%PDF-1.4 % 1 0 obj<> endobj 2 0 obj<>stream Hbd`ab`ddT pH)K-LNK-MuKI+NMO2!C oj~Y-`-AQ5?}.K?b`bdl_PYQ`hii\Y\[_T_XR_ZZT;N!X!Q(1%57([!?M'3/ U]!1/E?H!483%3(3XP-|?J}?tˌG/~|TCپ>]{on_^lE߱=a-W;g!3dtңIMf?u ki3 endstream endobj 3 0 obj<> endobj 4 0 obj<>stream HtT{PgawE anPWݙ(E"xkAVX4"E#ucW$K0A"fQ-|ճ6^Su3_׿kQ1,ˊs?'1Dú, llR%ݚƚc5gJRRr?&%m-nUD@լPyqU܏ml",a4SG mG[y;G=nx{{uwg#)]ZSl} Pyi;x!74E+K766n7Ĕ"߰o-Lno/|h=sSXPо0n%٦E {ϞVWwc뚤xh˞NUo_^Tsni: P8vbˆv糛^Hh#PZ%mEQr=.Dz >-2^1$Ř8q/&QD#f 2[!BڊSˍdŧ8 )IsO7T#”ȱ>vg۲ʇ#T|p_OPF /%WmWRo4g~ÕbOU;yHcR)|W*1P('w󉶹mPlk!9I=SS9dY"zC tvCH_isMkĈP=Z <$7mL1/+~g9?{ vJ a:JhzhE#cE'i. RIįDσ/ %j{JmaSa.EE3F Hz):FE Q#h )O`ex#Z:.ڡ.R3HJWrWE+5UWa6>^Jz.`>J!9\ց\JiYVȪfZ]N 򅚓Rs/9 &•Ci/%<4ޟNZɁ7M ,~Z-RUR F\$&A{utQlvNqsW KwEuqKla\ڻPTHЬ(@ADyl@Q1W%*]VBTa@ ؀KԛH퍬D2ؤwwMf#3;sϙs~~ю:H ce%["q#MHy0~IghiVF0/,Mhb Kw:g,} Z:A . M%VAuU@6SV"GmkC`.{Zg*z1ge/l⩏]s.N  gk₅{'oYZ0\% D"i)$Vܩ/Fp' #$%s|On*IS|(lMno*p#1~+'ѵ&A} d:{xޕYƒUEUmVq]lI~7{Ed׫L6mCcu졃ʴۍ :^1NR=uKNj>x+!)#aMQچBg۝U{dIiz0 uO&F냨U\<NWL1+ٜ]9Zpx/P Ĕ"uJP6 D /,A۩?[L_5F3C#+07KjX,kϰL?3 hpN~,#Ƒ0bY1&)%wOb:j?ΚW1K6D5ʪhC/oF%5l';xGNŋ{A1nwR=~~)}/0k؜f/-t+ܪtN$693TS ] ӮB;S9 sC+ftůލlD\!S*~s.FY I{Hi3\mNC11[g<;YTcNryYr!8vpLmljD}%^{!M6G a=dBU1K(sij< zJ,C)9C?\ϐ3ik?yưmz%o) 䞌&ݚKg`[CKYGc]`yqn8,,\TZ עlJיִ'Ko=*)p纩o&Pg\ ffH[vbC}өP|CL手Z}@ 頢\|FNN# z,wxt@;׊=[jUcYjmܖ?씑c8&]sHzM%r.*?Tq_HU~Qtu{uX ݻ-ȖJ詑>P=jnDj`Hsce.w̢f2GS bc XUyTV]n(֮+; rhϟREۋaBVzsa66 ^iճ(e *j;MQ}l(>$.I?:+A>Lhl8}@f1n +x0 e>^І!{nPK΃rѪyfVp;C_^ڂ݇+؊ZCqx^MrDDۢi)YZ$n2}UpQڼ̏\ַ٘Y չ5Ƈcۍ5jy~ˏKzzjL&g@dvM{~Dw jMZnVL;;4 qT&il딎2NiXF$2af3 !kuktȐ q{HD# 0SSO^>o` 3ǃpesSzO5&¬Zǫm}GXq+Y_ endstream endobj 5 0 obj<> endobj 6 0 obj<>stream Hbd`ad`ddwM,HM,LN u/-I+a!CGw/3Y;w.8{3##ws~AeQfzFFcJ~RBpeqIjng^r~QA~QbIjcNBH}BPjqjQP;MYԿ]wY~|aM/?΁g ;}#w5n5V7 endstream endobj 7 0 obj<> endobj 8 0 obj<> endobj 9 0 obj<>stream H|U{PSW!'1כnI"PDD@,u `䑘j,D3ZP@umQ-jQ*qNkG5~?ٓu?roFH$aɒԸDKq̚g^l)bm l1H"N*^dd85pJG"6:pUY9直1\6cR.*ͳ96̒ojcNmiqTݗ%hNY[0[J̎"@l-[1 6J}NkZ#aJ 3Eʨ|.cfIa0&a0>LY06C1b|ϙd I*xiL![(; c#X #{}FZ2(O;O&M8;7o&]~' ]O:iҤ t fcw;Q T=pц꼼wjV#ߞ'0ujК0 LL&ޟAIs %{@&I!\!r1AxGI2Suyl8gh( =hh,$q-bͰ::Uq_dMsף\i6ZCqu 7{ JAc3ޱHWہ\zEM`A헿 :V$(9]Nzj1xZU@ͰJ;NJZfkt-BdGV]15jcaJxHwn/i噩Bp;M6%dɿjh'Y`@dψQ#I(K5< <v,;{͊M׻5(%!s  ,p Zo8_Fz[G^F 2i-S0 + aL\}اW?ǿO_#UqF%om \Kʟ >Xd/W-?M = W(דxE-usCHu+ώ %V('UA5F>٣K;=Do6yBOMBnr,L,Gjrk>vHd;4z.PbXv4b tn:0jPGhRr!g[jKΫ:-@& J=T3AA!`}M 4%: R?N:Y*Nc9p5|DQ{aA#d:K7@7:lHh*TKHN*)Pyc9r\P*~84n;@5 vWbMFkXAG]cERr9vF_a:%Pb# )ZocKE %no[o;ןgjpKyt~Hz@%"L|_#W^N~I&nt&Ow_۬ b0m##YN>>'qδRy j'_*+0On5֋ UivqƎǮ ܝ޽ {ɞxqL])p>L駚+ܱ16-bcIѱ=7<&6 ^L4a&_؞kg@^j)I A endstream endobj 10 0 obj<> endobj 19 0 obj<>stream Hbd`ab`ddTv,K-*NK-/.,p !CX_?'~&=JpB ,켁&f 9(3=DA#YSB1%?)U!$5X3/9 ($5EOA1'G!X!(8 (M@G320U1032HY_t0XXG d^}w=Ƶ~&6c۶n\(wy7;@&f@ endstream endobj 20 0 obj<> endobj 21 0 obj<> endobj 22 0 obj<>stream HtUyPY&t'*%t8h=[5",0@Lȝt#r(1:¸^cn[cUήe퀵?{{ñ ۷~ ^.ڬKUd8H?ڵ7(>Fy̯ñf0 *kN17}b q\D6#?MiyZfuz _Sf,V(*8V)g )TZEBIPjr*uPTݤHUg|QEiZU*URj#ñ` a 0͞- bدpl9a1@3[ț H,Oc3[zbAS XG) ,pQᤔIw'Ϝ|zJCAO]5"^->/~l ~>-~髦w|rI!V/e Dбž<&G9tU{99{d{?FcʉoͅX"BiH9? ۾p.ri),Cq.!i0쟨ow>$"<=8-&۲)<9D: ᄸw/{"#yH&J Ҽ(B!<:Asm@q:/>$ G=r S7I/ xvs5!rqMwnF1P;6drxWһB+UVD0#LqtPƦ^:(l*:B3P#E@Aa'k3#xB%S2V 'H^{7~{DnJƞ}14:̐>62u4 cJ]Ҷ˰y<]sڟD͍[fђ1uv\ZNG5ٷCY.pG g[% N)D1Yn.UbːmD(%CFA/ ɍMD!CS a Y|\>Gܑ Aw KYE+sٲ0y#yHc$l.mr:` F_ZwL}Å~hC=DZg(0rXnvQ XJvm(18ˋ*T"r+PU$yz LD/+1o4e(g" r$G#8øs^rN#39#]N@+fv)gl2sT9j r;ScV/'y^~gR 1!0[p$P*J&',V`x*++dEV%f -Y woi0\&R'$m\07 =XW[#_ F P 0[{D]Wx IR2Mo2 |E02+^UјDD1@}h7f9!>-$dԢtj ܺxb! %TqIf1OoZ,tFg~%YOm&*'ZOO/ӛ v5Wog`RC畎_'M!/;I537,m9p`Ba?4^(%"Oc1r8?a2OHitFD>}2UX)T"YB6 c;rk,w#i5-G63Tt3̕R_{^G/8ZJ EE%rTjճg۰Aۻ&ɖnX">7߳峦ɸu2ҝ|ъζ!>;ݲ?Ł(%б!X6ݰC/!)4ʊ'uϱ皺Zpɰ&g汷ױ.F%XȦ;<d3C+,#`TC^'VUɑ}4$ecDBlP'I9ƅjmlSmu% l-~=_]S07SES=+$"~'_ο]&0֓aY{QdI+]/;=-TmY]aaN!Y'OIψH;NoA,j\ntW@6`fN>UVG=.=LڍV gFNΣ X GHKKS G_IDo?P9 "WelԼ4FfQ.yoh[^jzzoC{xN|mؾ~krh\wXww=Va _hohxAd uLZAWiL-`vYYY}np?__|Nt9w7y|fv9w<'Ւ{1Q6Cz~)Fsjw{}|UdY; RPlkmZ}BTSfpn&mpwfvwi zuxW\N9Wy|ukIsp|}l1qizTyyuuy{sxͩ V}bTw$Ę`0UCepaZrnci~{Xy~mvzzva f wfqv}]bV<`Ew~PG~y={[y!t}V^ns  Cְ endstream endobj 23 0 obj<> endobj 24 0 obj<>stream Hbd`ab`ddT ,K-*Nu/JM.,M,)RC"X_?~+Dpɏ!vFFv^aICCCSid" 4u/,L(QHT0PpLOJU,.I-VK/*/J,IMSPpQ/VJ-N-*v)Щ, :F l̩mvVV zSC7E\/說]1L'e׿٥bg+ůoK0lX/χ?>DzW> endobj 26 0 obj<> endobj 27 0 obj<>stream Hbd`ab`dd rM,HM,LN K*g!CG,wگY#8M!6FFv^!\CCcKijaidj$̍ *23J45 -- SR+KRs< KRSsr@RSʀX\tZ;3JR+ , 6 zyf?uEo֝Wcev eՉৎ ~60|a bߗ>gН߻&w{_w[4g rRuf-je[B1n=`]hc\I 钊y WMXZ˩q&):.8;m+a~讽%;9M.)HˡGCU>%;[ QJ7͚1irw/^Ȯ<.˿$eٓ['fWM&sQk7n\; F endstream endobj 28 0 obj<> endobj 29 0 obj<> endobj 30 0 obj<>stream HdUkTSWp5uou|T+L(ejK: }x fԱkGL7t~5 CUWj9p' >ʶ!3<6.ESm b*=`kT1PId>ږTdvIT! ml,'e]ǡb> ]n<_bQ.V'dm{0{ #A}l̥?pEƿ8䅌hdy="3xUJu̵oaN#[uS-U5].Z<aڽ7UY\!xk0C^z7Be|!as.FǧVX:JOJiB !Ga wV ȹ59 K4LDمTɏE۞[ 3kǝ,on_;+_N.OKav:$\8t~k{XH >I NU{LF؞S`)p<%0=r@_in-21hҬyhI w93h7f|L,択yڜlR6敩Jgh ,ڹ;g1eotX!^hOd 悾 1g'&36Sʴ&S_uNgQF4X\SM8HMzZ'=`H#S\WCda/Ķ]aY}ve_EQss4 !ס E{ĐH\8j}y5>m d:y_ $ШSwʣ^cadDЬs%Fbbќ?yy5Vd[IfY^$zɁG72݉ 3{/kΔWŬ4\!؍0Fr 9dJt7^0[&'mS0F俇G9p}I`;ꋵ( ej* 6 ڧY0ژ3N<"07_%Q4YΛ-]A!/`,#!pR4.껓M,D6~F0ؔ">`7FzZGY9MqMKcrb!rFH\Ri J3t-@m^OY.N28E e2T %ztݔ3uRvBss{Gz<>¦eİ<W8 Sv3!/JTG_SÒݓ<2jGZ w-Ρ"D#h)BRm޻%/|TA7O=ʈ+nɰ& ¯N7lD-^Q\w`7Z)Q(x='`FH%~0ôa|Y2bOfc泾Cu:՟wƠۓ<UC%hG!?ld|h_2[*bOټŰuv~dPr}Ca;wX/,gHZSKLp~vXn~c~fypj=d mjkslrK›^gb<_6|k'xxfUQy1u}V^ns Cy  yX3 endstream endobj 31 0 obj<> endobj 32 0 obj<>stream H|UkTWfaDdF1*"o]^bTfFA"8J(Rپpqq)[|)++MT +)#.c{]8fKʞ`KmEgϞ x ^{3l` uH5Fe=X|?`+SdA?B(%6;ࠨ)8xD*~D";]sTrcBZ[ٖQIR ީx.\AСM Y#^*R`Uw/B YA%pFc@w!-hL90O #V G9I^ q!2MNtL.9{3(C8L<*Qi ;|H4>E.!ĸz?@4UwN0C훷8{lsI |`G4>2|N1&6r1! M|1$Q"~6O ~;$؛ h_X-3x)~L.q߮K1X FINsx0TV%f6!6  Q` /@ւwE937˹Oie ?9{M8cg%ֲk Jr#cm HtdfQtd^*ls` MZ_V)xC"=:9[wu^(pZ^3 ]MU4\ Tx*M״˳Yyjp<ᆺ~ ]ڢVvmc$S;Xj[~qdܴ߳ʸQ++%닮C<żJNr(.&Wq\z|ţ{6ږ7J -OV_A_D>8x {vhHWs4y߂$mwQ_Өֈӣ$C~vB'HY\% )kLX8G-ni9/ˋm(Xu0 Y|ѵ5^*5Q@_؁LR?q(N+lEp ĝw9ln k#z*&.ur-=pf-e ~gUt#>HЕ%+x!^|\l}6 ӣVm;DX/n~yZaE0rutSΫtD9.Xzej3H"[F}!8e%Mep-Z>z(,F9.ȴ3!.>HE&a]虥VDI,n c~/Owr1ꤽ,r;U0͂ODpTPخ򨨮3Jg. D^_y=mժrlKD(e@DEY 300Ì3 }aQwm`QMNlb~ss?vC\ZVzVGJVgA(ӺVk:zBx-'vhISzSB1k/s[ )v~SYB-HZHE{WNdG>QFRcgj!*66caA'Aԫ8*iws4c|P{t2XRh}5B@'85ˌӤ0 =D^<sND\љI0s.Y{CUPyU%WyIc{YsCOJQ/̔ElncWZ1%nU$L G D?DͽRu}U.P0HEG>$;/7/ݟ5ݲ!܈ƷL˰K)!Kcz\swG@OhK_: |FGس]yfôozƮ>Q 0>:cED\O9OpG˹ammuDs"*t.Z PS5ga.Y"W{1v\Gw_4 7ː*՜/#hf^a!Ϡch1 liytg"|8,E:XD#%~>SɾūruDa T)SlV},5~EqlkCUU-:>ZK" Odhp 7Q BN<Gx ]N<05P5U[,jN_VݳS|^,7vS$K%׊YFU!m8tσ)u"pf<8< uܛNvo3 Q6(!@&}Q&+ӑ eh^O;ȗ&OT[凐(Io'tL=mJCXL=Y}vX~=}@v'JQiWx_ǣ50G$h).gXRB:?QK!xͣDhSCY`ӗ}Gvgua6o P!;Eո(9MNԨU;~v1_ uG(0'Y-9_hy.aA17@*7-;H;ppapimͩ~ ǜ X;a7̌^_yW:Ga}"f>;8W_>RF!vg|uteh QS Pl-x=u=e[e,߇(B!jG 3V\-dbbצ#RpQl˖׌NH1xl 9Cޏ/^n(,O(Fa'$d ҋVX*Pᒕ4po|gXbyoQea;uqNoT7iIxdɽ&a5чfyew(gxΟefN^}Bqăqdeb+ʓmaq hNqJsٱ#Zۏ4V3 zTDy|4s{ QQrԕ j#LWlV_96Ɉu/\dUT3ec1"tX y8'&:#I9 'uqxհm@WDfBa^zxkJh?OmAT;6K:wt0u?gJ.-IZٚ PGSK5M$ LJ\g<93M"b3:V)u ;yri J;, nE'NT8Q?,%M!wD62e\Sm<3vYD4BJia/ ~[ئ=oKСaG'TƓcB}jϟ4B۫V%LOgX9a &7=Hɢ\BM_ƯU'6V4TH&,n9)TOYuփ Ě39Vs|oC(BȎ(5l QV%\I"lz xFz3aY֥5}^Vd\G_8%lދw3(Q_wy|Pŕl鼠@<R/P,&/Y5gGWxNJ 3 endstream endobj 33 0 obj<> endobj 34 0 obj<>stream HlTkTg!d&(F8&$E-hA- T x"$$L"U H0®ܬ^j-vkSiv[uvwϞw># O$IURRB7S FeJ);ÍjE )yYr Mƍ"Ãuz]J%Oo䤛xOgL颳un.Yo:`ѥ 1ߨ3e 9"^=O8Kz!Ð/ H‹$rj )"HNL b&AČ$R .Ձ$^#R8O2dk2,5t)x:0ubyS$#G+ұ3簭y-ղ(&<*zeW1 9T᭘˵/_[>w^~ )#Kt 3?$75^]6, Nimt@$֛Xu"DoԪpJ(pB g,ium%ai2]PVlݐYkVEagq#Q0~Q5wrJ{3JB"LҖ[Z&w")ϥל.N@E5gJ;")\:!;+]a a)aŸR!N-X{%qbSc58w6-E,~z_C.+_V۾\Y3w]Aib!"U 9p7ǖY{qv Xރrx&=^5s`Y4b^twmݚ23Tݝ/|?Y#[D=3BؕU-1& yW1ja<hceMTƣfuVю hW%le?&W^+uz#A*Ȝ edG4If"OW58'@ⷕsg `&c0? ` 'Zwq6^P m;d׏!^ S!qxb)[gUڵδsL6T؃;v:`>!,:UJG|+$)̉FshgOKu֩Jt_f'8ϺJoŮkpE\{`+px^q |_rd|Y0l%5(3DΏڨU)|8i/kGWOXIw^uX24t»3s(0'7UKC (I[]v^|Ģq{=E6E=:/ QK9ߑeks8% ,`#FhQ#%:gB=M DQ.$zj[Rq2)$%佝d?p@"7\<>n%H/ȿdrX wE5fLb*QXl=7px }\f 36t {mhMvR[z!#xɫfL!\27C8\ba+29#r7%_^"x2Wեg(|'5ӒBc e44V*v¿K=fzLn ogN& 8IJ+㬃 -Q$,pv( 6p>h TЅL HfĪX9Q7hFUjRX\brd=#XcV9^Uؕ T [-HQq#۔ ɹ%޷ɒ-fOyss#1Xb21CAoi Um\=HnnS,:|/Y,B%ġ( ~y<o}v ~?OUH5a2!-f4m~m…D>;^f`]gVW!2ӖWYI!] g 3{s QH1nȺϽF{wgv[l? 7 5&1VJ:VjtVw쉤Pp+ uj[\N|*xϊ>≯Κ.%%=ϡ5}<@6j_cGIN+?$3k!,nE  T%=ȂMҴz5&kM-{=uϱRl5*''-x:56P@c[El0aۧGyxz~vPڏsSOdRIJtbvT t L塂OदyXv0C /'#@>>v$%$oS EXXqH^VF]Cq.r%F zN(вW6{*QnJ)0I"{$ JU))20Qмf 5up tLDQt_íaQq4Fq`FDcl5V>u3W&ꑲRvF8أ D=AX@> KF/m%=ǣZ*t;Nʳ+a t NHR endstream endobj 35 0 obj<> endobj 38 0 obj<>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;> endobj 55 0 obj<> endobj 56 0 obj<> endobj 57 0 obj<> endobj 60 0 obj<>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;>stream JFIFddDucky<&Adobed , z       h$3P!24@1"# 0!1AqBQa"2PRb @#0r3!1AQaq0@P P 禰rBtpvќeϤ3ÂCɂzl< !)#,^)RP #t'"0ϡ E6I2!| ,2@3ɈPS /IJ@lɈ F`JFR6 h#&,FhDFj^3Ls@6ʦ9ph:X,̳l&"0ϡ>| +KG͓ 6p6р} ^3JY. bX1 `>eDdKF !pT3 0Mr} [' ( S9bQ3S 2 ɉd4 ix'5sd'+JZ;*5,RYmF)y~+'uf!d[Ȝc1|>s9c1|>r9c1|>s9Y9c1|>s9c1|>sVJ名aw/Fݿt^klmzBD %6:xt :HYjӱQP uy^kƈl| X֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝i֝if?U?U?RhnTH5t*i$gK0Hl?${R!3C=]&/S18 yy=FX hک_? ǔ(7hX)v0R+<*+}'K`}KUJ*dTRJZJVJD au5v-D;?\acQp : `H9ȓRjN5qv%P&3{k1!DD1SN]$"ƣ[tM>ֈ 5 SO5-%,VzRrr#2D Ć6h&qԨؑ#UӦ(c4igGkw"ܢc뺪ABN΄"ԩLڞh5ZTq^"-Ek-kĪ[;ez5N_c,v 6ȧˡRm(IpTy ÙV׳lG6kz/Y *P|tFEUbִYjAEoRSOjQٺZ!\EkXZH5zDc:FMH;DlD`1޷c'5H~J*TRJ*T\*TROЮEJ*W"J*TRJrl~#*@?$E!%E}9vNCtr5i<15%K~k]vT_X]N\j[p(v7U/",f:7<~GrK;cj#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~F7oߑ#~Ctӝ?!+EرF;C I065)p \&X6q {e62-Fy9ĠAA\!|;ӲK, vľb/֍׬yUs"mb mi.Xd{5r.ͺ˯H (ag'N}gVg\7XG6CKD"IBe9 򀮄('-r5'c?3]9iIw)37.vzLB߁G ٬pηst˯j:(%{^h?Z]A&mskkn?9p%7B5q!N/]O'y ퟏX`=|<,EAa+4]BcyrEAt2B<1ٟ-hlrӠ^x)E3qP.:?L(6( j P) dNml$= ]]1k*@)Z:QbQ`Ġ[ZpMϱ f_e ݒu#pM?ktOan? /`Q>izOfP~ٟ-jq 3><>,65<ξ"3Gɉ<4mLw_[~6<3={pޖ_/9@y]&rBs^uy}_Sg|x|Xv}#f.@5YWiy|= F=w͞r"=W5zPyM_qֳ=<ۄ<\ >bDG:ЧGybGeS)Lyxy2 ;USwGj42_ѨUѠY[n*=GTKɦOr cKPZXH0PY.)HTPK~b ȵ8Df8M|iuCh^cVe"fIwk Kj \w#{7U3sF 01+1b uG#؜br='#؜br='#؜br='#؜brݓNG9{NG9{rA{NG9'#؜br='#؜br='#؜br=N(֭V`EsV (՚Լ-n iFb%nZWrk)1x0 s'4Y6C[\n7[n>>HUUQ p fJ#BCu{F\7A5K qgİ FH3aMt:M+,tD?;i&~upfSN E6&G{"4C볙Yߟ }B:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~pk?!?! I$I$I$I$I$A$I$I$I$H I$I$I$I$I$I$I$I$I$I$I$I$$A I$I$I$IA$ $I$I$I$I$I$@ I$I$I$HI$I$I$HI$I$IA H$H @ $@$A$I$IH$@$@$ H$ A AH @$  $H$I$I$I$I$I$@I$I$I$I$I$I$I$I$I$ I$H$@'?+SuFҢKm x3#ɬ~!Cs.wBD7 7 5!Rˈjv`23fT\Zjt5]\(U5R0/"RZpxcw :3\q*wpB8$XYҮ(8d4e[U wBG].*R&v4G3Fi+X\˂ ar5 =aOս[64Zab .-]jg3јm'0-Y)V~ڠUEziI 70ǣH"904M Ҳī}E0Պ @G`kQ+[j+45)𙌲r[B8VQXe)ikh3.Te6f K"z5ζn.*ȚTs {UL5[ӁsR*pZؽL3"#Ƿf4ERІ'4WE(GW*\UPzU2bv%%Sx+-^c>)gZry'W|"n:QYSO7~&€P^lǙxjr8L&u2# wy/8W=?<g/7v PU::Ǫi==?l^ ވf.y/)y <<ӊy{tz0уQ5Ɲhi!oXY5-@Ύ^ם y,3P*Mzǣ-iҌי=?< >͇<-w.V;S+"=)})-xkku\^9S|J򖻑\lEhp'em]naG(c)P] 1XR;> endobj 65 0 obj<> endobj 66 0 obj<> endobj 67 0 obj<> endobj 68 0 obj<> endobj 69 0 obj<> endobj 70 0 obj<> endobj 71 0 obj<> endobj 95 0 obj<>stream Q endstream endobj 96 0 obj<>stream q endstream endobj 97 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 98 0 obj<> endobj 99 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 100 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 101 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 102 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 103 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 104 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 105 0 obj<> endobj 106 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]/ExtGState<>>>/Type/Page/QInserted true>> endobj 108 0 obj<> endobj 109 0 obj<>>> endobj 110 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageC]>>/Type/Page>> endobj 111 0 obj<> endobj 112 0 obj<> endobj 113 0 obj[111 0 R 114 0 R 116 0 R 118 0 R 120 0 R] endobj 114 0 obj<> endobj 115 0 obj<> endobj 116 0 obj<> endobj 117 0 obj<> endobj 118 0 obj<> endobj 119 0 obj<> endobj 120 0 obj<> endobj 121 0 obj<> endobj 122 0 obj<>/Height 216/Type/XObject>>stream HpWݻKmJVku A`F:NZ팥J+S@ZA",V+(Ef;v ڱ a@R 9.ݻ%T;l ۷L~`H9>r$ S|]}`YjX.r[`he"%׎lX[4#-M0̓:_wΛ\=Qi!fif!\G7WjehdbffbD+z6JK+z #RǴC,=T-N 미o^VjǴC>ѻ{GsZQ`!ө&yt^[NJǴCŽv'ܞvW\ 3 J׾vwÏuُi϶x\ƢW&}__N7 X3ea;uPi4 hNGD,!U>dtNĵҒoΩ;O?W?q^ghDT]])Sf̘1ucG;~)_d;4MӅ FjTSYW=SrcR_ާF3rXId&jΧ-d#]װa}2K{.V`#Q]{eS jWUS/dvUT8-9 =%g8eG "6¶÷4zҧ] 8\~ȏ7[Mn\c|k `H&{ݽiKIUp # zWeUv3w˒ML|?)GD2]][|Yo+gw-YPCS.6|7 x#ŶoW3mf: R) ӫ@W]V'ݹ*(d-;mofi̙>z Qo;OuGg&HS>% !=mqW/dBTbՈ%Nɳ*ݪnb)UPQYX8.}Ic&+h}岥E#eY6F"np6cy=nbArsΧY)s!;֛AݛfzڴnA](;Zݟ&\V忽W ۶k̟W "~~qod/߹ b^+ȃbϷ~/b.3/n1=T$4$ZrqK':c6W In)ZMMFRWLWV~wq羔]ڶT b_J29#M/VxZ_8gs֜;&V`/6>7yȽޣʇɲSe-wձ8<`Zf_rϽ{}K3=;\i>GF %WeP%YkP~s,:jKݒoZl[;*_:c0 5zuyib7UX&/:衦n 4?=k+W,^V~͛esǡ|_r۾xG׌sp8<`-ggwo?ytęot>"@H \MUIP{%UWyXs9էK'wͦ:BiO<.}Lӿmkk7M3LR--gO NSTêՎS;, u~g>} ٶH$"sm-ݠD# d}͖Ս[UuePH=VA/8" 1X-ndcŨ ,ʕp  X,([@ + \2uo{/a%̑It{UxfΚ遏Eb#Fm_pЦf릛[LB".%O1CN0&l)SrS dL1dՂHmUTCsJm8yDͲ<Қ͌nxy{#_v;rgI8WsRԩKaO&8k"#CC(s/]~UVe"7=ۡC#&&:j~/-p{d?ƧY,6it+G˰ވS"RV#ğLu!F H"XbJRs2FEoHku?)bpq9jnm6Ol&ޝ'Nnذ_4GI3Gv$ř3|!\zm6\.oʡ{rȰӧ%8?]vt1s_Z8g֌k6MMU͆MFn0J.„X$.BIK hzIʎJ6TdLF2eB~Ie9,}x˙RD;?U+'Or\zǡB<eۦÆ9_9{>r-y-4=uR6睇w߾}{t 9cƬٙۿC Y]PrzNȠǒ)cbd8I Ljv@X32ۢ=#"+?V6(-6NNxl^ʒ{wH$>M=i,$6Caq1A ?ZxPmQ0byv G5k6d2a϶D'wR`ÒF FyY]vѣ|u`C-j| Z9$i;P [I&i LqV˹v;h@j".2:elt}BgUVUm&dDjd F b"%QƜ*˺v֩)HWܖ&ws޺C6nZ3Z7ݫd3RƌvbZՅx  ^?a2b !KKK+.UaΝy$qED[I(鍥uًzLt|$liC n (zCՙ+H!jB1*.DD35Edݒ2>̶>˶-//Ƥy>7C=H:>ߗO\s(ճ^夌ۖP%؊XJ%d0("ܲ3'a6ɪ2100b$I.$ᴥ482,Ǵд#%Ϻӥjaϳ>ɾ#<<}Amm]FijO!E?^FRo6y3OK-ܗ*+O3r헴cGAHHH-zknmN "ˁԒDL)}K䵆c`D̉\ NFeFK/ ]:zu j꓄0 duM|{t¸EC%`zM0`lnZ_A)MO8~sR oݹk9kr7l [bn~:{#3)r4~)jY9iݖJW8[Du0ň)6N1Эg>H RJNY_.@Qwq!.(>@$zHh a$jCF fvF37'h-@ 3O:we(>Sn:ݷwGYxf/Dc!~𱚰p"8 #'Fj'ĵeK[M2rC7?'AONMbgAh xzْq+U8zoGկ*)$VU{6CʅicM/1z`9nWvsya m4B @mz] ?w; μ?vЉ??10F3O+W]OJH`9V]v?<23:\TIQbUh@€VFc444ثgϭXL0:'/7 B @'u_4ǧ׳П[ϟmY B>#~qVʒŭ.W.֝=ԙ1`uND]K(3&r Fc:#1X~1~mio{!NkY k6@ QD\\YHFNF8ΆwX|LW.{ h^yE6; 7CAj´@އ:}AJ}ڱ4% fLO&O tOBRrVf`9 oz{AUKZ@BC@".^,%qL8k|^n6MVC  iqL&sDD"m4p3G?9RR\rmZLL)ޖ[loZ6ĹD-1d6|"a xn_v&%:gs4$*e ?I)Y{3yPHߺ=t+Xd !1*ْ~Cy) %fXfij12|rL{UUxX믯[m4€D={.]7}}-˞_%--0(j }Z)2j$:WYYE͸5˗/7~ڽQStⳊeh$ -(E\HԄgiL:\LyWQ.8jŻ Bc!Ipόߣ)1dx@REYy_F6+@KOd.g]axCll䛚gp11 :3 Ũ $j'袦`lzirJ]C~"pݫ&M!I2I)Y{3n;z2c! ë0tE[btKSRXSllkn^(@ #`]~1i֬]^}~kzzAA^3왳ڹsz[mx|^NNqtֺi#c@88γ[ 0FF۸estd;~E NGJ]}@? `/ɼy ݫ7q<{* ojWɩNNp8$Axc݆sa {]Y^"9N3w:%^# ݾq:Q !l~6쨭qTګ3OJl>Og7ssN0irR/u55w*+o:}$0:1\ W䨅=9wnPPIu#s"s\ǹs셛.p(!SҜـ W(/'*ɔN:kk8;F M0=8s2sWW'q@`w斗-\\ W:]ә,|ϞYh/z{xIbj5 x 32vܵTȌy-ee׮^9ˀP06o875W%O.u:7@,E"@ Lj ШAB i&Bn%/ZvlnSUk?xr o~2tl hTȼd d/MKv`$L* s+Gǝp王ή&5Ψ5FSվM4I͍ U-BSUe&$vYOhjl[-6K{ _]\T`eTPPPֽ^o?!SfqCM3pu 38N8ӀgZ[t0 ~<caa͖ho76UWs% wzݮl͞_?%˗:4+뗛6HI!p@ͱ#dhA>遈:j܇dI&cF*@.v!Eܺ3wut?0IX 贐DLDDM}n] q8BS j ^1ƻri#yQu-J;^:MF!UPPZtX+-Bcuh]f9oL; ׷ߞ6o)(<@_m؋Bz9uxK`H/ɓ' _qqqŜ6OU&39c5[nxa^d4EcWWy.!EDZj &b6;^ Nd&oM}s' $k䙴‚hq/ud3iFuewJ&= RBFG3lc=ojjF¬F XVimX6=@ <3M‹">x< %K?r\QTht8@kcMbbMfkscܐPWm^oioOOS)(Lzn ޓ[W[wyY)(((|ik]ykWSxVcqKβ$+faP(䀳⹏&sⰪՑwܚʜaӦՅX<='=>@^)$]=1R̘[E&Amf6C28 np8И-kc BtH8{hpGJg )!u) d{Hv%I!;+`68 f T^TƛjتFzd^_`3Jd2 fȶċ{vbo+Ķ>E3$$ɾMMQwȼx=ftkv1z}Kpɞ3JL/^xNfя=?;ֆ("@pp:]/)}gnN)))Y-2T v:% M>h=.CTv8f5=h{zseebju/7oY12Aу}8B{Cԙġ R8P 3 f8ҰATP?T&B<ư)F9$9WgpKȘ! asPqg.Q!Qgddf` ]s:Ml$I)\Z^ W޷Ew~DuM ,&&𸬨H>lK{v?1ҎǪ448*2)G/^::7latpΙw!LHŋJ哷mV)zp/dX7Yۺukt:;:JFDNL>$1%&%i4O`bw&K&+5O}V`cG bH0!--uJ5z;};dh5ʘ:0nkR2eĉmt{;: eHǪnz=(Q cJFcZL&l h\\JJ;|YNIIhj>?G+F6C'~vTMqqq&Jn+_/.-jG(/:rý{B@WwCYY^#|1۬^AHI$))L2C8ewwu^@*!aE299 Qa񴶶axRZD" DKs3x$BP\BԩS:*wOC@mm-=Iɛ~yU"!A.~%";UݻOacHd"(D@cdP 1{ty24X-pHw>=V~aȹ!;\~65E=.q8fڼy+1S̡Ȟ;cLhcŋF6ܿb O}<KIк^XX;`vjmR__a4Kkׯ lgB].]^( gf\dN7yh̙kW6C1bMJL`'1 Օq @R 4-5M{srㇳlh)[>)n7, 5!L--_]ֺE~\ˍEB TI&͘>#o~^VvV ._܇bb33dϚ5gA KXLM7_4W\"! ֝;{U `,^RS/ʢŋA-GS5%v T(pz}F-w; $.3''P+//7nŋ  t8 <.>^n/t^6 ֭[v C1Xy` !!!33iӲgJKME L.]ׅO\PgbcZaZTT|zbILbشOZ@A ^]E;/w(Xb $JJ!Dl` :1+cY,`" O< ҥ/V0a(3k7"_ ̀` W&SV`'Y//ɘ n#  / ?Us'r_rlXvZvhuuG"GZQB1xLuDڕC$B$܁$aP@L}y~<Feźj~-S=,b#6tZ7p?ۙ eh{rH4E6NE)i۩;hKmr)'*nT{z#]+-JCV@N?*Pd2H)d"X211JJ# @Rt4icdr^ioo?˽ zTYQngẅgMl[]RgX$ju* Q !P` C@ѓ9utRQ烩 h40ݑdrD"Je"$AW.0ȝ๊N VEB)2`ogg'<7%ή" Y<#{! }_bV7B &.сByܻ 22:MXK8GOĄH*:xyw݅G*5[7o9zxP`۷HL.aCf3O!s;geeݷwEuuÃkI ZӑH ֧gf%hg+cbj$Hb0q JK\.===r8W4?p8xJ;?ݙ^R188< bup8B78sn?zD,'K==..666@ݻ &7!!\}֘G#lW044t#}M_XXXSW 8HZ#S*>LKۑq.3q+99CІ`Ȥےss|WtWOK hDrTTuIf@4_?kNGFDޤ77B6=Xe_9dQpF2h $`oOwr fzsEeZnzu 2DQ[`K|- fDFFFGpsuIV{_0x#Ucf1ۘ /whaAPjZ3ݹWGLgۘr !>^[Rvrsw3M@`٪J0P(7n&o+H,WYrţ^aqͶm$⹒[uhG &P{ZZZB_&aSJG>KnK]vL𣴥.K!9rŭKL>[4*kyYX:VQS@(:eX7JqLEieTDhǯv",Z% [}yY *r߹{~&H$bLjfb*}&%yrOg**9;؋Dma ɺz؋]>|x-K=]΢S_q8\::~ouZ.Y=NVnnaa>X,mH9\YY 4;#vM"]U:8hۮ vఀ%?&7J2#U:1HY` Ӧ]xRZZSKO d}/]VbuvuM '] Ê"P\\-po؉lߟ, *&X+'Wȕ ) 2Dd*iҔ?X@I0r75iN 㦐ҮqIr0 <# #x x Lit.+ f,-[frnh &G471<<A=`̎>fw*yܠcqr'L E__bwwJ1PXIw"NQ= FJ8$@;~x=hmk;y:IP<>uwwL)?&;N8TGK ndf>{ᘛe2 KK'Ϟ GF.\ɨd`hhƌєN̬x*v`@`;uZԾi r8cP 9Ru*"@|5%FIʷJ QCXX"Z~Lʈȯd<Ӄ`#aE<U`d6 %RO%_C,,GH[ ZGgWP@ko}{edق|fF$F%%## ^tU`?!Z(?)5b㨏[Zpx<:8B`tiWR_.ҤIҮϙT)7[-[0nK=BBaa11bIAQ AUR :3aĴ|WrO? nq6>l#@55 :q=I.9Tx-!!Aٜ._LӨK$ᱚN*\$\O;˥5bXʰXd2 : QCcP F}At jąn6nXHax HBVNNSC8Cꩤ7y5% Xppp0Tr &׫7b222HD~{zxyPiy(d@ukײr,Z :eh-^lyͲQ O޸ J,`3nF댊ܼoZ @8ݳt޾HI=TQԈ|5kfHɤBADxx'Vo Ā:991f̈́r@'ќ̜n:I]%"lV٨lT]}bҵhxvclbYkFgeeII=Τs8AFlenjh5ƁкZm:}Ѣ oX('d H$ @K1/1]vu{k[RRRYi e6mbs뼋?j~7RWp_`w7ZMIƚcآR&٠ R?t2&x ؁B]N[42J^d,PGp8i4 `g?w_ )*|5"I%#C՟L cM; J\[Z;Zy2ӑH}Pb6zO{&I URQ2U/RZY b0hD1D#%Mh]\vޫQYUXXX^@Bӵu͟ʡ?vDک^R'Cq̎`hakgN3UߨLOKvj F5½7lZ·P, yCB% mrrg 9|㇓&y,gN"122ZTR U71yǢ"9Î+7w"UwSSRL6BUئд^{eK`Z^+*y6s&_*3;cm-ͯr髜?80މed8z?s@߂[3YJX7iQQII^ ۰(7_defeƣ!ҖTʍqJI"89|c2W\R\īU9)!v~董7~y6 Fo`2)$JDs7TVRB$D"e``@WOo.߽ ;7z ]f͞檢ym` ע<&kj5||nUUiQ D_GYΚ`ڬEՂ 6` i46!Wȁz \B)C!S=7&%35/;YcJ[;[]ݬXIRut}}q=ޯE1.U Zq] Eݽ~B D'%9)P(0eDDl޲NgG'#,WDn -*Y=?_J*g{# P$ĜNKT2[ CavvkV ~dw)d,VC A .V d &e)\ԊAkkj*+D"7%8jeQ,ͧ6]aLM;-70 Rz %% ^ 4:ԯw|#WꊋIIM"SDBooV̨Hܾ{7484(7*]' p:-/-b=~ rÁh m|$ܩ.,o`ii)B~~\\\Mm B ]vP(/<=&А ,Y˔]i?[,(ȕ!Y@4d,S-4&%NҴ0{AW$@p2"3^>/d'?8#+-RJV "J%!]'#"=]w| ɛȟ-_99wۢ 1)!nj' eD/Uԙ_ !! +nqNsDq $! jZR"(EB&!!$eeyy ?f.g͐Hr^Vfdw?\~@,`!r/4БvޮDQ qY:1{JMA]#_ց+o_0Y'״ظKp(~{셜j>#陳K㋦ETDRpxqbŽx\޽*,!n}dKJN=w Ȑ*x[:hNj pⅼX tNV!H*UA*X aDIDrw|FQ?I#Ewj9 ߭r?_-U mZ=I3N_;4EImܷu]I<?GRɤRyz[ sV,Wu \uW'1Ad/Rb:ր&ͩSO~ Jtì4P ټ@gם{n I]vj eGن5?7lڜv=2ʥR-#1!A` wBoUU]&.>~SiΜ 'GZk8'OlggW\ @.#?맜tIJJ,nEgfLfww7{,#W]ˌAƎ(.ؓ.wuu *x z666FGFTH矐8w 􈒓 A I~g΀B/;bPuU͑Çu;e2}8INL@j[;Z^YRJ+_ `'>  .ߵkבH7W7Υ/1 XL8 E=S~p4>H;Ɉα+sY,+,)ʱc/_89:j\mHzؕdOÓ ||RV"ܽWˈz )U-[HDݽb89AŋO={QG*IR+W )f .~W{[3#e^kgm / 4zҨ K;I€& n[ +m'{n!̛y@pز`ImԁyF9a 鹬 LI.CF(zh&jXHjsT/B6Wf S#`cL7yv-AfjaٟcxY Goߺܴ{tv{~tN> #&I?oXԧ p 9A76UW4xV1dڱH ><<c#1bLVjI#"! |*u k>(v:ҳ<1X4P{y"1h0ɽg_j!ն'Vzi(u:; t5AVCȽtyy hiPZ^Hn~6*vXG$1ͮimX77=l*JiZ?auà\-5T**-U߰hߦqcjyl 俕-F14pFNgTU0_Chg^tٜ9>MBR jmLƺZؔeX6?%tY'NΘA=J$_=wW bg>P)88X˗-Co0 9lk>9|towAqqO%%> 4BGgde>M%ΆPugn/ffh4'p8/:_3T RAcჇ4;u @bIkw j(_qtFqQ<-#{t=5%KxF?5- T|(3wegc+IWZ`2ϛ +`}^^ZZ@9=3gbvK;t $'OѸ/67䤤JI"1q̕5ܹ}7"v'2Y.S԰!6XN}]#:V)'Ɏ۶o?H&#M0ɓqaX9>aa :mm)d+uPׯ_(Ȍӑ:"8N/r''#stoK+ʢT''E̾}BQPټܼ'|>`yh!!aao="K3cc>@H@ўFKTtzzoZvjjk/AaV{"_߅GK}5u A(m"DPvQ. Xk벵t ACT* Z ) ;^p;;$}'q^'Ϟ=+34dv{9bs Ujjj=h7b2%2ZGNvQQQœXhR"^w[[ vZ$4K2W___yhi4hH)kfg'pHy95аޅ4U _7[dJS}݋.\)TT䂧] H[wrv߾m茉>FCmm˖{%b1y 咪+Ⱦ"G%R(;ֈ ͺennNZ0<ʼ\Q =0C/94Gh4_lIL>RGrB׮&%.ʑɉǏ)PN C#WZ! &&0^F&.}o/2*/~ШTpTKݽˠ+x8;08Xaq`p0.::R `oɱhVUVz}fwϧ~2ht|5A'i$MoV+>pBܚ6[dƆ]R|MJCCvqq6֪t=zlhh(MK ݻ4Y0L89z6 Ν(x`@)Rl6Hh6PL`bfIp a!$D`H4]Q~#;7&b342lkxT:ǵ |>2н4mQKKKm[A"9Tm‚+}}+>69zI˹KlfmEM}CñGZ[Z@'"T xz+UWUSSSt_@|cMHhok71?6>`! i箝ztݷ(^$TLNGgZQZH[8Td, EJo2T6B1(^XdeHBa_qT*6얊U&UT̼A [KiQX!}R $~J!$L f uEkS` 0o\0247^G?TVwI ogа4M`8q }RS_<4’`. {'甔LCwF~pbЈTT Es0C.[|o}юoЎT~%~?l;R Nh-ekm$U5e?=$r:c25 '+k +J_BC8Zd|P()X=D#]e6k>wm7Q'0UR_wO"W8OtUSS𒓗vH$"ߛtZekCii. kx<^YZjO-4YV'8 8YQ@!&1};Ilvϳ xlɆU&5MYUG]L/9( '`^I*n<): S tjio磮kEEW >V*y>]jB9Q>oTj#' cU0_=n[] 4D&'oL=wt \f @8ʎk?M ?/-+/,(hnlsB|B e$.I-!akUm0((.=-#z̉KUeU&]sW/h(eXېaXV%۷mOtqvtzA~!/3S$,#_|yrJ~{ءwqvhՂD F?`JTBjZ:,}c[s7 Kʘyp ݽS[uA: n?uuo0]HQ9j ,!1@ELk[ۚz, ހZo@D.pIRZ|1}Ǯ> sy"Ș 0=f800ƾdNcbXқ&9W.xg!hEK9qƨ̙Q1x~J幒c9C$"VDdætr W.UUnn S&01Z]=A2LjpIڋ|vGSb#aBq/=íB+؉@[([\c,3'`+ccwqcEmfj9|@J7h^.zһyNEEe]ULF8# T{~~w-&*rwXB]29&%cۖ)`b-H8bGF`MKKB/x{5ӸRy+k&p}দjqtFLdHG/_:s i8PO#" E?FR=iT]W}Yg4 TcfOh@`}uvqJfF'΂|'hԩGFFGtѼd䦐縲<=l 5jLQiT KE U+}֬aXiG(fgnf0bڏ}͝3ix5GElowga).D=!>7ӦQ(>p/f$}qLz&S(:>}FwW?yn|LJ&$X+0o…s8i \ ˎ wv1yWg?&  7lvH諔_>M1AX7mNLN9-s_ ɑH$LdXsErJ{^jkkvv:9:+ǁLx:Vk) H: P(lll|>\N*u{[͖ƫ FFăI1J5P=ab-Mvvvcr9&88x_hH` ],Z  3(ȚA<L8=WfAeT+@:A<Ƽ5: Wj Uf5  qSPfV6 BNC6kCdX1DՁ- J"T\uǼjƌ e@"/ 5MsMl0`vؒĊFrOmssbD%[hO[zBHIE 9llm/_~}eWbs'HN!ͬ9lW3ga5|l3Ƨf[%ሙes<siČtm"&A_.]ԩ/088Q=h-LG::֝\nGc+\аW#D{_xDl?T/S?  [%> n%eeXM9'_Z'.[Pzhr!mj @3{~צCCtc}ԴAJJp^!B8t@ųQEUDu bBڝFfĭYF/.g$@ ^!ݭڶz\V^[Ir0vCjaQ"aَB1b|VH$yGLPz'j5;1!Nn͎(=P`P:РDBlP9 VbmNuC/Kt9sLdAni~%ԣwŐm;#9Ӧjlv^=*UGW}_ IIVVj< >66+#I\׬KwE/$dgߐ iznQφ gs8; O? g+?7a2THrժȳ\E 2LBzڕ填KQq=Ɂ֪7Gsc>޲G!'Nmi1bBP&&,V+PG_՟ y\Qd2):@`kkZD7%61/sY|‡rJ :]\q΋PnnnZ7 #: 0'A1]z Zq-λʼn2E:" =wzr"#m'7 LOOINvw… :]vSb(̬vvpP"=v466JsEg#ŀq<rB|Ež-J546ͥKOQCKSFBL#>{|"ϞĪm//(C4`0;~tx;۸ qu߿bio>:6kvrHIT (!a䑄@ʑ P:IޘHa'C{I-ցeD5G T]ʜOtgXDZM &m5PTC* '##r'|pF\A-gʰ(GQㅄPre|4Iy/^^05`qj箤 ?L5;ŀ \cbԵdϯ/Y!~Pƶil:ĄBxgO|JFnYg&vF덇d㉃u{?<ԤӠA>׊(9E"Ξ3cG ./+3ֺ?tS^TK$bӫ .gqVռ8oo'vN|Xv2$ԌbcRI]]&YgEDr{zi&cHu{5S6m{ŒANh:h4gE.044xhhxÇXA,U,]M[YN d;"8>CF'e2y{'gl'; gg|%22b`F pY,::3Qo_%нlݚlfj*ihh,emƍ=wy Od2vFd>Νf"6|E#pppPnpG텸zK x0K׾ M6#+&)X"YA7֬ +bR%$#1 TLRTAqto5tBGӡ2z.a! vVȘ2l^U0/71Dib߈IM|(15\GtfZlHI&#v~!D-3C H8F#D̸~iD``hxzɘ 9yN-PVϯ{1M$_~D [֭_p|iS\Rz.* З0QGI&ٹ9sfς/U*#D47UԹ/d& W|UѪU Ķ,GY-  P. TU =XQxOHHX!aIp b<=o8޹?wLƎ`na`L46߾TQI:b:|Ppy~jTASd0֓&jg?4Xd03}}#@d7g9W'mkiLe`:/qTj泊']-Z >{VG" _#ݸsdhܼi( *͜cdXi\VJvwXOMZ|nGDķ,YBn3"X;+9XCQWeVzN'5cN*cH.