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BEGIN:VEVENT
DTSTAMP:20260614T132917Z
DTSTART;VALUE=DATE-TIME:20170510T130000
DTEND;VALUE=DATE-TIME:20170510T140000
SUMMARY:Seminar: Single-molecule studies of eukaryotic DNA replication\, 
 Dr Hasan Yardimci\, The Francis Crick Institute
TZID:Europe/London
UID:20170510-094d43f5596950890159696b50c5175e@warwick.ac.uk
CREATED:20170104T121917Z
DESCRIPTION:Abstract: Faithful duplication of the genome is crucial for p
 roper cell division and thus the genetic integrity of all organisms. Err
 ors in DNA replication can lead to genomic instability\, a characteristi
 c feature of most cancer cells. A key component of the replication machi
 nery (replisome) is the DNA helicase\, which separates the double helix 
 into its component strands so they can be copied. In this talk\, I will 
 first discuss our efforts to decipher the molecular mechanism of the Cdc
 45/MCM2-7/GINS (CMG) complex that acts as the replicative helicase in eu
 karyotes\, The basic mechanism by which this helicase unwinds DNA at the
  replication fork has been controversial. CMG was proposed to function a
 s a physically coupled pair of helicases that pumps double-stranded DNA 
 through the helicase central channel\, splitting the duplex apart when i
 t emerges from the protein complex. Others challenged this view and prop
 osed that they function as single hexamers that encircle and translocate
  along a single strand and unwind DNA by excluding the other strand from
  the central channel (“steric exclusion”). Determining which model is co
 rrect has profound implications for the spatial organization and inner w
 orkings of the replisome. To better understand how CMG interacts with DN
 A\, we developed novel methodologies that combine single-molecule imagin
 g and DNA nanomanipulation in extract-based systems. I will also present
  a new single molecule tool that we developed to perform fluorescence su
 per resolution imaging of DNA replication intermediates.
LOCATION:GLT2\, Medical School Building
CATEGORIES:BiomedicalSciences,Athena Swan,BMS_CDB
LAST-MODIFIED:20170509T124231Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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