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BEGIN:VEVENT
DTSTAMP:20260626T071454Z
DTSTART;VALUE=DATE-TIME:20100127T130000
DTEND;VALUE=DATE-TIME:20100127T140000
SUMMARY:Complexity Forum - Sarah Teichmann
TZID:Europe/London
UID:20100127-094d43d5385c299a01386c3bd8b16d62@warwick.ac.uk
CREATED:20100110T220715Z
DESCRIPTION:Speaker: Sarah Teichmann (Cambridge) Title: A genomic and qua
 ntitative view of gene expression levels and epigenetic modifications Ab
 stract: Gene expression levels are believed to be continuously distribut
 ed from very low to very high levels\, with most genes at an intermediat
 e level. We studied the transcriptome-wide distribution of expression le
 vels in T helper cells based on microarray and RNA-seq technology and in
 tegrated this with RNA-fish experiments for well-characterized genes\, a
 llowing the quantification of mRNA transcripts at single-molecule resolu
 tion. The results of these analyses and experiments show that virtually 
 all genes are expressed at > ~ 1 molecule per cell and that two major ex
 pression levels can be identified which vary by roughly one to two order
 s of magnitude\, giving rise to strongly bimodal expression distribution
 s. Analysis of histone modifications by ChIP-seq indicates that activati
 ng modifications such as H3K9/14ac and H3K4me3 are involved in this ‘dig
 ital’ expression switch. Our findings have broad implications for the an
 alysis of microarray\, RNA-seq and ChIP-seq data and for the understandi
 ng of the regulation of gene expression.
LOCATION:
CATEGORIES:Seminar Room D1.07,forum
LAST-MODIFIED:20120709T145408Z
ORGANIZER;CN=Colm Connaughton:
END:VEVENT
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