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BEGIN:VEVENT
DTSTAMP:20260614T173143Z
DTSTART;VALUE=DATE-TIME:20170713T123000
DTEND;VALUE=DATE-TIME:20170713T133000
SUMMARY:TEM Seminar: Characterizing Prdm1/Blimp1-expressing cells and Bli
 mp1 function at the murine foetal-maternal interface\, Dr Andrew Nelson\
 , School of Life Sciences\, University of ÌÇÐÄTV
TZID:Europe/London
UID:20170713-8a17841a5cf9d9f0015d0ddd37555232@warwick.ac.uk
CREATED:20170704T134947Z
DESCRIPTION:Abstract: Growth and survival of the mammalian embryo within 
 the uterine environment depends on the placenta\, a highly complex vascu
 larized organ comprised of both maternal and foetal tissues. The zinc fi
 nger transcriptional repressor Prdm1/Blimp1 is essential for specificati
 on of spiral artery trophoblast giant cells (SpA-TGCs) that invade and r
 emodel maternal blood vessels. To learn more about functional contributi
 ons made by Blimp1+ cell lineages here we perform the first single-cell 
 RNA-seq analysis of the placenta. To better understand the role of Blimp
 1 we performed microarray and ChIP-seq analysis of wild type and mutant 
 differentiating trophoblast stem cells. Our experiments provide new insi
 ghts into the functionally distinct cell types present at the maternal–f
 oetal interface\, advance our knowledge of dynamic gene expression patte
 rns controlling placental morphogenesis and vascular mimicry\, and highl
 ight the functional contributions made by Blimp1 during trophoblast diff
 erentiation.
LOCATION:CSRL Seminar Room\, Clinicial Sciences Building\, UHCW
CATEGORIES:BiomedicalSciences,BMS_TEM
LAST-MODIFIED:20170713T101831Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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