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BEGIN:VEVENT
DTSTAMP:20260626T003940Z
DTSTART;VALUE=DATE-TIME:20100505T130000
DTEND;VALUE=DATE-TIME:20100505T140000
SUMMARY:Complexity Forum - Jamie Luo
TZID:Europe/London
UID:20100505-094d43d5385c299a01386c3bd8b56e9c@warwick.ac.uk
CREATED:20100426T090551Z
DESCRIPTION:Speaker: Jamie Luo (����TV) Title: Functionality and Speciat
 ion in Boolean Networks Abstract: Boolean Networks have been used to mod
 el Genetic Regulatory Networks since Stuart Kauffmann proposed them as a
  model in the 1960s. Early work focused on how the topology of a network
  influenced its dynamics. We investigate the inverse problem asking which
  network topologies satisfy a specified dynamic. In earlier work by A. Wa
 gner et al [1\, 2] a biological function or cell process was specified by
  an initial condition v(0) and an end point v ∞ in the expression state 
 space. By so specifying a biological function one can then ask which net
 works perform this function. Our view is that in many cases a more appro
 priate means for defining a biological function would be by specifying th
 e entire path {v(0)\, v(1)\, ...\, v(T )}. We will report on how these t
 wo contrasting definitions of biological functionality lead to divergent 
 results for their respective functional topologies\, particularly regard
 ing the implications for neutral evolution\, multi-functionality and spe
 ciation. References [1] Ciliberti S\, Martin OC\, Wagner A (2007) Innova
 tion and robustness in complex regulatory gene networks. Proc Natl Acad 
 Sci USA 104:1359113596. [2] Martin OC\, Wagner A (2008) Multifunctionali
 ty and robustness trade-offs in model genetic circuits. Biophysical Jour
 nal\, 94 (8)\, pp. 2927-2937.
LOCATION:
CATEGORIES:Seminar Room D1.07,forum
LAST-MODIFIED:20120709T145408Z
ORGANIZER;CN=Colm Connaughton:
END:VEVENT
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