˖X;SEQ鑣Go^ )>^Ͷ,B Ӧ~%{ *wX>ϯH*2ϒg8@HѰݰo2²Ʋɷɏ˶᚜&⩼tLF+TjUe.Jcenz?y:]pes@H$Rffv]pF&.1!1vkhTZ}}h2j3 jq1cd -Bp|tTPh_z rOLMiin1$5͛QѮ"QNvΑ4qHGa  ֭Y;;9\99;iXQ x/gX0)LO_z. 6n 255Ɓsgς_[[7‚ann wrk)i[恎4&ۯ(H2¨ґtUN0FO)&l@#J&*KנE+[E2KC IZٗhg+xu`;]8'G> @hl +wi` _ Erl2% 4u=Bq(J:(}go!5)\JOnHhQ1\x=0|Fd +;_~+!Bk^ ;:p?sU# 404,<2+_JwĤhדA3 }X݃vL ssh gYURre{  ;82ǵ#+'9~/Xo]]h`i67+_Tp7Jk&W!G`|I /^T]hA 8<̹?a3˰$C^RPϲ3 EFXEg9j]]޾!iZë7}~xB"Vk@h{6~`m%ׯu-| zz9'̸cY)!H5qfvηse,F,"`6T`___P0ːF@T;̜iQn3D}Iif郎,b۶{.OM;0s,_"G2W,(nwOOZT^|@[(򊌉7nFN4à|~GrZ&KILHKL9 ~566rӹt:T+2af&&Zb(-fr>Ჹ뾱9+<*jgX+jJHOGB DZ R(c$BGX Br3жH' nU"$UaP`" b$-x\ y;цS9CMH*~ ȀUF \$)T.-S1xBᦁP(D8b9НLiތ&fߴyyxtiPRx xx"m1v\bq(&P~~h Ex<#C*rۊN@o9H8\D3K,'=lU8WalR\V͂´tX-ߺ\㭾v@pgd%&,l],0`<۔XkQ!{1pl시*F}CdP[9.qIyg tAxǯ= MSUS<@!B>Ѭ==<~م0md׮;u{=A/PM o1a@KMݸY,4{X޹ ᅭ&&4Kev&qϞ 7FƴJֱ۷n:*Keko@/g7SGd[Z CEK())64L)pHhx?ku^#HDzjj;03p"y__լ}Q;򔶃7k D ֳ1!% *'PT  WVLbEW!! iI|.jęGG޼&J9$SȉHsA6M"i< mHoG&E!9 ГQЭ+F(_:]fߴyyxvG1s<[dq%EBZ '8Fv,A _ 4X. cԂ^/Sdg h6Oˬ5!!]4ĤJ__ťs;wC;\T:/0hBfNx PX`u\ H$oy-'*+V)@i󗒁R(d1ډK{cuD9DDK~:())/B$jc [0v=}œߣ{w!J6኿䝣M,/+E ?ߵ?73)f;>2 AC@"d=zh6/#iibqRl zZ~8Q7C܈7ΝF[ vs_ǹµktDh~mH28cu[4u P\2'8_]߸'8H:<<6b/f..-3ZwIV?6t- ^+dm ~agw|`'gݻFFFO!v46 R]} +(l4Vh'% ?_xquuDg~;\]]mB냑!Z#"iTC5xVlUe%e,~gGg7- )2w}NkY*UeeKRsPKt0RV)~#h7*jG DnsCgpdEsDp;w?jnohhPl 䧤3L66HKolMR%S!aa,7U33?}P(]bboPH /w H$F:"}: OrkԡnCEt`3ڏàka"A?UP2K 0(D#ta n4V"?\ObrE yϻA:b.6cFggkԦ ?+uEsuTQk4{D~U5S>ޞVjPn#d{`H6+Ղ_=1b9Vj^[`pHl KJ!Q%)9%xQ5y3d:|ل-8:>4ᣅd̈́ xO70e200}PV&Dxpp4ީ͸mH%Mdkk׷fZav:Hܙ%ȨjUz{yefe3J&e Ugu*K$vvĥ27 O&޻Gv4*j& 009%ޞaNFZz7 t`Q,&ӂW>Oz..S؜m۷QdX/eyC? %F P& !Tr6pCMx `@H:vcy E*0b>_` Li?6ˡ idka~@tA#0A@gC$0 8k|H\:"QYD8c S1:_E6;V_4pT~$1) r1ȈAD v~+}2(xæ{ a7UVVkR ֩: io`HiƎgEόMMNEq% /q8ҮQrlދ{$bzaDԁd=]^Zz։y2f?o5>./|w5jWU!L&@=d2DI鲥KTP(._vmm`;8:zxxl߀T k08cbjڗXYk yk;~9Rx,O_c=fsWͺ+&)3<^Nx$T3 v:U~Q'c*c׮=_߸nieů⭹\t%&" "(WyXSWI$=c:8Mv|culGvI!YXAZV6E sFTʨVH Hls<2w9s=qEW\UQYNAU5ܬ o5^1#G.Y2G?y<$  IFZlMɠTZ\/(A9Yn חvO]ΎNx^R%  LJOolgkkcc3:6M#/OOLhj-xŋ/\")֎l$C!=+զ0&'O܁S8] QQQٙaC}ÅА/"(˫V-[̛g1\n:xqwJqvqa%$Ʊ57]t:8`x@``^AE ojxvGF2%ͩ=W F aRS^D$DbQ@|~˧/Ԟg''r0D=MPW}VV&:hbˋJػoMM33}d{FVRs-T33ե%%T+rsف(*,PhV =?޹oƾB.޳Ν;YYm[]]\W^-(v>pNT*Uje;Ұ\[(99c |>ٰ7Ȉ9ϳ2d>ڻ帾ڱo@З*?9-<F@L5'z1 Hik] UJRMx-x2>)mv:ԁ/VF,& !PG{usQ] ٝ>(HpxHjG vp:(x3%<}dr°$ykT)hoA1(҄|ƝykMC^3Dk_͹d,BO ZUƭcO <|ȼ"۷Gp1pp(TOwãk_a鎘XMYW}ީkgbرR⒈0,u|PNN7lXu=t 2r!m  hh}w'$Y;Frk~ucry.4A(_98[e|tM=mǙ|491a 2rJ,9j aju\;YC,z.,/_{{LqSP&iѠP( Va_ɔ|]^ZzdJ{fnApO$Adrbfvz?  J!L< v? )=R<Z%uMi@{).ti91f]ޝ; t SҬ/)=K~|iZ @Ȇ63k oVn޼po󆟯oRRjpX`%<PQ<AhrrrB9kdgg~0;-dkkC$nעbOOOdK6GFE)J%3gGFHvCa`R~+s~NOKr劧;ת5Qoɩionog ED"P_RI7fs8K}X Wkk{z+11.!/_df4468:8܈lLd0$'\_k#5%|/4"QW;'4hc326(>4*Ƞ,n>٩Um(-666Űɷɰ䰿g1D͙~=@Tj`0,4dm3U࠘J\1 \\vui]6yߋ_*8k]\Z*ܙܜy,Y̬\]AH-_^Pmjhr8ϟ?srMO5Z&LSB Gǃ%8^zNC}P|qRVF1בX=ԱZ=TIAYw\a^芹+z8MV6R*HV*5K6o+!aʁ $~8#7y<ȴNpxÎS-QifjTˁe a_^g&/^ +t Q LF1I8$Nk&dB`EOFFQZhD B}2y S(W_kU?pL kϡUƭBqtm&>i U~cw9E A8qc;~MðN81ɼ Gxws.ԹFCC""=|-\"XSwwEJ2u]5r[څ>>U QrEd$]GJ է:E8f-t0_aM]Y%!!!q).uOA XJi]+ $aEŶvZWpSvHX$ $dECG}{νhU7YJe崩S&bn֞?=q쥆h^ _hyٹgfeߵڴ8hb' (·"o\-aQS1l~s͚gU+2`ʯV/5o"~1_|1 F+ '$x%cYe%E=̠'pzm[7Y[@ ܽ{zB;8c+W\4?۹=@&d@iczf&fzzSR._aJWe7w&MJL Y6&6%u: XyBNVVOw$ |DʩۢEbܡ=|~8A#u_\^R"B[y+}qq+Vx]wn7EG%HA¨+ZyYYjjjkk ؀- @y_p'A3]gPz}4;;nXhhl|a꾲#hhD!1;},(̙ |[ITr|VpRR?\2o4EhϟJe2?H70b47'kKprvFD><tzwW5$`PF|ŒE9YC$ >ӳ> ireԊ*'Gvo"-c5φD68?V]0d`ӢYbvЦ[7ut&I܀m[&Νukó"YjMc0<[vdfMIJc,.,XQmQ:@ zȁCa V]`0x\.1 P*y[neXg2?whxl A \wR6D޽lvdGN`D"+`x_?O/O2 ٶ u_Fa]U{ PVRRpd'h<鿉,@B BmQP@TEvELYe](2 -[AP`DAX{ↀ3,I ;yBx 42LN朗w/5]z aU,bC/ θUQ;KFP*?Ș몸&D3|Jd$s:y͜ttvvw#YHu1K9E 4_8_pQ&c> &ŋS6O=@w,ddlV18zHj‚1Xh ia&|o\bM |11-Dgifvo/s26%ѦWc_oHF&'+]݁~ JD'@+y'*9ꕷ`Meet<{hLy)gG ÇN:Y tkAgBAvPV%>1ɕJRn߾l 2qN馱%m_k,l@gͲKJ yӧ;2L L)1!u*]- 4# eD>" Mh&3ll8VV4cH"hopY")1q͚tܻw?>6?5cFdTԶp #1+., S)\4{?=9@F*pM6}Nʤ/_m|lZw|B]qqFA^ h&ǹpN`|tŋYZ_ M*)QTY3.utu9ZUQ*F! I;Օ_ndhhȄNLN^ J%hC,x|Az*+4ccJ, ,KQQ_FF_]u*';޽,P$T(YZrll6a0φEB_`UwJL :T#ʥ=7ٵ=z L歛->}zK{,O ;1^>F****HP,zgnz;::RU,s16ۼiTBAAAk덠;wR(I;>["2cTEUԌ*$QHJTCx UNBf$| 8I*-J*aQ8aU$#$Tm]iK&%b[3V + rO^QTbJ x*s !QdS9t4`!cP(G&ԀW2br)f?O6/Ճ{^w#4Z"hb ڄK'Х.dԞܸNZpC3.δBמ|kpIE &1}/#•TԾ;n2%@ce^#8fdwlucd\ h;|7)7ycB@4;:lU$ʹ ;#‘ (߶9][k=7 ~AؕL"&_ABQH" 1NE {z@D;U͛5뗋Dl M#v'-9ޱգLh@jHJ3,eHU1V>QlO >삨=Q`㑘hbEQQLb0*`y(b(e);.!?`ΝsO~Ug222++l6:- t̙nbAT!jߟ8yG"8BTϔ)eˀE"{{ss&SZYFZZyK lJrرHeS|vvv E޹㿹w(otZV03 CZmmm=yҤ-۶yyyq-ÅlmlSp=\C}}ss#""""Ο?/C=hxFrs"FlP |O, agڦf@v{}RY5tZP(rGRDooN"Pǩ&A$_2\"D)HB-3H!(XQKz%k%(2؁0J[z"Ӯ4r_^݄BsA0rZz1K1܃~QyP"8c;`"@`?!5탑 *[z 3RMHuMNޱ㘲*!.[(Csh<3Ҍp, zY(χW[UA 7Ϝ~f#󏅋tSCYi׹s;1\. jܸo Ba'OvpϾȄn=<KǞ[wdKpgW:Wߟn=sEBb|:k8g|imUH;.ݧ $:c ٹ[6odKpڏ #,Y_VUGH|"=yimIG?]08SFރ.f91%uwk6m\<Ĵ{6uMZK82gzB;+$ؤ. 97|!C@*K`'(P \\&xzn*&2_"Ath@]%#Gd2anI k t$6Pu[b'AޏKKss.SiiUju@Kt<0ޓ~ mD'X[Bu9s1M׮߈ѐq0O?R.kھYx#3TAAAӧ\u \F88 eӉGJd T U777?߹!+V? 6_v#9)JKQ9:9 tqd766x\ g$rw3ujtcGS'hl\u[;Sm ?~,o=r0 \,A=e-@MQB_`3N9([`pi` QL1( # o72 L?&*T^azɖ"竴D]C3,Se/;QI|g-zxI$ *&6|(2>pXzXM,'H-)5Ok=)LքO1Dq=txF9YL_iF'|+3͚jf, }L7=Mg>I^NQb;gV75mݞfmP,=;X(CnǗ!z5H 8!)qc;զT*{wnwA=_z.,`WJt(/v- S#2RSE /#0y<^ 1meBZ[R7uuMx49I()W\Ux`͏zDk.7ESqc>l[&fmȉ;Zծ}/jfi[vT֤}ed 4-h" ,{-.._>=ƒ]2~ZI9>grvfp?p+BCL[eEw[>4̜g%]p/^,(}~2 XZZgfQ~~Lshp`ߞ@TL|tdWoK 34D㧿an֙랉b@4\.W(U.:s@ٙW 0L(XXYr,0SER6 MVr+>JhяuEٯ(3>3~yG"FEk=T_AӊD U#&hjDkDM=mOZ[$>PQdswe3oβ#?pg=w?L!W?R[{w^P(1``1pKWDH9rDIѩ`Fh AΌ i44II1'&s׭kU^}v]]C~#Ə?5.6Tݸqw 8Z8#"4 6btÖ.[:PVnݹ3g>Jj"j1́󷡍ʫ[.<%JCBCFGGO2qMoO*2 002"rڋ/L4ߟyރ; kVm߈$ TTaP%д(Àwu[[Z&ļ:;ze?_dz¤p[[ZerYf}vlpg/W\&)(U)" [e~,}vdžsp`\&W)(Ψ[v;8k*ebҼ)Sb%bІ'7oT_q&L|\`/13gVWU #1/23&fN'?n4̦RH]$TjB$b(j},rmm瞛;/!8(ȧ%MOxv;ࠐ^5kd>RCHXfFU5*m11йP; D)3,v.^2+ mE2MkVg`JYPt{Gt]"Laq 315iyĎZ;R'.kik7琉 X74ٓN{i&,XY(1ko?5ɩK?jTBw3l9?Q|P~s9(a!CS?x%5mIa.0هظ#U*ܾS09dXAd{[KKk9s LpAK Kʷn|$7#ݿha򐻳xk>;cު؉9K=ա1LoZߩ O gΘ>_V\IOK cgseʥ-c2 |׶j{C(L(uz4 vasֺ{Ϭ0oNBG[+8cL\h޼!wh]r0jt m3Vr5LX"b!F*CGGjEtJ@#C8Ȱ$6<`X̃cUnw@p: NH;ڜ$%hw{qZN$IZ-FK!HP5nwkj`[># MMv@0ZMhhhP/ԣfbNp$qZB..4!@) Cv8V' l|'<\!k`kk[ \Ӆ[G'$r@ ^U@0`'E s+ksg S\R pD W/ +"N/q 5imR :8*>XKQ^Q*}bm444m ["N~]hjnwhh J_xD`on$)tR$æDb^ 17x` v8pNa>,yT_` Pذ_{ :dSn&d &VVB$]sE㰰A4G{Q}u'd%%AKŒ5 ޞ856jjpZNl퉢W~}d's%+q,h Ll6oʪ_w?abGe„/LJD^/ǒ-+.#=-?p!3ʛgӧ'V& 櫁Lk訑C¶`_<ⴸ/E.HAp]}|u~Ƭs2B9} ||P >#q_:XE7$&$ KU w܅Yon܅ rֶ҇\Sy*OJgqadsHn)~X"د;|< ME6$Ng& "T3A (iI&CYhSՙͣ`a(=s{w:.{qιjp_"TҒv@4)!!NxT%AvFy_hjFvj <L{`D,cv"r_~ IYp ¥c(R e% 7|MYB Wt=RdPi ɺ}5o &E(XV{{wp #CG֣rr^ZA@d2=c_Pj<"1%Db̟]ͷdL[<`2zvÇjlڒף RY810pvEtz ,qܽar6&͊{a}4k*`DT2#:ꁑ{6-55PZZqKj祠r$I(kd{>>+xq1#=Ѫպ<!d$\ֶ׶(d:z>e-PTR@(-HuQ.~v9q+W9cۗS~fMuUp_2 zGYwP lAQyEv5#i+/ItV{cjʄ[2Nܝ '} #zzWX1ߏׁntMH:N~%; cC*,+w|C' T5r[ APbqHPqՒ z0 Q4IHJƄ-XGG.HSqooG@00 sH͢؁n 8ո%%Q}E (̎l~Cmt&0ck=Fo/pɄe"$$UW#Baq 1C BA$=9n_׿MIJJEZm[ƿ;RsϿP. @3v;VaSxHXXOVGg'U4Nd^'OX̝0ן/ V&'r ( M?r4/䚎✲3 b q2%ez ((qDTTlwy%uubȦ.wR9bE89 !lcpW/ XQUFr`I*~!2"((DBxD0ҿ̟HHhPҰ2TӸ;vVk|b'&y GѢ86 F H_4 i k @hݐm$2|SZy `5t].Q U%@Bn_M="46`e j5w;wBD^%डg6M^aj²򜬌_Plm>A|,9)4h<=/pP5ݝ a%_78t*|>iսaU lRэ\/DEJkh,6w/eYΞʏJqEevj5#7idC +r{={kPQAW9xmȪ(UX>1>HA2E_Sw:!'[- 5-7;}CW @za\<`\SCrkeX|,Kn /yħ>YX`Q0bbIxa&),7^{ QC& aԲDBNq4&tb̝3LYH9 fϋ0ld}2( $gT‚-NG2+Jq>D%9;A9Ӂ§x˸ոҰկ`T#許!--5:܌Ű=ʼn;տ޲puʻ"ڲԳ3Z:ڰڴEw)Vٷ宆*芧Ǵ.]@&<^\[ ~ۗ333 s3R ҭ2*gWTfgV3nS?!cnVxKm" A,yqYW$S@}xVkx=S_:}(,-w|o()v (;BJEzɢ>.jBgʡPSϊ]OuRBx1`=3bwjIؿ?u +>b|ڠhrSmLctew%XmM#EA,¢h҈. iL!hi#J|4uYf:s},/qsν} GOR)AJpo,6 HQl^g(`hm…j=,m<{z*nTV\ޮV:]@4%m9$ٺ0hS=r], ;s`au/kWe_4bG2:K 1bM=đ?y{|0x톍֥Ӱ}g aZFdpi=|YW/|.'i#"?~YZ _lD:=+vFr< Gf׫T)r?\xβmm /RR?hh lFxr5׉I !?MlgF]gL8[: 6nGejUk' kWI†la>uܸV%_݁ϯL&Khؗ^;pԙTf>3(MG 7nJfm>e,䝷?|u:1pGE-֨(]xng{} d'_蛾뚕i.uӽfL{AӈG ?V6Zvg@%OcW Lj1pxJX"8֌ 8-ZcU*gl $}Na"$ I!^1)H$Ϭh${ .'A$3|(g\af0PlIj0/.Aadxc})$ՍH/$"a*y0@ϳqJ!q&W|هlZJ*x,zڸ)Ō{aV\-_Mefmu&g >V39z 1o|T|]7-NM8S ],ώߗL:bڕ&4a4:%z?l8RdԘА/KNnuDq:4[EE>T}ٲs%*?f~o73=RT/'Y=|5#e'D .Gf1$IL -[D3m)5U YPXf>EAHR0s1;Eܪ\aÓ4˒UI/L+!pԙTuEiw=Z8/ILrrui9ܼu[Ѷg bp:kn)JN< |Yd$7kY첰|ܜ "˫{vO/sR$a'ꠐDPBHfh0Iv%z΂ KA%ˋMCӏ%3'). y1[ zerHÐ2ÅI.Xd?Xuq .;dΧJnBS,{-0OTdn!^>27QPJp W.$)ܰ?Gl}^Ip'6SP|1@CK?w$B ~*d2]v=1~i筛mcryaJb5j26I H_z[̔h'TsgŚK6Do.XXc|zÇZmJ빳X?ڠ0ͷ=rEFYþnk4)Z[?\rzmvuuB!~OOOZzɿz1oE@ry2o8V:^qyR\fPXztՌBs/gLZp|CԮ]q:C)4ƌ(~F~z̑,hE p LW*ݹ+lN *$7kY{o4]DA<:raF`@ pũ'FiUbHT kکS$.cGʇƽ-G΢I.(1N!P䢔@hAJ@>(z_@  LM} 3fR4vTz~rw0TJh h'Js4HͳTy1 @Pmn?p:k^&;)JL[}j-ڜ+z>峧=l<6|f_GfVgb[)wm6qsި1H$܎j 4go j|KA 4ED"plv]MzrCx+qWڿe)__iٱ{r/F7`RGspnKApEƪ}^+~/Lfilrl?mZs6nʨ35ab|bbRҀ\8qLV-aN+{|e^wg f[CZӼsyWh6~ ]`837ZΔxng]6N{CKKvDo,-i:}! e2"Wlf\?+23{F%|n"`8)<'W{Fʢ[)_bB7cy i)ifdrmM5F)Ցaf yq:C1j2⢝ZHZ!($*(4ҋ0mL"l;g !τySuKwr?34ɶ3Ј]tPY-:=OR%mg#t˴{G?яom6YiJN!%֌<'c7S\e-P"JYc–Z7ؿ_*;U4Ⱦz''8Ӹ 2 ;oaA"+ AG d 0a:SL3mXFp8ѹujZC{ -+20Hh2>"clwE(~׭߸1/U@_2 ]cFr4 ŽwmSx);_HNћwքZ]b.[WުlGķhi4~Bˋ9 cV`/FʜKӍE;C)ؓ~~ґ~}Nkk&s@HOV/\η%ķ.>lWJbFmT9kUa{ZQA+(6XV>iw|0u!|: ؠq"gM*P}`ZeYqgd<wjX% m/MyA,W_Nan|URW->^W034ɡV7B-:=@/M]2mBя~Msɍ,6IlvY kehNVH QgGVUiLW,W M PYqqa䌳 )/(97r:-`vQEBL,4L&l-!Ŏ`My>G$Pe`ZzYJz;2*` *By8t;AG^BK JS"wWVoOMsޞUy712%=cN\L' k=?h63ǩg E{;G[ACС>ٽU1p=o!)E?oAt'ȉlh5F1;'j3M䐂|Lݾw|{d0%-$݊\UD3Vm݂7Df'NpY`ٓ'E:Γ3ʫZvʋ!.1 hTdGD\󛟺,#>6--Q?w#UES_(Gk4p@O;!4L./G8ÖCme `. \#~ܳ/1>֖FU+<`{gK$&.;/ܷ?X[+( 7޿۞>FOX} %bՇ$6.R*'HbϮ0_mۚmJB:Ymٲ2zu$N?XM7 -y[͔'K&s M #ݥh= Y~o5Y%lh?3,f+* wngffJMz%\WV*rUv];f(ks/}2)ﮨKѳ6-h@z3cIݷ|mR}Y`oҲQteƝ6~ua4ǎ 왋/h.֒aDݐ PDFZ%V8}S0"Dh떮2!f,+4q/^K>]7(\IN;KF7/Qa\c5j'r }FV|Ώ_zM](dˊcݰyH.BOpEˍ&.yvko|'4mSu 3675o#Xl|ŷ{%ăNoF.-]+~<2S'OUsby6$nM7=rc+S%%zԤo_զ ;&ɧ1mߏzH;H  lͱ ax )@Pxr ɠ=f=NjREV9rs|.z-ۋon,fP~+?5*유a;P mq}?-?s93Ce~:EлweeZ|]u"()@scssFZZV/YxGf)GƝIYE?2"*f[HSXg\x 7nKۗXIXBjR?0o"E )SiI :NaA Y!#Orsݳwh`7eyڙB=֖*4ILV3t:*E$*8^~J>>:Q!>^PsKkHՠKgn vgh ILVdzicgwmLk4"hLU/(++urrSl>pp{Kf/*+1~|Bj~BGw:+*m4ߖL^PX.8ǃ3>չE666Ceg$yTULpfn==aW/Q g3oB@R%n \_Py 6(kcc.Q1Ov VXzjzF2rcحxJjLL!q/Kļ>vYA&%rGm.3a:4Dզ-_d$#3HH i:; t>&o+/p8ݖ[/{xY ŋ[)B_p6B?;IHS}[4K$W_^hH/ҋ+Ij^Gǂo楗Fgmۋjmdy'4!ۑ}gpqQǠr p_D3lJ*H̭@Gބ 6DrD'2rs '6R8vxX cDgSxwwǾݏ*\ӋY[9 zH YH )ZLwJ\ɖ8@é&; t8 \LӁV fMHؚ͠+DsKkHmYSACQF4YQf,-llOzYN(*BY1M fУ}_ڟ=ﴵ Do?kBQ9n\OĉrY>"ܑW(U^S̶lU1P36JKsAaQf  ե˄jmUIbѲuR[8puwWTUY6B kj )M&~̛Pnoo7UՒm($A:y T5 [b(0s#,Xnqiۋh܇04x#J>1ta=׮61VٙM-`Ga$?gwߓJ&yA_ Wjsڐ$5mp㍗tZ-`Qh3H'kKfA,yOs-tt>ήLk8!Zk? $$֋jvϮ=s\FpQl34F1k뒤_7~kZs~ܹN2uQ[[+/;+ w3i8{Ȧ"] X(D!)H1j U0i ) @"%30+.N/.w|Gk?S|Bi1+Ibt!Q%мpFp?\ 4:rL>z8'u8%O6N> |L+fr5Xz U^c_(戈J< P?,K(:Ĵl04YYM~(3-ՠbt py/,}$KS+,AOOOhh}>䜹 tZ%i%z% `=.TjıO3-n=5}{cgt/ρ9bxH}7.I4p㍗u:Ŝ)tbW5e8HlyIvf80 (x'(˖=a^!A]Zʨ񲄔p[Qk]dNLG^(㏽_ijoܔ+U.|'<0\2~HS͛mqǎX[5{u"QRJHSZ65/uϽ "Vb[_3Ie6 ,KVKA"v`Rk}GjҴQAlyF6{{wZg}ܼ^〄D/%y!bϋɍ$1*"3eg$APk;,D=HZi%W9iZ\+l[OgWpHX%xv N;6TC$ .G0e}H ~tތjohhRhos,cݪ蘒Eh"CPsD v8pDs^K&.P$IfYdgC:;p$uzÒŋ4 ׊L9ghQX\r_sNJx?O>H8rl+rvlXUY9x`-d (~dZ]t?$K"*+}`jؑLN33{$Q0R1#ܱj(Qg*ʇ$~?eRYټ0,TgpYٹӧ78 =W}E0s֯6>{ec\k '0č]qb 7[<#k.P*uIyla++Vtwwr`uroqO~~ݤD~WǓٔQ⩋ںn{?"6𹩚\B=H|˯4,4tgEHCw;%r>6捛Ǐ!O0}=!%8QS"̳0%ﲹ?+!Gy)&9ӊɁ*jZqі^lFVR wpgMuOJ ziY$a,ŗoml|QVTVQU+Ϲ :KU;U:ɩAA`#bƭzppK*rh73j“]&j0T)O|w_vOR%z|:F&@z{-GVwVKNɡUtn/?p`3F칖 JpNJJxu߿2:?s +\UYlcmpo_)Swl5+Wtuq\Ɋv =#?I XcpRMX@)iٟ]=U2t8xEցĄiiS48z{{/_oׯ˼ϟZ'_vȟZ5\/^p> _[92WIx{CK j'$z/d%bRKR?ZWX f?Vpr:VduIzJ ^_0ewٮUK $8ż$$A8a3!4+FҜ+)B`v$j%uRXu'49;]÷hcGƭwbcb:ڀB3ɘk%{/ 5:e8UV!dPc~PT!\285Ͽ0}EP6?-+g;nLWMn7`\nL9gk$a_)@xpBq;us=&Wu5G>>݈X1]괸a萇,q뮰r\>G/'԰:wb<8R!K4gLM<]r'TZ/#¢u1HkV!)SĎN f~@x۪;E,8s6?|R"W6h{ lBnmD' Y(, !sP#8a׆]-sԠfK& F){ꂗoѢK4F1q[N#hn&:[Wet. [febŭrplIy֋/ 2M6:7̞fDC ]nOSل%[oOqH$ GB_B uFeo\`alK|ܺ/;2|qDUU\3?@L^ LuK.ƂMw=&;ʟS]+9.ϞWPTUqŘ༜gI,76͛;y|m渱b9{G IrkK^H.U>%'{N7SԪWZ@*k!+h2L5OnzV*N‘7o.q _,WE9gZR9$8:?]6)GS=1((ucgRi26IcbTUV83fkVIOueNJ\k$FO T0i ~.4k=I2?pOQ F Glk" <]ۿG2|Xipjăӌ@S;r08'$IJ>(zڴ Z}f;< EL0K<22:d뫫/8W(r2xph9{n]LckFf;)-9r[c|}ku 5_@С%J!bdɓ渴}~)f g-pn񗼱}00ge<|ATQ0s\ܪZ߇y  ǍW_VDX(mY+GdK!Ohl 쉠RPXRVy"CeybX"ol7wXC.E85ګr0z:bBl ҸtI Դ gzCP q*|.Xm2lzI'C2E.|.-sϴ%'9+p.0'7%)GPXX~ŋ gX$ݮsfgg-}'MsEw`ػgo۵HbeHtm\|iFΎ;͖]&`##H@3Llv9*(F;N5.2F<@qh E"ߊG=9$؁6ybcߧ]1aJy]nSd00mgI2|[] fC wrd-1^ a exu< P@Q۝wQnFOzydtY%&d뫫xBW(N57(EQ)yaFΜ=X͸c"|ÝυAA0]kMСBa+ |m[t\*? ol‡̩7}T֛LtR+Jp?^_HP{75nѩVEwܸ W,!7tk cL>()Q<{^AQUAAaV,560RqK,>Ś={BB7lD%eV(7SfTMv3ł%bT,\j%er\* eA~A(nJepQcMJD,b+I%RcH[|R_}vm3A?=i򔬜ؘ24%i =IHrSz{ES&yuOWooHwNdY!lL9Xr$"qFZUhL5Vy-9nLִ z((խ[ N"!ˢTŃK4L겍UgOQ+kt۶=_%PM]i  [Ţ.vƱ",FM-jU(H.S贎g#XE˨*hM+$ $d#^/۽ 72xt^T40/E3 %Q'_FaNjX40|:Bloilu+h>aB,!3; zXgf(UH[;ã遵Uxr_bL&w}@YFz]{w}Do E|>?x /FNzXAA5x!S|w4}B^q,W[ %gϜ!,1h2аY?A5HKM122nA0XObB7is'Oyt,TSWرsoK՚Zq%> ڽ皞Ne5)7Qe;0`894XoUbWʼV{:vv[퍍&==D44 GΌ/ B[G5̟;:\34GG7;M70$ds"qz{GgcCcMUUG;{Db9z) βAIm-}Ğ6'[M8Nb19l.ŵJ6i QXNPϫWu̺zt9SzϚB$ ;98L8''+ٳ:%AgfnU ȕ֥`,$y7( -#Y)_(h//^E`}"іfX ylR,Z n/c1k[Zqy\s e,ߟJ˲FoGсˈ> >h锪y,J%*UHK\B}y@dߥ >'/R`J%X(d/@h7Ira##\9YgBPCMK1X(a|f erO a,+AI/zp$H*}OHJc^q-o 4ϟB#?ON}}02^PzXe5{ ,& +PzOKRRϒ sAڹ+eCbS2s׉{QьlH]\553/,tvrԉE-o+2`˪s20ts¡X\XqSHB&ax6ff|c|`=}ãöD"iψ=yw q,}m~Aĝ6l?++6E`T2y mqk)GK=4|Pypz%77̌Hy+6m|1<Ȃ{"RmmwDRZpXFY`%kB^alW[׎Ʀ>}DMi*! HFNǂy׿ý zT_MfLa!4p!JӐ64ZaQ([ݔOW_K z%O hޞjiJ| hI_ߨ uCh>%4Xo@KNJz{XsKK\llٕd0-::opy%EŗJKXOi72$=& Ef =њ-]77@y 7hH"^ <<Κ]UUݻGsh˥ݽPLD115+'S5Α{P^vfHd`@zI$C+kk[Lŗ!7mjn_YSeeǠXFFFzy{i ܼUZZd2l6xcAvuuRVNk|,[jBk:;;neѬmDP6A$ra'U.Y& A|A xmmTKu"Db^rbnHOoIg8;-Z쯫Vi. |ֶGkjj565;;;Kπ$EQUhٔ(RɄQv),M*UK| 3tY>p-BĂli .tjiWܗ^}rz˜muy%HL!de˵lcApQ"[JDwZ?N(E@* Aŋ<@YJuoS_ƈьyPr f8;ĢpyvU Q#:(V}#G!Lj+ODŏ?==b$cb2F`U5amc{!W_<N|ZVG9槥jQZ$^f9EіAIT_JZ> rL)fߖi)&D~ړW]'hbR:phfjWT6U_ X{TRb߫^ʼn:,z[v|s߾s7RheavCá5(یܼ[MAՕ?]Rx]_QM]y@BP: V\PA: NJ JXD S[Q W R@`T5ӊˑEQ"}KKbܼw-} #e4z]~=@ʨz osCjP|{֞ݻϤZϱ p;:ATTbUCrzQ 7oO8YSSmkkp'L0S./TU1Y~M]ӝq6-.!^xW8;}4.WU]se" enQGxww'S>?ϒ /ҋ3g/Z`iɮ^HO+//Js]fkg6լ俅EL)gv>V!HTѓGϟ=kjl|2l6lt諡!T|^~~mw,Zrf0RQ$mdd'18?" F+N76(Q ((֖jQz8$RsA< XcH"def]})Hj53AgyqaaQyEImlܸqگ4MGGG񵢻VW[[--o[Z5r8'OŽ~Pԡ⢶v)px6C/v7j+zco7pF-DWv!S~`>P @&Y=8F!"s{"lKa`+h}:e>[HoPA\opވDj8N1h S)ʰUL^ő٣ MMƏ\0/x$jT 4$*\#1*/H:#9'`ᾠm^ڊ h̜nxaFvTϴt0kK\]\=f0dgfYZ<.!P LM( \Չ㱠\.,)0]:!_T^#n26TLǙfdg !F:;;]]=|tYErR"? IS#B쵪szrDA4,9zQ0pqbR9hCʹSVS_٣£cy'{~of \+CoUSj^> 3g\NA޻_#E \3zzzCl{p&}ȁk w]ewn#tF=u'O %#UVs祦_c9{=@(@J=)&Z@_X|OjIUaP k_[{ݿ9($dwzY[ 4 bfɒ%#" aG<1Ap˖-[zۋ 7oFG߸>q#yB\rPd+K;v{& p"PEDhxERRzz,fY88fzM֖*eGcrώX>X:2,>..#=Am}ccCڨyyWHt>%91M"+,84lݺ$ǎ''&1smrT*+ D*M3c'M vb(PQwwFc6+Vѡ+4!LU97w,mRٴ}~iqJ gϦZɚ;Y,t\{ZQ.aaa jGc޻Hۖ`!W R[ŶvYio߱ceeiBy\Y wng> ߤoc";\Z%q |` "'EqJRdB)p67! Olb`Ƣf3y\DTEg hE-iP0@ MSqǐ \2Aza;k]hAQ|1fS>V`C0%"FFT)r:=qvtJ(∨Yϟ?gHi*QREMF5$0n%tF&5{~?!gS4+^ "g:!#+sH=quu|@3hsș$[ݯsDNKz>?fՊd D82܋~wF!׭1μ Zgjn@1 FzN졷*~k>^XY굿[}RT kqVnI gm&WªGvyMFDS$Zñ؟U?l"Qsë:j#G'{[Pmbf!I<ёZWiPSY.&Q@Zq!vϴ{[3=a B mȢ5 VhPq-qm,IH2/h_R77s}}+D4@{O2y >--hНa8,olhrgʀK `F,هk ਩rd##HD͙ӥ˗|o[x8nP5661Q> 0d *:Yy`BĿO 5wDS +Ooo6m"_ >\j?l΢ sv>|8##d26݊:ŀZΒĦ˖gd8Rm[VZ*x| jR-:c&ˣR~++f2~+EjGhFM-D,p͚$Ra1fd>l`@AuqvupE! 23/_ O'v988k֮)QA}4~ h9"h4fA2 ț!;# Պ\P(Pxyd87$'S?W'j^O]sƯf7544EF1*(/4/TZ;`J (J-wȍ5`DtG}C:yX&Ջ/9,va1; IgZkܾSɇP(MA[h`{`)y@f梢/)F;,ݸ p8e / aڢ#slpfRxإcI|(_3֬~Nax,4ӱ/,;l7ݫFPȣgeAh޴%T }uc'P}$CbD04{߱χ!/><rxޜoFߪ~s+?1@0n--;w߭uqmPkXt oܼoеAϊ 8&Uwߴ=Dz>B9!:1=S=/ݽ4ô#Y* Mn..*Dt5~T#؝z/8f^PѽƧϞG;t2~WB2,++;-{<< V;.oh ݱsw$AI߾eS\T}]vUW߱ Mceii%駤>^^pX|݃[[YJ]HKPz5z͍:8L (EEI֙LoNGl:A,?_$R*fmgN%TjRb0?q/\ H8 zfb.NpwSRx|XŒa}׿**.񸵵,-]]vv‚bz LKd2Y,OG1}GE\ΏU*3)3՝A)*,&$<"cq8'*!6lkkrKJ*m9LwwW/DD\X1 (gP(de ÖŦDRo_/a=Q!!x0"z*JłdŋVxtJR$QG6 ,Z&4 1l!԰RAZMhfj,xeH\?8iҴBѰ2P~)mF7W|G02, X`SSA=X8% 0%XZҷyu]xZ\nX)o@eˁm;F @HI$ӳc5<* nf䂢" 01;3}(x&@*y3X% (la!**hD⸨E]3x :./5frb/ )<;-%Qst\Gy)uɓӦNy*V WowE}~aXaCPWS=9v8ѝp,a^CB+ΕNZmn_ߍ$S%_͢b_Xr2TRK7 sҌtx^T\2o7oUyzЦ=ܢq Gɳ-AAMo1YCZnT'=p-1Xq#6ƦfoOAoܕ+OWmwx0̔ &M6\^Nutv"+JOzӒ~2z*CB~uJ'otCR ں۶ӣ_͈TW[ p}Ts[=.Nbw#%H|f꺙LO,_V)rt r7?I$TXTRdaq/]*'v$R3;"*lחv/{]eQt%+'\9HgO6o| 6j5ŮUUp8L“~7 t'hK{w8P( %PQ6m&,--=% eɒLZd;s3`UՌd{2^^3 @_,fz>vS r&J7ʉƦ[<^,p|fYrv{Ɩ.[DO ۠-ovwM}G$U*@ G(ZRPk'4<О.sNc)E)[{ Wk݂}R)X QM'UPzb5%C' F~ -Ѩij.]#.v$ -!` !m5A V=6X"{i鯏'OCC^<}K00 J 7jFaux_@k|u &alHTi̜}T]>ᵪyJd75`CPZڰ¯f׊*v!'{ڳ<?qJii X5k 啂|>іg*ݼr i\ݛZZ\>\>Fsˤݤ\gj@,9l]w|/\YP9[Fom"+% =5rłwVtBntbG"j:~ܮ:}+vnh)@lQJ>7#{/-#s/ܳ?ё9ϫ5)_ܜ7a<؄CYi?oBm}#7i9Hmv8{]R>dy? $_i^ 2Y17Ln ?J{9Lfkk5kkk Zd#2=%2&&-=gm֧T*+;]VyB>"`&ͱ8+ݥʳJ@0&<@1;4,NJ<Çf?'OgH%ѻ -).xtGG!kxGˎW۷o'Jڹϼ ѽuC@WMMd[TXf֧ltLYEP8.K=Pi:bFEagbDeX,҆îb N;eX0fR)JR$,/,.PgQt>91!ӬŒ< :F(khQɕ? ysNb{i Bq;fYY\$u>*񮴴̳Bf<#hUHTTL'Lw/0R[#zRdHR-),3* _+nh7HdH+?5\R+b 3<V)d*A=ZMG\u짟o7lu; ߒ'*ۣ]{\V\T`r.vS$n4++'&zWǎq*:i۬'yw]k npkvNN`xk޳V04HPrŘp7goў? A8(|{hXXgsAG* kYl<.l  =77wŊEK@ XXXLHLHNM533o/_,kkBڼus+ja6jxh\!={y_+ 3yd|ŕfZ9u]].\HQo/^\^^Sd+ _4mdlNOJIaFE2DZVTVI+mhxe6fr{N[-tD ~ rONuU_ [={0|\(ܝ_hkm,>.N:::8--TK pn`mE3 y>+kD$P`9!( g'RQ4QiŞ8MU<"_*Ӥ ΜLfMk?9Uv@&CxTRT0N84kj,An%;^c )Jl|[vc8^x~zf @Q'-kCJBo R.56hD :IR47vmowt!@x;YU>ӚްհڣY~ qL I[YD"QP " ~4oҥ7lpss07:w&vB+* XH7ЉS'oqB!=}>>?"?˰@d2ٙ#Ȥ@q">7&F繸rr@@(«r׳0< UeRJF7HYÃVT`D0n4b;QY)iVC..`Y`И_PtH'Y66 r qkjd 绺&GCnj w76B!//W4WiTSg&! $"XϱnSʎ Ȏ(ŀbp .U@g2QQ*3E Y&L}Xyjvܹy`-4<<&v%5شA)rP>]==SSh% PTQ `0VT F+u91ܫOAZ&\bH> *b( ֑pvbg g(L B{@.<֚M`m8|;9\K/*4 $;|ӏ?4yt"y' K6A;bkR$*J@ gΘ>㪺w?,d7-=8h0͓w.z~@}qI)"#$ `㚇ĩ&",9{ƚuϞ{{ ڐc͝=FP!4do_q ۆ4,sxax?uɕxՅh)bAw܌~VȦڼ-<9) c(:}dnL/#;،ݾ@|2KhIӂ6Q?urL{[ :\?!7o ްP>/}Ln06Z7;}ORvl 2y?{ſ]&%=m|݅~vAH`BVUYye<S$Zs Y,?p`ecmCT&hfYnn@y dRϞ9ojj7FđP,"\\/_E$𧆆kVV4,]$33s{ 6wrP%bǟ|&uKNV։'ͩT*&ޙ'0WXpHTQ)`~S=?P*W46>vի?|ɶbXW·oId(|=vDÂ_絷2Ll'po"T;~(Ўi. 5k=Tš2HAmrkdl f0, Fz 7tѩΎ&6222<:B&aH⣢KJl+R%˗yEV>'ǩ}֥޹u`}pXDD+߼iU46̙ ̈́Ҏ}y[T:45XTiԈVU8A `U\J1N9+R)yM*>11/fTDzQD7jm``-T^ɯZH؟Z ٖ1!, lDGԹ#BO^2/h‚#E\w"m(7pafF-i% hi~  t+@2p akHڵuԔ=H, X;u9@YZ^:eHW*j[h+q%Ng{'++kLW Ig_DEFhlӰs((887y3EzI>*f crLnk!{0qr]bb/;[pB ?.3geK;:*ZW66KK]--7a/x|pܼL6@ZzƩo@?:B)2fn܀s5^@?x1/G~`jJ %N 8dJcw|_.Йc\dp!p>rظ#~m~ݽ]/qyfg5yWoƮzpRwl 2y?ś\'wuIfTDҨU؁S^CBHFӭP(,tP4ZTϤI9\zEv_ (ƒeIBP1L*J,\S:Ƕ=}H$X[0) %b͟n- w/>.caLȱ;$<Jsss0.Xb_8I 4x+/+fff _$&ћƑPRQA 'i)<<>7b"W?yڭ;w7ŷb2waށ'lKKB j=̧0`^^X,fHj'1pS8\T8 mGGkbRZOdy*,H,\[BB" }%]yE@d2] c4Fu6[PWd8Z^?޾manT@s nbѣ`X,HSXɓ&lJ52CT ~5ueHB¢Pwkl&8!H6 j:Zju).($!!d{//a1?z>?s=s~?'{;P7P7QYt?KՎ? J$@,Y|8#tW7XRviS'™ݑ,n9H58J?v0YY2,^  ]#hʔagje N\gxgQJQL_@L4Ss%Q,yn(VA2tY/5A_[sK4VfbPMŜcuOtZsUx{֬iqw1=91^fN|pz?8@¾gp<3H+.YzX~>ix{@*lw$GQ* ġ )tϷT]{%h*d̬3k &н}jnTdlEEL:a[םT9e_xjy/C?X#d2nyo.ut)D20sczz>awwT,3"`kg氧N1?xWr===bG  7W Y>o뿎rڞ HB|dlKMMmxX{4Xڵ#;l6Ä^zV4jyK/ɉezD@tb1`GF⛣KR\AY {{{gǰ9vv] (}[M˯_O?LүlX,l6%%N53+9vhڑWTjOo$#^:'$ddf sL-L@% |B2||BPFRzi@1tDW(b /[P`bd<80([۬N92sL5m 옘ʊd2ip`@ÁAbH* H e\źͦMzo˾dx{hrq*"vg yNVd(Iaf ,(Eڤ$-夃2 `T  E$ҞǫUiɌ4?tbTi"` a&.Cvе tZm/gC`xkD&{q?4=kzԉw34A< ҲEY|QpCafǓGmZc&9E/Y#&{؜ܬL5$P Y0x<>ݛpıK,xvLFD:kkk8OZUBr-\k;/;KjɋB/jQW}]ɡUNgجLC9r[[sY[R|}+`W>oƐ:Hp/O7؎ ݨ}K f3}hŚh(D%*!b?%Oq4Fo '.!9r.^87|< yCbnnyqta3ApQ~^.BEIeuhh;#ȏM8{tOM QRԆ/C'Lݴ^W?hٲQק锃Hѕ`kىe5>'~ѵʄ+?00*21d2%,Գ$#D">P+ܹ<~L!D*-\r(V~}(.\jypd[Xtwy2+OOO7w7cEr^F#CCx_,`g8 XѴW/TZwwٔ]tCH?1)##O(P-,L0=ئ$#L /d h>~~!diX OzڀB $3"&Âs L~;Cg͘1&&L& Z[m6єk*"DBaPP\O|D,.[ųѬֶ6V$BթJ;Lω0QB)SJɫ+y !_Y)XE5@\{Cxj"tIh諭ړ iitJ`({3Č0Zt}v8"&382Mvmݩe d\4ݮwqrT"^H OVY/l]nWW  P`&;/OF+"ǿf \`1X^OǛ{D|Θ=`|hlv| ŋ?5+ $E*:kQcGp|Uk) hbH! OADTJS%uV@ $(vGYs>;#K_BjD*VutW,uorD"YWO֌BE"`0**|zv)~5Ǟߔ=bb}>mmA)ҲTCj}ɓ&urC>[ mF } xQ /VBDx,yvNV|RqA>G]/Vm"{yb? H39w{dd*xJNJڈ,x(䱷&3dī=2߯p תVh,WT\\D$kxFVvZXnȈDHNjvv^A֤۱9r| Խ{*bRb=?&wt$0 PL֔¡a55&p:E :zp/Y]~C}cuUUͿpxF Q42:991̥KL|wX/XpFy] ) IEg +Ų({G{LqAbiNFzVv6d`?( RAaRi%%"qI$#}8,V>lxHHyEhttD4q'GRsKK+#&B2S!$"Q>=; 6Ȇo-XE1 R5@HWLkjGS4tXZF^f:$ DAiH[CpxqQ9'mm9/8] m7e쒖2[kxP=~0{|?ĵW#ioԌt(ZdQQP8`ph&.!90q.׮+\nimpr `^*J<.޽.+\<>°@E^7ݺ$0/:;߻并6]/H9ܰp8%1P("9Ҳe:_;瓌-N!7Ų²zܾ( <$BydT<,ٰiSJjbԬ2b45EPԠC"Q>7W#5k I$a ^|9;'f۶Ԍ9Y9J0!޹Bމq xP( -}(D:F#aa$TkX`+2( ZڄQʞ}5y~nYMA5QNoF*>~.TۥGWabX3~(ߟ;0ܓ*qӑG'('[c)πZ"BOM?0~z>*ԯNSpw3Ѹ)rl `bO?'q3.۷Ҍi9x6BDF$%ę;sK P0!00`0Ǜ+b.vdCZ gi>p<,-ؑ 9<,NP(sf[[)$V9$ _чjt9\SuPe99ٌ/] /@Dž$'NLÙUo7"B6E"oUoT}W*.b[ZbM?pϻn{sǬյ5ӦN1Եtջ l<@Ju!fmG*9YLC~q`4l^0w~*A'\ì̓M$#m(1$"Q}F6c]\f sjEyX  mظqgAڊ{G͛gV,v|=`/]`0h3$Yڙ(`xΖ=!1qcg0**230nii"o[/R{]]-а:zfƉ˗?\'xyyp8dR︹3>YZƍ  PQpM+-<&i@eAEU]MPꊯteeGK s,Us *(K+$*W,Mk vBTr!mx ʑD`ielOHn9~ 2z*]c߷ly򖈱l9ldU늋 ~[Pϣǁ/9]T5Ii-aԴGu=&]!~ PJ1[w~ ޸Q@UԵOB"$G "^kgv"쪠@PAQ ddF(}`E\Yb8^ [Css%]"+9>g_eU-{n']OCCo\`\SMj2 B#o/(-SY!5 Bfu_!L[3$ho3sXz >_-j#6bcճ,h2L 37x#8fB]uzg,>׺YB`ް޷*6?̹ Ls)U.S %;9g0  R*KM4wmN?ܭ`Bd`*r nev&j{ r3Ӂ;jy~qǫVG룷F3xݖdc7#sfϚ1ST'5kDS״ekVeYd*:M4EINnQ^܌@xյ-))yٲW woILH+*՜dR$^#(8%6.Jt0/((,R(H$ROoB{dH;uɺ{JJ{=P>sf_oinme!O@0VwZ^nH/~;JKijml t(spP.( RH81Y,x\+>BK*._"=3i}{Tύ 5 F&؜553J%\\2-2@kjjf'.^$[^gojM0;{rraibru~ggr"m4+;?qB&hmcgk͟Tm#{D%>j4ɡ18lǫUЁ!dzϬIGʴԧs[(Ȉ`DZdzܷH <KODvo*GSj0V4Z;.vxq>^F'%gJJ&5`B2/$>].\,׼ZI]n$ Fn c'2+t5qRm[P{9vJ?ڠy}8ZZZN AIqBm+Waq6L(t8;T/:Xr ئ_D(N(V70@RAmoVU}hf[Ǻ^Xvïsv܅:5̶#w~ɻ_f=>&C>Gƭ}wX[!$E1#kQ@-jj,37m&tio/r"ϊ`l?ZvNhw@? BeUw'鼮 )aagOz~ {Ow\RS[3sƌ)o ڃ*-/o77 (J${?.[o\NdURr2M3ԏ㙬P]u!0(=pxA,.TťO==B-"bǯɜ$[-HM1% @Iqބ9,W+VJ= n-gGԝ?]j`1o߹r1a" $ROoEl[xT*Qiё}U⒢Ҭh}ɕC\Wdg?Ϝ5kGLL@P9̔@&e尙Bu-,v\7N oΙ5K+_ṹq&0돟/ۯR)G]]p8U.s`##kuT*.Vge/Zh ;)T2eHff-"iT+tP&]TVz̸8 z߾MYٻ/μ|!zW_y55+ڊj27 d#A@qJXE}MR Y(QY,l%TUɁ\Ie ,IJ$ߨd23 4}Q4842B~4R !7, BNkdXXN28$ccڱQa-1NjDKQS݄h n߭Ət[~?Q5y{2c?&ή_xP uU@_&{6Zr W$Uƒ}}o?1=2Ur9&[f,15RKWiTS!H dg( ZOjVkA,d"@I,ʳVEũJ: $Lpo. vG=ܽ9}ΑdhH3<8;5yqəY\g--.! UceFFƪX q8oU'ZM`dGF?H9x6PeAep"A]e@_:ݻ``xXyhUV+,r>QKB_꡹&VgGA|SӔt;[L;/07= B!\Y.//y?>U***uՒ/گ_Đ-)+{=4?Oس⺵Ѿ6,ԶɒҲⰪ((28ƙ+˲۲ϰuӳn޾Ұqθs܅$<g;=SR^uiKvNْ%ʮ|F㗮̃CC@/=%dZvV9}&55v^^14Mط\o!LY,;5 IɈJRzZ4Crrǩ9](/ x.+ lw֭["_tXŵ潞qF6)>舳$(<0]A\b ;GPuwtba19+#@x2=6H$y|@Ii醲d;}RWW,!ׇh_ ͑Ba2^VQD-V%fK)Tڶ϶IRV^@ 4}IJs;e!R-EӨcT>rP(קge-?OύdJ-A( -ݟϐ\ldh_A&jjffg1c1zFRcf6p2s#^TxQH'F2RwC*Wa fN# itXB?);!xH;³$XbhvLL F40} K?{tWY x<Ͼ;mpS@ջ-2+z4k4 4Axң;n"h4=0>8  ?6YEIA(B5mܔ0hIqYrob)%&e~`!&2>?3&+p괱<=䟣wRV0!9eӆOfv;_y^eE$)+_m3?E%Izw{~@n< { X\"45c]vnn`ϞDDD67\sl钜kLasM//{FJKkii qk.B+dei)I*Gch9{Z {?ןO?