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BEGIN:VEVENT
DTSTAMP:20260614T195908Z
DTSTART;VALUE=DATE-TIME:20170426T100000
DTEND;VALUE=DATE-TIME:20170426T110000
SUMMARY:Seminar: How cancer cells respond and become resistant to microtu
 bule-interacting drugs\, Dr Patrick Meraldi\, Translational Research Cen
 tre in Oncohematology\, Cell Physiology and Metabolism Department\, Univ
 ersity of Geneva
TZID:Europe/London
UID:20170426-8a17841a5b3d6cd7015b8a66ea092b0c@warwick.ac.uk
CREATED:20170420T080732Z
DESCRIPTION:Abstract: Microtubule-interacting drugs are amongst the most 
 efficient chemotherapeutic agents used in the treatment of breast cancer
 \, prostate cancer or leukemia. Although it is often assumed that these 
 drugs act in a general\, cytotoxic manner by disrupting mitosis\, the ex
 act mechanisms by which these agents kill cancer cells remains unclear. 
 Here we compared taxol to two next generation microtubule interfering dr
 ugs: the halichrondrin B analogue eribulin\, which is approved for breas
 t cancer treatment since 6 years\, and BAL27682\, which is currently in 
 Phase 1/2A clinical evaluation in advanced cancer patients. While taxol 
 has been extensively studied\, the two other drugs have never been exten
 sively investigated at the cell biological level. I will present data sh
 owing that these drugs kill cancer cells via mechanisms that are distinc
 t from taxol\, and that they elicit separate resistance mechanisms\, ind
 icating that each drug targets cancer cells via specific pathways.
LOCATION:MBU\, A1.51\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,BMS_CDB
LAST-MODIFIED:20170420T081332Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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