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BEGIN:VEVENT
DTSTAMP:20260613T230813Z
DTSTART;VALUE=DATE-TIME:20170303T140000
DTEND;VALUE=DATE-TIME:20170303T150000
SUMMARY:Bridget Penman. “The influence of pathogens on the human genome: 
 malaria and beyond”
TZID:Europe/London
UID:20170303-8a17841a5a849635015a8517e8985ab1@warwick.ac.uk
CREATED:20170228T142021Z
DESCRIPTION:The Seminar Speaker this Friday is SLS’ Dr Bridget Penman DAT
 E: Friday 3 March 2017 LOCATION: GLT2 - Gibbet Hill Campus TIME: 14.00 t
 o 15.00 SEMINAR TITLE: “The influence of pathogens on the human genome: 
 malaria and beyond” Infectious diseases generate profound selective pres
 sures on their hosts. Human adaptation to malaria provides us with our b
 est examples of recent human evolution. Diseases other than malaria must
  surely too have affected the human genome\, but it is surprisingly diff
 icult to link known human genetic variation to natural selection from no
 n-malaria pathogens. I shall first explore some of the outstanding quest
 ions in malaria-human coevolution\, specifically : (i) why do different 
 populations under malaria selection display different suites of malaria 
 protective haemoglobinopathies?\, and (ii) why is the fixation of Duffy 
 negativity limited to sub Saharan Africa? In the second half of the semi
 nar I will consider the HLA genes\, which encode a critical part of the 
 human adaptive immune system – and ask what sorts of signatures of patho
 gen selection they might display.
LOCATION:GLT2 - Gibbet Hill Campus
CATEGORIES:Seminars
LAST-MODIFIED:20170228T142021Z
ORGANIZER;CN=Matt Keeling:
END:VEVENT
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