~) T X$zf/4]T+2' tzUM (#Q܏38C}l=>fdf=ztxx8h`89BG[G[ , :mVYGEG;;W^RvpJ$I$H*C;y0y<РQ;w*3iiw63pbqy ح53[ Xz~ku}M閖+N^ bjy |LݿMR6 &K؃9s繺tv={ƆUUU]]@a Xfsml(11V+W5>Pojlכ "1ϳ\iN(+]ihغeTiQړpi5EaOZoJLHt}rZŇwtP"TU<ԘW)L{`Hȹsҝ%pc-QY__~DP8x{y``hLx1vuぐ`jBBެ|SBCB,3 U/#3fJ7EhxU^ʻp10L%E֑ -a,-I bH>%@  7녅c "D}Y990X1)0I;elArd `$C\ъCp1E3KI()ȗH# Ur$ r̵kQ3新>ivQS){AQr}/LԞ{ Djel1ӦDe0ˊ F9]㰱3 g_ I#`TeQ Xh@Ac⠢,1, EUP[6ul7Բ]Y2 +vv̜!?w^\nl\µbػ+]_2R:d%C@GWtv^Ue$'NO?%f-B^bH$rvg'? m*0fTʻD(._PGMqyJV%G^_ WJ( UoV9}6(<|FݧV2 ɿ~\9.G &hӋr(zjGDJskP!?_9O|*i6ҽvzۧS}@ E" MBvnL~y04QS|y+:ZPmn=]M*JJJjjTқܷ&IQlvP{wUF>9 맾ߐwvwuHԖBҧy3O!mk@QGFFP($qAG&AccJBbMu5A x<896!~8hrRQq VxQ}Њ{<:*~G wRX18u2B7,ZHԐmssQGFӕ\*(x*|$8˟)..=y/ bUߚ˛\RܤC$jjjP(cm-4585Cq+a043W`2pma`l9w6'ĉp[CC2KVYˣGz۷mc2 V"װ"vuxyzzxyo$I̻xMkpy$ewOQiqJJ9A}=@4sp;<""+nYFzFmmPߐO :p@D:}TA~jPW;R?)QzttԐLAv)l9g<308֖Ha۷c6uik8w=zQGۃB Tyh:Xi9L4LB1Ub+-Y,: B0|Gp5YYz=p,}J$BccrƋ/E"Ha&ݑpz@H/H}8s7&Bߐ=99/H(A;%p.S>""ݾ؄~><4 saNq4Ç꿗f4O5GGY>bfJ8?@=jQ!lR΁ɲV;`x{}0o枴e̺*>WRx416zw^FYԴo/MSsR:N1D)#˵.gk?GGq9l:(j;ɆsfgwvRS[kP(P9 daa9>65ɞQq]$WओZ`r8C(y=i[{L4*{R Z=ztɢSn9vxXfN':ظ=.6FOOwZ{|y0#09:?WU))OU]`Ca;:QIvd* F >8q|ؘ؆J`R,R8T۪]嫹g%?V0qң"y̢|I=4)l|y eF'oߺE}CJgWwll, 4-1*MKRҬ,#ٵ4TUT7ԗWa l.wy#rbff-Y`0*++GXH#@ @!W99e9CZTς?rnF FqIi-/ܱ?pHK=wF9l2y7m$h4N/Գ󬺱ձڱՅ뮱CK.R۳۩"<7jCOݿ.JS禼i{>'P B|(A!U cs׬Xa&W$v_vDwa\O@C<1vc;P aC0Ñis_BNV^^~YFBpKNf|媷i.}~ۯr]ŠMAc_;{GNj1ɩ&AUVۚ?فK/a DoU).VH4IfເOtd[kegN\QqfaIrsS͝貱?Q\Ƅ1+;'++kNJ2gƕv ӧ,6#o۹+os=1Q !3,:&4_܍｝pCDw@~ huaqk%%%8// 4Z#謩_Uyˇm[nLp켃</֬ߐ:.6Dz/S]zc4߼iMݜt)( P^V/sA*r4Fusgaou^^^ t8q8LpxdC36؏Z?ᖭW.}ZZ՚zX,vHH09rK74:;gU4*ѥP b{55p6;8x:Hh:E2sYᡓ^[[wBCÃ7gR\( ,6;999gZ}$|R 2N ]p5a3FMW}˗{""A޷!0~q[|h%;^}vodd5[ ,@`$'0\=WTThT*, !'iVKJJFl6LJO `62N*2N $Vc F8=}[c&ܻ' 1X\tt렯W9\9lsT*=\pNQ%xXa&AT/, ݕjLJ^~Dʥ e4%nx`6:!0; D.qj&,ٱ 0f=䁱}b\i:b3})s|7oT z茌ܽW+˵CCfE+{J<XBN.M8졳;k0 zzؠ0Lo*A C!Sx\NB|+xt[J6'N9s'+{>R鹉cd;Uɓ7C㓒 @H$~A)U]MMՕtCCcEmwA$q~w#.nn9HxGǀJHJٻooltTylhL!ZǨ:RԆ$6`0T*HZ??_69[yeQk?h[cK(6ZQGό࿲K])ϗI9"I@8tmpsD߿?1!nr37~@E]Vz` Ehs !2/o̘X-/r-m@{Q&vt;FL&hNyqC3Y(yƉj]M.WzQQ3@_P`@bՀƦ[7Z-ҙ7BPvo6mp|JJp^sJDC݇K ـ*%(^^1lNd-K4F&jb #J"1وf5:A. 9TMU}G}}Eׯ_\] F&N|A;Hd@hh`6޻_Wj9u;H5Zm/n2֭[E8SUiw8|}}G5bԈ>}`6 Hi߸ikkBE  ܸq3P-m} ^M0=~<#|r 7i4>?|8*|P/9}FNP4rE@55AA9UT6&"~/@o4~ܹ}¿ҟJkkkӷWacƍ 4+9` pD§bj&S@"e?)Ϩ1XכnZds#U$MiD*=Fh/[}C)ƨix Dq ΔV,RTG{R<9+W,/k>رe3E뺳C__eH,Ա`o߾Cw)KiZrDGKϟލZ;.ݍ)^FׇL&*,#Nә}uQo"6CBftԫ_N+wL& 4pfR…oAKVYuKksho$C|Tݚw.=FȒaBT%8Wju7nH0ʚd M6#ީRZ?5l;zHJ$)w٘5 OW)⾠Krj)ymѲԄxyI6 a`0{ɺ9h箛E/w*0v9;  e4Y6OT'-6n<ÿC$ GŎ‚d'RELJyV'EE_x ,DXX:;vS"\٫?Xi6 V#㦕$c1PHpB1h&ezōctoim{m6*B& BK;"6 QZ'$ZyfAH} ^j;%MM6h`Ӡ)Ybo60l6sZKk+vZe2yt2VƒFk ޾ZHzvJ]]]KK3GVe4z[Tom`(H (@I.{`^Ŗb'{F]*1tʷ8Q3)|`/Q\)B}eyϿB6&3~(G E Ț1X% i>6'6DWx-f2`;۵/eF氨<:^%K C6}|&8noݞi^\P6 R`^-:>!%5%9#d{57_~2]v l_BlyL ɩsӞVeccP;1+5A f7)Q%ooݗ!W-s&Y!- ˯FΚ4BF"#];yPfׇ4PapT|5VbOZJ㦉'囼I2 4';狗_ۑHH'Κ:H74N\gk1hxm ϥew5|f$ɭ`J8YLMpI>з$= ( =~W}LXXw\WRO| `؂]{ )o:ϥ7~>]\~>d~l)=6+؂NI2 V;w-RTUyY;cgFh`4'NNLrP\rRG)2{e>9߽8Sk߯>Tx")H&7LVo01n?\v+kjj*|H׌@KӒƌ;7= [p܅ ֡9ܗ$ {E=#=#= ZU\B]SpuCumlg$c #YtOs ck$?p9mނK-]|ivV֭t4-|)9v3 w%׻ɟU QFMFyBcy\M;c3{}'vt_\oz.u|J\Y3Ҿ8%KV,_6aQȮp$pbzI9îv)cx(1W%!%Yf/I>Uy,E%dcģ M&Ӿ~gBCC.{嗮Bci<}&eu9BXrŌiE7|a*8cwvOlâ1H ^߁-G$eY:뾹ϟТgL1F jğ0N)%$V?0dÑKSKq$V9%𤗸kZ%:˹r͛A|cpԔF$FGEUT E<,㰐 ,J,-Yo1 @,9dDJ_4䓖v+[f -G?޵6McGuV}(++H4f w83=?pHϝ٩UJqrL{iӊ ]iif9sc8YkKk[kKG[kpp0>+ OɅ3gFC # 6%׽۱cZ[[[;/ X 4kI9999gLG'V8,|~kYQfg5auV vtvO7hp @٬)No8 dh( j bvoB3IIQdQ+XXh>ڈ0Xٵ1DE0X0Ӭ<5OC-GC{"x$ə2^VpPZ^Q$Їɝhx \E   >_G$35Rwa4@nl\h\Ө|($ p[YXDڼ #tDF!`Mߩhhdμ/V%]0J+j*AB\RgFf[T  |۷/ LUpEXƈ"ЂBT@QgP >TT\ sRD3J6JR[' G6_ iTO6?g6FiyER>2'##)t   )@VF S % ̂hMPBB4KL@G38*hQ%d4e7m,'K>2o6흮<=(++Ż33S50AAAREqۺ30_eN5@p\BsX!aX(Q9bD1LN_da¤o/WCEF^oCɆMMBOBlJ-?EƘm+p@H<*r=w83j<z   H* jq#T2PH +0@C8/\}AŠ(D\fHJde2fzc 4׃6D)ؚ߽:GRZֽ=DBjOm+OAAI-}UIHe BDD)\cm`̙\I܋!m~MxkDIԼ,#)-R MqDpfdVyj \:dž   HʑU{>eDF `a-g@aDQA#" 1ZV͵+[@T$; dvk/uu%n{V`6WxܕРRKStf=5|CAAd40,'Ǖjּ@:'?_Ը1Fu!16rʤ1";ix:=f SJD9f-t:M"efج"xRF2$,'5I픳~t/;&1<2H4-&3~z0_h6m~nxReeV˝~FI*mfS\(su2h ^z(% %4 m4j*+;WZ<S |Stt,Meh{ hKo%ً0Xfv͚WE %>OaEGw.̦x s-}\o߫^AS\]4U^ß(Է޽g/= rdf)2">iEE xm"8pclcvVcM攟}vԳÆtXV^bo_/tGoVVv R?Fx2fYN0k-\fwlhSR :iS>1`3_+ƏwՆ풞j]΀_ӤAwGn~OΝ*m$á^Qi֬u>iX%v3Ν>4GOT5Jߺz{ƛ7o2 c;׭Zά"[QnB ZeY{ y.3VK1%9_`KHXI$js=6oV򋬾EB/RysҵL v|ZhOo^&^(ݽRܶi7 vA"NsyE?y M r4PP6heiJ/omlJ(|#L*d^^^|\lٹv}(&.wxb{n=zdxq;K ƚ(wBd|B K֩L}?gΙҢ%)䩅ʪ֭ҒKgϜ9q۷yl9iё$%1q@LL$EGz^W=Z-6]tIoh…cF=.+gy???Sݪ(+w:졔g/ CyogDdQz`xcʔ ZnYoXN""$iX;>;Դubҏ(ܰߔ왊&a*kSv>`ʊd<豧G;zTLLo-ϝqCJ}KYtW/O>1}KNNo:ߗ*/n1WMKLߵK6IlSIݶ p@`i:++_=(댟,산 (ĶN,FLlh'`#63h+c #ڦ֘ΤVD'>kc }^X{9߹+r~{|z7oY^XSORMc$)8888888888.\Nn{z^{6 2$JRC/BPDEE|`ADڕgOimmNn=.mx~;|IDZ[[o߾.==F ?)WE1 fdǏ/1bݰ$g 'ohlo22,^.!'S ~;̶Uϕ-RM^EG 6[ CQ COϝV '%%Sp8ےe62htNlBDx`(N_|$qP8Ðcǎe^ioityvy$.';+k„9cƬ\b֬2ǽpOɓgO4}>ossskK`Fi/ÇOJf{OO].ju8z}aM'HR(EEE+bܸqHrg~b˔Jg=^2y=D!IR)pppppppppp]n|{mY'A^p敕-]8l2Yrr C)s(32VmoV:#3+sذ\KN"boj^SsIۣ7Ϟ3{ y$y($IJ5= ϓiNdٲ>zTp͚7}&S]R2y02RUƳgόDojgѧ%.'6mݴF^vN9j֮Ճ7P~kn^B{IAPko.R]K?eKgU !р(_Գt-iAP!܅/Kv.P#pÖox$]~Ye @+cU,`gت7Ads!L&@A> WX2e,$y%k;bcmc" @悸<p)R%cMU({zv 'EAKm#ODdM_cVĠ'ug>Xdlxz` lnwNM4{SU{hx,YjVKNvRr|~w,99^' oNpv-"! u7>Uejq5U) z%sCoHDHQD |I-4J\ZaugB](7> 4h&.^Ee'Ȋt !G" C_fK(+>_0JFh6UKi^-ԅec B@>㺰$ţNI:ʓ(447_8[nVd4FяTW_t1bxcVTUh "BG><\YQy BR4]X`& ̹t܂}0 :8ioM>!MRKnQ@]sR;jpqh6j(LODZqip_&B+v@b; a;H|@V9` \"v)+[L:JD)E'<$?+ʁ HDxohKuÎsq.۽vP5B-Cnj rfŽRLS"L[?hh[YƺzЫu*neIDh;%l$E%!p ]\pw7͙RD4̯YzT/ao:LF?0iκ3f F紥?a5Ђ;&ue5*k.jܽ'ͺ !,䟽_ ^^9w.7;;du #Ӿj0Q|v#Lfkׯ>1`Pvo@NP5nk4-BV LIn\G1I ||4` bʠ{e=85h) xҦmi X?.͏H}L=԰xڂF3P=h0m',%'j``dYhIAcZ4戸a&D)7 |oԚe4AָD@ &<&hxXf' 9W/3걯S3@R(.(I"1юR`.ƍW )T[|.xi! vmݾ}(ej:]p1H\mįd1$fiшvRP7թ1b͌:MMIE?,rCݽ}.4#.<}o;?s֬mܾO>=v٬MLL֧߰h4L8ׯ]ۿK ߟmee[$'F6?Z;aq\tXy鐸hEzXdRcw~QX4X#7*)`J _}1/7t4^Ə!+ɠR!aBU@Ūk i&i}_%"ٶmk:qY8t`ﾓ'OpOos+:yMÑ}h'=0W< ӓMPQ΃B_@\C.扎ai#fcp-a1AV2D| HNJ^TV =: !)2ɿ IT|@P6)6f4,YKg C)H(QpJXQh~缭ɷzhLWB=dU)EɆP*G]|SG(({ZC l!ee8>3LVle*'m(ɀ>4}1 J2ԎC4t/:_Q" ~4`D@RS4B`zM9ț W!jԸ#O⠑W jldkw7xPM2Y"'vb䳒u9vY?Ǐ#618t0xn- jM9gPljjn2 m䜜U[ka\:,]t.WO y;{z̛%:mSͭF^_h>!A~]6[ĉˊꬻ~CŅ)AZs-HKKh{:-n墥)A|>}@OOSC$a4A[5|@KpEQL&%+;}{knL֮[cGS)˺''lܴbϮq]=^݂jHM5?":۬m3B~~^37nf/_,kPaimh$&=;/}l'4yR"lVc e5zFQ5瓜 %9xlQL,H]}GhL$3Q!>-_Dވ%'FcgFe1aa *P!SF' HFv|n"]@F ÞD6~:Zh"m0%$iPPouv/3:U8oZ*݂5zr\JO'zƻ}ebMF};wXtmv!w=efXgV↷.ߵiSG鹳^7^rՖp($D"I* ׬)yWpsݮT1[ed~׹ӱjNMtfeVCzơCribnrvyAR®e7ȿnkoh4?%Kǒo[Rij.\h2M1,),ܼ;N CSM߹s[bT{v Sn3֏Э45Z[nua ³Ѹ+Z'mmm݂`f믽wysY GxR0 +;kJVkiߗe[n~MBh4RfΞ]\reJ:o' N#ZLS uhx@E"ZNJLAWQPpG!P dPC.Y{>}%-5cxXas3dXit:0"R|V] Wdf&'O}Q_w׮u?DQNZnL1jwlߞ$IeWr=QT\++*:{;t6M'Ojܹ{{#Hj)ՐM!R<1)~B9Ѣ,& zt/>>>wA`YMuMֹ|?88d2c ѶdWsj[7nle"ww*$ljkmuwsg181w6hOf\\6 r=,'$.]kZ(,,>w.A9P)jzT.[jubr]t63`UH>KrsfApS2LKIyB">s2\~(tvxvv]]]Fɨjy{gff>~~ yPC&p|z"TB}Y$P2Aƻp6pl0FUƻD CC#JtDu;{跓W(?!CfxI"VdC38Q F)"T bu6S&p B 2ؓR`ϫPUjF n"s&FApjDGN;$efr,Ї e4ƑsH3,.|Lj";㹾b~ @JvMV84^pZ3^. n~:cˀh4I'-̬CMEo A:ןؔ q|CP90Q-y#necH<*\+~iؓnnof+3#ӚeZ~WwO2x(n$AB{GGZJjqQgVܐY_>EEE>cc xXqq^r\,Ө#7rodggKY Zy$ESRRbjfjeaAP5(Z&!) d1SS~jONW?|ȱX"3+봴uv X?"߿_%@*!~P*---ŝ8_?Ɩbrk;Sq>@*ٱ\86֭< ըõ>r$re+*]q8ʪNĄ-ut⥞I[f=@PUY9*y/޽kwa_:KgΤ>r8 Ř<?UՑ{Af8dUW@_xP,]h48ILNLMKՕUOzӳW|#"rL!tv~_^ZzdDžG&LyYweExUWgeΝ3֬ǀa  E8!IkjjCC01?OťA3/ d8@eږs5ǨJzϞ/?|0"|MzFƜysR*?Ͽ7r;l>?Cg0?{FzZ4;#+kCL pD}߾\/B1ApIYo@pJ+<7U2B lV(̀F)6ųiC9kȨ sGԉ\@O*Y2$;ڋL1za9N2#0t=u. N4|ANDr{ S.mvPA!fl { [`"pӲ%MK=Zi2]ے?w`Ur5^l(RqR x8PŐ$ BL"xqpY_%u/TUm_cиL zI^|ĭ pl* TaIT=ݫ大 B:wua_~q"'9nGGDQQcPݽCCnnаЂ‚ٳ!Η(y`pvqIJNILNqu4 8;/~s{QQpHC[,/'۷]\u:OVvv\\Q '&6Suق+aU74(E^n~᪝;d0)i>cPr%"| /w…ءȇz̃KLIzCTQ^.JYL lٲ5+QƀǸq:VniLKI/grc6=X_SW7ѱ1nnm20'ZK TiBBCjj%|?>M*W$}} ~;yr=c߉$vΝ;e8ř+ DAc y?zLq9=}}x6%&Ma]:]HXhDGܓJ9nZ7EnNƘh6>m˘jN%/wv V3&aD,) xìa 0L CzK7Gc#"ȩs- `LkM q4)&{0ۆ1e`KƭzKءk#N% 5ecMWO )hhG('cQƐN4+c=͖ oLk"ZXo) O$PcP0JtB$tZȘR$T3,o9l.r 5qfc2hf4DOt ( 3r^5>[57F,ƴ eȴ ( IeX&bzk{Qa#F)nց_MW>|` th2C ǤHt4>oellp  a:ir%@!ٲdIJ۷k%O(~}｟JVm̠s&"b+::woy앳GO kguMM ! f{aN{;ߛ9ktv:xp4qؔiS _]"Lvvç" mdڌsfx9m+ R ֿ8[%E%7[nHeR˰l޶%RRT|הrT*[n]Ԛ]m##EEogI_jjr8tˋ w-nEѣyܴWNi²톹]QT9ĤI˖/4;w^9% r+K6bwToD}8a .-"m\ iץvd`H St;ljuIRta=uqn2J#)R`F_؇ш`#(:>v ѦCƒdTmԎ}T#ې )(9.| Z00p!?*:9'B1Gp\]A;¼0|eTLPf>S"'1 A&L'2ޤ 'CeEnWȶ$01{d?]pNnV?ڜo: pqh:K~婋a!m֐܇?#0Pns  ! e) b%d# `Jjl4:G\aE2/eԜ0pĿL݈aL)@G !\lk*:Mk530ēV|uT&<4ԇw(I_ 77g?,fK<gNKW?_a71I2@tbp0c- 6 )NT:57[MbciJ 0t%%X~0YN*%@aP6 838ΰ]bS$p2زw]Xtq?C[ne\Sw[z^@`dQ2v^5 9m!}Jya\x u::ʟP#6K'&a~<} uP֔ZD|+DZ1e$MK=A"C|Y$WB5bG1ѱYYYss ǍW ,[ZQ#N<+EJxukEE)Úڮv)AMJNqz޾}{ӦMyҨ5^P\\]jmmݚW2 gY]T?$)yree{ՀVΞѪ5v~<.t f`U厏gaa#5{z*ǏS)4i?6lH)gݾu/s58qbNNol`[ۆ-8e ֬!pv{þÇfcqy\x jwgF2&nݺuͺOȈf׮nO\¢^2<7Gm60 UTRR6aS[{2)rdʍ=#} mv%K gҞR aDG2$M/UY[hA )%3մN紘8=D{pCnD)PJԑڨUSi5KM3Mq}=yݿD=q`|-{Ӱ. 'fO a(VCb3u'&v~gnP[Ҏ1'9xn5G% f \5.,H*sxVPQf`/QMǗ}ZX%-q㴴QinFD$=)_%h$8S+aHH 1Nqie8Xa(Hi*'ɞ&4_,kM^ 2ـy.l?[%^H)+R[Դ2jpx" Q\tz߇V[%Rl+`dD%<>$7ʋ{M)/*VklzS⺠@a^'CSX奞o~ SVm-e{ݺ p'%(ޤy;4&ց^xb0RHksf S7]eq+|DdTY/2Vy,5_[KP,.~%5 -+߬0;Tc3O\?lUVZ[Y BY\B]`a`K (\a2G̹tMR_(ݔ@ ,ϖH" VV:Fy4Gu~&[̬C^kuRg.IkXU}`e_@ꭰ<ě,]Eq➨.)CSi`SElfG=(h\aiC~'k\f`ƆRE[Pl_/X?GţG""jU珏3nNY~;7Wgqثք;F{uu ))w } @e&Ott##Q"dx&idNS9y]浌PAa=d(CCq328N]C0z:D.cuJJ4jR] x$'fBv,B=<"TU-̍qqmJ eƪO/ .,DP#":&JҲ(:iSP1&.FSSslo|-R3b&'̩6@tP#"D8uk\TTNL6d'I$&S׎OxNNF=19$FY; uLŦ>lB4T6gO eoeq1*vj?73_g| WJp:=ｊ2rp^YX ȋ)ڂ/ͦd̳-5+ы1 ѥHG)*gVmMB^\/92 䕪2 k>*x8_5(@[]_Wհa!-[?]Fy g OZQ+~`Nv Y ;V(Llʢ~bEG/q$BGVdBÄG~řHh@2B3^HW#Dz~vz+RUBQؠ@)7 ֲw HuCM#+ꆰԺ]F)[}$4`:@l_n}S p7|JtG3-$%z옢"uFloV{eeeCJ |Ȼϟx}.C,vs8E(o7<5>6ҥXes4fj ?⌝pyE9 Xlvgw*UPژmTؕ+IIW8ׯp|WHh 4:f3 j`P4w@Scԕ+N 333vr~^(<G!x  TWSV^^\[JYIYRBdtZ[9ube'CCTThc]6EDhaTӔTJ$iJ&聭q`P`gG"Qf`x͝6K{uw /_ZRRBJJzxzx⤆X z/"< "u( (0CQ^~:r"TvNǶࣁYwlm⤤ *DHf-#Í?}jlhGvvaaч&i)):{ZZY[l0 + M"MpV[C8uw⦔q J`w{wj߾jr W*B23M?dbvo{N p8&wO=~pM.#z>q܃aBE_ab1p5e伍L-IÇs.UCӶ06T lև,[<p`v|B*Ez~"⍢ <#&qsYW<\;:cVQжeo?ؤT\#lgM8P%NQ6Tg'Y05 ĭ7#ۑx>?'|19ǃDt_ஜ_|澮7"#4aяۇ۹ζw+k/,P=H @8p8Ѡ 7Xj/|n0ר|?wcłWSoj0ͅD)B\yEyT]YO{I]nmx7e9h|˚ztoD:HgQmg,Ƚ:b1k]22y A,z&9G"' 0A $@8KWuV!&?;gRy|" ļ8}-ɸgOl 0$R]B v޾ty 4}\oyDeJ 㻌,Sx`m'IuHDOI)x>~=ѻQ'=10󸿆6"?o>#՟W7e'*?AU鳧vij ֢Q(V 9eHX=ʾ!. d@OBm{cŔI-8Zز'T;_X(f xx+C )7a WӬ D UE>zUF4kaB Rx`kt(*kHCKCEPQ Z."XQ\V( EPb? r%J@ȝM ~hC233<?R-S/$ h pVI0{5 jZ\@p+ mM[ˊ|rUDkf x.,$yÀ/@FX7cs8|ts ZnYwR*zTra_݆9YgN+purq/ȇ&%9f͏X 31%e}}}}{7ݪ**&&Ko pP#E;PTMV1s )H$N{\iiwjo++*|{,2FZ1ofhjB0+*סRC͢;9/Y:)?0rQsXaIhR4 >ʰ³>;#ɷ쌱ʰ°Ÿ*1<<2\-MM{{`+U୧OHMg0pJEEE팎wp_{162633swwglMo}I( Lrrܕ~+}R!B `Z1UEZ"yc#h~{#L-85NBND-w?f3ڜ{慘 91vnOv6#a|vþ[!dMN8#ZWd1Y:?oݒ`7^.\ҙ'ERLGrg^p¡Gu?h6?lŧR}D}S`$ 4fgQ^:ۏ L@pg&lq )uU@)2Ʌ+= Fޡ,LA9 oPBflO36Mu(Oi.+測߻ Ru]kw7; pou @/zJksEqix7 \Mǐoƺj@\V`zґ:bs&_?2g$}eokƌ+M"zWM))VpoK^LUhw„\njݟy KHAN27yҬÕ{A4 emX%G aڰgVQp$" mR9ī詥knED. ODH[?t񁇷ׄ/weo,KYdOnF|f*؞aC]NCygk (occ*/}rG؋&adH*=N v"pgM&$@Q)8al;L08E ;wvg 'cpxwgb1D})NzaH'Qָ aN\0 v!qmȐ,F@:&&Nw?S.!q^#%<%1ꋅ6/z}'M!9/^how't2g8[EDTeskY_7`1uap W*%#?(y ZsSsV&憞PQQ I4P(1;<1[hA$zCyBQgiϜkhheiA\\~%))yK(뛛?`U]LIIaq8!l ںouufM 0O88A X16 Դ97KKstdTӓTC&1p ( )=ACM~L[__oJrʏ׮pXuM+K2)Z@`0Km튋lʉ fEb-A[Ru 52!1.򪢢"Դt5I1&~Y7bn۱]SZ}=%>.UMat|!S "ݸ4? F 8*:S.@ؾ!Hg|Nei (JA8lebYw/}!}AG=#N^-zm{R< 64c_ϑBv3M-' G0fJ6s Wkf.ۅrxoL/bcƳ&6Kk0N: $NDMΥY`odfI4yt8sڲ+9Yx-? p*`xhǁbqbQI@%/*F7شҊoo-ZHzyB@MSQCm]`~-+ZB.y_:?Kk O^ӯwfv@(r@UCE7ROXG.8=|'bF'08Ēr[<|9!˔@{=)NėvWJ%KW8`PK:+96g$[)[}-g7v9QD'lNgKôy+~ץVoA\ 1Wmל2;SoB[T+ S(hr7.āK#7'oD~Oo$ %!hq0{ᨮaO<ޝ;*V"R D 374x qyԬS0e! ؾ<7IIyW~'##::U?imiu@PUUwtvtuP(9s(.s5%թ9)]|yܞ=behj*^0-Mk#vjki}dF[[45펉")N5QZ ,nJXee__Vkh`0VO,DbUU5;"#_q℥ҽ>4DݽMW@xծ*,]\$&6^ s*C\2b`hDJvx*q;ЎrQ<0Es/ֿ#C^phw)/Xz.G)Աh*-P~?봥Ep7%1)ً.*ʳ(ĸ3%,3(Y!{4Z ~UbH,$ 蒀G0̍{/Vb!8U˛ߺe!g[0Vl#YL4Wu^<}rY6[&V%9^jٚb9دE4-$+NN}* xƋ4N: $%BvK]'.X!gW^wbaTI̗s xC?Q[[8 f\)RpDBӒa:ks*$`[ S vFdCvd])Η;^7UaRQ(OKV\-A<ʰ khh 0~ιc߲4LBO9iR%SnܻhuZO3] 5μ4W L@ɚ-wZ_*@I>9O ԋ3ѻ#Jj 4tݶ/r25>&:wQ Op#)39k犞u@\DE8D[mW<$rTc4oK32%Mq*,*RA0D FOC#eIPIFyǘ'A6%$a+!T\+Ն͞~?`Z" %BY˸'dyD6i ?D/L} M1#;Oۛmk\X{/L\剮a ܙt z f?{^Yi&mazzRmҒSpF?XvIIN3~k.,rt:ϏNK$%\6rAݻv튎b*!uuuU N!QEܜ7ZZo SSUo .=_PP١0?`U^Al*JS zIF) q`XlLJ7oɳJ9AYYQJPOHR잞iׯ%x3BBI`FƉ3ml23wΧgpGރ1=ʖegfiidh4S pgdbtCKKZ$[AS'>N)}q$ RY QC=-pfs]OhԾ|D.z}if1%Zͽ]r`T%? S_;(hD`!ZXFˊlMBc7w60kqzE;oȓ7FjtKA]sDcHh\8~7MOhK4錟^.>J!"ϐ>;< ڥNR1y3؋cR3%KU 5t;GBv3ɰ뛟jc~Qh:M(u7+o[Ǧoxgeo;~G7&;P|?[{aeEə_yp DJERQ o7Dvt}m LKr^AFqm3M$Te U4E49$PVQ l}rӢu%:?w%y~Iz7ʘ`ɚZ4:4ñ>X,AV="hkj]G435HZĵWfn>N5+?G3md1Wmm'uo߽]J}|# WV^^,#Hq & 's455%&$\)@oV}xM.Kk2F 0k`tzzJr Fz֮/2WdE`!9-;J=a$HCSsA8uWil|O/-. ji#^!JRZTN9݉bC3 h4W|s[XH蕟HST0'br\0;]td.U ?cE/>w2M%obRRSRSQhАp8 ވ ɤ$Ȉ`Uϝk`b4oݮs=wtpYf߼~x#BU/XبQJR)%}Ψ(!K*$m%ۭr,/&k#yR,&^B#Дi/'~-PқH4WH.;/%T 0 <*!f gCVdj:wuSۛ%";Q`ئ˹@FV7UuD"7|tkm+Xp)z1:FǤPOl}ŃmE*7.@K܅P?pw/;u5]'N=1;%hS^@!+<Ww )/`<BLD:&xLugQMW?P"\cz tub~͖i7ʉC 8mmļp XMW/!$<^t>Q+S[}(q0UĤ,n#qruCM{R-YlPb} ]A(4aEcR@rcRHvN]}zY1P<2@5ʿ_/ȀC,e($'/0s,شuѲ^Vai!h@(4 WA-aSVnzv *+7\ TĽn1.Zz!-N>- !Ģ+tڬңaN*o5CiARRm2w>0>.5|K99I|) {i;0ΊihpD&'pQ*7:߂ ēOl udECM$_ahpg:%jx yMfNKzZ%I)%.;n]u+wVN,LTc?|pp;w- rRďs _ {gdDUy,zù2_1\tѢg NU`|a7FL޻ 2d^MwUZ}ҝmJ"Wo'ytcHdeihE>l`-$Q򏐗#u\ k* !]/,>g;3g& %1[2.$N]$a%u-fOX3}'{o{VuuƔ'P*JEVP>vz:nj{X;Cj0AA@~ru}[_T={'ݫ:1}02 z #: WImO%&47«k=FL%*i 58jR^@gfg A#iD>4M(7nR(8p5F#&)%[W@0$&ykTWSSUVb|BEQ {;񚥥7_-ao6PID'UZRÁTT({CԧfJHhyM F }5Ԉk+KBGg{B*P0=L&{܉V€W3-=L@ul\W˾!DSU$wWyTI# P9AY@Qg<:"g 8"EQUWEݕCPPQ@BAN:쟻~toʸx+k+l?"h$ŶKZڣi%%Lм?/ՒeRSO`B67gFEGݳ7 nzJ2#"VA jWW'¢BijT=g/8v@KO2.IHLR)P@RW==R%=.ie^r m2Ab7q[H'~n=OqT/lVzv D)?!s )8@Qg,d*+%EN %Bllyɍ+uR!g`oO ӛ[~*Q Lp[R@߹x1D${gԞv HgdT5Y{Uq_7:J7ꨒ݊?&C5~Ѷ. xddOCJO~a}e`OqZ'kAASpf ߥ|FCod"'#H/-⠋nx-7@/'/ Q3?Lw'gU>E=О}֫2]H^ ߲P41ND1PQgWO.f/ҋUTAI )-rƥٺsٌ׀8%`Q%[d`^T%OLLs{ub 3D #cBmaX RN4 ߸L $6fIb1Nȥ{[ԩ G(p1nz2 Wfp/suk®7 fbnW xR +O(~eMK+p04UT;M RQ\$T!-#W3_x# t 9Htnʸ5g3Dr4lk}4Yw\/D9䆐HnMg/BHBFo؜8! J+?_WZMM7!| )'m s]'t4>T#V@MZ$E9E/fQejP%R!Lݼuw8#4Ӂ\yGĜ^#LIp6-mߺ%͑$&,IM(w}Bm z͔V Ǜvͣ8| J9N[am9z{X|Tdd4}ljy8+Y"mA.y ??baۮupO=P [XLN[!oHMMKO716a0 JIDdx _łPuuO/8yp<]]P/o/2٦ȍ?-pݱ6<-%*^7'%.NSU מ^!aa_rZCã-7eS)Ԫ[qu55d5!srz7-A&{0{8'Ȇa*`ut/86*NgTLDIKNH_khhy;k4n]jk4Hv]kk-#1q:T+K0r=84tqJJ5Po_mMMPP CHo & 4yF`,wUhR*֔Ω[pڌyv tk;8:X PElF͎ɰq\n8khYWkc<2z+ Vu&%e-M/@_74qELi*e!6L1\>7Ez:>31ӝfew;٠3פ&8 *_ٯ֨,|{oDPRj XPF׌E]]i-Eѵ|*C BV[|Lqf)NQdFu27 y&ᑄ$Ͻ7MU̿XdA^myxAfAm (tf>x{6A1j puEȲI{J[ݱ>R,}ͷɋl@-4ڎ^0ɴL٘75< KS?I]9g[ڢ(/'hmiGmo ؅)#a݃~r_Vį ]hD ;z?O:Md $ߩ\}:W7D (PMs%S"J!(ͶsHQp˩{cY #Y]LDR抮nհ;:W>UuKK H-)/+nL@(siL[x1w>27tf[hdSokwPq󙪲"׸dꩡE懮 x3xIlnG@3ݳ×(M7ܳ'-]-9q8&/<% B! 9yǎڂo ssT?LIJr{XLȚ5{n>24sgsssmmm*U\\C Lj.eefVTFQeccc˝7o^٢Vݺq#)9iG;zᓄN /Ү_+Qk4>>Yo_O?}QG~}"葜ߺ~ݻ11R?]ksH(B:ƵR.ݟ%bznphcg;}R_Ww\Pp`̪DtIy\52m6obogs\>WP(ˇzt>#9%y݆۷y`Pd*b=岍hX闔ql,wfB9RNh%HOKKܸ);K.Hv$vu}ELL?n7ڋ vikגY-pvvNNJ^1Q(sѣ{{xp`;5087=m+5ڂS9̴ptBJB&c#ryn(BTɉ|eAjl|t|bhKuI;wM;F-]ZpLŋ*{Fyyy`ǫ_ Wp{E <<1,@0|k;D0'#_OM|6PHh''ƐF5ϲ)!V5h+%Ia#f-%WN囀>vG qk AQ!#,:$}Yc&b :-7.Cz=eunV0M De#̸U͌U8+ϷLc*Wlgy8s, ǦLB0 Xg0`y(dL'>C I %38~=v==?3Xl4Zej.@ >7:08 H[ԨYNipR@\4sLͭe\G"9'l 1 *֔ z ٹLW @@JE[-=Z"h q`:-0^˜ŸNg+C,gX]}S L%$aNFCZK/<#:B@'siY 'K]Z)`VMXg]e%kbNxعbHEtfb1!LӁݤּ!A3h9peqJ5I7j5k~d~~ay7{l ٙwq9t0^4sЖ%=rHB!\BJJmUUb8#5uJ#9qB!.JL[1TZ߽{LL=>}Nȶ۷FEGTUy Ұ}UW7~QFZ؆ 6iʻ+*<^WgJuwwegAAB!ͭɧN6prIIIKs[[[D„JJ\>,,wl~r;Sz{z"JKaJrvmT\&}WA}|,,,Qq|P*?~|@p42i&: vr2d}<8o,0aM򊋋Z=yHI3 ႂ}ʥ+ǎ\OԩeʸcNq8c'YfF7o:;F)*iu@/YuE_YLܦ˵ Ѫ[a:zbtWE*Ǚ΢ z~Ԛͦܧ0xb342y40B ve :6_^Yɇ z"9R[Cx&O1 `!i< h\ITk,ڟd@4 O__ C*O^z;pH˜o6X|@BT*dXS('8U`'D+;܎0蝶61D Nk" \PȡuQBRt!eBD[mPK(ǁ 2¦`G,C\=$@ JY)tկu} gQhGZ mb\8mp7 W6JTꀰRE1R'haw'ꥃ!J8^Սև_J*;3+77;kknt=DPggo.]XVv3fFGEy%𰦗/lJ_a? ܌?cyق*++j͛ff'Slmn`zz,̬իM՛.njDFϞ3+&"x „?>VxD)TӦOOHwuq -*+,(JB;E9u$WMM/Qluvv 2bĈ!Ƣ6r_7oZYXrMt玐]S?qJo*oy,Z|8L.[lپ8a3)RDϿs(>϶=Lkȹuܻܳv<~+Ο9Q?y'$O6M%IJH<}d|X"7,lYۍkGgOsB.ܼ}esϞ5K$J\frz (/bY<9#+mrpLeA3:gϞ5b0Dbmk?p VVvw{ǀkׯ_4nP"ܸcKKKWW׸qcnxqfZX*57lzrժ[jZIO\]]llg7=+Kr:m0 ֣ eΤɐ:1g<D/85z1Skl@_цg 'EPO=`<QpCxFIĠLc<c &at4t6 YohkS!P@nT>Fhx!0rhS}Dـg~M&c Ь &4SP1R4 @5JP"~n(9~FEcc=D,B iFX~cN܋OgP2Bh IMoCc|.A  >jv@} - sq{_>aѰݳT(9\y&Ƴ݃ܳٴڰڰㆆ/'67˫eyjua~;E :?h눣Gry 郶V@jbe  e?߹:qFsž>dg' ZU}=.C㛚~< (-t:tP0n:_+*oݾS_pXWZ9 wf 2zJYIIx盿9sV23x+W_<<<._0.ǽ$;ů o7 ]n / O  g@$N`6G+X@`ReD.LQm X$SI/[~u1y!&xGH G,̠Y [YFXxm"/pB蛕F#Wd $s 6XkI?A[DŽrȰ7&B']A3Ɣ]>ثacaSFX6 ˔wl=\8I\;`WU([[[ZZʮT݀jDAݡҴ3L Jhԁ0 Zryl.Q$-m]z99Ҳ+|AF`^d@vtvtvuyxe˗7gh"=j0'hWsg'爈?%vOK?|#TVS+dyTVE3D' 230h4[ Y~̎taIs?Yۓ'---5|>ߠ+m;flѯ#|{ivN}GRkjEQ?IK:'{6O/Ą%}Q *J/|~o]Pw#ڵkroR(VfdddDEGG>M_iGb:J wuRa32fݨ~JB7Z&MI]dR:&(tz޾… Bl`v|&a =dꭧ&\.Tvvo۱ci`_gYz 3HÏVAҥKsjoւ'$'&DZL[6m>Hվz/?p"Nq2C 1?_t 4Hhhڔ0{v DX/E 'Nfg456t(De۱s\.w''"W?7c˟8\"]BBB._<+Ru?seyuuuB;h V_aVVslVbvoooUU 5bX I g,lRYUa1tZ !!`{?9qBSI$<FZh0Ed3Dсb4Ro9- nb_q0ME~Ey^7.  ^( xh;A M鏌`NhtbN?uu2D:32jvQzKA(X-( ~}wa}syw{Y{ssyTs]&uWY֒gĉ'~ ,-+koxiqcJի;:wܗ_*?-͜Es6o>α̪+<z䊊EO>~inԩSk_[ W|iƌ'NEbk_{<[XbEeuk'X6;ľq'Ol'?lGP JB߀桫g2-rĉErbsʨO<>bɳDxnf72|i(lNL}1{#MJk458MP4TWCzRS5@oHNAB jEPnRŰYJ0T|`#@OH:?bG H^\ _:Loq׍a<V (KJb̷ܫIV:" ?-Uh I7X߿g ߗbR2$#P?J(2*RT LvqPC;r!%yRSnj+--7kvUr7Pىm <=3f|o̞HNNG_49>[7rS>G/XlٳE ȟWZz٦3JK+N%G޾s\ ??wBQQYY9қ7nR\Q1ax䤯~ooPx;]̌L>nwuily`LUك,E*:/گ]+ϯ0ck R(ze4ܛT.G5kk =:--3Mg\9|rq!SW!~4+Ew>LOO &S-s>RQQ+`0-=Cu[Z.Y\\%mZw:)oXñ8 ]ԕ$% z*NA},[=q'z%J"Snj"iD]Qf3&ƣU.";ʥ/KQ7GkN,-#'6)Dx>_nQERl +#3.4D34.,[#l24A,P$EaB#E%g&.Ǥm<4خغdiMKb3S:S:m2]~ 5s]=F/ٹqgj&%-iIKZ@w'= `}XnٷXq$>Ф!.b+eKDVA!pB26@Yh>9rBZ9|v.oǁOZҒ%- xIbЛiLv%"*Eta3~y#WҦ1܀2DHJXJ(* ը,J[R6Dn( d;Ht捳AX-;BLZDD Sij~gރ`ґ#>ϢagrAh'(nҕGI[fF :iF SgyDӒemrHnX64vruWnY̶c˚I܊1vgBe}a\=X݌`W; Uʤ%-iIKZ F%T@%f DDnA׺F41U$U@ѕ(h SpNK$MZB`# G: ņQbN8WRMIC1%Eess"\ Z $94&J$@3>˦BW>䳓c64}BE*VkXOhbHjr$ v(m}*tXv lqټϫ3"O5.ս>7 5g.DCoTa`HcIokJslH>Z5^d e!lݣPE+PN?C}r@ɫj;qXK: endstream endobj 123 0 obj<> endobj 124 0 obj<> endobj 125 0 obj<> endobj 126 0 obj<>stream q 518.3920898 0 0 86.3986816 42.3039551 621.6013184 cm /Im0 Do Q 0 g 1 i BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 10 0 0 10 265.1101 417.9997 Tm (ISSN: 1524-4563 )Tj -16.392 1 Td (Copyright \251 2007 American Heart Association. All rights reserved. Pri\ nt ISSN: 0194-911X. Online)Tj 18.656 1 Td (72514)Tj -18.635 1 Td (Hypertension is published by the American Heart Association. 7272 Greenv\ ille Avenue, Dallas, TX)Tj 12 0 0 12 178.1762 457.9998 Tm (DOI:\24010.1161/HYPERTENSIONAHA.107.095471 )Tj 6.887 1 Td ( published online Sep 4, 2007; )Tj /T1_1 1 Tf -5.388 0 Td (Hypertension)Tj /T1_0 1 Tf 2.182 1 Td (Brunner and Michael G. Marmot )Tj -10.345 1 Td (Miller, Frances M. Taggart, Meena Kumari, Jane E. Ferrie, Martin J. Ship\ ley, Eric J. )Tj 0.403 1 Td (Francesco P. Cappuccio, Saverio Stranges, Ngianga-Bakwin Kandala, Michel\ le A.)Tj 26.665 1 Td ( )Tj /T1_2 1 Tf -20.253 0 Td (Incident Hypertension. The Whitehall II Study)Tj -5.595 1 Td (Gender-Specific Associations of Short Sleep Duration With Prevalent and)Tj /T1_0 1 Tf 21.277 -15.333 Td ( )Tj 0 0 1 rg -11.11 0 Td (http://hyper.ahajournals.org)Tj 0 g -1.679 1 Td (located on the World Wide Web at: )Tj -9.014 1 Td (The online version of this article, along with updated information and s\ ervices, is)Tj ET 0 G 1 w 10 M 0 j 0 J []0 d 93 81 417 112 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S BT /T1_0 1 Tf 10 0 0 10 221.33 86.9997 Tm ( )Tj 0 0 1 rg -11.833 0 Td (http://www.lww.com/reprints)Tj 0 g 0 1 TD (Reprints: Information about reprints can be found online at )Tj 0 1 TD (\240 )Tj 12.226 1 Td ( )Tj 0 0 1 rg -12.226 0 Td (journalpermissions@lww.com)Tj 0 g 0 1 TD (410-528-8550. E-mail: )Tj 37.774 1 Td (Fax:)Tj -37.774 0 Td (Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone: \ 410-528-4050. )Tj T* (Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a\ division of Wolters)Tj T* (\240 )Tj 16.944 1 Td ( )Tj 0 0 1 rg -16.944 0 Td (http://hyper.ahajournals.org/subscriptions/)Tj 0 g 0 1 TD (Subscriptions: Information about subscribing to Hypertension is online a\ t )Tj 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg -8.72 0 Td (hyper.ahajournals.org)Tj 0 g -7.554 0 Td (Downloaded from )Tj ET endstream endobj 127 0 obj<> endobj 128 0 obj<> endobj 129 0 obj[127 0 R] endobj 130 0 obj<> endobj 133 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs 56.165 758.384 492 -27 re f 224.952 757.384 154.423 -19 re f BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 18.5 0 0 18.5 64.2898 695.3835 Tm [(Gender-Specific)-333(Associations)-333(of)-333(Short)-333(Sleep)-333(Duration)-333(With)]TJ 4.832 -1.054 Td [(Prevalent)-333(and)-333(Incident)-333(Hypertension)]TJ 15 0 0 15 225.9148 655.3835 Tm [(The)-333(Whitehall)-333(II)-333(Study)]TJ /T1_1 1 Tf 11.5 0 0 11.5 90.4545 630.8835 Tm [(Francesco)-333(P.)-333(Cappuccio,)-333(Saverio)-333(Stranges,)-333(Ngianga-Bakwin)-333(Kandala,)-333(Michelle)-333(A.)-333(Miller,)]TJ 3.957 -1.13 Td [(Frances)-333(M.)-333(Taggart,)-333(Meena)-333(Kumari,)-333(Jane)-333(E.)-333(Ferrie,)-333(Martin)-333(J.)-333(Shipley,)]TJ 6.969 -1.13 Td [(Eric)-333(J.)-333(Brunner,)-333(Michael)-333(G.)-333(Marmot)]TJ /T1_2 1 Tf 10 0 0 10 56.1648 579.8835 Tm (Abstract)Tj /T1_1 1 Tf 3.445 0 Td [(\227Sleep)-473(deprivation)-473(\()]TJ /T1_3 1 Tf 9.056 0 Td (\001)Tj /T1_1 1 Tf 0.833 0 Td [(5)-473(hour)-473(per)-473(night\))-473(was)-473(associated)-473(with)-473(a)-473(higher)-473(risk)-473(of)-473(hypertension)-473(in)-473(middle-aged)]TJ -12.134 -1.2 Td [(American)-434(adults)-434(but)-434(not)-434(among)-434(older)-434(individuals.)-434(However,)-434(the)-434(outcome)-434(was)-434(based)-434(on)-434(self-reported)-434(diagnosis)-434(of)]TJ 0 -1.2 TD [(incident)-372(hypertension,)-372(and)-372(no)-372(gender-specific)-372(analyses)-372(were)-372(included.)-372(We)-372(examined)-372(cross-sectional)-372(and)-372(prospective)]TJ 0 -1.2 TD [(associations)-270(of)-270(sleep)-270(duration)-270(with)-270(prevalent)-270(and)-270(incident)-270(hypertension)-270(in)-270(a)-270(cohort)-270(of)-270(10)-250(308)-270(British)-270(civil)-270(servants)-270(aged)]TJ 0 -1.2 TD [(35)-514(to)-514(55)-514(years)-514(at)-514(baseline)-514(\(phase)-514(1:)-514(1985\2261988\).)