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BEGIN:VEVENT
DTSTAMP:20260510T083205Z
DTSTART;VALUE=DATE-TIME:20210707T130000
DTEND;VALUE=DATE-TIME:20210707T140000
SUMMARY:BMS Divisional Webinar: Axial organisation in animal development:
  A synthetic approach\, Dr Vikas Trivedi\, EMBL Barcelona
TZID:Europe/London
UID:20210707-8a17841a75b719120175d04dc9052555@warwick.ac.uk
CREATED:20210629T085929Z
DESCRIPTION:Abstract: Emergence of multicellular forms (tissues\, organs 
 and organisms) from cells through changes in their shape\, size\, number
  and organization is central to understanding the process of morphogenes
 is. While molecular players are known\, we do not know how the activity 
 of genes and proteins is translated into 3D structures in space and time
 . Pre-existing spatial cues\, species-specific geometry and extraembryon
 ic signalling centers\, confound studying these processes in vivo. It ha
 s been shown that 3D cell aggregates from different species (mouse embry
 onic stem cells and zebrafish blastula cells\, which we term gastruloids
  and pescoids respectively) generate spatial asymmetries in gene express
 ion and cell behaviour within otherwise equivalent groups of cells\, to 
 develop a global coordinate system (body axes) de novo. Combining light-
 sheet imaging with genetic labelling of cells we are now gaining some in
 sights into the spatio-temporal precision and species-independent manner
 \, with which such 3D embryonic cell aggregates generate the major body 
 axes even in the absence of any embryonic information. Using these embry
 onic organoids\, as a minimal alternate system\, sufficient to generate 
 embryonic axes\, we aim to understand early development in embryos as an
  emergent phenomenon of the self-organisation of pluripotent cells. Biog
 raphy 2006-2010: Bachelor of Technology (undergraduate)at Indian Institu
 te of Technology 2010-2015: PhD at Caltech (with Dr. Scott Fraser)\, foc
 used on 2-photon light sheet imaging for imaging zebrafish heart 2015-20
 16: Career Break 2016-2017: Short postdoc at University of Cambridge (wi
 th Dr. Alfonso Martinez Arias) 2018-now: Group Leader at EMBL Barcelona 
 Joint appointment: Developmental Biology Unit\, EMBL Heidelberg
LOCATION:via Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20210629T085929Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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