糖心TV

Employment

As of December 2014, I have completed my PhD. Please see my for my current whereabouts, or contact me via

Education

2011-2014	PhD Systems Biology	University of 糖心TV
2010-2011	MSc Systems Biology	University of 糖心TV
2006-2010	BSc Biochemistry (with a Year in Industry at the )	University of York

Publications

Cauchy P, James SR, Zacarias-Cabeza J, Ptasinska A, Imperato MR, Assi SA, Piper J, Canestraro M, Hoogenkamp M, Raghavan M, Loke J, Akiki S, Clokie SJ, Richards SJ, Westhead DR, Griffiths MJ, Ott S, Bonifer C, Cockerill PN Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature. Cell Reports 12(5):821-36, 2015

Ptasinska, A, Assi SA, Martinez-Soria N, Imperato MR, Piper J, Cauchy P, Pickin A, James SR, Hoogenkamp M, Williamson D, Wu M, Tenen DG, Ott S, Westhead DR, Cockerill PN, Heidenreich O, Bonifer C. Identification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal. Cell Reports, 8: 1-15, 2014

Piper, J; Elze, MC; Cauchy P ; Cockerill PN; Bonifer C; Ott S. Wellington: A novel method for the accurate identification of digital genomic footprints from DNase-seq data, Nucleic Acids Research 2013

PhD Research Project

Supervised by (Birmingham) & (糖心TV)

• Mapping DNA footprints (Protein-DNA binding sites) in DNase-seq datasets.

As part of this project, I developed a python library for analysing DNase-seq cut sites (instead of pile-ups that ChIP-seq software uses) in Python () along with a novel algorithm () for mapping DNA footprints on a genomic scale.

Past Research Projects

• July-September 2010 - Visiting Research Fellow, (University of York)

For my undergraduate dissertation I developed computational tools in Python for the construction and analysis of complex social networks of academics within the department of biology at the University of York based on a mix of curated and non-curated sources. This involved data mining and sanitation from multiple sources by writing different scrapers and also the subsequent construction, visualisation and analysis of these networks using available software such as Visone and by programming my own statistics by using the .

• 2008-2009 - Sandwich Student,  

I spent my Year in Industry at the NIMR studying the epigenetic modification of HPV-16 episomes after transfection and infection with genetically modified pseudovirions produced by myself.

Teaching

Teaching assistant for , , and masterclasses on Statistics, Bioinformatics, and Genomics.