-514(Data)-514(were)-514(gathered)-514(from)-514(phase)-514(5)-514(\(1997\2261999\))-514(and)-514(phase)-514(7)]TJ T* [(\(2003\2262004\).)-354(Sleep)-354(duration)-354(and)-354(other)-354(covariates)-354(were)-354(assessed)-354(at)-354(phase)-354(5.)-354(At)-354(both)-354(examinations,)-354(hypertension)-354(was)]TJ T* [(defined)-302(as)-302(blood)-302(pressure)]TJ /T1_3 1 Tf 10.652 0 Td (\002)Tj /T1_1 1 Tf 0.833 0 Td [(140/90)-302(mm)-250(Hg)-302(or)-302(regular)-302(use)-302(of)-302(antihypertensive)-302(medications.)-302(In)-302(cross-sectional)-302(analyses)]TJ -11.485 -1.2 Td [(at)-410(phase)-410(5)-410(\(n)]TJ /T1_4 1 Tf 5.561 0 Td (\001)Tj /T1_1 1 Tf 0.833 0 Td [(5766\),)-410(short)-410(duration)-410(of)-410(sleep)-410(\()]TJ /T1_3 1 Tf 13.185 0 Td (\001)Tj /T1_1 1 Tf 0.833 0 Td [(5)-410(hour)-410(per)-410(night\))-410(was)-410(associated)-410(with)-410(higher)-410(risk)-410(of)-410(hypertension)]TJ -20.411 -1.2 Td [(compared)-372(with)-372(the)-372(group)-372(sleeping)-372(7)-372(hours,)-372(among)-372(women)-372(\(odds)-372(ratio:)-372(2.01;)-372(95%)-372(CI:)-372(1.13)-372(to)-372(3.58\),)-372(independent)-372(of)]TJ 0 -1.2 TD [(confounders,)-315(with)-315(an)-315(inverse)-315(linear)-315(trend)-315(across)-315(decreasing)-315(hours)-315(of)-315(sleep)-315(\()]TJ /T1_5 1 Tf 30.817 0 Td (P)Tj /T1_4 1 Tf 0.611 0 Td (\001)Tj /T1_1 1 Tf 0.833 0 Td [(0.003\).)-315(No)-315(association)-315(was)-315(detected)-315(in)]TJ -32.261 -1.2 Td [(men.)-277(In)-277(prospective)-277(analyses)-277(\(mean)-277(follow-up:)-277(5)-277(years\),)-277(the)-277(cumulative)-277(incidence)-277(of)-277(hypertension)-277(was)-277(20.0%)-277(\(n)]TJ /T1_4 1 Tf 45.333 0 Td (\001)Tj /T1_1 1 Tf 0.833 0 Td (740\))Tj -46.166 -1.2 Td [(among)-303(3691)-303(normotensive)-303(individuals)-303(at)-303(phase)-303(5.)-303(In)-303(women,)-303(short)-303(duration)-303(of)-303(sleep)-303(was)-303(associated)-303(with)-303(a)-303(higher)-303(risk)]TJ T* [(of)-293(hypertension)-293(in)-293(a)-293(reduced)-293(model)-293(\(age)-293(and)-293(employment\))-293(\(6)-293(hours)-293(per)-293(night:)-293(odds)-293(ratio:)-293(1.56)-293([95%)-293(CI:)-293(1.07)-293(to)-293(2.27];)]TJ /T1_3 1 Tf T* (\001)Tj /T1_1 1 Tf 0.833 0 Td [(5)-383(hour)-383(per)-383(night:)-383(odds)-383(ratio:)-383(1.94)-383([95%)-383(CI:)-383(1.08)-383(to)-383(3.50])-383(versus)-383(7)-383(hours\).)-383(The)-383(associations)-383(were)-383(attenuated)-383(after)]TJ -0.833 -1.2 Td [(accounting)-297(for)-297(cardiovascular)-297(risk)-297(factors)-297(and)-297(psychiatric)-297(comorbidities)-297(\(odds)-297(ratio:)-297(1.42)-297([95%)-297(CI:)-297(0.94)-297(to)-297(2.16];)-297(odds)]TJ T* [(ratio:)-404(1.31)-404([95%)-404(CI:)-404(0.65)-404(to)-404(2.63],)-404(respectively\).)-404(Sleep)-404(deprivation)-404(may)-404(produce)-404(detrimental)-404(cardiovascular)-404(effects)]TJ T* [(among)-333(women.)]TJ /T1_0 1 Tf 6.581 0 Td (\()Tj /T1_2 1 Tf 0.333 0 Td (Hypertension)Tj /T1_0 1 Tf 5.556 0 Td [(.)-333(2007;50:694-701.\))]TJ -12.386 -1.8 Td [(Key)-333(Words:)]TJ /T1_1 1 Tf 5.61 0 Td [(sleep)-333(duration)]TJ /T1_6 1 Tf 6.154 -0.1 Td (\001)Tj /T1_1 1 Tf 0.989 0.1 Td [(blood)-333(pressure)]TJ /T1_6 1 Tf 6.376 -0.1 Td (\001)Tj /T1_1 1 Tf 0.989 0.1 Td (hypertension)Tj /T1_6 1 Tf 5.599 -0.1 Td (\001)Tj /T1_1 1 Tf 0.989 0.1 Td [(gender)-333(differences)]TJ /T1_6 1 Tf 7.928 -0.1 Td (\001)Tj /T1_1 1 Tf 0.989 0.1 Td (confounders)Tj /T1_6 1 Tf 5.376 -0.1 Td (\001)Tj /T1_1 1 Tf 0.989 0.1 Td (comorbidities)Tj ET 0 0 0 1 K 0.5 w 10 M 0 j 0 J []0 d 56.165 356.634 m 548.165 356.634 l S BT /T1_1 1 Tf 26.7472 0 0 26.7472 56.1648 322.8836 Tm (S)Tj 9.5 0 0 9.5 72.0367 334.3836 Tm [(leep-disordered)-643(breathing)-643(\(SDB\))-643(has)-643(been)-643(linked)-643(to)]TJ -0.001 -1.224 Td [(elevated)-614(blood)-614(pressure)-614(and)-614(risk)-614(of)-614(hypertension)-614(in)]TJ -1.67 -1.224 Td [(several)-590(epidemiological)-590(observational)-590(studies.)]TJ 6.5 0 0 5.5 241.054 313.6648 Tm (1\2265)Tj 9.5 0 0 9.5 256.4123 311.1336 Tm (Growing)Tj -21.079 -1.224 Td [(evidence)-432(indicates)-432(that)-432(sleep)-432(deprivation)-432(is)-432(also)-432(associated)]TJ 0 -1.224 TD [(with)-626(a)-626(number)-626(of)-626(health)-626(outcomes,)-626(including)-626(hyperten-)]TJ 0 -1.224 TD (sion.)Tj 6.5 0 0 5.5 74.3753 278.7898 Tm [(6)-120(\22614)]TJ 9.5 0 0 9.5 90.7536 276.2585 Tm [(For)-274(example,)-274(in)-274(a)-274(recent)-274(longitudinal)-274(analysis)-274(of)-274(the)]TJ -3.641 -1.224 Td [(first)-597(National)-597(Health)-597(And)-597(Nutrition)-597(Examination)-597(Survey)]TJ 0 -1.224 TD [(\(NHANES-I\),)-312(short)-312(sleep)-312(duration)-312(\()]TJ /T1_3 1 Tf 14.607 0 Td (\001)Tj /T1_1 1 Tf 0.833 0 Td [(5)-312(hours)-312(per)-312(night\))-312(was)]TJ -15.44 -1.224 Td [(associated)-268(with)-268(a)-268(60%)-268(higher)-268(risk)-268(of)-268(incident)-268(hypertension)-268(in)]TJ 0 -1.224 TD [(middle-aged)-267(\(32)-267(to)-267(59)-267(years\))-267(American)-267(adults)-267(without)-267(appar-)]TJ T* [(ent)-541(sleep)-541(disorders)-541(during)-541(a)-541(mean)-541(follow-up)-541(of)-541(8)-541(to)-541(10)]TJ T* (years.)Tj 6.5 0 0 5.5 78.5836 209.0398 Tm (13)Tj 9.5 0 0 9.5 87.2344 206.5085 Tm [(No)-226(association)-226(was)-226(found)-226(in)-226(individuals)]TJ /T1_3 1 Tf 16.135 0 Td (\002)Tj /T1_1 1 Tf 0.833 0 Td [(60)-226(years)-226(of)]TJ -20.238 -1.224 Td [(age.)-639(However,)-639(the)-639(outcome)-639(was)-639(based)-639(on)-639(self-reported)]TJ 0 -1.224 TD [(diagnosis)-463(of)-463(incident)-463(hypertension,)-463(and)-463(no)-463(gender-specific)]TJ 0 -1.224 TD [(analyses)-329(were)-329(included.)-329(Furthermore,)-329(a)-329(cross-sectional)-329(anal-)]TJ 0 -1.224 TD [(ysis)-230(from)-230(the)-230(Sleep)-230(Heart)-230(Health)-230(Study)-230(on)-230(a)-230(sample)-230(of)]TJ /T1_4 1 Tf 21.8 0 Td (\002)Tj /T1_1 1 Tf 0.833 0 Td (6000)Tj -22.633 -1.224 Td [(US)-364(adults)-364(showed)-364(a)-364(significant)-364(higher)-364(prevalence)-364(of)-364(hyper-)]TJ 27.158 19.579 Td [(tension)-416(among)-416(individuals)-416(with)-416(usual)-416(sleep)-416(duration)-416(above)]TJ 0 -1.224 TD [(or)-518(below)-518(the)-518(median)-518(of)-518(7)-518(to)]TJ /T1_4 1 Tf 13.181 0 Td (\003)Tj /T1_1 1 Tf 0.833 0 Td [(8)-518(hours)-518(per)-518(night.)]TJ 6.5 0 0 5.5 521.9636 325.2898 Tm (14)Tj 9.5 0 0 9.5 533.3871 322.7586 Tm (The)Tj -23.076 -1.224 Td [(association)-349(was)-349(stronger,)-349(ie,)-349(a)-349(66%)-349(higher)-349(risk)-349(of)-349(hyperten-)]TJ 0 -1.224 TD [(sion,)-399(among)-399(short)-399(sleepers)-399(\()]TJ /T1_4 1 Tf 11.788 0 Td (\003)Tj /T1_1 1 Tf 0.833 0 Td [(6)-399(hours)-399(per)-399(night\).)-399(Although)]TJ -12.621 -1.224 Td [(this)-466(study)-466(attempted)-466(to)-466(account)-466(for)-466(a)-466(number)-466(of)-466(potential)]TJ 0 -1.224 TD [(confounders,)-222(including)-222(psychiatric)-222(and)-222(cardiovascular)-222(comor-)]TJ T* [(bidities,)-271(the)-271(cross-sectional)-271(design)-271(did)-271(not)-271(allow)-271(inference)-271(on)]TJ 0.0197 Tc T* [(the)-678(temporal)-678(relationship)-678(between)-678(sleep)-678(duration)-678(and)]TJ 0 Tc T* (hypertension.)Tj 1 -1.224 Td [(Several)-347(studies)-347(in)-347(humans)-347(indicate)-347(potential)-347(pathophysio-)]TJ -1 -1.224 Td [(logical)-356(mechanisms)-356(supporting)-356(the)-356(biological)-356(plausibility)-356(of)]TJ 0 -1.224 TD [(the)-361(association)-361(between)-361(sleep)-361(deprivation)-361(and)-361(hypertension.)]TJ T* [(For)-541(example,)-542(acute)-541(curtailments)-541(of)-541(sleep)-541(may)-541(induce)-541(an)]TJ T* [(overactivity)-472(of)-472(the)-472(sympathetic)-472(nervous)-472(system)-472(leading)-472(to)]TJ T* [(higher)-274(blood)-274(pressure)-274(in)-274(both)-274(normotensive)-274(and)-274(hypertensive)]TJ 0 -1.224 TD (individuals.)Tj 6.5 0 0 5.5 358.765 162.5398 Tm (15\22617)Tj 9.5 0 0 9.5 377.777 160.0085 Tm [(Other)-291(contributing)-291(mechanisms)-291(may)-291(include)]TJ 0.0033 Tc -6.696 -1.224 Td [(overactivity)-662(of)-662(the)-662(renin-angiotensin-aldosterone)-662(system,)]TJ ET 56.165 118.134 m 548.165 118.134 l S BT /T1_1 1 Tf 0 Tc 8 0 0 8 64.1648 108.3836 Tm [(Received)-333(May)-333(30,)-333(2007;)-333(first)-333(decision)-333(June)-333(24,)-333(2007;)-333(revision)-333(accepted)-333(August)-333(3,)-333(2007.)]TJ 0 -1.125 TD [(From)-281(the)-281(Clinical)-281(Sciences)-281(Research)-281(Institute)-281(\(F.P.C.,)-281(S.S.,)-281(N-B.K.,)-281(M.A.M.,)-281(F.M.T.\),)-281(TV)-281(Medical)-281(School,)-281(Coventry,)-281(United)-281(Kingdom;)-281(and)-281(the)]TJ -1 -1.125 Td [(International)-223(Centre)-223(for)-223(Health)-223(and)-223(Society)-223(\(M.K.,)-223(J.E.F.,)-223(M.J.S.,)-223(E.J.B.,)-223(M.G.M.\),)-223(University)-223(College)-223(London)-223(Medical)-223(School,)-223(London,)-223(United)-223(King)]TJ 59.475 0 Td (dom.)Tj -58.475 -1.125 Td [(Correspondence)-379(to)-379(Francesco)-379(P.)-379(Cappuccio,)-379(Clinical)-379(Sciences)-379(Research)-379(Institute,)-379(TV)-379(Medical)-379(School,)-379(UHCW)-379(Campus,)-379(Clifford)-379(Bridge)-379(Rd,)]TJ -1 -1.125 Td [(Coventry)-333(CV2)-333(2DX,)-333(United)-333(Kingdom.)-333(E-mail)-333(sleepresearch@warwick.ac.uk)]TJ 1 -1.125 Td [(\251)-333(2007)-333(American)-333(Heart)-333(Association,)-333(Inc.)]TJ /T1_2 1 Tf 0 -1.625 TD (Hypertension)Tj /T1_0 1 Tf 5.889 0 Td [(is)-333(available)-333(at)-333(http://hyper.ahajournals.org)-14759(DOI:)-333(10.1161/HYPERTENSIONAHA.107.095471)]TJ /T1_2 1 Tf 9.5 0 0 9.5 295.0398 32.3835 Tm (694)Tj 0 0 0 0 k /T1_0 1 Tf 20 0 0 19 224.9517 738.3835 Tm [(Sleep)-333(Deprivation)]TJ 0 g ET /GS1 gs BT /T1_7 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_7 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_7 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 134 0 obj<> endobj 135 0 obj<> endobj 136 0 obj[134 0 R] endobj 137 0 obj<> endobj 140 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 56.1648 719.8835 Tm [(proinflammatory)-350(responses,)-350(endothelial)-350(dysfunction,)-350(and)-350(re-)]TJ 0 -1.218 TD [(nal)-241(impairment.)]TJ 6.5 0 0 5.5 116.2401 710.8467 Tm (18,19)Tj 9.5 0 0 9.5 133.1554 708.3154 Tm [(On)-241(the)-241(other)-241(hand,)-241(intervention)-241(studies)-241(to)]TJ -8.104 -1.218 Td [(improve)-312(duration)-312(and)-312(quality)-312(of)-312(sleep)-312(have)-312(been)-312(effective)-312(in)]TJ T* [(reducing)-511(both)-511(daytime)-511(and)-511(nighttime)-511(blood)-511(pressures.)]TJ 6.5 0 0 5.5 275.5497 687.7103 Tm (19,20)Tj 9.5 0 0 9.5 56.1648 673.6108 Tm [(However,)-346(there)-346(is)-346(concern)-346(that)-346(sleep)-346(habits)-346(may)-346(represent)-346(a)]TJ T* [(marker)-260(of)-260(health)-260(status)-260(and)-260(quality)-260(of)-260(life)-260(rather)-260(than)-260(a)-260(casual)]TJ T* [(factor)-333(for)-333(hypertension)-333(and)-333(other)-333(health)-333(outcomes.)]TJ 6.5 0 0 5.5 252.6823 653.0057 Tm (21)Tj 9.5 0 0 9.5 65.6648 638.9063 Tm [(In)-469(the)-469(present)-469(analysis,)-469(we)-469(sought)-469(to)-469(examine)-469(both)-469(the)]TJ -1 -1.218 Td [(cross-sectional)-264(and)-264(prospective)-264(associations)-264(of)-264(sleep)-264(duration)]TJ T* [(with)-336(prevalent)-336(and)-336(incident)-336(hypertension)-336(in)-336(the)-336(Whitehall)-336(II)]TJ T* [(Study,)-472(a)-472(prospective)-472(cohort)-472(of)-472(10)-250(308)-472(white-collar)-472(British)]TJ T* [(civil)-244(servants)-244(aged)-244(35)-244(to)-244(55)-244(at)-244(baseline)-244(\(phase)-244(1:)-244(1985\2261988\).)]TJ T* [(Because)-295(reduced)-295(durations)-295(of)-295(sleep)-295(might)-295(be)-295(associated)-295(with)]TJ T* [(more)-329(detrimental)-329(effects)-329(on)-329(cardiovascular)-329(outcomes)-329(among)]TJ 0 -1.218 TD (women,)Tj 0.1198 Tc 6.5 0 0 5.5 86.5062 560.4603 Tm [(6\226)120(9)]TJ 0 Tc 9.5 0 0 9.5 103.2935 557.929 Tm [(unlike)-659(previous)-659(investigations,)-659(we)-659(conducted)]TJ -4.961 -1.218 Td [(gender-specific)-406(analyses)-406(with)-406(the)-406(inclusion)-406(of)-406(a)-406(number)-406(of)]TJ 0 -1.218 TD [(potential)-333(confounding)-333(variables.)]TJ /T1_1 1 Tf 11.5 0 0 11.5 151.767 511.7245 Tm (Methods)Tj 10.5 0 0 10.5 56.1648 496.1563 Tm [(Study)-333(Population)]TJ /T1_0 1 Tf 8.5 0 0 8.5 56.1648 485.5881 Tm [(The)-281(Whitehall)-281(II)-281(Cohort)-281(was)-281(recruited)-281(in)-281(1985\2261988)-281(\(phase)-281(1\))-281(from)]TJ 0 -1.126 TD [(20)-414(London-based)-414(civil)-414(service)-414(departments.)-414(The)-414(rationale,)-414(design,)]TJ T* [(and)-291(methods)-291(of)-291(the)-291(study)-291(have)-291(been)-291(described)-291(in)-291(detail)-291(elsewhere.)]TJ 6 0 0 5 284.1751 468.7159 Tm (22)Tj 8.5 0 0 8.5 56.1648 456.8836 Tm [(Briefly,)-520(the)-520(initial)-520(response)-520(rate)-520(was)-520(73%,)-520(and)-520(the)-520(final)-520(cohort)]TJ T* [(consisted)-615(of)-615(10)-250(308)-615(participants;)-615(3413)-615(women)-615(and)-615(6895)-615(men.)]TJ T* [(Follow-up)-346(screening)-346(examinations)-346(took)-346(place)-346(in)-346(1991\2261993)-346(\(phase)]TJ 0 -1.126 TD [(3\),)-328(1997\2261999)-328(\(phase)-328(5\),)-328(and)-328(2003\2262004)-328(\(phase)-328(7\),)-328(whereas)-328(postal)]TJ 0 -1.126 TD [(questionnaires)-476(were)-476(sent)-476(to)-476(participants)-476(in)-476(1989)-476(\(phase)-476(2\),)-476(1995)]TJ T* [(\(phase)-276(4\),)-276(and)-276(2001)-276(\(phase)-276(6\).)-276(The)-276(participation)-276(rates)-276(of)-276(the)-276(original)]TJ T* [(cohort)-313(\(n)]TJ /T1_2 1 Tf 3.701 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(10)-250(308\))-313(were)-313(83%,)-313(76%,)-313(and)-313(68%)-313(at)-313(phases)-313(3,)-313(5,)-313(and)-313(7,)]TJ -4.534 -1.126 Td [(respectively.)-334(In)-334(this)-334(report,)-334(we)-334(used)-334(data)-334(from)-334(phases)-334(5)-334(and)-334(7.)-334(The)]TJ 0 -1.126 TD [(total)-351(sample)-351(at)-351(phase)-351(5)-351(consisted)-351(of)-351(7204)-351(participants.)-351(The)-351(present)]TJ 0 -1.126 TD [(analyses)-418(were)-418(restricted)-418(to)-418(white)-418(individuals)-418(\()]TJ /T1_3 1 Tf 19.336 0 Td (n)Tj /T1_2 1 Tf 0.5 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(6592\),)-418(given)-418(the)]TJ -20.669 -1.126 Td [(low)-248(numbers)-248(of)-248(other)-248(ethnic)-248(groups)-248(\()]TJ /T1_3 1 Tf 14.819 0 Td (n)Tj /T1_2 1 Tf 0.5 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(612\).)-248(For)-248(the)-248(cross-sectional)]TJ -16.152 -1.126 Td [(analyses,)-405(only)-405(participants)-405(with)-405(a)-405(complete)-405(set)-405(of)-405(data)-405(at)-405(phase)-405(5)]TJ T* [(were)-365(included)-365(\()]TJ /T1_3 1 Tf 6.45 0 Td (n)Tj /T1_2 1 Tf 0.5 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5766:)-365(4199)-365(men)-365(and)-365(1567)-365(women\).)-365(Their)-365(char-)]TJ -7.783 -1.126 Td [(acteristics)-397(were)-397(comparable)-397(to)-397(the)-397(overall)-397(sample)-397(\(see)-397(Appendix\).)]TJ T* [(For)-266(the)-266(longitudinal)-266(analyses,)-266(the)-266(incidence)-266(of)-266(hypertension)-266(at)-266(phase)]TJ T* [(7)-288(was)-288(assessed)-288(among)-288(participants)-288(who)-288(were)-288(normotensive)-288(at)-288(phase)]TJ 0.3329 Tc 0 -1.126 TD (5\()Tj /T1_3 1 Tf 0 Tc 1.166 0 Td (n)Tj /T1_2 1 Tf 0.5 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(3691:)-333(2686)-333(men)-333(and)-333(1005)-333(women\).)]TJ /T1_1 1 Tf 10.5 0 0 10.5 56.1648 283.2245 Tm [(Sleep)-333(Duration)]TJ /T1_0 1 Tf 8.5 0 0 8.5 56.1648 272.6563 Tm [(At)-253(phases)-253(5)-253(and)-253(7,)-253(sleep)-253(duration)-253(was)-253(elicited)-253(by)-253(the)-253(question,)-253(\223How)]TJ 0 -1.126 TD [(many)-518(hours)-518(of)-518(sleep)-518(do)-518(you)-518(have)-518(on)-518(an)-518(average)-518(week)-518(night?\224)]TJ T* [(Response)-321(categories)-321(were)]TJ /T1_4 1 Tf 10.794 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-321(hours,)-321(6)-321(hours,)-321(7)-321(hours,)-321(8)-321(hours,)-321(and)]TJ /T1_4 1 Tf -11.627 -1.124 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(9)-333(hours.)]TJ /T1_1 1 Tf 10.5 0 0 10.5 56.1648 223.4063 Tm (Covariates)Tj /T1_0 1 Tf 8.5 0 0 8.5 56.1648 212.8495 Tm [(For)-257(the)-257(present)-257(analyses,)-257(age)-257(and)-257(other)-257(covariates)-257(were)-257(derived)-257(from)]TJ 0 -1.124 TD [(the)-418(questionnaires)-418(at)-418(phase)-418(5.)-418(Employment)-418(grade)-418(was)-418(determined)]TJ T* [(from)-326(the)-326(participant\222s)-326(last)-326(known)-326(civil)-326(service)-326(grade)-326(title)-326(\(19%)-326(had)]TJ 0 -1.124 TD [(retired)-594(by)-594(phase)-594(5\))-594(and)-594(divided)-594(into)-594(3)-594(categories)-594(in)-594(order)-594(of)]TJ 0 -1.124 TD [(decreasing)-363(salary:)-363(administrative,)-363(professional/executive,)-363(and)-363(cleri-)]TJ T* [(cal/support.)-242(Participants)-242(were)-242(allocated)-242(to)-242(1)-242(of)-242(4)-242(smoking)-242(categories:)]TJ T* [(never,)-248(ex-smoker,)-248(pipe)-248(and/or)-248(cigar)-248(only,)-248(or)-248(current)-248(cigarette)-248(smoker)]TJ T* [(\(manufactured)-446(or)-446(hand-rolled)-446(cigarettes\).)-446(Alcohol)-446(consumption)-446(in)]TJ 0 -1.124 TD [(the)-543(previous)-543(week)-543(was)-543(recorded)-543(\(units)-543(per)-543(week\).)-543(Leisure-time)]TJ 0 -1.124 TD [(physical)-486(activity)-486(was)-486(categorized)-486(by)-486(energy)-486(use)-486(in)-486(2)-486(categories:)]TJ T* [(\223vigorous\224)-223(\(subjects)-223(who)-223(reported)]TJ /T1_4 1 Tf 13.89 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(1.5)-223(hour)-223(of)-223(vigorous)-223(activity)-223(per)]TJ -14.723 -1.124 Td [(week\))-341(and)-341(no)-341(vigorous)-341(activity.)-341(General)-341(health)-341(status)-341(was)-341(assessed)]TJ T* [(using)-374(the)-374(physical)-374(and)-374(mental)-374(health)-374(component)-374(summaries)-374(of)-374(the)]TJ T* [(Short)-468(Form-36)-468(\(SF-36\))-468(health)-468(survey)-468(questionnaire)]TJ 6 0 0 5 239.8782 90.875 Tm (23)Tj 8.5 0 0 8.5 245.8786 88.6108 Tm [(:)-468(low)-468(scores)]TJ -22.319 -1.124 Td [(indicate)-440(low)-440(functioning.)-440(Psychiatric)-440(morbidity,)-440(including)-440(depres-)]TJ 0 -1.124 TD [(sion,)-425(was)-425(assessed)-425(with)-425(a)-425(modified)-425(General)-425(Health)-425(Questionnaire)]TJ 0 -1.124 TD [(score.)-271(Participants)-271(taking)-271(sleep)-271(medication)-271(\(hypnotics\))-271(or)-271(cardiovas-)]TJ 0 -1.124 TD [(cular)-331(drugs)-331(were)-331(identified)-331(through)-331(a)-331(questionnaire)-331(item)-331(on)-331(current)]TJ 30.353 78.823 Td [(medication.)-337(At)-337(both)-337(phase)-337(5)-337(and)-337(7)-337(screening)-337(examinations,)-337(anthro-)]TJ 0 -1.128 TD [(pometric)-517(measures)-517(were)-517(recorded,)-517(including)-517(height,)-517(weight,)-517(and)]TJ T* [(waist)-526(circumference;)-526(body)-526(mass)-526(index)-526(\(BMI\))-526(was)-526(calculated)-526(as)]TJ T* [(weight)-476(in)-476(kilograms)-476(divided)-476(by)-476(height)-476(in)-476(meters)-476(squared.)-476(Blood)]TJ T* [(pressure)-257(was)-257(measured)-257(3)-257(times)-257(using)-257(a)-257(standard)-257(mercury)-257(manometer)]TJ T* [(by)-254(trained)-254(and)-254(certified)-254(technicians)-254(in)-254(both)-254(examinations.)-254(The)-254(onsets)]TJ T* [(of)-529(the)-529(first-phase)-529(\(systolic\))-529(and)-529(fifth-phase)-529(\(diastolic\))-529(Korotkoff)]TJ T* [(sounds)-346(were)-346(recorded.)-346(The)-346(mean)-346(of)-346(the)-346(second)-346(and)-346(third)-346(measures)]TJ T* [(were)-337(used)-337(in)-337(the)-337(analyses.)-337(At)-337(both)-337(examinations,)-337(hypertension)-337(was)]TJ T* [(defined)-624(as)-624(blood)-624(pressure)]TJ /T1_4 1 Tf 11.939 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(140/90)-624(mm)-250(Hg)-624(or)-624(regular)-624(use)-624(of)]TJ -12.772 -1.128 Td [(antihypertensive)-333(medications.)]TJ /T1_1 1 Tf 10.5 0 0 10.5 314.1648 603.8835 Tm [(Ethical)-333(Approval)]TJ /T1_0 1 Tf 8.5 0 0 8.5 314.1648 593.2927 Tm [(Ethical)-370(approval)-370(for)-370(the)-370(Whitehall)-370(II)-370(Study)-370(was)-370(obtained)-370(from)-370(the)]TJ 0 -1.128 TD [(University)-282(College)-282(London)-282(Medical)-282(School)-282(committee)-282(on)-282(the)-282(ethics)]TJ 0 -1.127 TD [(of)-333(human)-333(research.)]TJ /T1_1 1 Tf 10.5 0 0 10.5 314.1648 553.5427 Tm [(Statistical)-333(Analysis)]TJ /T1_0 1 Tf 8.5 0 0 8.5 314.1648 542.9631 Tm [(For)-636(continuous)-636(and)-636(categorical)-636(variables,)-636(respectively,)-636(Kruskal)]TJ T* [(Wallis)-246(and)]TJ /T1_4 1 Tf 8.5 0 1.321 8.5 352.8188 533.3835 Tm (\003)Tj /T1_0 1 Tf 5 0 0 5 357.5446 536.6335 Tm (2)Tj 8.5 0 0 8.5 362.1387 533.3807 Tm [(tests)-246(were)-246(used)-246(to)-246(determine)-246(the)-246(statistical)-246(significance)]TJ -5.644 -1.127 Td [(of)-306(any)-306(difference)-306(in)-306(the)-306(distribution)-306(of)-306(baseline)-306(variables)-306(at)-306(phase)-306(5)]TJ 0 -1.127 TD [(across)-254(categories)-254(of)-254(sleep)-254(duration.)