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BEGIN:VEVENT
DTSTAMP:20260614T173148Z
DTSTART;VALUE=DATE-TIME:20170329T130000
DTEND;VALUE=DATE-TIME:20170329T140000
SUMMARY:Seminar: Systems level understanding of cell polarity regulation\
 , Dr Attila Csikasz-Nagy\, Kings College London
TZID:Europe/London
UID:20170329-094d43f5596923990159694e6ff00555@warwick.ac.uk
CREATED:20170104T114745Z
DESCRIPTION:Abstract: All cells - including those in our body - possess s
 ome degree of asymmetry or ‘polarity’\, which is key to their healthy fu
 nction and if disrupted can lead to serious cellular malfunctions like t
 hose found in cancer. In collaboration with the group of Rafael Carazo S
 alas (University of Cambridge) we have reconstructed with unprecedented 
 spatiotemporal resolution the molecular networks that regulate cell pola
 rity using an interdisciplinary strategy - combining genetics\, microsco
 py and computational approaches - and focusing on the polarity machinery
  of the archetypal model organism Schizosaccharomyces pombe (fission yea
 st). Using network analysis methods\, we have identified the core set of
  genes/proteins that regulate cell polarity in fission yeast and obtaine
 d a basic interaction ‘network’ map connecting those genes/proteins\, as
  well as discovered new molecular links between cell polarity\, cell cyc
 le and cytokinesis control. We determined the detailed network topology 
 and the functional hierarchy among polarity regulators in this species a
 nd incorporated these results into a mathematical model that captures th
 e polarity pattern changes throughout the cell cycle of fission yeast ce
 lls. In this talk I will present results and ongoing work of this interd
 isciplinary collaboration.
LOCATION:GLT2\, Medical School Building
CATEGORIES:BiomedicalSciences,BMS_CDB
LAST-MODIFIED:20170208T161725Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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