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BEGIN:VEVENT
DTSTAMP:20260625T140428Z
DTSTART;VALUE=DATE-TIME:20091214T090000
DTEND;VALUE=DATE-TIME:20091214T180000
SUMMARY:EPSRC Symposium Workshop - From molecules to bodies: spanning lev
 els of biological organisation in medicine (M2B)
TZID:Europe/London
UID:20091214-094d43f624ee1758012501d2e0431bf5@warwick.ac.uk
CREATED:20091117T110654Z
DESCRIPTION:14-15 December 2009 - Organisers: Paul J Thornalley\, Anatoly
  Shmygol\, Hugo A van den Berg The coming decades will see the advent of
  molecular medicine in the daily routine of clinical practice\, with cus
 tomized care based on patient genotyping and genetic recombination targe
 ting the patient’s own cells and tissues. The success of such developmen
 ts will depend critically on the ability to predict reliably how perturb
 ations by either the disease or therapy at the molecular level will affe
 ct the behaviour at the level of the whole system. This calls for a rene
 wed focus on the individual as an integrated dynamical system\, in which
  links are forged between levels of biological organisation\, from molec
 ules\, cells\, and tissues up to organ systems. Various deep mathematica
 l problems are engendered by the need to establish inter-level connectio
 ns that are\, in some suitable sense\, functionally meaningful. The typi
 cal problem is to characterize the functional consequences at the higher
  level of the structures modelled at the lower level\, e.g. the translat
 ion of molecular heterogeneity of cell-cell contacts to the statistics o
 f the fluctuations of a functional parameter at the systemic level. Such
  problems call for sophisticated statistical sampling techniques. Anothe
 r example is the reduction of dynamic degrees of freedom as one passes t
 o coarser spatiotemporal scales\, for instance\, from a network of endoc
 rine interactions to the input-output behaviour at the whole-organism le
 vel. We will discuss novel mathematical techniques which are being devel
 oped to address these problems\, with an emphasis on a small number of s
 elected model systems which can serve as case-studies for an in-depth di
 scussion: (i) regulation of epitope recognition in the immune system\, w
 hich could hold the key to a cure for auto-immune disease\, aids and can
 cer\; (ii) regulation activation patterns in smooth muscle cells and the
  myocardium\, focussing on cell-to-tissue signalling\; (iii) regulation 
 of energy intake and expenditure\, which we need to understand better in
  order to control diabetes and obesity\, with a focus on lipoprotein met
 abolism\, nutrigenomics linking diet and health\, and trans-fatty acids 
 impact on the risk of vascular disease. Confirmed speakers: Martin Adiel
 s (Gothenburg) — Ellen Baake (Bielefeld) — Michael Berridge (Cambridge) 
 — Carla Ferreri (Bologna) — Kevin Hall (Bethesda) — Leighton T. Izu (Cal
 ifornia) — Pierre de Meyts (Gentofte) — Ben van Ommen (Zeist) — David A.
  Price (Bethesda & Cardiff) — Barbara M. Sanborn (Colorado) — Kenton M. 
 Sanders (Nevada) — Andrew K. Sewell (Cardiff) — Withrow Gil Wier (Maryla
 nd)
LOCATION:Mathematics Research Centre\, Zeeman Building
URL:http://www2.warwick.ac.uk/fac/sci/maths/research/events/2009_2010/sym
 posium/m2bwks
ATTACH:http://www2.warwick.ac.uk/fac/sci/maths/research/events/2009_2010/
 symposium/m2bwks
CATEGORIES:Symposia
RRULE:FREQ=DAILY;UNTIL=20091216;INTERVAL=1
LAST-MODIFIED:20091117T110654Z
ORGANIZER;CN=Alison Rodger:
END:VEVENT
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