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BEGIN:VEVENT
DTSTAMP:20260510T094419Z
DTSTART;VALUE=DATE-TIME:20210401T123000
DTEND;VALUE=DATE-TIME:20210401T133000
SUMMARY:BMS webinar: On the (im)possibility of elephants\, Dr Vincent J L
 ynch\, Department of Biological Sciences\, University of Buffalo
TZID:Europe/London
UID:20210401-8a17841a785a72cd017869201d093b3d@warwick.ac.uk
CREATED:20210325T112335Z
DESCRIPTION:Abstract: The risk of developing cancer is correlated with bo
 dy size and lifespan within species. Between species\, however\, there i
 s no correlation between cancer and either body size or lifespan\, indic
 ating that large\, long-lived species have evolved enhanced cancer prote
 ction mechanisms. Elephants and their relatives (Proboscideans) are a pa
 rticularly interesting lineage for the exploration of mechanisms underly
 ing the evolution of augmented cancer resistance because they evolved la
 rge bodies recently within a clade of smaller bodied species (Afrotheria
 ns). Here\, we explore the contribution of gene duplication to body size
  and cancer risk in Afrotherians. Through comparative genomics we identi
 fied a duplicate SOD1 gene Proboscideans that we functionally characteri
 ze and show may underlie some aspects of their remarkable anti-cancer ce
 ll biology. These data suggest that duplication of tumor suppressor gene
 s facilitated the evolution of increased body size by compensating for d
 ecreasing intrinsic cancer risk. Biography: Received my BS University at
  Albany and worked with Caro-Beth Stewart on sperm protein evolution in 
 humans and other primates. Received by PhD and did a post-doc with Günte
 r Wagner at Yale\, working on the evolution of pregnancy and how transcr
 iption factor proteins evolve new functions. Moved on to an Assistant Pr
 of position in the Dept. of Human Genetics at the University of Chicago\
 , where I still worked on the evolution of pregnancy but started a new r
 esearch project on why some animals seem to be (almost) cancer free. Mov
 ed last year to the University at Buffalo and still work on the evolutio
 n of pregnancy and how that impacts human pregnancy complications\, and 
 expanded the research program on cancer-free species to elephants\, arma
 dillos\, whales\, bats\, and most recently Galapagos tortoises.
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars,CSRL
LAST-MODIFIED:20210325T112335Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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