-254(The)-254(statistical)-254(significance)-254(of)-254(the)]TJ 0 -1.127 TD [(interaction)-343(between)-343(each)-343(baseline)-343(characteristic)-343(and)-343(sleep)-343(duration,)]TJ T* [(adjusted)-315(for)-315(other)-315(important)-315(baseline)-315(variables,)-315(was)-315(tested)-315(in)-315(multi-)]TJ T* [(variate)-345(logistic)-345(regression)-345(models)-345(that)-345(included)-345(this)-345(interaction)-345(and)]TJ T* [(the)-328(corresponding)-328(main)-328(effect)-328(terms.)-328(The)-328(interaction)-328(between)-328(sleep)]TJ T* [(duration)-356(and)-356(gender)-356(was)-356(significant)-356(\()]TJ /T1_3 1 Tf 15.387 0 Td (P)Tj /T1_2 1 Tf 0.611 0 Td (\003)Tj /T1_0 1 Tf 0.833 0 Td [(0.05\);)-356(therefore,)-356(all)-356(of)-356(the)]TJ -16.831 -1.127 Td [(analyses)-328(were)-328(stratified)-328(by)-328(gender.)-328(No)-328(significant)-328(interactions)-328(were)]TJ 0 -1.127 TD [(found)-359(between)-359(sleep)-359(duration)-359(and)-359(age)-359(or)-359(other)-359(relevant)-359(covariates.)]TJ T* [(Univariate)-386(and)-386(multivariate)-386(regression)-386(analyses)-386(were)-386(conducted)-386(to)]TJ T* [(test)-319(the)-319(association)-319(between)-319(categories)-319(of)-319(sleep)-319(duration)-319(and)-319(preva-)]TJ T* [(lent)-251(hypertension)-251(at)-251(phase)-251(5)-251(\(cross-sectional)-251(analyses\),)-251(as)-251(well)-251(as)-251(the)]TJ T* [(association)-399(between)-399(sleep)-399(duration)-399(at)-399(phase)-399(5)-399(and)-399(incident)-399(hyper-)]TJ T* [(tension)-411(at)-411(phase)-411(7)-411(\(prospective)-411(analyses\).)-411(Covariates)-411(included)-411(the)]TJ 0 -1.127 TD [(following:)-390(baseline)-390(age,)-390(employment,)-390(alcohol)-390(consumption,)-390(smok-)]TJ T* [(ing,)-509(physical)-509(activity,)-509(BMI,)-509(cardiovascular)-509(disease)-509(\(CVD\))-509(drugs)]TJ T* [(\(other)-509(than)-509(antihypertensive)-509(medications\),)-509(the)-509(SF-36)-509(mental)-509(and)]TJ T* [(physical)-286(health)-286(component)-286(scores,)-286(depression,)-286(and)-286(use)-286(of)-286(hypnotics.)]TJ T* [(In)-441(these)-441(analyses,)-441(7)-441(hours)-441(of)-441(sleep)-441(was)-441(selected)-441(as)-441(the)-441(reference)]TJ T* [(category.)-333(All)-333(of)-333(the)-333(techniques)-333(were)-333(implemented)-333(using)-333(Stata)-333(9.0.)]TJ /T1_1 1 Tf 11.5 0 0 11.5 413.2812 320.2131 Tm (Results)Tj 10.5 0 0 10.5 314.1648 304.6335 Tm (Descriptives)Tj /T1_0 1 Tf 9.5 0 0 9.5 314.1648 293.554 Tm [(Characteristics)-337(for)-337(both)-337(male)-337(and)-337(female)-337(participants)-337(\(Table)]TJ 0 -1.219 TD [(1\))-386(at)-386(phase)-386(5)-386(\(baseline\))-386(are)-386(reported)-386(by)-386(categories)-386(of)-386(sleep)]TJ T* [(duration.)-333(Among)-333(men,)-333(participants)-333(sleeping)]TJ /T1_4 1 Tf 18.219 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(9)-333(hours)-333(were,)]TJ -19.052 -1.219 Td [(on)-434(average,)-434(older)-434(than)-434(other)-434(participants;)-434(in)-434(addition,)-434(they)]TJ 0 -1.219 TD [(were)-290(less)-290(likely)-290(to)-290(be)-290(physically)-290(active)-290(and)-290(more)-290(likely)-290(to)-290(be)]TJ T* [(on)-533(medication)-533(for)-533(CVD)-533(drugs.)-533(On)-533(the)-533(other)-533(hand,)-533(male)]TJ T* [(participants)-559(sleeping)]TJ /T1_4 1 Tf 9.117 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-559(hours)-559(had)-559(a)-559(lower)-559(employment)]TJ -9.95 -1.219 Td [(status,)-351(higher)-351(mean)-351(levels)-351(of)-351(BMI)-351(and)-351(waist)-351(circumference,)]TJ T* [(were)-515(more)-515(likely)-515(to)-515(be)-515(depressed)-515(and)-515(on)-515(medication)-515(for)]TJ T* [(hypnotics,)-285(and)-285(reported)-285(lower)-285(scores)-285(for)-285(mental)-285(and)-285(physical)]TJ T* [(health)-405(than)-405(other)-405(participants.)-405(No)-405(significant)-405(differences)-405(in)]TJ T* [(drinking)-306(and)-306(smoking)-306(habits)-306(were)-306(reported)-306(across)-306(categories)]TJ T* [(of)-344(sleep)-344(duration.)-344(For)-344(blood)-344(pressures,)-344(no)-344(consistent)-344(pattern)]TJ T* [(of)-222(association)-222(was)-222(noted;)-222(however,)-222(the)-222(mean)-222(levels)-222(of)-222(systolic)]TJ 0 -1.219 TD [(blood)-455(pressure)-455(\(and)-455(pulse)-455(pressure\))-455(and)-455(the)-455(prevalence)-455(of)]TJ T* [(hypertension)-516(were)-516(significantly)-516(higher)-516(among)-516(participants)]TJ T* [(sleeping)-333(8)-333(hours)-333(than)-333(in)-333(other)-333(participants.)]TJ 1 -1.219 Td [(Among)-277(women,)-277(participants)-277(at)-277(the)-277(2)-277(extreme)-277(categories)-277(of)]TJ -1 -1.219 Td [(sleep)-346(duration)-346(\(ie,)]TJ /T1_4 1 Tf 7.731 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-346(hours)-346(and)]TJ /T1_4 1 Tf 5.204 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(9)-346(hours\))-346(were)-346(character-)]TJ -14.6 -1.219 Td [(ized,)-239(in)-239(general,)-239(by)-239(a)-239(poorer)-239(health)-239(status)-239(and)-239(lifestyle)-239(profile.)]TJ T* [(In)-318(particular,)-318(they)-318(had)-318(a)-318(lower)-318(employment)-318(status,)-318(were)-318(less)]TJ T* [(likely)-239(to)-239(be)-239(physically)-239(active,)-239(more)-239(likely)-239(to)-239(be)-239(on)-239(medication)]TJ /T1_1 1 Tf 10 0 0 10 252.6761 748.9148 Tm [(Cappuccio)-333(et)-333(al)-2000(Short)-333(Sleep)-333(Duration)-333(and)-333(Hypertension)]TJ /T1_5 1 Tf 28.053 0 Td (695)Tj 0 g ET /GS1 gs BT /T1_6 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_6 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_6 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 141 0 obj<> endobj 142 0 obj<> endobj 143 0 obj[141 0 R] endobj 144 0 obj<> endobj 147 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 56.1648 84.1279 Tm [(for)-247(CVD)-247(drugs)-247(or)-247(hypnotics,)-247(more)-247(likely)-247(to)-247(be)-247(depressed,)-247(and)]TJ 0 -1.184 TD [(reported)-462(lower)-462(scores)-462(for)-462(mental)-462(and)-462(physical)-462(health)-462(than)]TJ T* [(other)-397(categories.)-397(No)-397(significant)-397(differences)-397(in)-397(drinking)-397(and)]TJ T* [(smoking)-583(habits)-583(were)-583(reported)-583(across)-583(categories)-583(of)-583(sleep)]TJ 27.158 3.553 Td [(duration.)-330(For)-330(blood)-330(pressures,)-330(there)-330(was)-330(a)-330(consistent)-330(pattern)]TJ T* [(of)-301(association)-301(among)-301(female)-301(participants)-301(sleeping)]TJ /T1_1 1 Tf 20.527 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-301(hours,)]TJ -21.36 -1.184 Td [(who)-378(reported)-378(higher)-378(mean)-378(levels)-378(of)-378(systolic)-378(blood)-378(pressure)]TJ T* [(\(and)-321(pulse)-321(pressure\),)-321(as)-321(well)-321(as)-321(a)-321(significantly)-321(higher)-321(preva-)]TJ /T1_2 1 Tf 9 0 0 9 104.1648 720.3835 Tm [(TABLE)-333(1.)-1000(Baseline)-333(Characteristics)-333(\(Phase)-333(5:)-333(1997\2261999\))-333(Across)-333(Categories)-333(of)-333(Sleep)-333(Duration:)-333(The)]TJ 0 -1.167 TD [(Whitehall)-333(II)-333(Study)-333(\(n)]TJ /T1_3 1 Tf 8.289 0 Td (\001)Tj /T1_2 1 Tf 0.833 0 Td (5766\))Tj ET 0 0 0 1 K 0.75 w 10 M 0 j 0 J []0 d 104.17 703.509 m 500.156 703.509 l 104.17 154.037 m 500.156 154.037 l S 0.5 w 211.906 688.884 m 459.801 688.884 l S 0.75 w 104.17 671.759 m 500.156 671.759 l S BT /T1_4 1 Tf 8 0 0 8 104.1705 675.6335 Tm (Characteristics)Tj 26.203 2.188 Td [(Sleep)-333(Duration)]TJ /T1_5 1 Tf 21.258 -2.188 Td (P)Tj /T1_4 1 Tf 0.606 0 Td (*)Tj /T1_1 1 Tf -33.312 0 Td (\001)Tj /T1_4 1 Tf 0.3327 Tc 0.833 0 Td [(5h)-4587(6h)-4931(7h)-4931(8h)]TJ /T1_1 1 Tf 0 Tc 25.47 0 Td (\002)Tj /T1_4 1 Tf 0.3327 Tc 0.833 0 Td (9h)Tj 0 Tc -41.891 -1.75 Td [(Men)-333(\(n)]TJ /T1_6 1 Tf 2.648 0 Td (\001)Tj /T1_4 1 Tf 0.833 0 Td (4199\))Tj -2.481 -1.613 Td [(No.)-333(of)-333(subjects)-8408(265)-4932(1383)-4619(1886)-4859(620)-5412(45)]TJ 0 -1.613 TD [(Age,)-333(y)-10204(54.6)-240(\(5.6\))-3430(54.6)-240(\(5.7\))-2446(55.5)-240(\(6.1\))-3430(57.5)-240(\(6.1\))-3010(57.7)-240(\(5.4\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(DBP,)-333(mm)-240(Hg)-7777(79.2)-240(\(10.9\))-2950(78.2)-240(\(10.4\))-1966(78.6)-240(\(10.5\))-2950(79.0)-240(\(10.9\))-2530(78.1)-240(\(10.6\))-2883(0.57)]TJ 0 -1.613 TD [(SBP,)-333(mm)-240(Hg)-7354(124.0)-240(\(16.7\))-2470(122.3)-240(\(15.4\))-1486(123.9)-240(\(15.8\))-2470(125.1)-240(\(17.3\))-2050(122.5)-240(\(16.6\))-2883(0.009)]TJ T* [(Pulse)-333(pressure,)-333(mm)-240(Hg)-3782(44.7)-240(\(11.5\))-2950(44.1)-240(\(10.7\))-1966(45.3)-240(\(11.0\))-2950(46.1)-240(\(12.4\))-2530(44.4)-240(\(11.1\))-2883(0.003)]TJ T* [(Lowest)-333(employment,)-333(n)-333(\(%\))-3150(26)-240(\(9.8\))-4150(66)-240(\(4.8\))-3166(62)-240(\(3.3\))-4150(18)-240(\(2.9\))-4210(3)-240(\(6.7\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(BMI,)-333(kg/m)]TJ 5 0 0 5 143.4239 574.3296 Tm (2)Tj 8 0 0 8 212.8892 571.3296 Tm [(27.0)-240(\(4.1\))-3430(26.4)-240(\(3.5\))-2446(25.9)-240(\(3.4\))-3430(25.4)-240(\(3.3\))-3010(25.7)-240(\(3.3\))]TJ /T1_6 1 Tf 32.854 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(Waist,)-333(cm)-8833(94.9)-240(\(11.6\))-2950(92.8)-240(\(10.2\))-1966(91.6)-240(\(9.7\))-3430(90.2)-240(\(9.9\))-3010(91.5)-240(\(8.5\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(Weekly)-333(alcohol,)-333(units)-4595(18.0)-240(\(21.2\))-2950(16.9)-240(\(15.9\))-1966(16.5)-240(\(15.9\))-2950(16.3)-240(\(17.1\))-2530(17.7)-240(\(20\))-3603(0.58)]TJ 0 -1.613 TD [(CVD)-333(drugs,)-333(n)-333(\(%\))-6738(49)-240(\(18.6\))-3190(185)-240(\(13.4\))-2206(259)-240(\(13.8\))-3190(111)-240(\(18.0\))-3730(9)-240(\(20.0\))-2884(0.013)]TJ 0 -1.613 TD [(Physical)-333(activity,)-333(n)-333(\(%\))-4244(108)-240(\(40.8\))-3190(687)-240(\(49.7\))-2206(930)-240(\(49.3\))-3190(320)-240(\(51.6\))-3250(17)-240(\(37.8\))-2884(0.022)]TJ T* [(SF-36)-333(mental)-333(\(score\))-4633(47.1)-240(\(12.2\))-2950(50.5)-240(\(9.2\))-2446(52.5)-240(\(8.2\))-3430(53.7)-240(\(7.5\))-3010(52.0)-240(\(9.9\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(SF-36)-333(physical)-333(\(score\))-4152(50.2)-240(\(8.8\))-3430(52.1)-240(\(7.1\))-2446(52.4)-240(\(6.4\))-3430(51.9)-240(\(6.8\))-3010(50.9)-240(\(8.5\))-3363(0.019)]TJ T* [(Use)-333(of)-333(hypnotics,)-333(n)-333(\(%\))-4906(7)-240(\(2.7\))-4630(8)-240(\(0.6\))-3646(4)-240(\(0.2\))-4630(2)-240(\(0.3\))-4210(0)-240(\(0.0\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(Depression)-333(cases,)-333(n)-333(\(%\))-4111(62)-240(\(23.8\))-3190(178)-240(\(13.1\))-2206(173)-240(\(9.3\))-4149(55)-240(\(9.0\))-4210(4)-240(\(8.9\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(Current)-333(smoking,)-333(n)-333(\(%\))-4480(30)-240(\(11.5\))-3190(123)-240(\(8.9\))-2686(154)-240(\(8.2\))-4149(49)-240(\(7.9\))-4210(4)-240(\(8.9\))-3364(0.45)]TJ 0 -1.613 TD [(Hypertensive,)-333(n)-333(\(%\))-5927(84)-240(\(31.7\))-3190(358)-240(\(25.9\))-2206(533)-240(\(28.3\))-3190(205)-240(\(33.1\))-3250(14)-240(\(31.1\))-2884(0.014)]TJ 1 -1.613 Td [(No)-333(medication)-6904(45)-240(\(17.0\))-3190(218)-240(\(15.8\))-2206(323)-240(\(17.1\))-3190(115)-240(\(18.6\))-3730(9)-240(\(20.0\))]TJ /T1_7 1 Tf 0.2397 Tc 45.368 -0.25 Td (\002\002\002)Tj /T1_4 1 Tf 0 Tc -45.368 -1.363 Td [(Medication)-8254(38)-240(\(14.3\)\206)-2708(140)-240(\(10.1\))-2206(208)-240(\(11.0\)\207)-3187(90)-240(\(14.5\))-3730(5)-240(\(11.1\))]TJ /T1_7 1 Tf 0.2397 Tc 45.368 -0.25 Td (\002\002\002)Tj /T1_4 1 Tf 0 Tc -47.368 -1.363 Td [(Women)-333(\(n)]TJ /T1_6 1 Tf 3.832 0 Td (\001)Tj /T1_4 1 Tf 0.833 0 Td (1567\))Tj -3.665 -1.613 Td [(No.)-333(of)-333(subjects)-8408(157)-5412(511)-5099(597)-4860(272)-5412(30)]TJ 0 -1.613 TD [(Age,)-333(y)-10204(56.4)-240(\(5.9\))-3430(56.1)-240(\(6.1\))-2446(55.7)-240(\(6.1\))-3430(56.8)-240(\(6.1\))-3010(54.7)-240(\(5.7\))-3363(0.07)]TJ T* [(DBP,)-333(mm)-240(Hg)-7777(75.7)-240(\(10.4\))-2950(74.9)-240(\(10.1\))-1966(74.4)-240(\(9.8\))-3430(74.2)-240(\(10.0\))-2530(74.0)-240(\(10.0\))-2883(0.50)]TJ T* [(SBP,)-333(mm)-240(Hg)-7354(124.2)-240(\(18.3\))-2470(121.2)-240(\(16.8\))-1486(120.3)-240(\(17.1\))-2470(121.4)-240(\(16.8\))-2770(118)-240(\(17.2\))-2883(0.07)]TJ T* [(Pulse)-333(pressure,)-333(mm)-240(Hg)-3782(48.5)-240(\(13.8\))-2950(46.3)-240(\(12.3\))-1966(45.9)-240(\(12.3\))-2950(47.2)-240(\(11.6\))-2530(44.0)-240(\(10.9\))-2883(0.07)]TJ T* [(Lowest)-333(employment,)-333(n)-333(\(%\))-3150(52)-240(\(33.1\))-3190(143)-240(\(28.1\))-2206(162)-240(\(27.2\))-3669(67)-240(\(25.0\))-3250(11)-240(\(36.7\))-2884(0.003)]TJ 0 -1.613 TD [(BMI,)-333(kg/m)]TJ 5 0 0 5 143.4239 316.3182 Tm (2)Tj 8 0 0 8 212.8892 313.3182 Tm [(27.1)-240(\(5.8\))-3430(26.2)-240(\(5.1\))-2446(25.9)-240(\(4.4\))-3430(26.3)-240(\(5.0\))-3010(25.8)-240(\(4.6\))-3363(0.31)]TJ -12.59 -1.613 Td [(Waist,)-333(cm)-8833(82.5)-240(\(14.3\))-2950(80.2)-240(\(11.8\))-1966(80.1)-240(\(11.2\))-2950(80.4)-240(\(11.9\))-2530(81.5)-240(\(12.0\))-2883(0.66)]TJ 0 -1.613 TD [(Weekly)-333(alcohol,)-333(units)-5075(7.3)-240(\(10.8\))-3430(8.0)-240(\(8.5\))-2926(8.2)-240(\(9.5\))-3910(8.4)-240(\(10.0\))-3010(9.8)-240(\(9.4\))-3363(0.10)]TJ 0 -1.613 TD [(CVD)-333(drugs,)-333(n)-333(\(%\))-6738(36)-240(\(23.1\))-3670(58)-240(\(11.4\))-2686(94)-240(\(15.8\))-3670(46)-240(\(16.9\))-3730(4)-240(\(13.3\))-2884(0.007)]TJ 0 -1.613 TD [(Physical)-333(activity,)-333(n)-333(\(%\))-4724(38)-240(\(24.2\))-3190(169)-240(\(33.1\))-2206(215)-240(\(36\))-3910(108)-240(\(39.7\))-3730(6)-240(\(20.0\))-2884(0.006)]TJ T* [(SF-36)-333(mental)-333(\(score\))-4633(42.9)-240(\(13.1\))-2950(49.0)-240(\(10.3\))-1966(50.8)-240(\(9.2\))-3430(52.6)-240(\(8.8\))-3010(46.9)-240(\(15.0\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(SF-36)-333(physical)-333(\(score\))-4152(46.0)-240(\(12.5\))-2950(50.2)-240(\(8.4\))-2446(49.8)-240(\(9.0\))-3430(49.9)-240(\(8.8\))-3010(45.2)-240(\(10.1\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(Use)-333(of)-333(hypnotics,)-333(n)-333(\(%\))-4906(2)-240(\(1.3\))-4630(5)-240(\(1.0\))-3646(4)-240(\(0.7\))-4630(2)-240(\(0.7\))-4210(1)-240(\(3.3\))-3364(0.60)]TJ T* [(Depression)-333(cases,)-333(n)-333(\(%\))-4111(50)-240(\(32.5\))-3670(72)-240(\(14.4\))-2686(66)-240(\(11.2\))-3670(20)-240(\(7.4\))-4210(5)-240(\(16.7\))]TJ /T1_6 1 Tf 45.444 0 Td (\003)Tj /T1_4 1 Tf 0.833 0 Td (0.001)Tj -46.277 -1.613 Td [(Current)-333(smoking,)-333(n)-333(\(%\))-4480(20)-240(\(12.9\))-3670(79)-240(\(15.5\))-2686(76)-240(\(12.8\))-3670(31)-240(\(11.4\))-3730(1)-240(\(3.3\))-3364(0.22)]TJ 0 -1.613 TD [(Hypertensive,)-333(n)-333(\(%\))-5927(58)-240(\(36.9\))-3190(124)-240(\(24.3\))-2206(152)-240(\(25.5\))-3669(66)-240(\(24.3\))-3730(7)-240(\(23.3\))-2884(0.024)]TJ 1 -1.613 Td [(No)-333(medication)-6904(27)-240(\(17.2\))-3670(72)-240(\(14.1\))-2686(69)-240(\(11.6\))-3670(29)-240(\(10.7\))-3730(5)-240(\(16.7\))]TJ /T1_7 1 Tf 0.2397 Tc 45.368 -0.25 Td (\002\002\002)Tj /T1_4 1 Tf 0 Tc -45.368 -1.375 Td [(Medication)-8254(31)-240(\(19.7\))-3670(52)-240(\(10.2\))-2686(83)-240(\(13.9\))-3670(37)-240(\(13.6\))-3730(2)-240(\(6.7\))]TJ /T1_7 1 Tf 0.2397 Tc 45.368 -0.25 Td (\002\002\002)Tj /T1_4 1 Tf 0 Tc -46.369 -1.469 Td [(Data)-333(are)-333(expressed)-333(as)-333(the)-333(mean)-333(\(SD\))-333(or)-333(as)-333(n)-333(\(%\).)-333(DBP)-333(indicates)-333(diastolic)-333(blood)-333(pressure;)-333(SBP,)-333(systolic)-333(blood)-333(pressure.)]TJ 0 -1.25 TD (*)Tj /T1_5 1 Tf 0.352 0 Td (P)Tj /T1_4 1 Tf 0.817 0 Td [(value)-336(for)-336(comparison)-336(across)-336(sleep)-336(duration)-336(groups)-336(using)-336(the)]TJ /T1_1 1 Tf 8 0 1.2443 8 308.9056 134.662 Tm (\003)Tj /T1_4 1 Tf 5 0 0 5 313.3535 137.662 Tm (2)Tj 8 0 0 8 318.4442 134.6591 Tm [(analysis)-336(for)-336(categorical)-336(variables)-336(and)-336(Kruskal-Wallis)-336(test)-336(for)]TJ -26.785 -1.25 Td [(continuous)-333(variables.)]TJ 1 -1.25 Td [(\206One)-333(value)-333(is)-333(missing.)]TJ T* [(\207Two)-333(values)-333(are)-333(missing.)]TJ /T1_8 1 Tf 10 0 0 10 56.1648 752.3835 Tm [(696)-2000(Hypertension)]TJ /T1_9 1 Tf 11.056 0 Td [(October)-333(2007)]TJ 0 g ET /GS1 gs BT /T1_10 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_10 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_10 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 148 0 obj<> endobj 149 0 obj<> endobj 150 0 obj[148 0 R] endobj 151 0 obj<> endobj 154 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 56.1648 438.3835 Tm [(lence)-309(of)-309(hypertension)-309(than)-309(other)-309(participants)-309(\(in)-309(both)-309(treated)]TJ 0 -1.237 TD [(and)-333(untreated)-333(individuals\).)]TJ /T1_1 1 Tf 10.5 0 0 10.5 56.1648 402.1336 Tm [(Cross-Sectional)-333(Analysis)]TJ /T1_0 1 Tf 9.5 0 0 9.5 56.1648 390.8836 Tm [(Table)-530(2)-530(displays)-530(the)-530(odds)-530(ratios)-530(\(ORs\))-530(and)-530(95%)-530(CIs)-530(of)]TJ T* [(prevalent)-321(hypertension)-321(across)-321(categories)-321(of)-321(sleep)-321(duration)-321(at)]TJ T* [(phase)-436(5,)-436(using)-436(7)-436(hours)-436(of)-436(sleep)-436(as)-436(the)-436(reference)-436(category.)]TJ 0 -1.237 TD [(Among)-323(men,)-323(no)-323(consistent)-323(pattern)-323(of)-323(association)-323(was)-323(noted.)]TJ 0 -1.237 TD [(Among)-329(women,)-329(in)-329(fully)-329(adjusted)-329(analyses,)-329(short)-329(duration)-329(of)]TJ T* [(sleep)-238(\()]TJ /T1_2 1 Tf 2.626 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-238(hours)-238(per)-238(night\))-238(was)-238(associated)-238(with)-238(a)-238(significantly)]TJ 23.699 11.184 Td [(higher)-246(risk)-246(of)-246(hypertension)-246(compared)-246(with)-246(the)-246(group)-246(sleeping)]TJ T* [(7)-419(hours)-419(\(OR:)-419(2.01;)-419(95%)-419(CI:)-419(1.13)-419(to)-419(3.58\),)-419(independent)-419(of)]TJ T* [(several)-629(potential)-629(confounders,)-629(with)-629(a)-629(significant)-629(inverse)]TJ 0 -1.237 TD [(linear)-333(trend)-333(across)-333(decreasing)-333(hours)-333(of)-333(sleep)-333(\()]TJ /T1_3 1 Tf 18.879 0 Td (P)Tj /T1_4 1 Tf 0.611 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td (0.003\).)Tj /T1_1 1 Tf 10.5 0 0 10.5 314.1648 378.6336 Tm [(Prospective)-333(Analysis)]TJ /T1_0 1 Tf 9.5 0 0 9.5 314.1648 367.3836 Tm [(Table)-358(3)-358(displays)-358(the)-358(ORs)-358(\(and)-358(95%)-358(CIs\))-358(of)-358(incident)-358(hyper-)]TJ T* [(tension)-378(at)-378(phase)-378(7)-378(among)-378(participants)-378(who)-378(were)-378(normoten-)]TJ T* [(sive)-452(at)-452(phase)-452(5.)-452(During)-452(a)-452(mean)-452(follow-up)-452(of)-452(5)-452(years,)-452(the)]TJ 0 -1.237 TD [(cumulative)-508(incidence)-508(of)-508(hypertension)-508(was)-508(20.0%)-508(\(740)-508(of)]TJ /T1_5 1 Tf 9 0 0 9 56.1648 720.3835 Tm [(TABLE)-333(2.)-1000(OR)-333(\(95%)-333(CI\))-333(of)-333(Prevalent)-333(Hypertension)-333(Across)-333(Categories)-333(of)-333(Sleep)-333(Duration)-333(at)-333(Phase)-333(5)-333(\(1997\2261999\):)-333(The)-333(Whitehall)-333(II)-333(Study)]TJ 0 -1.167 TD (\(n)Tj /T1_6 1 Tf 0.796 0 Td (\001)Tj /T1_5 1 Tf 0.833 0 Td (5766\))Tj ET 0 0 0 1 K 0.75 w 10 M 0 j 0 J []0 d 56.185 703.509 m 548.145 703.509 l 56.185 514.259 m 548.145 514.259 l S 0.5 w 123.935 688.884 m 469.886 688.884 l 482.057 688.884 m 548.145 688.884 l S 0.75 w 56.185 671.759 m 548.145 671.759 l S BT /T1_7 1 Tf 8 0 0 8 56.1847 675.6335 Tm [(Sample)-333(Models)]TJ 27.333 2.188 Td [(Sleep)-333(Duration)]TJ /T1_8 1 Tf 29.552 0 Td (P)Tj /T1_7 1 Tf 0.606 0 Td (*)Tj /T1_2 1 Tf -45.609 -2.188 Td (\001)Tj /T1_7 1 Tf 0.3327 Tc 0.833 0 Td [(5h)-8192(6h)-5162(7h)-5569(8h)]TJ /T1_2 1 Tf 0 Tc 33.716 0 Td (\002)Tj /T1_7 1 Tf 0.833 0 Td [(9)-333(h)-5096(Linear)-1985(Nonlinear)]TJ -47.265 -1.75 Td [(Men)-333(\(n)]TJ /T1_4 1 Tf 2.648 0 Td (\001)Tj /T1_7 1 Tf 0.833 0 Td (4199\))Tj -2.481 -1.625 Td [(No.)-9376(265)-8538(1383)-5450(1886)-4657(620)-9424(45)]TJ /T1_9 1 Tf 0.2397 Tc 53.211 -0.25 Td [(\002\002\002)-3506(\002\002\002)]TJ /T1_7 1 Tf 0 Tc -53.211 -1.375 Td [(Cases,)-333(n)-7839(84)-9018(358)-5930(533)-4657(205)-9424(14)]TJ /T1_9 1 Tf 0.2397 Tc 53.211 -0.25 Td [(\002\002\002)-3506(\002\002\002)]TJ /T1_7 1 Tf 0 Tc -53.211 -1.375 Td [(Model)-333(1\207)-4040(1.18)-2065(0.89)-1645(1.55)-1708(0.89)-1583(0.76)-1645(1.04)-3085(1)-2041(1.25\206)-1583(1.03)-1645(1.52)-1708(1.15)-1583(0.61)-1645(2.17)-1811(0.06)-3452(0.015)]TJ 0 -1.625 TD [(Model)-333(2\247)-4040(1.23)-2065(0.92)-1645(1.63)-1708(0.93)-1583(0.79)-1645(1.09)-3085(1)-2041(1.11)-2065(0.91)-1645(1.36)-1708(0.99)-1583(0.52)-1645(1.90)-1811(0.70)-3452(0.09)]TJ T* [(Model)-333(3\266)-3966(0.88)-2065(0.63)-1645(1.23)-1708(0.86)-1583(0.72)-1645(1.03)-3085(1)-2041(1.12)-2065(0.89)-1645(1.41)-1708(0.92)-1583(0.44)-1645(1.92)-1811(0.05)-3452(0.54)]TJ -1 -1.625 Td [(Women)-333(\(n)]TJ /T1_4 1 Tf 3.832 0 Td (\001)Tj /T1_7 1 Tf 0.833 0 Td (1567\))Tj -3.665 -1.625 Td [(No.)