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BEGIN:VEVENT
DTSTAMP:20260624T152532Z
DTSTART;VALUE=DATE-TIME:20121023T150000
DTEND;VALUE=DATE-TIME:20121023T160000
SUMMARY:Comp. Bio. Seminar Prof. Gunter Schumann (KCL)
TZID:Europe/London
UID:20121023-094d43a23a31199d013a3152703906ca@warwick.ac.uk
CREATED:20121005T142657Z
DESCRIPTION:Neurobehavioural analysis of reinforcement and its relevance 
 for substance abuse: results from the IMAGEN study. Gunter Schumann\, MR
 C-SGDP Centre\, Institute of Psychiatry\, King’s College\, London Adoles
 cent behaviour has been associated with substance abuse and dependence l
 ater in life. Individual variability in reinforcement processes (i.e.\, 
 (impulsivity\, novelty seeking\, reward dependence) predict risk for add
 ictions and describe motivations for drug use. Investigating how motivat
 ional and emotional cues affect individual variability in reinforcement 
 behaviour at the genetic\, neurobiological and cognitive levels might in
 form us about neurobehavioural mechanisms conferring risk for addictions
 \, thus potentially maximizing the efficacy and efficiency of early inte
 rventions. In the EC-FP6 Integrated Project IMAGEN\, a European multicen
 tric longitudinal gene x neuroimaging study\, we aim to identify the gen
 etic and neurobiological basis of individual variability in reinforcemen
 t behaviour and determine their predictive value for the development of 
 addictions and other psychiatric disorders. Comprehensive behavioural an
 d neuropsychological characterization\, functional and structural neuroi
 maging and genome-wide association analyses of 2000 14-year-old adolesce
 nts at baseline are coupled with ongoing longitudinal follow-up at 16 an
 d 19 years\, and combined with functional genetics in animal and human m
 odels. This lecture will focus on our recent investigations in 14 year-o
 ld adolescents of reinforcement mechanisms known to confer later risk fo
 r addictions. I will present structural and functional brain correlates 
 of impulsivity (Schilling et al.\, Mol Psychiatry\, in press) and descri
 be how they relate to reward anticipation (Peters et al. Am J Psychiatry
  2011) and risk taking (Schneider et al. Am J Psychiatry 2012) in substa
 nce abusing adolescents. I will discuss how gender and genetic factors i
 nfluence neural mechanisms underlying novelty seeking and impulsivity (N
 ymberg et al.\, in review\, in preparation)\, and how ADHD symptoms and 
 early substance abuse are associated with distinct brain activity networ
 ks (Whelan et al.\, Nature Neuroscience\, 2012\; Jia et al\, in preparat
 ion). Finally\, I will discuss a novel mechanism underlying alcohol drin
 king behaviour\, which has been discovered through translational researc
 h integrating animal\, molecular and human gene x neuroimaging studies (
 Stacey et al. in preparation).
LOCATION:CS.007
URL:http://www2.warwick.ac.uk/fac/sci/dcs/research/combi/seminars/
ATTACH:http://www2.warwick.ac.uk/fac/sci/dcs/research/combi/seminars/
CATEGORIES:
LAST-MODIFIED:20121005T142657Z
ORGANIZER;CN="":
END:VEVENT
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