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BEGIN:VEVENT
DTSTAMP:20260510T172220Z
DTSTART;VALUE=DATE-TIME:20210316T120000
DTEND;VALUE=DATE-TIME:20210316T130000
SUMMARY:SLS/WMS Micro Webinar: Whole-cell spatial proteomics of apicomple
 xans: mapping genome-level complexity onto these divergent cells\, Dr Ro
 ss Waller\, Department of Biochemistry\, University of Cambridge
TZID:Europe/London
UID:20210316-8a17841a77156a4d0177263e29a24575@warwick.ac.uk
CREATED:20210309T133918Z
DESCRIPTION:Abstract: Our appreciation of the complexity and evolution of
  taxonomically diverse eukaryotic cells is highly constrained by our lim
 ited knowledge of the locations and functions of most of the cell’s prot
 eome. Typically\, few\, if any\, proteins have been located in a given t
 axon\, and even the better studied eukaryotes\, such as some human patho
 gens\, have only a very small fraction of proteins’ locations experiment
 ally determined. At best\, many protein locations are predicted based on
  studies of homologues from distant relatives. But\, more often\, protei
 ns predicted from genomes or transcriptomes are ‘hypotheticals’ unique t
 o a taxon’s lineage\, stymying even predictions of location or function 
 by comparative biology. To address this deficit in our basic understandi
 ng of the compositional organisation of the cell\, we have used a spatia
 l proteomics method called hyperLOPIT to simultaneously capture the stea
 dy-state subcellular association of thousands of proteins in the apicomp
 lexan Toxoplasma. We have resolved almost 4000 proteins to locations inc
 luding endosymbiotic organelles\, secretory compartments related to inva
 sion\, discrete cytoskeletal structures\, sub-nuclear compartments and l
 arge molecular complexes. These protein atlases reveal: protein associat
 ions throughout the cell providing testable hypotheses of their function
 \; coordinated transcriptional control of discrete cell compartments\; c
 onservation and novelty of compartment proteomes both between apicomplex
 ans\, and other eukaryotes\; different paces of evolution across the dif
 ferent cell compartments and structures in Toxoplasma\; and clear instan
 ces of protein relocation from one organelle or structure to a different
  one over evolutionary time. This new\, global view of the cell proteome
  provides a much more complete framework for understanding the mechanism
 s of function and evolution of these cells. Biography: Bio-Sketch: Ross 
 Waller completed a PhD in 2000 in Melbourne\, Australia (School of Botan
 y\, University of Melbourne) working on the newly discovered remnant pla
 stid in apicomplexan parasites Plasmodium and Toxoplasma with Geoffrey M
 cFadden. He undertook postdoctoral training from 2000-3 as a Peter Doher
 ty Fellow with Malcolm McConville working on Leishmania cell biology (De
 partment of Biochemistry\, University of Melbourne)\, and then from 2003
 -5 as a Canadian Institutes of Health Research and Michael Smith Foundat
 ion for Health Research Fellow with Patrick Keeling working on molecular
  evolution in diverse eukaryotes (University of British Columbia\, Canad
 a). In 2005 be joined the faculty of the School of Botany\, University o
 f Melbourne\, and in 2013 relocated his laboratory to the Department of 
 Biochemistry\, University of Cambridge. Teams link available here: https
 ://warwick.ac.uk/fac/sci/med/staffintranet/divisions/bms/virtual_communi
 ty/
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars,Joint WMS/SLS Micro
LAST-MODIFIED:20210309T133918Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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