-9376(157)-9018(511)-5930(597)-4657(272)-9424(30)]TJ /T1_9 1 Tf 0.2397 Tc 55.792 -0.25 Td (\002\002\002)Tj /T1_7 1 Tf 0 Tc -55.792 -1.375 Td [(Cases,)-333(n)-7839(58)-9018(124)-5930(152)-5137(66)-9904(7)]TJ /T1_9 1 Tf 0.2397 Tc 55.792 -0.25 Td (\002\002\002)Tj /T1_7 1 Tf 0 Tc -55.792 -1.375 Td [(Model)-333(1\207)-4040(1.72\206)-1583(1.18)-1645(2.49)-1708(0.94)-1583(0.71)-1645(1.23)-3085(1)-2041(0.94)-2065(0.67)-1645(1.31)-1708(0.89)-1583(0.37)-1645(2.12)-1811(0.13)-3452(0.06)]TJ T* [(Model)-333(2\247)-4040(1.64\206)-1583(1.11)-1645(2.42)-1708(0.90)-1583(0.68)-1645(1.19)-3085(1)-2041(0.83)-2065(0.58)-1645(1.17)-1708(0.98)-1583(0.40)-1645(2.40)-1811(0.12)-3452(0.15)]TJ T* [(Model)-333(3\266)-3966(1.72\206)-1583(1.07)-1645(2.75)-1708(0.92)-1583(0.67)-1645(1.28)-3085(1)-2041(0.74)-2065(0.50)-1645(1.11)-1708(0.70)-1583(0.21)-1645(2.37)-1811(0.037\206)-2490(0.31)]TJ -0.002 -1.719 Td (*)Tj /T1_8 1 Tf 0.352 0 Td (P)Tj /T1_7 1 Tf 0.814 0 Td [(value)-333(for)-333(test)-333(of)-333(linear)-333(and)-333(nonlinear)-333(trends.)]TJ -1.166 -1.25 Td (\206)Tj /T1_8 1 Tf 0.482 0 Td (P)Tj /T1_4 1 Tf 0.481 0 Td (\003)Tj /T1_7 1 Tf 0.833 0 Td (0.05.)Tj -1.796 -1.25 Td [(\207Model)-333(1:)-333(unadjusted.)]TJ 0 -1.25 TD [(\247Model)-333(2:)-333(adjusted)-333(for)-333(age)-333(and)-333(employment.)]TJ T* [(\266Model)-333(3:)-333(model)-333(2)]TJ /T1_4 1 Tf 7.29 0 Td (\004)Tj /T1_7 1 Tf 0.833 0 Td [(alcohol)-333(consumption,)-333(smoking,)-333(physical)-333(activity,)-333(BMI,)-333(SF-36)-333(mental,)-333(SF-36)-333(physical,)-333(depression)-333(cases,)-333(hypnotics)-333(use,)-333(and)-333(CVD)-333(drugs.)]TJ /T1_5 1 Tf 9 0 0 9 56.1648 305.8836 Tm [(TABLE)-333(3.)-1000(OR)-333(\(95%)-333(CI\))-333(of)-333(Incident)-333(Hypertension)-333(at)-333(Phase)-333(7)-333(\(2002\2262003\))-333(Across)-333(Categories)-333(of)-333(Sleep)-333(Duration)-333(at)-333(Phase)-333(5)]TJ 0 -1.167 TD [(\(1997\2261999\):)-333(The)-333(Whitehall)-333(II)-333(Study)-333(\(n)]TJ /T1_6 1 Tf 15.569 0 Td (\001)Tj /T1_5 1 Tf 0.833 0 Td (3691\))Tj ET 56.17 289.009 m 548.156 289.009 l 56.17 99.759 m 548.156 99.759 l S 0.5 w 123.764 274.384 m 472.872 274.384 l 484.886 274.384 m 548.156 274.384 l S 0.75 w 56.17 257.259 m 548.156 257.259 l S BT /T1_7 1 Tf 8 0 0 8 56.1705 261.1335 Tm [(Sample)-333(Models)]TJ 27.511 2.188 Td [(Sleep)-333(Duration)]TJ /T1_8 1 Tf 29.554 0 Td (P)Tj /T1_7 1 Tf 0.606 0 Td (*)Tj /T1_2 1 Tf -45.827 -2.188 Td (\001)Tj /T1_7 1 Tf 0.3327 Tc 0.833 0 Td [(5h)-8374(6h)-5364(7h)-5123(8h)]TJ /T1_2 1 Tf 0 Tc 33.668 0 Td (\002)Tj /T1_7 1 Tf 0.833 0 Td [(9)-333(h)-5371(Linear)-1799(Nonlinear)]TJ -47.178 -1.75 Td [(Men)-333(\(n)]TJ /T1_4 1 Tf 2.648 0 Td (\001)Tj /T1_7 1 Tf 0.833 0 Td (2686\))Tj -2.481 -1.625 Td [(No.)-9098(160)-8959(900)-6133(1224)-4452(372)-8957(30)]TJ 0 -1.625 TD [(Cases,)-333(n)-7561(29)-8959(179)-6613(243)-4932(85)-9437(3)]TJ T* [(Model)-333(1\207)-4020(0.89)-2045(0.58)-1626(1.37)-1688(1.00)-2045(0.81)-1626(1.24)-3065(1)-1689(1.20)-1563(0.90)-1626(1.58)-1688(0.45)-2285(0.13)-1866(1.49)-1626(0.60)-3506(0.53)]TJ T* [(Model)-333(2\247)-4020(0.96)-2045(0.62)-1626(1.48)-1688(1.07)-2045(0.86)-1626(1.34)-3065(1)-1689(1.07)-1563(0.80)-1626(1.42)-1688(0.36)-2285(0.11)-1866(1.19)-1626(0.51)-3506(0.42)]TJ T* [(Model)-333(3\266)-3946(0.89)-2045(0.55)-1626(1.43)-1688(1.02)-2045(0.80)-1626(1.31)-3065(1)-1689(1.11)-1563(0.80)-1626(1.53)-1688(0.13\206)-1803(0.02)-1866(0.98)-1626(0.55)-3506(0.18)]TJ -1 -1.625 Td [(Women)-333(\(n)]TJ /T1_4 1 Tf 3.832 0 Td (\001)Tj /T1_7 1 Tf 0.833 0 Td (1005\))Tj -3.665 -1.625 Td [(No.)-9577(75)-8959(330)-6613(394)-4452(186)-8957(20)]TJ T* [(Cases,)-333(n)-7561(20)-9439(77)-7093(64)-4932(37)-9437(3)]TJ T* [(Model)-333(1\207)-4020(1.88\206)-1563(1.05)-1626(3.34)-1688(1.56\206)-1563(1.08)-1626(2.27)-3065(1)-1689(1.28)-1563(0.82)-1626(2.01)-1688(0.91)-2285(0.26)-1866(3.20)-1626(0.029\206)-2544(0.38)]TJ T* [(Model)-333(2\247)-4020(1.94\206)-1563(1.08)-1626(3.50)-1688(1.56\206)-1563(1.07)-1626(2.27)-3065(1)-1689(1.17)-1563(0.74)-1626(1.86)-1688(0.92)-2285(0.26)-1866(3.27)-1626(0.015\206)-2544(0.42)]TJ T* [(Model)-333(3\266)-3946(1.31)-2045(0.65)-1626(2.63)-1688(1.42)-2045(0.93)-1626(2.16)-3065(1)-1689(0.99)-1563(0.59)-1626(1.69)-1688(1.07)-2285(0.29)-1866(3.94)-1626(0.12)-3506(0.61)]TJ -0.001 -1.719 Td (*)Tj /T1_8 1 Tf 0.352 0 Td (P)Tj /T1_7 1 Tf 0.814 0 Td [(value)-333(for)-333(test)-333(of)-333(linear)-333(and)-333(nonlinear)-333(trends.)]TJ -1.166 -1.25 Td (\206)Tj /T1_8 1 Tf 0.482 0 Td (P)Tj /T1_4 1 Tf 0.481 0 Td (\003)Tj /T1_7 1 Tf 0.833 0 Td (0.05.)Tj -1.796 -1.25 Td [(\207Model)-333(1:)-333(unadjusted.)]TJ 0 -1.25 TD [(\247Model)-333(2:)-333(adjusted)-333(for)-333(age)-333(and)-333(employment.)]TJ T* [(\266Model)-333(3:)-333(model)-333(2)]TJ /T1_4 1 Tf 7.29 0 Td (\004)Tj /T1_7 1 Tf 0.833 0 Td [(alcohol)-333(consumption,)-333(smoking,)-333(physical)-333(activity,)-333(BMI,)-333(SF-36)-333(mental,)-333(SF-36)-333(physical,)-333(depression)-333(cases,)-333(hypnotics)-333(use,)-333(and)-333(CVD)-333(drugs.)]TJ /T1_1 1 Tf 10 0 0 10 252.6761 748.9148 Tm [(Cappuccio)-333(et)-333(al)-2000(Short)-333(Sleep)-333(Duration)-333(and)-333(Hypertension)]TJ /T1_10 1 Tf 28.053 0 Td (697)Tj 0 g ET /GS1 gs BT /T1_11 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_11 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_11 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 155 0 obj<> endobj 156 0 obj<> endobj 157 0 obj[155 0 R] endobj 158 0 obj<> endobj 161 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 56.1648 719.8835 Tm [(3691)-305(total:)-305(539)-305(of)-305(2686)-305(in)-305(men)-305(and)-305(201)-305(of)-305(1005)-305(in)-305(women\).)]TJ 0 -1.263 TD [(Among)-409(men,)-409(no)-409(consistent)-409(pattern)-409(of)-409(association)-409(was)-409(seen)]TJ T* [(across)-488(categories)-488(of)-488(sleep)-488(duration.)-488(Among)-488(women,)-488(short)]TJ T* [(duration)-488(of)-488(sleep)-488(was)-488(associated)-488(with)-488(significantly)-488(higher)]TJ T* [(risks)-454(of)-454(hypertension)-454(compared)-454(with)-454(the)-454(group)-454(sleeping)-454(7)]TJ 0 -1.263 TD [(hours)-339(in)-339(unadjusted)-339(analyses,)-339(as)-339(well)-339(as)-339(in)-339(a)-339(reduced)-339(model)]TJ T* [(\(age)-300(and)-300(employment;)-300(6)-300(hours)-300(per)-300(night:)-300(OR:)-300(1.56)-300([95%)-300(CI:)]TJ T* [(1.07)-268(to)-268(2.27],)]TJ /T1_1 1 Tf 5.665 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-268(hours)-268(per)-268(night:)-268(OR:)-268(1.94)-268([95%)-268(CI:)-268(1.08)-268(to)]TJ -6.497 -1.263 Td [(3.50]\).)-547(However,)-547(these)-547(associations)-547(were)-547(attenuated)-547(after)]TJ T* [(accounting)-533(for)-533(cardiovascular)-533(risk)-533(factors)-533(and)-533(psychiatric)]TJ T* [(comorbidities)-404(\(OR:)-404(1.42)-404([95%)-404(CI:)-404(0.94)-404(to)-404(2.16];)-404(OR:)-404(1.30)]TJ T* [([95%)-342(CI:)-342(0.65)-342(to)-342(2.62],)-342(respectively\).)-342(The)-342(proportion)-342(of)-342(the)]TJ T* [(variance)-295(of)-295(the)-295(risk)-295(of)-295(developing)-295(hypertension)-295(explained)-295(by)]TJ T* [(the)-329(age-)-329(and)-329(employment-adjusted)-329(model)-329(was)-329(2.95%.)-329(In)-329(the)]TJ 0 -1.263 TD [(fully)-318(adjusted)-318(model)-318(it)-318(was)-318(6.14%.)-318(The)-318(major)-318(contributor)-318(in)]TJ T* [(the)-295(full)-295(multivariate)-295(model)-295(was)-295(body)-295(mass)-295(index)-295(\(explaining)]TJ T* [(2.23%)-281(of)-281(the)-281(added)-281(variance\),)-281(whereas)-281(the)-281(remaining)-281(covari-)]TJ T* [(ates)-535(all)-535(accounted)-535(for)]TJ /T1_2 1 Tf 9.915 0 Td (\003)Tj /T1_0 1 Tf 0.833 0 Td [(1%)-535(of)-535(the)-535(remaining)-535(difference.)]TJ -10.747 -1.263 Td [(Results)-274(were)-274(virtually)-274(unchanged)-274(after)-274(further)-274(adjustment)-274(for)]TJ T* [(the)-600(baseline)-600(values)-600(of)-600(systolic)-600(blood)-600(pressure)-600(\(data)-600(not)]TJ T* (shown\).)Tj /T1_3 1 Tf 10.5 0 0 10.5 314.1648 719.3835 Tm [(Other)-333(Analyses)]TJ /T1_0 1 Tf 9.5 0 0 9.5 314.1648 708.4404 Tm [(We)-491(also)-491(carried)-491(out)-491(linear)-491(regression)-491(analyses)-491(to)-491(test)-491(the)]TJ 0 -1.205 TD [(association)-297(between)-297(sleep)-297(duration)-297(and)-297(blood)-297(pressures)-297(\(sys-)]TJ T* [(tolic,)-642(diastolic,)-642(and)-642(pulse)-642(pressures\))-642(at)-642(phase)-642(5)-642(\(cross-)]TJ 0 -1.205 TD [(sectional)-333(analyses\),)-333(as)-333(well)-333(as)-333(the)-333(association)-333(between)-333(sleep)]TJ 0 -1.205 TD [(duration)-336(at)-336(phase)-336(5)-336(and)-336(changes)-336(in)-336(blood)-336(pressures)-336(between)]TJ T* [(the)-381(2)-381(phases)-381(\(prospective)-381(analyses\),)-381(among)-381(participants)-381(not)]TJ T* [(taking)-333(antihypertensive)-333(medications.)-333(In)-333(cross-sectional)-333(anal-)]TJ T* [(yses,)-421(there)-421(were)-421(consistent,)-421(significant)-421(inverse)-421(associations)]TJ 0 -1.206 TD (\()Tj /T1_4 1 Tf 0.333 0 Td (P)Tj /T1_2 1 Tf 0.611 0 Td (\003)Tj /T1_0 1 Tf 0.833 0 Td [(0.05\))-271(between)-271(duration)-271(of)-271(sleep)-271(and)-271(either)-271(systolic)-271(blood)]TJ -1.777 -1.206 Td [(pressure)-566(\()]TJ /T1_1 1 Tf 9.5 0 1.4773 9.5 354.3555 605.429 Tm (\004)Tj /T1_2 1 Tf 9.5 0 0 9.5 360.1597 605.429 Tm (\001\005)Tj /T1_0 1 Tf 1.666 0 Td [(1.24)-566(mm)-250(Hg)-566(per)-566(hour)-566(of)-566(sleep;)-566(95%)-566(CI:)]TJ /T1_2 1 Tf -6.507 -1.206 Td (\005)Tj /T1_0 1 Tf 0.833 0 Td [(2.23)-305(to)]TJ /T1_2 1 Tf 3.139 0 Td (\005)Tj /T1_0 1 Tf 0.833 0 Td [(0.24)-305(mm)-250(Hg)-305(per)-305(hour)-305(of)-305(sleep\))-305(or)-305(pulse)-305(pressure)]TJ -4.804 -1.206 Td (\()Tj /T1_1 1 Tf 9.5 0 1.4773 9.5 317.3281 582.52 Tm (\004)Tj /T1_2 1 Tf 9.5 0 0 9.5 323.1323 582.52 Tm (\001\005)Tj /T1_0 1 Tf 1.666 0 Td [(0.91)-500(mm)-250(Hg)-500(per)-500(hour)-500(of)-500(sleep;)-500(95%)-500(CI:)]TJ /T1_2 1 Tf 18.162 0 Td (\005)Tj /T1_0 1 Tf 0.833 0 Td [(1.63)-500(to)]TJ /T1_2 1 Tf -21.605 -1.206 Td (\005)Tj /T1_0 1 Tf 0.833 0 Td [(0.20)-441(mm)-250(Hg)-441(per)-441(hour)-441(of)-441(sleep\),)-441(only)-441(among)-441(women,)-441(in)]TJ -0.833 -1.206 Td [(fully)-281(adjusted)-281(models.)-281(In)-281(prospective)-281(analyses,)-281(no)-281(significant)]TJ 0 -1.206 TD [(associations)-656(were)-656(found)-656(for)-656(any)-656(of)-656(the)-656(blood)-656(pressure)]TJ T* [(measures)-309(among)-309(either)-309(male)-309(or)-309(female)-309(participants)-309(\(data)-309(not)]TJ 0 -1.206 TD (shown\).)Tj /T1_3 1 Tf 11.5 0 0 11.5 405.2898 502.2927 Tm (Discussion)Tj /T1_0 1 Tf 9.5 0 0 9.5 314.1648 491.3381 Tm [(Findings)-226(from)-226(the)-226(Whitehall)-226(II)-226(cohort)-226(showed)-226(gender-specific)]TJ 0 -1.206 TD [(associations)-398(between)-398(sleep)-398(duration)-398(and)-398(hypertension.)-398(Spe-)]TJ /T1_5 1 Tf 9 0 0 9 56.1648 454.3836 Tm [(APPENDIX.)-1000(Baseline)-333(Characteristics)-333(\(Phase)-333(5:)-333(1997\2261999\):)-333(The)-333(Whitehall)-333(II)-333(Study)]TJ ET 0 0 0 1 K 0.75 w 10 M 0 j 0 J []0 d 56.165 448.009 m 548.162 448.009 l 56.165 89.759 m 548.162 89.759 l S 0.5 w 185.506 433.384 m 288.014 433.384 l 315.58 433.384 m 418.088 433.384 l 445.653 433.384 m 548.162 433.384 l S 0.75 w 56.165 416.259 m 548.162 416.259 l S BT /T1_6 1 Tf 8 0 0 8 56.1648 420.1336 Tm (Characteristics)Tj 20.791 2.188 Td (n)Tj /T1_2 1 Tf 0.463 0 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td [(6592*)-12626(n)]TJ /T1_2 1 Tf 15.361 0 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td [(5766\206)-12801(n)]TJ /T1_2 1 Tf 15.666 0 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td (612\207)Tj -37.076 -2.188 Td [(Men)-5927(Women)-5926(Men)-5927(Women)-5926(Men)-5927(Women)]TJ -17.704 -1.75 Td [(No.)-333(of)-333(subjects)-11869(4724)-6210(1868)-6210(4199)-6210(1567)-6449(329)-6690(283)]TJ 0 -1.625 TD [(Age,)-333(y)-14324(55.6)-240(\(6.0\))-4528(56.3)-240(\(6.1\))-4528(55.4)-240(\(6.0\))-4528(56.1)-240(\(6.1\))-4528(57.7)-240(\(5.9\))-4528(56.2)-240(\(5.4\))]TJ T* [(DBP,)-333(mm)-240(Hg)-11897(78.6)-240(\(10.6\))-4048(74.6)-240(\(10.0\))-4048(78.6)-240(\(10.6\))-4048(74.6)-240(\(10.0\))-4048(79.2)-240(\(10.8\))-4048(78.5)-240(\(10.2\))]TJ T* [(SBP,)-333(mm)-240(Hg)-11474(123.5)-240(\(16.0\))-3568(121.1)-240(\(17.1\))-3568(123.6)-240(\(16.0\))-3568(121.1)-240(\(17.1\))-3568(125.6)-240(\(17.3\))-3568(127.5)-240(\(19.1\))]TJ T* [(Pulse)-333(pressure,)-333(mm)-240(Hg)-7902(44.9)-240(\(11.2\))-4048(46.5)-240(\(12.4\))-4048(45.0)-240(\(11.2\))-4048(46.5)-240(\(12.3\))-4048(46.4)-240(\(12.6\))-4048(49.0)-240(\(14.1\))]TJ T* [(Sleep)-333(duration,)-333(n)-333(\(%\))]TJ /T1_1 1 Tf 1 -1.625 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td [(5)-333(h)-13841(296)-240(\(6.4\))-4768(190)-240(\(10.4\))-4288(265)-240(\(6.3\))-4768(157)-240(\(10.0\))-4768(43)-240(\(13.6\))-4768(34)-240(\(12.8\))]TJ -0.833 -1.625 Td [(6)-333(h)-14194(1521)-240(\(32.8\))-4288(602)-240(\(32.9\))-3808(1383)-240(\(32.9\))-4288(511)-240(\(32.6\))-4288(121)-240(\(38.2\))-4768(94)-240(\(35.3\))]TJ T* [(7)-333(h)-14194(2090)-240(\(45.0\))-4288(687)-240(\(37.6\))-3808(1886)-240(\(44.9\))-4288(597)-240(\(38.1\))-4768(95)-240(\(30.0\))-4288(101)-240(\(38.0\))]TJ T* [(8)-333(h)-14674(683)-240(\(14.7\))-4288(310)-240(\(17.0\))-4288(620)-240(\(14.8\))-4288(272)-240(\(17.4\))-4768(45)-240(\(14.2\))-4768(31)-240(\(11.7\))]TJ /T1_1 1 Tf T* (\002)Tj /T1_6 1 Tf 0.833 0 Td [(9)-333(h)-14321(53)-240(\(1.1\))-5248(40)-240(\(2.2\))-5248(45)-240(\(1.1\))-5248(30)-240(\(1.9\))-5248(13)-240(\(4.1\))-5728(6)-240(\(2.3\))]TJ -1.833 -1.625 Td [(Lowest)-333(employment)-333(grade,)-333(n)-333(\(%\))-4348(207)-240(\(4.4\))-4768(545)-240(\(29.5\))-4288(175)-240(\(4.2\))-4768(435)-240(\(27.9\))-4768(65)-240(\(19.8\))-4288(181)-240(\(64.4\))]TJ T* [(BMI,)-333(kg/m)]TJ 5 0 0 5 87.4182 253.1336 Tm (2)Tj 8 0 0 8 189.8438 250.1336 Tm [(26.1)-240(\(3.5\))-4528(26.2)-240(\(4.9\))-4528(26.0)-240(\(3.5\))-4528(26.2)-240(\(4.9\))-4528(25.7)-240(\(3.2\))-4528(28.1)-240(\(5.1\))]TJ -16.71 -1.625 Td [(Waist,)-333(cm)-12953(92.1)-240(\(10.1\))-4048(80.4)-240(\(11.9\))-4048(92.0)-240(\(10.1\))-4048(80.5)-240(\(11.9\))-4048(90.6)-240(\(9.0\))-4528(85.1)-240(\(11.4\))]TJ T* [(Weekly)-333(alcohol,)-333(units)-8715(16.7)-240(\(16.6\))-4528(7.8)-240(\(9.5\))-4528(16.7)-240(\(16.5\))-4528(8.1)-240(\(9.6\))-4528(10.3)-240(\(18.3\))-4528(2.7)-240(\(5.4\))]TJ T* [(CVD)-333(drugs,)-333(n)-333(\(%\))-10378(719)-240(\(15.3\))-4288(299)-240(\(16.1\))-4288(613)-240(\(14.6\))-4288(238)-240(\(15.2\))-4768(89)-240(\(27.2\))-4768(93)-240(\(32.9\))]TJ T* [(Physical)-333(activity,)-333(n)-333(\(%\))-7885(2277)-240(\(48.2\))-4288(601)-240(\(32.2\))-3808(2062)-240(\(49.1\))-4288(536)-240(\(34.2\))-4768(99)-240(\(30.1\))-4768(47)-240(\(16.6\))]TJ T* [(SF-36)-333(mental,)-333(score)-8995(51.6)-240(\(9.0\))-4528(49.7)-240(\(10.4\))-4048(51.7)-240(\(8.9\))-4528(49.7)-240(\(10.4\))-4048(50.0)-240(\(10.4\))-4048(49.1)-240(\(10.8\))]TJ T* [(SF-36)-333(physical,)-333(score)-8514(60.0)-240(\(7.1\))-4528(49.1)-240(\(9.6\))-4528(52.1)-240(\(6.9\))-4528(49.5)-240(\(9.3\))-4528(49.2)-240(\(8.7\))-4528(44.5)-240(\(10.4\))]TJ T* [(Use)-333(of)-333(hypnotics,)-333(n)-333(\(%\))-8546(26)-240(\(0.55\))-4768(17)-240(\(0.9\))-5248(21)-240(\(0.5\))-5248(14)-240(\(0.9\))-5728(2)-240(\(0.6\))-5728(0)-240(\(0.0\))]TJ T* [(Depression)-333(cases,)-333(n)-333(\(%\))-7751(545)-240(\(11.8\))-4288(255)-240(\(14.1\))-4288(472)-240(\(11.4\))-4288(213)-240(\(13.8\))-4768(66)-240(\(21.4\))-4768(57)-240(\(22.2\))]TJ T* [(Current)-333(smoking,)-333(n)-333(\(%\))-8120(436)-240(\(9.3\))-4768(266)-240(\(14.3\))-4288(360)-240(\(8.6\))-4768(207)-240(\(13.3\))-4768(40)-240(\(12.3\))-4768(13)-240(\(4.63\))]TJ T* [(Male)-333(hypertensive,)-333(n)-333(\(%\))-7033(1194)-240(\(25.3\))-4288(407)-240(\(21.8\))-3808(1194)-240(\(28.4\))-4288(407)-240(\(26.0\))-4288(110)-240(\(33.4\))-4288(117)-240(\(41.3\))]TJ 1 -1.625 Td [(No)-333(medication)-10544(630)-240(\(13.3\))-4288(153)-240(\(8.2\))-4768(713)-240(\(17.0\))-4288(202)-240(\(12.9\))-4768(35)-240(\(10.6\))-4768(32)-240(\(11.3\))]TJ T* [(Medication)-11895(564)-240(\(11.9\))-4288(254)-240(\(13.6\))-4288(481)-240(\(11.5\))-4288(205)-240(\(13.1\))-4768(75)-240(\(22.8\))-4768(85)-240(\(30.0\))]TJ 0 -1.719 TD [(Data)-333(are)-333(expressed)-333(as)-333(the)-333(mean)-333(\(SD\))-333(or)-333(as)-333(n)-333(\(%\).)]TJ 0 -1.25 TD (*n)Tj /T1_2 1 Tf 0.815 0 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td [(6592)-333(for)-333(all)-333(white)-333(participants.)]TJ -1.648 -1.25 Td (\206n)Tj /T1_2 1 Tf 0.945 0 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td [(5766)-333(for)-333(white)-333(participants)-333(with)-333(complete)-333(data)-333(on)-333(blood)-333(pressure.)]TJ -1.778 -1.25 Td (\207n)Tj /T1_2 1 Tf 0.945 0 Td (\001)Tj /T1_6 1 Tf 0.833 0 Td [(612)-333(for)-333(ethnic)-333(minorities)-333(excluded)-333(from)-333(the)-333(analysis.)]TJ /T1_7 1 Tf 10 0 0 10 56.1648 752.3835 Tm [(698)-2000(Hypertension)]TJ /T1_3 1 Tf 11.056 0 Td [(October)-333(2007)]TJ 0 g ET /GS1 gs BT /T1_8 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_8 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_8 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 162 0 obj<> endobj 163 0 obj<> endobj 164 0 obj[162 0 R] endobj 165 0 obj<> endobj 168 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 56.1648 719.8835 Tm [(cifically,)-361(short)-361(duration)-361(of)-361(sleep)-361(was)-361(associated)-361(with)-361(higher)]TJ 0 -1.215 TD [(risks)-551(of)-551(prevalent)-551(and)-551(incident)-551(hypertension)-551(only)-551(among)]TJ T* [(women.)-373(We)-373(could)-373(not)-373(detect)-373(consistent)-373(associations)-373(among)]TJ 0 -1.215 TD [(men)-391(or)-391(for)-391(long)-391(duration)-391(of)-391(sleep.)-391(For)-391(the)-391(latter)-391(finding,)-391(it)]TJ 0 -1.215 TD [(should)-330(be)-330(noted,)-330(however,)-330(that)-330(there)-330(were)-330(very)-330(few)-330(individ-)]TJ T* [(uals)-244(\()]TJ /T1_1 1 Tf 2.188 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(1.3%)-244(of)-244(the)-244(overall)-244(sample\))-244(in)-244(our)-244(study)-244(who)-244(reported)]TJ -3.021 -1.215 Td (sleeping)Tj /T1_2 1 Tf 3.573 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(9)-240(hours)-240(per)-240(night,)-240(thus)-240(yielding)-240(a)-240(limited)-240(statistical)]TJ -4.406 -1.215 Td [(power)-267(to)-267(examine)-267(the)-267(association)-267(between)-267(sleep)-267(duration)-267(and)]TJ 0 -1.215 TD [(hypertension)-569(in)-569(this)-569(subgroup.)-569(Furthermore,)-569(our)-569(findings)]TJ -0.0198 Tc T* [(point)-251(to)-251(the)-251(importance)-251(of)-251(a)-251(comprehensive)-251(scrutiny)-251(of)-251(potential)]TJ T* [(confounders)-474(and)-474(mediators)-474(when)-474(examining)-474(the)-474(associations)]TJ T* [(between)-434(durations)-434(of)-434(sleep)-434(and)-434(health)-434(outcomes.)