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BEGIN:VEVENT
DTSTAMP:20260514T014631Z
DTSTART;VALUE=DATE-TIME:20190625T120000
DTEND;VALUE=DATE-TIME:20190625T130000
SUMMARY:WMS/SLS Micro Seminar: Real-time visualization of drug resistance
  acquisition by horizontal gene transfer reveals a new role for AcrAB-To
 lC multidrug efflux pump\, Christian Lesterlin\, University of Lyon
TZID:Europe/London
UID:20190625-8a17841a6b2d9fac016b46074227413f@warwick.ac.uk
CREATED:20190625T091059Z
DESCRIPTION:Abstract: Drug resistance dissemination by horizontal gene tr
 ansfer remains poorly understood at the cellular scale. Using live-cell 
 microscopy\, we reveal the dynamics of resistance acquisition by transfe
 r of the F conjugative plasmid encoding the tetracycline-efflux pump Tet
 A. We show that the entry of the ssDNA plasmid into the recipient cell i
 s rapidly followed by complementary strand synthesis and expression of n
 ewly acquired genes. TetA production is enhanced by zygotic induction re
 sulting in the optimized establishment of resistance. In the presence of
  protein synthesis-inhibiting antibiotics\, acquisition of resistance be
 comes strictly dependent on AcrAB-TolC multidrug efflux pump. We demonst
 rate that AcrAB-TolC is required for maintenance of protein synthesis ac
 tivity and therefore TetA production following plasmid acquisition. This
  work uncovers a novel essential role of multidrug efflux systems in the
  acquisition of drug-specific resistance by horizontal gene transfer and
  helps to understand the dissemination of antibiotic resistance in bacte
 ria
LOCATION:MBU (A151)\, Medical School Building
CATEGORIES:BiomedicalSciences,BMS_MI,Joint WMS/SLS Micro
LAST-MODIFIED:20190625T091059Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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