vascular origin. An interplay
  among these cell types and factors in the local environment is key to t
 he establishment\, progression and spread of these lesions. An unbiased 
 single cell transcriptomic approach to comprehensively identify all the 
 cellular components of ectopic lesions and their microenvironment is ess
 ential for understanding the environmental etiology and pathophysiology 
 of endometriosis. We generated single cell transcriptomic (scRNAseq) dat
 a from peritoneal and ovarian endometriosis lesions from stage III-IV en
 dometriosis patients\, using a droplet-based RNAseq platform. Matched eu
 topic endometrium were also analyzed by scRNAseq. Our unbiased single ce
 ll approach allows us to capture multiple cell types from both ectopic a
 nd eutopic endometrium. We identified the major cell types composing the
  ectopic endometrium as well its microenvironment in the adjacent perito
 neum. Cell types identified within the microenvironment included T cells
 \, B cells\, macrophages\, endothelial\, fibroblast\, muscle cells and p
 ericytes. Notably\, we were able to identify several subtypes of myeloid
  cells and their differential gene expression analysis revealed substant
 ial differences revealing their role in angiogenesis and immunosuppressi
 on. We identified a lesion-specific pericyte subtype\, implicated in imm
 une cell trafficking. Image Mass Cytometry analysis of the lesions revea
 led important clues on the spatial organization and the cellular interpl
 ays withing cell types that were characterized transcriptionally. Our ap
 proach allows to study the diversity of cells composing the endometriosi
 s lesions and their microenvironment\, and to compare ectopic lesions to
  eutopic endometrium. Together\, the unbiased study of endometriosis and
  its microenvironment at the single cell level offers a powerful insight
  into the key cellular players of endometriosis. Biography: My research 
 career began in Spain where I worked on human-based stem cell therapies 
 for Parkinson’s disease during my PhD. I expanded my stem cell training 
 as a postdoctoral fellow by joining a team working at the intersection o
 f tumor biology and mouse genetics\, with a particular focus on lung and
  colorectal cancers during my postdoc at the Institute for Molecular Bio
 logy\, A-STAR in Singapore. Later I joined the Robson lab at the Genome 
 Institute of Singapore\, A-STAR\, where I continued to study the biology
  of lung and colorectal tumors\, using and generating novel single-cell 
 profiling technologies. In my current role as an Associate Director for 
 the Single Cell Biology Lab at The Jackson Laboratory for Genomic Medici
 ne (JAX-JGM\, USA)\, I continue to investigate the cellular heterogeneit
 y of human tissues using state-of-the-art single-cell ‘omics’ approaches
 \, 3D- cell culture models and high content screening systems.
LOCATION:MS Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_TEM,CSRL
LAST-MODIFIED:20210415T104654Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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