-434(In)-434(fact,)-434(the)]TJ T* [(observed)-598(associations)-598(among)-598(women)-598(were)-598(attenuated)-598(after)]TJ T* [(accounting)-226(for)-226(a)-226(number)-226(of)-226(cardiovascular)-226(risk)-226(factors,)-226(measures)]TJ 0 -1.215 TD [(of)-313(general)-313(health,)-313(and)-313(psychiatric)-313(comorbidities.)]TJ 0 Tc 1 -1.215 Td [(A)-496(substantial)-496(amount)-496(of)-496(evidence)-496(exists)-496(about)-496(the)-496(link)]TJ -1 -1.215 Td [(between)-301(SDB)-301(and)-301(hypertension.)]TJ 6.5 0 0 5.5 180.0342 537.6876 Tm (1\2265)Tj 9.5 0 0 9.5 192.6425 535.1563 Tm [(The)-301(epidemiological)-301(data)]TJ -14.366 -1.215 Td [(have)-440(been)-440(corroborated)-440(by)-440(findings)-440(of)-440(mechanistic)-440(studies)]TJ 0 -1.215 TD [(emphasizing)-401(the)-401(critical)-401(role)-401(of)-401(sympathetic)-401(overactivity)-401(in)]TJ 0 -1.215 TD [(the)-298(etiology)-298(of)-298(SDB-related)-298(hypertension,)]TJ 6.5 0 0 5.5 217.104 503.0512 Tm (24,25)Tj 9.5 0 0 9.5 234.5648 500.52 Tm [(although)-298(other)]TJ -18.779 -1.215 Td [(mechanisms)-293(are)-293(likely)-293(to)-293(be)-293(involved.)]TJ 6.5 0 0 5.5 202.2568 491.5057 Tm (19)Tj 9.5 0 0 9.5 211.5383 488.9745 Tm [(More)-293(recently,)-293(sleep)]TJ -16.355 -1.215 Td [(deprivation)-454(has)-454(been)-454(indicated)-454(as)-454(a)-454(risk)-454(factor)-454(for)-454(several)]TJ 0 -1.215 TD [(chronic)-424(health)-424(outcomes)-424(in)-424(individuals)-424(without)-424(overt)-424(sleep)]TJ 0 -1.215 TD (disorders.)Tj 6.5 0 0 5.5 93.3649 456.8694 Tm [(6)-120(\22612)]TJ 9.5 0 0 9.5 110.5358 454.3381 Tm [(However,)-357(we)-357(are)-357(aware)-357(of)-357(only)-357(2)-357(population-)]TJ -5.723 -1.215 Td [(based)-252(studies)-252(so)-252(far,)-252(both)-252(coming)-252(from)-252(the)-252(United)-252(States,)-252(that)]TJ 0 -1.215 TD [(have)-551(attempted)-551(to)-551(examine)-551(the)-551(association)-551(between)-551(self-)]TJ 0 -1.215 TD [(reported)-565(durations)-565(of)-565(sleep)-565(and)-565(risk)-565(of)-565(hypertension.)]TJ 6.5 0 0 5.5 275.543 422.233 Tm (13,14)Tj 9.5 0 0 9.5 56.1648 408.1563 Tm [(Specifically,)-508(in)-508(a)-508(longitudinal)-508(analysis)-508(of)-508(the)-508(NHANES-I)]TJ 0 -1.215 TD (\(n)Tj /T1_1 1 Tf 0.833 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(4810\),)-486(short)-486(sleep)-486(duration)-486(\()]TJ /T1_2 1 Tf 12.247 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-486(hours)-486(per)-486(night\))-486(was)]TJ -14.746 -1.215 Td [(associated)-240(with)-240(a)-240(60%)-240(higher)-240(risk)-240(of)-240(incident)-240(hypertension,)-240(in)]TJ 0 -1.215 TD [(fully)-375(adjusted)-375(models,)-375(among)-375(middle-aged)-375(\(32)-375(to)-375(59)-375(years\))]TJ 0 -1.215 TD [(American)-654(adults)-654(without)-654(apparent)-654(sleep)-654(disorders.)]TJ 6.5 0 0 5.5 265.8541 364.5057 Tm (13)Tj 9.5 0 0 9.5 278.5703 361.9745 Tm (No)Tj -23.411 -1.215 Td [(association)-583(was)-583(found)-583(in)-583(individuals)]TJ /T1_2 1 Tf 16.47 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(60)-583(years)-583(of)-583(age.)]TJ -17.303 -1.215 Td [(However,)-232(in)-232(this)-232(study,)-232(the)-232(diagnosis)-232(of)-232(incident)-232(hypertension)]TJ 0 -1.215 TD [(was)-295(based)-295(on)-295(self-report)-295(with)-295(a)-295(potential)-295(of)-295(misclassification)]TJ 0 -1.215 TD [(\(underdiagnosis\),)-413(as)-413(suggested)-413(by)-413(a)-413(lower)-413(cumulative)-413(inci-)]TJ T* [(dence)-646(\(647)-646(of)-646(4810)-646([)]TJ /T1_1 1 Tf 9.913 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(13.5%]\))-646(as)-646(compared)-646(with)-646(that)]TJ -10.746 -1.215 Td [(observed)-373(in)-373(our)-373(study)-373(\(740)-373(of)-373(3691)-373([20.0%]\),)-373(despite)-373(com-)]TJ T* [(parable)-602(age)-602(ranges)-602(between)-602(the)-602(2)-602(studies)-602(and)-602(a)-602(longer)]TJ 0 -1.215 TD [(follow-up)-364(period)-364(in)-364(the)-364(NHANES-I)-364(\(8)-364(to)-364(10)-364(years)-364(versus)-364(5)]TJ T* [(years,)-324(respectively\).)-324(In)-324(addition,)-324(no)-324(gender-specific)-324(analyses)]TJ T* [(were)-559(included)-559(in)-559(the)-559(NHANES-I.)-559(Moreover,)-559(in)-559(a)-559(cross-)]TJ T* [(sectional)-497(analysis)-497(of)-497(the)-497(large)-497(sample)-497(of)-497(the)-497(Sleep)-497(Heart)]TJ T* [(Health)-603(Study)-603(\()]TJ /T1_1 1 Tf 6.538 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(6000)-603(US)-603(adults\),)-603(a)-603(significantly)-603(higher)]TJ -7.371 -1.215 Td [(prevalence)-345(of)-345(hypertension)-345(was)-345(reported)-345(among)-345(either)-345(short)]TJ 0 -1.215 TD (\()Tj /T1_1 1 Tf 0.333 0 Td (\003)Tj /T1_0 1 Tf 0.833 0 Td [(6)-260(hours)-260(per)-260(night\))-260(or)-260(long)-260(sleepers)-260(\()]TJ /T1_2 1 Tf 14.374 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(9)-260(hours)-260(per)-260(night\))-260(as)]TJ -16.372 -1.215 Td [(compared)-260(with)-260(the)-260(median)-260(duration)-260(of)-260(sleep)-260(of)-260(7)-260(to)]TJ /T1_1 1 Tf 20.817 0 Td (\003)Tj /T1_0 1 Tf 0.833 0 Td [(8)-260(hours)]TJ -21.65 -1.214 Td [(per)-462(night.)]TJ 6.5 0 0 5.5 94.5879 179.7898 Tm (14)Tj 9.5 0 0 9.5 105.4745 177.2585 Tm [(However,)-462(the)-462(association)-462(was)-462(stronger)-462(among)]TJ -5.19 -1.214 Td [(short)-487(sleepers)-487(than)-487(in)-487(long)-487(sleepers)-487(\(ie,)-487(66%)-487(versus)-487(30%)]TJ 0 -1.214 TD [(higher)-615(risk)-615(of)-615(hypertension,)-615(respectively\).)-615(Although)-615(this)]TJ 0 -1.214 TD [(study)-285(accounted)-285(for)-285(a)-285(number)-285(of)-285(potential)-285(covariates,)-285(includ-)]TJ 0 -1.214 TD [(ing)-389(psychiatric)-389(and)-389(cardiovascular)-389(comorbidities,)-389(the)-389(cross-)]TJ T* [(sectional)-330(design)-330(does)-330(not)-330(allow)-330(us)-330(to)-330(exclude)-330(the)-330(possibility)]TJ T* [(of)-315(residual)-315(confounding)-315(by)-315(unknown)-315(variables,)-315(as)-315(well)-315(as)-315(to)]TJ 0 -1.214 TD [(exclude)-462(the)-462(potential)-462(of)-462(reverse)-462(causality.)-462(In)-462(addition,)-462(the)]TJ 0 -1.214 TD [(Sleep)-455(Heart)-455(Health)-455(Study)-455(sample)-455(cohort)-455(was,)-455(on)-455(average,)]TJ T* [(older)-389(than)-389(those)-389(in)-389(both)-389(NHANES-I)-389(and)-389(Whitehall)-389(II,)-389(thus)]TJ T* [(with)-265(a)-265(higher)-265(likelihood)-265(of)-265(geriatric)-265(comorbidities)-265(potentially)]TJ T* [(affecting)-333(sleep)-333(patterns.)]TJ 6.5 0 0 5.5 148.2217 52.9148 Tm (26)Tj /T1_3 1 Tf 10.5 0 0 10.5 314.1648 719.3835 Tm (Strengths)Tj /T1_0 1 Tf 9.5 0 0 9.5 314.1648 708.3381 Tm [(Unlike)-333(these)-333(earlier)-333(investigations,)-333(our)-333(study)-333(examined)-333(both)]TJ 0 -1.215 TD [(cross-sectional)-410(and)-410(prospective)-410(gender-specific)-410(associations)]TJ T* [(between)-225(sleep)-225(duration)-225(and)-225(hypertension)-225(with)-225(the)-225(inclusion)-225(of)]TJ 0 -1.215 TD [(a)-436(number)-436(of)-436(potential)-436(confounding)-436(variables.)-436(Our)-436(findings)]TJ 0 -1.215 TD [(suggest)-258(a)-258(potential)-258(role)-258(of)-258(sleep)-258(deprivation)-258(in)-258(the)-258(etiology)-258(of)]TJ T* [(hypertension)-333(and)-333(other)-333(adverse)-333(health)-333(outcomes.)]TJ 1 -1.215 Td [(First,)-234(the)-234(observation)-234(that)-234(reduced)-234(duration)-234(of)-234(sleep)-234(may)-234(be)]TJ -1 -1.215 Td [(associated)-468(with)-468(a)-468(higher)-468(risk)-468(of)-468(hypertension)-468(only)-468(among)]TJ 0 -1.215 TD [(women)-357(is)-357(a)-357(novel)-357(finding.)-357(Indeed,)-357(although)-357(previous)-357(inves-)]TJ T* [(tigations)-315(have)-315(emphasized)-315(the)-315(potential)-315(impact)-315(of)-315(both)-315(short)]TJ T* [(and)-410(long)-410(durations)-410(of)-410(sleep)-410(on)-410(chronic)-410(disease)-410(risk)-410(among)]TJ T* (women,)Tj 0.1198 Tc 6.5 0 0 5.5 344.5062 583.8694 Tm [(6\226)120(9)]TJ 0 Tc 9.5 0 0 9.5 359.6827 581.3381 Tm [(the)-489(mechanisms)-489(underlying)-489(the)-489(gender-specific)]TJ -4.791 -1.215 Td [(association)-342(between)-342(sleep)-342(deprivation)-342(and)-342(hypertension,)-342(ob-)]TJ 0 -1.215 TD [(served)-265(in)-265(our)-265(study,)-265(are)-265(unknown.)-265(Given)-265(the)-265(mean)-265(age)-265(of)-265(our)]TJ 0 -1.215 TD [(female)-551(participants)-551(falling)-551(around)-551(the)-551(menopausal)-551(period)]TJ 0 -1.215 TD (\()Tj /T1_1 1 Tf 0.333 0 Td (\002)Tj /T1_0 1 Tf 0.833 0 Td [(55)-259(years\),)-259(we)-259(can)-259(speculate)-259(that)-259(the)-259(periods)-259(marking)-259(shifts)]TJ -1.166 -1.215 Td [(in)-392(the)-392(reproductive)-392(stages,)-392(such)-392(as)-392(menopause,)-392(are)-392(particu-)]TJ T* [(larly)-229(vulnerable)-229(times)-229(for)-229(women,)-229(because)-229(they)-229(are)-229(associated)]TJ T* [(with)-369(major)-369(hormonal)-369(turmoil)-369(and)-369(psychosocial)-369(stresses)-369(that)]TJ 0 -1.215 TD [(may,)-254(in)-254(turn,)-254(lead)-254(to)-254(adverse)-254(health)-254(outcomes.)]TJ 6.5 0 0 5.5 489.0822 491.5057 Tm (27)Tj 9.5 0 0 9.5 497.9944 488.9745 Tm [(For)-254(example,)]TJ -19.35 -1.215 Td [(in)-604(our)-604(sample)-604(of)-604(female)-604(participants,)-604(the)-604(prevalence)-604(of)]TJ 0 -1.215 TD [(depression)-401(cases)-401(was)-401(higher)-401(among)-401(women)-401(reporting)-401(short)]TJ 0 -1.215 TD [(duration)-458(of)-458(sleep)-458(\()]TJ /T1_2 1 Tf 7.928 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-458(hours)-458(per)-458(night\))-458(than)-458(in)-458(other)-458(sub-)]TJ -8.761 -1.215 Td [(groups.)-277(In)-277(addition,)-277(as)-277(shown)-277(in)-277(our)-277(descriptive)-277(analyses,)-277(the)]TJ 0 -1.215 TD [(distribution)-274(of)-274(correlates)-274(of)-274(short)-274(sleep)-274(duration)-274(that)-274(have)-274(the)]TJ T* [(potential)-440(to)-440(affect)-440(hypertension)-440(risk)-440(was)-440(different)-440(between)]TJ T* [(genders)-371(and)-371(may)-371(have)-371(partially)-371(contributed)-371(to)-371(the)-371(observed)]TJ 0 -1.215 TD [(associations.)-447(Finally,)-447(we)-447(cannot)-447(rule)-447(out)-447(the)-447(possibility)-447(of)]TJ T* [(differential)-425(self-reporting)-425(of)-425(sleep)-425(habits)-425(between)-425(men)-425(and)]TJ T* [(women,)-376(as)-376(suggested)-376(in)-376(a)-376(previous)-376(analysis)-376(from)-376(the)-376(Sleep)]TJ T* [(Heart)-364(Health)-364(Study)-364(examining)-364(the)-364(relationship)-364(of)-364(gender)-364(to)]TJ T* [(subjective)-333(measures)-333(of)-333(sleepiness.)]TJ 6.5 0 0 5.5 446.3273 352.9603 Tm (28)Tj 9.5 0 0 9.5 323.6648 338.8836 Tm [(Second,)-478(although)-477(findings)-478(from)-477(cross-sectional)-478(analyses)]TJ -1 -1.215 Td [(consistently)-268(showed)-268(a)-268(strong,)-268(significant)-268(association)-268(between)]TJ 0 -1.215 TD [(short)-298(sleep)-298(duration)-298(and)-298(risk)-298(of)-298(hypertension)-298(among)-298(women,)]TJ 0 -1.215 TD [(in)-444(prospective)-444(analyses,)-444(the)-444(risk)-444(estimates)-444(were)-444(attenuated)]TJ 0 -1.215 TD [(after)-342(accounting)-342(for)-342(cardiovascular)-342(risk)-342(factors,)-342(measures)-342(of)]TJ T* [(general)-518(health,)-518(and)-518(psychiatric)-518(comorbidities.)-518(Thus,)-518(these)]TJ T* [(findings)-401(emphasize)-401(the)-401(importance)-401(of)-401(a)-401(comprehensive)-401(ex-)]TJ T* [(amination)-286(of)-286(correlates)-286(that)-286(are)-286(likely)-286(to)-286(confound)-286(or)-286(may)-286(be)]TJ 0 -1.215 TD [(on)-260(the)-260(causal)-260(pathway)-260(between)-260(sleep)-260(deprivation)-260(and)-260(adverse)]TJ T* [(health)-450(outcomes.)-450(Nevertheless,)-450(recent)-450(prospective)-450(analyses)]TJ T* [(from)-319(the)-319(Monitoring)-319(Trends)-319(Determinants)-319(in)-319(Cardiovascular)]TJ T* [(Disease)-416(Augsburg)-416(survey)-416(indicate)-416(a)-416(modest)-417(but)-417(significant)]TJ T* [(association)-384(between)-384(short)-385(sleep)-384(duration)-384(and)-384(incident)-385(myo-)]TJ T* [(cardial)-323(infarction)-323(in)-323(middle-aged)-323(women,)-323(but)-323(not)-323(men,)-323(from)]TJ 0 -1.214 TD [(the)-333(general)-333(population.)]TJ 6.5 0 0 5.5 403.0679 179.7898 Tm (29)Tj 9.5 0 0 9.5 323.6648 165.7245 Tm [(Third,)-491(our)-491(descriptive)-491(analyses)-491(clearly)-491(demonstrate)-491(that)]TJ -1 -1.214 Td [(both)-435(short)-435(and)-435(long)-435(duration)-435(of)-435(sleep)-435(may)-435(indeed)-435(identify)]TJ 0 -1.214 TD [(population)-416(subgroups)-416(with)-416(a)-416(distinct)-416(cluster)-416(of)-416(sociodemo-)]TJ 0 -1.214 TD [(graphic)-366(characteristics,)-366(lifestyle)-366(behaviors,)-366(and)-366(disease)-366(con-)]TJ 0 -1.214 TD [(ditions)-295(that)-295(are)-295(likely)-295(to)-295(be)-295(affected)-295(by)-295(the)-295(cultural)-295(setting)-295(in)]TJ T* [(which)-254(the)-254(research)-254(is)-254(being)-254(conducted.)]TJ 6.5 0 0 5.5 461.5829 110.5853 Tm [(30)-120(\22633)]TJ 9.5 0 0 9.5 481.0295 108.054 Tm [(In)-254(this)-254(regard,)-254(the)]TJ -17.565 -1.214 Td [(study)-295(of)-295(health)-295(consequences)-295(related)-295(to)-295(curtailments)-295(of)-295(sleep)]TJ 0 -1.214 TD [(seems)-344(to)-344(be)-344(epidemiologically)-344(relevant)-344(in)-344(the)-344(general)-344(popu-)]TJ 0 -1.214 TD [(lation,)-302(given)-302(the)-302(downward)-302(trends)-302(in)-302(the)-302(average)-302(duration)-302(of)]TJ 0 -1.214 TD [(sleep)-309(and)-309(the)-309(increasingly)-309(higher)-309(prevalence)-309(of)-309(\223short)-309(sleep-)]TJ T* [(ers\224)-297(in)]TJ 0.02 Tc 2.982 0 Td [(many)-297(Western)-297(countries.)]TJ 6.5 0 0 5.5 442.1026 52.9148 Tm (34,35)Tj 9.5 0 0 9.5 460.2054 50.3835 Tm [(Conversely,)-297(it)-297(may)-297(be)]TJ /T1_3 1 Tf 0 Tc 10 0 0 10 252.6761 748.9148 Tm [(Cappuccio)-333(et)-333(al)-2000(Short)-333(Sleep)-333(Duration)-333(and)-333(Hypertension)]TJ /T1_4 1 Tf 28.053 0 Td (699)Tj 0 g ET /GS1 gs BT /T1_5 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_5 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_5 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 169 0 obj<> endobj 170 0 obj<> endobj 171 0 obj[169 0 R] endobj 172 0 obj<> endobj 175 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0.02 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.5 0 0 9.5 56.1648 719.8835 Tm [(difficult)-310(for)-310(epidemiological)-310(studies)-310(to)-310(examine)-310(the)-310(health)]TJ 0 -1.237 TD [(consequences)-421(of)-421(long)-421(durations)-421(of)-421(sleep)-421(in)-421(middle-aged,)]TJ T* [(healthy)-384(populations)-384(considering)-384(the)-384(relatively)-384(low)-384(preva-)]TJ 0 -1.237 TD [(lence)-262(of)-262(\223long)-262(sleepers\224)-262(in)-262(the)-262(absence)-262(of)-262(overt)-262(psychiatric)]TJ 0 -1.237 TD (comorbidities.)Tj 6.5 0 0 5.5 113.4518 675.4148 Tm (36)Tj /T1_1 1 Tf 0 Tc 10.5 0 0 10.5 56.1648 650.179 Tm (Limitations)Tj /T1_0 1 Tf 9.5 0 0 9.5 56.1648 638.929 Tm [(There)-256(are)-256(limitations)-256(in)-256(this)-256(study.)-256(First,)-256(the)-256(population)-256(under)]TJ 0 -1.237 TD [(investigation)-305(is)-305(an)-305(occupational)-305(cohort)-305(of)-305(white-collar)-305(work-)]TJ T* [(ers)-389(and)-389(limited)-389(to)-389(whites,)-389(which)-389(may)-389(reduce)-389(the)-389(generaliz-)]TJ 0 -1.237 TD [(ability)-440(of)-440(our)-440(findings)-440(to)-440(other)-440(populations.)-440(However,)-440(this)]TJ 0 -1.237 TD [(would)-521(not)-521(affect)-521(the)-521(internal)-521(validity)-521(of)-521(our)-521(results)-521(with)]TJ T* [(respect)-606(to)-606(the)-606(prospective)-606(analyses.)-606(Second,)-606(information)]TJ T* [(about)-460(sleep)-460(duration)-460(was)-460(self-reported)-460(by)-460(the)-460(participants.)]TJ T* [(Nevertheless,)-593(self-report)-593(assessments)-593(of)-593(sleep)-593(have)-593(been)]TJ 0 -1.237 TD [(shown)-260(to)-260(be)-260(valid)-260(measures)-260(compared)-260(with)-260(quantitative)-260(sleep)]TJ T* [(assessments)-303(with)-303(actigraphy.)]TJ 6.5 0 0 5.5 167.2054 535.7103 Tm (37,38)Tj 9.5 0 0 9.5 184.7144 533.179 Tm [(Moreover,)-303(because)-303(the)-303(out-)]TJ -13.532 -1.237 Td [(come)-352(was)-352(also)-352(assessed)-352(prospectively,)-352(any)-352(misclassification)]TJ 0 -1.237 TD [(of)-455(sleep)-455(duration)-455(would)-455(be)-455(nondifferential)-455(with)-455(respect)-455(to)]TJ 0 -1.237 TD [(incident)-222(hypertension,)-222(thus)-222(resulting)-222(in)-222(underestimation)-222(of)-222(the)]TJ 0 -1.237 TD [(true)-272(effects.)-272(A)-272(further)-272(limitation)-272(of)-272(this)-272(study)-272(is)-272(the)-272(relatively)]TJ T* [(short)-284(time)-284(of)-284(follow-up)-284(\(5)-284(years\),)-284(which)-284(may)-284(have)-284(precluded)]TJ T* [(us)-573(from)-573(detecting)-573(larger)-573(and)-573(significant)-573(effects)-573(of)-573(sleep)]TJ 0.0101 Tc T* [(deprivation)-669(on)-669(subsequent)-669(hypertension)-669(incidence.)-669(The)]TJ 0 Tc 0 -1.237 TD [(strengths)-329(of)-329(this)-329(study)-329(include)-329(the)-329(simultaneous)-329(inclusion)-329(of)]TJ T* [(a)-447(number)-447(of)-447(covariates)-447(known)-447(to)-447(be)-447(related)-447(to)-447(both)-447(sleep)]TJ T* [(patterns)-569(and)-569(hypertension.)-569(A)-569(further)-569(strength)-569(is)-569(that)-569(the)]TJ T* [(diagnosis)-267(of)-267(incident)-267(hypertension)-267(was)-267(also)-267(based)-267(on)-267(directly)]TJ T* [(measured)-412(blood)-412(pressures)-412(at)-412(both)-412(examinations,)-412(thus)-412(mini-)]TJ T* [(mizing)-472(the)-472(potential)-472(of)-472(misclassification)-472(that)-472(occurs)-472(when)]TJ 0 -1.237 TD [(using)-333(self-report)-333(alone.)]TJ /T1_1 1 Tf 10.5 0 0 10.5 56.1648 345.9745 Tm (Conclusions)Tj /T1_0 1 Tf 9.5 0 0 9.5 56.1648 334.7245 Tm [(In)-402(summary,)-402(findings)-402(from)-402(the)-402(Whitehall)-402(II)-402(cohort)-402(suggest)]TJ 0 -1.237 TD [(gender-specific)-356(associations)-356(between)-356(sleep)-356(duration)-356(and)-356(hy-)]TJ T* [(pertension)-261(risk.)-261(Specifically,)-261(cross-sectional)-261(analyses)-261(showed)]TJ 0 -1.237 TD [(a)-648(significant,)-648(consistent)-648(association)-648(between)-648(short)-648(sleep)]TJ 0 -1.237 TD [(duration)-336(\()]TJ /T1_2 1 Tf 4.002 0 Td (\001)Tj /T1_0 1 Tf 0.833 0 Td [(5)-336(hours)-336(per)-336(night\))-336(and)-336(risk)-336(of)-336(hypertension)-336(only)]TJ -4.835 -1.237 Td [(among)-262(women,)-262(which)-262(was)-262(attenuated)-262(in)-262(prospective)-262(analyses)]TJ T* [(after)-333(multivariate)-333(adjustment.)]TJ /T1_1 1 Tf 10.5 0 0 10.5 56.1648 241.5086 Tm (Perspectives)Tj /T1_0 1 Tf 9.5 0 0 9.5 56.1648 230.2586 Tm [(Sustained)-222(sleep)-222(curtailment,)-222(ensuing)-222(excessive)-222(daytime)-222(sleep-)]TJ 0 -1.237 TD [(iness,)-604(and)-604(the)-604(higher)-604(cardiovascular)-604(risk)-604(are)-604(causes)-604(for)]TJ T* [(concern.)-257(Emerging)-257(evidence)-257(also)-257(suggests)-257(a)-257(potential)-257(role)-257(for)]TJ 0 -1.237 TD [(sleep)-349(deprivation)-349(as)-349(a)-349(predictor)-349(or)-349(risk)-349(factor)-349(for)-349(conditions)]TJ 0 -1.237 TD [(like)-413(obesity,)-413(diabetes,)-413(and)-413(metabolic)-413(syndrome)-413(not)-413(only)-413(in)]TJ T* (adults)Tj 6.5 0 0 5.5 78.8591 174.0398 Tm (39)Tj 9.5 0 0 9.5 89.9076 171.5086 Tm [(but)-479(also)-479(in)-479(children.)]TJ 6.5 0 0 5.5 171.892 174.0398 Tm (40)Tj 9.5 0 0 9.5 182.9405 171.5086 Tm [(Further)-479(prospective)-479(studies)]TJ -13.345 -1.237 Td [(with)-412(improved)-412(assessment)-412(of)-412(long-term)-412(exposure)-412(\(repeated)]TJ 0 -1.237 TD [(self-reported)-234(sleep)-234(duration)-234(or)-234(repeated)-234(actigraphy\))-234(and)-234(better)]TJ 0 -1.237 TD [(control)-399(for)-399(confounders)-399(are)-399(needed)-399(before)-399(causality)-399(can)-399(be)]TJ 0 -1.237 TD (determined.)Tj /T1_1 1 Tf 11.5 0 0 11.5 128.1335 100.1336 Tm (Acknowledgments)Tj /T1_0 1 Tf 8.5 0 0 8.5 56.1648 89.3835 Tm [(We)-303(thank)-303(all)-303(of)-303(the)-303(participating)-303(civil)-303(service)-303(departments)-303(and)-303(their)]TJ 0 -1.147 TD [(welfare,)-553(personnel,)-553(and)-553(establishment)-553(officers;)-553(the)-553(Occupational)]TJ T* [(Health)-309(and)-309(Safety)-309(Agency;)-309(the)-309(Council)-309(of)-309(Civil)-309(Service)-309(Unions;)-309(all)]TJ T* [(of)-336(the)-336(participating)-336(civil)-336(servants)-336(in)-336(the)-336(Whitehall)-336(II)-336(Study;)-336(and)-336(all)]TJ T* [(members)-333(of)-333(the)-333(Whitehall)-333(II)-333(Study)-333(team.)]TJ /T1_1 1 Tf 11.5 0 0 11.5 382.6136 718.3835 Tm [(Sources)-333(of)-333(Funding)]TJ /T1_0 1 Tf 8.5 0 0 8.5 314.1648 707.8722 Tm [(The)-526(Whitehall)-526(II)-526(Study)-526(has)-526(been)-526(supported)-526(by)-526(grants)-526(from)-526(the)]TJ 0 -1.119 TD [(Medical)-465(Research)-465(Council;)-465(British)-465(Heart)-465(Foundation;)-465(Health)-465(and)]TJ T* [(Safety)-373(Executive;)-373(Department)-373(of)-373(Health;)-373(National)-373(Heart)-373(Lung)-373(and)]TJ 0 -1.119 TD [(Blood)-390(Institute)-390(\(HL36310\),)-390(National)-390(Institutes)-390(of)-390(Health;)-390(National)]TJ 0 -1.119 TD [(Institute)-237(on)-237(Aging)-237(\(AG13196\),)-237(National)-237(Institutes)-237(of)-237(Health;)-237(Agency)]TJ T* [(for)-390(Health)-390(Care)-390(Policy)-390(Research)-390(\(HS06516\);)-390(and)-390(the)-390(John)-390(D.)-390(and)]TJ T* [(Catherine)-248(T.)-248(MacArthur)-248(Foundation)-248(Research)-248(Networks)-248(on)-248(Success-)]TJ T* [(ful)-517(Midlife)-517(Development)-517(and)-517(Socioeconomic)-517(Status)-517(and)-517(Health.)]TJ 0.0107 Tc 0 -1.119 TD [(J.E.F.)-670(is)-670(supported)-670(by)-670(the)-670(Medical)-670(Research)-670(Council)-670(\(grant)]TJ 0 Tc 0 -1.119 TD [(G8802774\),)-228(M.J.S.)-228(by)-228(a)-228(grant)-228(from)-228(the)-228(British)-228(Heart)-228(Foundation,)-228(and)]TJ T* [(M.G.M.)-333(by)-333(a)-333(Medical)-333(Research)-333(Council)-333(research)-333(professorship.)]TJ /T1_1 1 Tf 11.5 0 0 11.5 403.3807 591.2472 Tm (Disclosures)Tj /T1_0 1 Tf 8.5 0 0 8.5 314.1648 580.7358 Tm [(F.P.C.)-522(holds)-522(the)-522(Cephalon)-522(Chair,)-522(an)-522(endowed)-522(post)-522(at)-522(TV)]TJ 0 -1.119 TD [(Medical)-437(School,)-437(the)-437(result)-437(of)-437(a)-437(donation)-437(from)-437(the)-437(company.)-437(The)]TJ T* [(appointment)-535(to)-535(the)-535(chair)-535(was)-535(made)-535(entirely)-535(independent)-535(of)-535(the)]TJ 0 -1.119 TD [(company,)-369(and)-369(the)-369(postholder)-369(is)-369(free)-369(to)-369(devise)-369(his)-369(own)-369(program)-369(of)]TJ 0 -1.119 TD [(research.)-427(Cephalon)-427(do)-427(not)-427(have)-427(any)-427(stake)-427(in)-427(intellectual)-427(property)]TJ T* [(associated)-279(with)-279(the)-279(postholder,)-279(and)-279(the)-279(chair)-279(has)-279(complete)-279(academic)]TJ T* [(independence)-376(from)-376(the)-376(company.)-376(The)-376(remaining)-376(authors)-376(report)-376(no)]TJ T* (conflicts.)Tj /T1_1 1 Tf 11.5 0 0 11.5 404.3523 492.645 Tm (References)Tj /T1_0 1 Tf 7.5 0 0 7.5 317.9148 482.6335 Tm [(1.)-500(Young)-370(T,)-370(Peppard)-370(P,)-370(Palta)-370(M,)-370(Hla)-370(KM,)-370(Finn)-370(L,)-370(Morgan)-370(B,)-370(Skatrud)-370(J.)]TJ 1.25 -1.201 Td [(Population-based)-316(study)-316(of)-316(sleep-disordered)-316(breathing)-316(as)-316(a)-316(risk)-316(factor)-316(for)]TJ 0 -1.201 TD (hypertension.)Tj /T1_3 1 Tf 5.749 0 Td [(Arch)-333(Intern)-333(Med)]TJ /T1_0 1 Tf 6.831 0 Td [(.)-333(1997;157:1746)-120(\2261752.)]TJ 0.0095 Tc -13.82 -1.201 Td [(2.)-509(Nieto)-562(FJ,)-562(Young)-562(TB,)-562(Lind)-562(BK,)-562(Shahar)-562(E,)-562(Samet)-562(JM,)-562(Redline)-562(S,)]TJ 0 Tc 1.24 -1.201 Td [(D\222Agostino)-265(RB,)-265(Newman)-265(AB,)-265(Lebowitz)-265(MD,)-265(Pickering)-265(TG.)-265(Association)]TJ 0 -1.201 TD [(of)-390(sleep-disordered)-390(breathing,)-390(sleep)-390(apnea,)-390(and)-390(hypertension)-390(in)-390(a)-390(large)]TJ T* [(community-based)-333(study.)]TJ /T1_3 1 Tf 10.249 0 Td (JAMA)Tj /T1_0 1 Tf 2.499 0 Td [(.)-333(2000;283:1829)-120(\2261836.)]TJ -13.998 -1.201 Td [(3.)-500(Peppard)-491(PE,)-491(Young)-491(T,)-491(Palta)-491(M,)-491(Skatrud)-491(J.)-491(Prospective)-491(study)-491(of)-491(the)]TJ 1.25 -1.201 Td [(association)-268(between)-268(sleep-disordered)-268(breathing)-268(and)-268(hypertension.)]TJ /T1_3 1 Tf 26.629 0 Td [(N)-268(Engl)]TJ -26.629 -1.201 Td [(J)-333(Med)]TJ /T1_0 1 Tf 2.554 0 Td [(.)-333(2000;342:1378)-120(\2261384.)]TJ 0.0053 Tc -3.799 -1.201 Td [(4.)-505(Duran)-558(J,)-558(Esnaola)-558(S,)-558(Rubio)-558(R,)-558(Iztueta)-558(A.)-558(Obstructive)-558(sleep)-558(apnea-)]TJ 0 Tc 1.245 -1.201 Td [(hypopnea)-390(and)-390(related)-390(clinical)-390(features)-390(in)-390(a)-390(population-based)-390(sample)-390(of)]TJ T* [(subjects)-533(aged)-533(30)-533(to)-533(70)-533(yr.)]TJ /T1_3 1 Tf 12.169 0 Td [(Am)-533(J)-533(Respir)-533(Crit)-533(Care)-533(Med)]TJ /T1_0 1 Tf 12.442 0 Td [(.)-533(2001;163:)]TJ -24.611 -1.201 Td [(685\226)-120(689.)]TJ -1.25 -1.202 Td [(5.)-500(Haas)-228(DC,)-228(Foster)-228(GL,)-228(Nieto)-228(J,)-228(Redline)-228(S,)-228(Resnick)-228(HE,)-228(Robbins)-228(JA,)-228(Young)]TJ 1.25 -1.201 Td [(T,)-382(Pickering)-382(TG.)-382(Age-dependent)-382(associations)-382(between)-382(sleep-disordered)]TJ T* [(breathing)-333(and)-333(hypertension.)]TJ /T1_3 1 Tf 11.636 0 Td (Circulation)Tj /T1_0 1 Tf 4.612 0 Td [(.)-333(2005;111:614)-120(\226)-120(621.)]TJ -17.498 -1.201 Td [(6.)-500(Ayas)-284(NT,)-284(White)-284(DP,)-284(Manson)-284(JE,)-284(Stampfer)-284(MJ,)-284(Speizer)-284(FE,)-284(Malhotra)-284(A,)]TJ 1.25 -1.201 Td [(Hu)-287(FB.)-287(A)-287(prospective)-287(study)-287(of)-287(sleep)-287(duration)-287(and)-287(coronary)-287(heart)-287(disease)]TJ T* [(in)-333(women.)]TJ /T1_3 1 Tf 4.638 0 Td [(Arch)-333(Intern)-333(Med)]TJ /T1_0 1 Tf 6.831 0 Td [(.)-333(2003;163:205\226209.)]TJ -12.719 -1.201 Td [(7.)-500(Ayas)-248(NT,)-248(White)-248(DP,)-248(Al-Delaimy)-248(WK,)-248(Manson)-248(JE,)-248(Stampfer)-248(MJ,)-248(Speizer)]TJ 1.25 -1.201 Td [(FE,)-337(Patel)-337(S,)-337(Hu)-337(FB.)-337(A)-337(prospective)-337(study)-337(of)-337(self-reported)-337(sleep)-337(duration)]TJ T* [(and)-333(incident)-333(diabetes)-333(in)-333(women.)]TJ /T1_3 1 Tf 13.58 0 Td [(Diabetes)-333(Care)]TJ /T1_0 1 Tf 5.888 0 Td [(.)-333(2003;26:380)-120(\226384.)]TJ -20.718 -1.2 Td [(8.)-500(Patel)-243(SR,)-243(Ayas)-243(NT,)-243(Malhotra)-243(MR,)-243(White)-243(DP,)-243(Schernhammer)-243(ES,)-243(Speizer)]TJ 1.25 -1.2 Td [(FE,)-453(Stampfer)-453(MJ,)-453(Hu)-453(FB.)-453(A)-453(prospective)-453(study)-453(of)-453(sleep)-453(duration)-453(and)]TJ 0 -1.2 TD [(mortality)-333(risk)-333(in)-333(women.)]TJ /T1_3 1 Tf 10.471 0 Td (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-333(2004;27:440)-120(\226)-120(444.)]TJ -13.887 -1.2 Td [(9.)-500(Patel)-531(SR,)-531(Malhotra)-531(A.)-531(White)-531(DP,)-531(Gottlieb)-531(DJ,)-531(Hu)-531(FB.)-531(Association)]TJ 1.25 -1.2 Td [(between)-490(reduced)-490(sleep)-490(and)-490(weight)-490(gain)-490(in)-490(women.)]TJ /T1_3 1 Tf 22.333 0 Td [(Am)-490(J)-490(Epidemiol)]TJ /T1_0 1 Tf 6.868 0 Td (.)Tj -29.201 -1.2 Td (2006;164:947\226954.)Tj -1.75 -1.2 Td [(10.)-500(Tamakoshi)-446(A,)-446(Ohno)-446(Y.)-446(Self-reported)-446(sleep)-446(duration)-446(as)-446(a)-446(predictor)-446(of)]TJ 1.75 -1.2 Td [(all-cause)-462(mortality:)-462(results)-462(from)-462(the)-462(J)-462(Am)-462(Coll)-462(Cardiol)-462(study,)-462(Japan.)]TJ /T1_3 1 Tf 0 -1.2 TD (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-333(2004;27:51\22654.)]TJ -3.916 -1.2 Td [(11.)-500(Gangwisch)-474(JE,)-474(Malaspina)-474(D,)-474(Boden-Albala)-474(B,)-474(Heymsfield)-474(SB.)-474(Inad-)]TJ 1.75 -1.2 Td [(equate)-439(sleep)-439(as)-439(a)-439(risk)-439(factor)-439(for)-439(obesity:)-439(analyses)-439(of)-439(the)-439(NHANES)-439(I.)]TJ /T1_3 1 Tf T* (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-333(2005;28:1289)-120(\2261296.)]TJ -3.916 -1.2 Td [(12.)-500(Kohatsu)-281(ND,)-281(Tsai)-281(R,)-281(Young)-281(T,)-281(VanGilder)-281(R,)-281(Burmeister)-281(LF,)-281(Stromquist)]TJ 1.75 -1.2 Td [(AM,)-551(Merchant)-551(JA.)-551(Sleep)-551(duration)-551(and)-551(body)-551(mass)-551(index)-551(in)-551(a)-551(rural)]TJ T* (population.)Tj /T1_3 1 Tf 4.861 0 Td [(Arch)-333(Intern)-333(Med)]TJ /T1_0 1 Tf 6.831 0 Td [(.)-333(2006;166:1701\2261705.)]TJ -13.442 -1.2 Td [(13.)-500(Gangwisch)-418(JE,)-418(Heymsfield)-418(SB,)-418(Boden-Albala)-418(B,)-418(Buijs)-418(RM,)-418(Kreier)-418(F,)]TJ 0.0042 Tc 1.75 -1.2 Td [(Pickering)-557(TG,)-557(Rundle)-557(AG,)-557(Zammit)-557(GK,)-557(Malaspina)-557(D.)-557(Short)-557(sleep)]TJ 0 Tc T* [(duration)-354(as)-354(a)-354(risk)-354(factor)-354(for)-354(hypertension:)-354(analyses)-354(of)-355(the)-355(first)-354(National)]TJ 0.0155 Tc T* [(Health)-568(and)-568(Nutrition)-568(Examination)-568(Survey.)]TJ /T1_3 1 Tf 19.371 0 Td (Hypertension)Tj /T1_0 1 Tf 5.574 0 Td [(.)-568(2006;47:)]TJ 0 Tc -24.945 -1.2 Td [(833\226)-120(839.)]TJ -1.75 -1.2 Td [(14.)-500(Gottlieb)-381(DJ,)-381(Redline)-381(S,)-381(Nieto)-381(FJ,)-381(Baldwin)-381(CM,)-381(Newman)-381(AB,)-381(Resnick)]TJ 1.75 -1.2 Td [(HE,)-297(Punjabi)-297(NM.)-297(Association)-297(of)-297(usual)-297(sleep)-297(duration)-297(with)-297(hypertension:)]TJ T* [(the)-333(Sleep)-333(Heart)-333(Health)-333(Study.)]TJ /T1_3 1 Tf 12.58 0 Td (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-333(2006;29:1009)-120(\2261014.)]TJ 0.0201 Tc -16.496 -1.2 Td [(1)20(5)20(.)-480(Tochikubo)-396(O,)-396(Ikeda)-396(A,)-396(Miyajima)-396(E,)-396(Ishii)-396(M.)-396(Effects)-396(of)-396(insufficient)]TJ 1.75 -1.2 Td [(sleep)-251(on)-251(blood)-251(pressure)-251(monitored)-251(by)-251(a)-251(new)-251(multibiomedical)-251(recorder.)]TJ /T1_3 1 Tf T* (Hypertension)Tj /T1_0 1 Tf 5.629 0 Td [(.)-353(1996;27:1318)-120(\2261324.)]TJ /T1_4 1 Tf 0 Tc 10 0 0 10 56.1648 752.3835 Tm [(700)-2000(Hypertension)]TJ /T1_1 1 Tf 11.056 0 Td [(October)-333(2007)]TJ 0 g ET /GS1 gs BT /T1_5 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_5 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_5 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 176 0 obj<> endobj 177 0 obj<> endobj 178 0 obj[176 0 R] endobj 179 0 obj<> endobj 182 0 obj<>stream q 360 0 0 149 129 259 cm /Im0 Do Q 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 7.5 0 0 7.5 56.1648 720.8835 Tm [(16.)-500(Lusardi)-279(P,)-279(Mugellini)-279(A,)-279(Preti)-279(P,)-279(Zoppi)-279(A,)-279(Derosa)-279(G,)-279(Fogari)-279(R.)-279(Effects)-279(of)]TJ 1.75 -1.188 Td [(a)-396(restricted)-396(sleep)-396(regimen)-396(on)-396(ambulatory)-396(blood)-396(pressure)-396(monitoring)-396(in)]TJ 0 -1.188 TD [(normotensive)-333(subjects.)]TJ /T1_1 1 Tf 9.582 0 Td [(Am)-333(J)-333(Hypertens)]TJ /T1_0 1 Tf 6.553 0 Td [(.)-333(1996;9:503\226505.)]TJ -17.885 -1.188 Td [(17.)-500(Lusardi)-369(P,)-369(Zoppi)-369(A,)-369(Preti)-369(P,)-369(Pesce)-369(RM,)-369(Piazza)-369(E,)-369(Fogari)-369(R.)-369(Effects)-369(of)]TJ 1.75 -1.188 Td [(insufficient)-226(sleep)-226(on)-226(blood)-226(pressure)-226(in)-226(hypertensive)-226(patients:)-226(a)-226(24-h)-226(study.)]TJ /T1_1 1 Tf T* [(Am)-333(J)-333(Hypertens)]TJ /T1_0 1 Tf 6.553 0 Td [(.)-333(1999;12:63\226)-120(68.)]TJ -8.303 -1.188 Td [(18.)-500(Miller)-369(MA,)-369(Cappuccio)-369(FP.)-369(Inflammation,)-369(sleep,)-369(obesity)-369(and)-369(cardiovas-)]TJ 1.75 -1.188 Td [(cular)-333(disease.)]TJ /T1_1 1 Tf 5.803 0 Td [(Curr)-333(Vasc)-333(Pharmacol)]TJ /T1_0 1 Tf 8.999 0 Td [(.)-333(2007;5:95\226102.)]TJ -16.552 -1.188 Td [(19.)-500(Wolk)-379(R,)-379(Somers)-379(VK.)-379(Sleep)-379(and)-379(the)-379(metabolic)-379(syndrome.)]TJ /T1_1 1 Tf 26.018 0 Td [(Exp)-379(Physiol)]TJ /T1_0 1 Tf 4.934 0 Td (.)Tj -29.202 -1.188 Td (2007;92:67\22678.)Tj -1.75 -1.188 Td [(20.)-500(Scheer)-266(FA,)-266(Van)-266(Montgrans)-266(GA,)-266(van)-266(Someren)-266(EJ,)-266(Mairuhu)-266(G,)-266(Buijs)-266(RM.)]TJ 1.75 -1.188 Td [(Daily)-310(night-time)-310(melatonin)-310(reduces)-310(blood)-310(pressure)-310(in)-310(male)-310(patients)-310(with)]TJ 0 -1.188 TD [(essential)-333(hypertension.)]TJ /T1_1 1 Tf 9.526 0 Td (Hypertension)Tj /T1_0 1 Tf 5.388 0 Td [(.)-333(2004;43:192\226197.)]TJ -16.664 -1.188 Td [(21.)-500(Zee)-281(PC,)-281(Turek)-281(FW.)-281(Sleep)-281(and)-281(health:)-281(everywhere)-281(and)-281(in)-281(both)-281(directions.)]TJ /T1_1 1 Tf 1.75 -1.188 Td [(Arch)-333(Intern)-333(Med)]TJ /T1_0 1 Tf 6.831 0 Td [(.)-333(2006;166:1686)-120(\2261688.)]TJ -8.581 -1.188 Td [(22.)-500(Marmot)-422(MG,)-422(Davey)-422(Smith)-422(G,)-422(Stansfeld)-422(S,)-422(Patel)-422(C,)-422(North)-422(F,)-422(Head)-422(J,)]TJ 1.75 -1.188 Td [(White)-393(I,)-393(Brunner)-393(E,)-393(Feeney)-393(A.)-393(Health)-393(inequalities)-393(among)-393(British)-393(civil)]TJ T* [(servants:)-333(the)-333(Whitehall)-333(II)-333(study.)]TJ /T1_1 1 Tf 13.469 0 Td (Lancet)Tj /T1_0 1 Tf 2.722 0 Td [(.)-333(1991;337:1387\2261393.)]TJ -17.941 -1.188 Td [(23.)-500(Brazier)-315(JE,)-315(Harper)-315(R,)-315(Jones)-315(NM,)-315(O\222Cathain)-315(A,)-315(Thomas)-315(KJ,)-315(Usherwood)]TJ 1.75 -1.188 Td [(T,)-409(Westlake)-409(L.)-409(Validating)-409(the)-409(SF-36)-409(health)-409(survey)-409(questionnaire:)-409(new)]TJ T* [(outcome)-333(measure)-333(for)-333(primary)-333(care.)]TJ /T1_1 1 Tf 14.688 0 Td (BMJ)Tj /T1_0 1 Tf 1.888 0 Td [(.)-333(1992;305:160)-120(\226164.)]TJ 0.0155 Tc -18.326 -1.188 Td [(24.)-516(Narkiewicz)-568(K,)-568(Somers)-568(VK.)-568(The)-568(sympathetic)-568(nervous)-568(system)-568(and)]TJ 0.0019 Tc 1.75 -1.188 Td [(obstructive)-554(sleep)-554(apnea:)-554(implications)-554(for)-554(hypertension.)]TJ /T1_1 1 Tf 24.058 0 Td [(J)-554(Hypertens)]TJ /T1_0 1 Tf 0 Tc 5.127 0 Td (.)Tj -29.185 -1.188 Td (1997;15:1613\2261616.)Tj -1.75 -1.188 Td [(25.)-500(Fletcher)-306(EC.)-306(Sympathetic)-306(overactivity)-306(in)-306(the)-306(etiology)-306(of)-306(hypertension)-306(of)]TJ 1.75 -1.188 Td [(obstructive)-333(sleep)-333(apnea.)]TJ /T1_1 1 Tf 10.08 0 Td (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-333(2003;26:15\22619.)]TJ -13.996 -1.189 Td [(26.)-500(Quan)-325(SF,)-325(Zee)-325(P.)-325(Evaluating)-325(the)-325(effects)-325(of)-325(medical)-325(disorders)-325(on)-325(sleep)-325(in)]TJ 1.75 -1.189 Td [(the)-333(older)-333(patient.)]TJ /T1_1 1 Tf 7.248 0 Td (Geriatrics)Tj /T1_0 1 Tf 4.111 0 Td [(.)-333(2004;59:37\226)-120(42.)]TJ -13.109 -1.189 Td [(27.)-500(Parry)-356(BL,)-356(Newton)-356(RP.)-356(Chronobiological)-356(basis)-356(of)-356(female-specific)-356(mood)]TJ 1.75 -1.189 Td (disorders.)Tj /T1_1 1 Tf 4.249 0 Td (Neuropsychopharmacology)Tj /T1_0 1 Tf 11.054 0 Td [(.)-333(2001;25:S102\226S108.)]TJ -17.053 -1.189 Td [(28.)-500(Baldwin)-383(CM,)-383(Kapur)-383(VK,)-383(Holberg)-383(CJ,)-383(Rosen)-383(C,)-383(Nieto)-383(FJ.)-383(Sleep)-383(Heart)]TJ 0.0008 Tc 1.75 -1.189 Td [(Health)-553(Study)-553(Group.)-553(Associations)-553(between)-553(gender)-553(and)-553(measures)-553(of)]TJ 0 Tc 34.4 36.833 Td [(daytime)-421(somnolence)-421(in)-421(the)-421(Sleep)-421(Heart)-421(Health)-421(Study.)]TJ /T1_1 1 Tf 23.059 0 Td (Sleep.)Tj /T1_0 1 Tf 2.837 0 Td (2004;27:)Tj -25.895 -1.229 Td (305\226311.)Tj -1.75 -1.229 Td [(29.)-500(Meisinger)-297(C,)-297(Heier)-297(M,)-297(Lo)]TJ 11.963 0 Td [(\250)-83(wel)-297(H,)-297(Schneider)-297(A,)-297(Do)]TJ 9.795 0 Td [(\250)-83(ring)-297(A.)-297(Sleep)-297(duration)]TJ -20.008 -1.229 Td [(and)-402(sleep)-402(complaints)-402(and)-402(risk)-402(of)-402(myocardial)-402(infarction)-402(in)-402(middle-aged)]TJ 0 -1.229 TD [(men)-498(and)-498(women)-498(from)-498(the)-498(general)-498(population.)-498(The)-498(MONICA/KORA)]TJ T* [(Augsburg)-333(Cohort)-333(Study.)]TJ /T1_1 1 Tf 10.305 0 Td (Sleep.)Tj /T1_0 1 Tf 2.749 0 Td [(In)-333(press.)]TJ -14.804 -1.229 Td [(30.)-500(Moore)-440(P,)-440(Adler)-440(N,)-440(Williams)-440(D,)-440(Jackson)-440(J.)-440(Socioeconomic)-440(status)-440(and)]TJ 1.75 -1.229 Td [(health:)-333(the)-333(role)-333(of)-333(sleep.)]TJ /T1_1 1 Tf 10.302 0 Td [(Psychosom)-333(Med)]TJ /T1_0 1 Tf 6.609 0 Td [(.)-333(2002;64:337\226344.)]TJ -18.661 -1.229 Td [(31.)-500(Groeger)-373(JA,)-373(Zijlstra)-373(FR,)-373(Dijk)-373(DJ.)-373(Sleep)-373(quantity,)-373(sleep)-373(difficulties)-373(and)]TJ 1.75 -1.229 Td [(their)-403(perceived)-403(consequences)-403(in)-403(a)-403(representative)-403(sample)-403(of)-403(some)-403(2000)]TJ T* [(British)-333(adults.)]TJ /T1_1 1 Tf 6.028 0 Td [(J)-333(Sleep)-333(Res)]TJ /T1_0 1 Tf 4.72 0 Td [(.)-333(2004;13:359)-120(\226371.)]TJ -12.498 -1.227 Td [(32.)-500(Adams)-550(J.)-550(Socioeconomic)-550(position)-550(and)-550(sleep)-550(quantity)-550(in)-550(UK)-550(adults.)]TJ /T1_1 1 Tf 1.75 -1.227 Td [(J)-333(Epidemiol)-333(Community)-333(Health)]TJ /T1_0 1 Tf 12.887 0 Td [(.)-333(2006;60:267\226269.)]TJ -14.637 -1.227 Td [(33.)-500(Patel)-276(SR,)-276(Malhotra)-276(A,)-276(Gottlieb)-276(DJ,)-276(White)-276(DP,)-276(Hu)-276(FB.)-276(Correlates)-276(of)-276(long)]TJ 1.75 -1.227 Td [(sleep)-333(duration.)]TJ /T1_1 1 Tf 6.304 0 Td (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-333(2006;29:881\226)-120(889.)]TJ -10.22 -1.227 Td [(34.)-500(National)-455(Sleep)-455(Foundation.)]TJ /T1_1 1 Tf 13.587 0 Td [(Sleep)-455(in)-455(America)-455(Poll)-455(2005:)-455(Summary)-455(of)]TJ -11.837 -1.227 Td (Findings.)Tj /T1_0 1 Tf 4.139 0 Td [(Washington,)-333(DC:)-333(National)-333(Sleep)-333(Foundation;)-333(2005.)]TJ -5.889 -1.227 Td [(35.)-500(Egan)-266(BM.)-266(Sleep)-266(and)-266(hypertension:)-266(burning)-266(the)-266(candle)-266(at)-266(both)-266(ends)-266(really)]TJ 1.75 -1.227 Td [(is)-333(hazardous)-333(to)-333(your)-333(health.)]TJ /T1_1 1 Tf 11.691 0 Td (Hypertension)Tj /T1_0 1 Tf 5.388 0 Td [(.)-333(2006;47:816)-120(\226)-120(817.)]TJ -18.829 -1.227 Td [(36.)-500(Knutson)-409(KL,)-409(Turek)-409(FW.)-409(The)-409(U-shaped)-409(association)-409(between)-409(sleep)-409(and)]TJ 1.75 -1.227 Td [(health:)-249(the)-249(2)-249(peaks)-249(do)-249(not)-249(mean)-249(the)-249(same)-249(thing.)]TJ /T1_1 1 Tf 19.24 0 Td (Sleep)Tj /T1_0 1 Tf 2.166 0 Td [(.)-249(2006;29:878)-120(\226)-120(879.)]TJ 0.0027 Tc -23.156 -1.227 Td [(37.)-503(Hauri)-555(PJ,)-555(Wisbey)-555(J.)-555(Wrist)-555(actigraphy)-555(in)-555(insomnia.)]TJ /T1_1 1 Tf 24.618 0 Td (Sleep)Tj /T1_0 1 Tf 2.179 0 Td [(.)-555(1992;15:)]TJ 0 Tc -25.048 -1.227 Td (293\226301.)Tj -1.75 -1.227 Td [(38.)-500(Lockley)-387(SW,)-387(Skene)-387(DJ,)-387(Arendt)-387(J.)-387(Comparison)-387(between)-387(subjective)-387(and)]TJ 1.75 -1.227 Td [(actigraphic)-318(measurement)-318(of)-318(sleep)-318(and)-318(sleep)-318(rhythms.)]TJ /T1_1 1 Tf 21.915 0 Td [(J)-318(Sleep)-318(Res)]TJ /T1_0 1 Tf 4.69 0 Td [(.)-318(1999;)]TJ -26.604 -1.227 Td (8:175\226178.)Tj -1.75 -1.227 Td [(39.)-500(Knutson)-360(KL,)-360(Spiegel)-360(K,)-360(Penev)-360(P,)-360(Van)-360(Cauter)-360(E.)-360(The)-360(metabolic)-360(conse-)]TJ 1.75 -1.227 Td [(quences)-333(of)-333(sleep)-333(deprivation.)]TJ /T1_1 1 Tf 12.246 0 Td [(Sleep)-333(Medicine)-333(Rev)]TJ /T1_0 1 Tf 8.052 0 Td [(.)-333(2007;11:163\226178.)]TJ -22.048 -1.227 Td [(40.)-500(Currie)-357(A,)-357(Cappuccio)-357(FP.)-357(Sleep)-357(in)-357(children)-357(and)-357(adolescents:)-357(a)-357(worrying)]TJ 1.75 -1.227 Td [(scenario.)-375(Can)-375(we)-375(understand)-375(the)-375(sleep)-375(deprivation)-375(\226)-375(obesity)-375(epidemic?)]TJ /T1_1 1 Tf 0 -1.227 TD [(Nutr)-333(Metab)-333(Cardiovasc)-333(Dis)]TJ /T1_0 1 Tf 11.388 0 Td [(.)-333(2007;17:230)-120(\226232.)]TJ /T1_2 1 Tf 10 0 0 10 252.6761 748.9148 Tm [(Cappuccio)-333(et)-333(al)-2000(Short)-333(Sleep)-333(Duration)-333(and)-333(Hypertension)]TJ /T1_3 1 Tf 28.053 0 Td (701)Tj 0 g ET /GS1 gs BT /T1_4 1 Tf 9 0 0 9 277.9965 32 Tm ( at UNIVERSITY WARWICK on September 6, 2007 )Tj 0 0 1 rg ET /GS1 gs BT /T1_4 1 Tf 9 0 0 9 199.5166 32 Tm (hyper.ahajournals.org)Tj 0 g ET /GS1 gs BT /T1_4 1 Tf 9 0 0 9 131.5307 32 Tm (Downloaded from )Tj ET endstream endobj 183 0 obj<>stream StampPDF Batch 2.7 for Solaris - SPDF 1045 2007-08-31T13:37:29Z 2007-09-06T03:57:19Z 2007-08-31T13:37:29Z XPP application/pdf uuid:6a306b29-1dd2-11b2-0a00-4c776c0874d4 uuid:6a306b2e-1dd2-11b2-0a00-000000001c63 dc:creator dc:title dc:description endstream endobj xref 0 184 0000000011 00000 f 0000000016 00000 n 0000000039 00000 n 0000000456 00000 n 0000000688 00000 n 0000004784 00000 n 0000005258 00000 n 0000005567 00000 n 0000005774 00000 n 0000005829 00000 n 0000009155 00000 n 0000000012 00000 f 0000000013 00000 f 0000000014 00000 f 0000000015 00000 f 0000000016 00000 f 0000000017 00000 f 0000000018 00000 f 0000000036 00000 f 0000009542 00000 n 0000009882 00000 n 0000010091 00000 n 0000010154 00000 n 0000015061 00000 n 0000015384 00000 n 0000015873 00000 n 0000016106 00000 n 0000016190 00000 n 0000016857 00000 n 0000017084 00000 n 0000017159 00000 n 0000019660 00000 n 0000019955 00000 n 0000027547 00000 n 0000028097 00000 n 0000033311 00000 n 0000000037 00001 f 0000000039 00001 f 0000033710 00000 n 0000000040 00001 f 0000000042 00001 f 0000041562 00000 n 0000000043 00001 f 0000000045 00001 f 0000049414 00000 n 0000000046 00001 f 0000000048 00001 f 0000057266 00000 n 0000000049 00001 f 0000000051 00001 f 0000065118 00000 n 0000000052 00001 f 0000000058 00001 f 0000072970 00000 n 0000080822 00000 n 0000080992 00000 n 0000081650 00000 n 0000081801 00000 n 0000000059 00001 f 0000000061 00001 f 0000082375 00000 n 0000000062 00001 f 0000000072 00001 f 0000090227 00000 n 0000098079 00000 n 0000098168 00000 n 0000098330 00000 n 0000098788 00000 n 0000098963 00000 n 0000099127 00000 n 0000099581 00000 n 0000100201 00000 n 0000000073 00001 f 0000000074 00001 f 0000000075 00001 f 0000000076 00001 f 0000000077 00001 f 0000000078 00001 f 0000000079 00001 f 0000000080 00001 f 0000000081 00001 f 0000000082 00001 f 0000000083 00001 f 0000000084 00001 f 0000000085 00001 f 0000000086 00001 f 0000000087 00001 f 0000000088 00001 f 0000000089 00001 f 0000000090 00001 f 0000000091 00001 f 0000000092 00001 f 0000000093 00001 f 0000000094 00001 f 0000000107 00001 f 0000100682 00000 n 0000100732 00000 n 0000100782 00000 n 0000101158 00000 n 0000101273 00000 n 0000101661 00000 n 0000102050 00000 n 0000102475 00000 n 0000102938 00000 n 0000103388 00000 n 0000103789 00000 n 0000103824 00000 n 0000000131 00001 f 0000104237 00000 n 0000104361 00000 n 0000104579 00000 n 0000104798 00000 n 0000104899 00000 n 0000104960 00000 n 0000105018 00000 n 0000105118 00000 n 0000105194 00000 n 0000105294 00000 n 0000105360 00000 n 0000105464 00000 n 0000105524 00000 n 0000105625 00000 n 0000105686 00000 n 0000258813 00000 n 0000258904 00000 n 0000258996 00000 n 0000259086 00000 n 0000261398 00000 n 0000261499 00000 n 0000261560 00000 n 0000261586 00000 n 0000000132 00001 f 0000000138 00001 f 0000261660 00000 n 0000273453 00000 n 0000273554 00000 n 0000273615 00000 n 0000273641 00000 n 0000000139 00001 f 0000000145 00001 f 0000273715 00000 n 0000290337 00000 n 0000290438 00000 n 0000290499 00000 n 0000290525 00000 n 0000000146 00001 f 0000000152 00001 f 0000290599 00000 n 0000301466 00000 n 0000301567 00000 n 0000301628 00000 n 0000301654 00000 n 0000000153 00001 f 0000000159 00001 f 0000301728 00000 n 0000311632 00000 n 0000311733 00000 n 0000311794 00000 n 0000311820 00000 n 0000000160 00001 f 0000000166 00001 f 0000311894 00000 n 0000323630 00000 n 0000323731 00000 n 0000323792 00000 n 0000323818 00000 n 0000000167 00001 f 0000000173 00001 f 0000323892 00000 n 0000339478 00000 n 0000339579 00000 n 0000339640 00000 n 0000339666 00000 n 0000000174 00001 f 0000000180 00001 f 0000339740 00000 n 0000355662 00000 n 0000355763 00000 n 0000355824 00000 n 0000355850 00000 n 0000000181 00001 f 0000000000 00001 f 0000355924 00000 n 0000365577 00000 n trailer <]>> startxref 367587 %%EOF