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(in)-450.3 (this)-450.3 (case,)-450.3 (a)]TJ 0.0001 -1.2213 Td [(significant)-509.3 (linear)-509.3 (association)-509.2 (was)-509.3 (also)-509.2 (observed)-509.2 (\()]TJ /T1_1 1 Tf 21.1067 0 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf (0.01\))Tj -21.1066 -1.2213 Td [(\(Table)-455.4 (2\).)-455.4 (In)-455.4 (women,)-455.4 (as)-455.4 (in)-455.4 (men,)-455.4 (there)-455.4 (was)-455.4 (a)-455.4 (consistently)]TJ T* [(higher)-363.3 (level)-363.3 (of)-363.3 (vWF)-363.3 (in)-363.3 (those)-363.3 (individuals)-363.3 (who)-363.3 (slept)-363.3 (8)-363.3 (hours)]TJ T* [(per)-424.6 (night)-424.6 (or)-424.6 (more)-424.6 (compared)-424.6 (with)-424.6 (those)-424.6 (who)-424.6 (slept)-424.6 (7)-424.6 (hours)]TJ T* (\()Tj /T1_1 1 Tf (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.05\).)-321.2 (After)-321.2 (adjustment)-321.2 (for)-321.2 (serum)-321.1 (IL-6,)-321.2 (there)-321.1 (was)-321.2 (still)-321.2 (a)]TJ 0.0001 -1.2213 Td [(significant)-536.8 (nonlinear)-536.8 (relationship)-536.8 (\()]TJ /T1_1 1 Tf 14.6637 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.02\);)-536.8 (the)-536.8 (values)-536.8 (in)]TJ -14.6636 -1.2213 Td [(long)-475.5 (sleepers)-475.5 (were)-475.5 (significantly)-475.5 (higher)-475.5 (than)-475.5 (in)-475.5 (those)-475.5 (who)]TJ T* [(slept)-252.1 (7)-252.1 (hours)-252.1 (\(1.11)-252.1 ([95%)-252.1 (CI,)-252.1 (1.05)-252.1 (to)-252.1 (1.07];)]TJ /T1_1 1 Tf 17.2671 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.05)-252.1 (for)-252.1 (model)]TJ -17.267 -1.2213 Td [(5)-349 ([employment])-349 (with)-349 (IL-6)-349 (adjustment\).)-349 (Similar)-349 (results)-349 (were)]TJ T* [(observed)-485.6 (when)-485.6 (substituting)-485.6 (marital)-485.6 (status)-485.6 (for)-485.6 (employment)]TJ T* [(status)-407.9 (\()]TJ /T1_1 1 Tf [0.1 (P)]TJ /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.02)-407.9 (for)-407.9 (model)-407.9 (5)-407.9 (only)-407.9 (and)]TJ /T1_1 1 Tf 16.0477 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.02)-407.9 (for)-407.9 (model)-407.9 (5)]TJ -16.0475 -1.2213 Td [(with)-332.8 (IL-6)-332.8 (adjustment\).)]TJ /T1_3 1 Tf 10.5 0 0 10.5 56.1648 326.5086 Tm [(Factor)-332.8 (VII)-332.8 (and)-332.8 (Fibrinogen)]TJ /T1_0 1 Tf 9.5 0 0 9.5 56.1648 315.4063 Tm [(In)-348.4 (men,)-348.4 (both)-348.4 (the)-348.4 (linear)-348.4 (and)-348.4 (nonlinear)-348.4 (trends,)-348.4 (when)-348.4 (adjusted)]TJ T* [(for)-336.1 (age,)-336.1 (BMI,)-336.1 (smoking,)-336.1 (and)-336.1 (sampling)-336.1 (time,)-336.1 (were)-336.1 (not)-336.1 (signif-)]TJ T* [(icant)-657.3 (\()]TJ /T1_1 1 Tf [0.1 (P)]TJ /T1_2 1 Tf (\002)Tj /T1_0 1 Tf [(0.43)-657.3 (and)]TJ /T1_1 1 Tf 8.8866 0 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf [(0.31,)-657.3 (respectively\).)-657.3 (Likewise,)-657.3 (no)]TJ -8.8865 -1.2201 Td [(significant)-610.9 (effect)-610.9 (was)-610.9 (observed)-610.9 (in)-610.9 (women)-610.9 (\()]TJ /T1_1 1 Tf 19.3829 0 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf [(0.16)-610.9 (and)]TJ /T1_1 1 Tf -19.3828 -1.2201 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf [(0.28,)-455.7 (respectively\).)-455.7 (These)-455.7 (associations)-455.7 (were)-455.7 (unchanged)]TJ 0.0001 -1.2201 Td [(after)-490.4 (multiple)-490.4 (adjustments,)-490.4 (and)-490.4 (no)-490.4 (significant)-490.4 (associations)]TJ 0 -1.2201 TD [(were)-316.1 (observed)-316.1 (when)-316.1 (adjustment)-316.1 (was)-316.1 (made)-316.1 (for)-316.1 (marital)-316.1 (status)]TJ T* [(instead)-336.1 (of)-336.1 (employment)-336.1 (grade)-336.1 (\(Table)-336.1 (3\).)-336.1 (A)-336.1 (small,)-336.1 (but)-336.1 (signif-)]TJ T* [(icant,)-350.2 (increase)-350.2 (\(2%\))-350.2 (in)-350.2 (factor)-350.2 (VII)-350.2 (in)-350.2 (the)-350.2 (male)-350.2 (short)-350.2 (sleepers)]TJ T* [(was)-330.4 (observed)-330.4 (in)-330.4 (the)-330.4 (fully)-330.4 (adjusted)-330.4 (model)-330.4 (\(Table)-330.4 (3\))-330.4 (and)-330.4 (was)]TJ T* [(maintained)-413.3 (when)-413.3 (adjusted)-413.3 (for)-413.3 (IL-6)-413.3 (\(1.02)-413.3 ([95%)-413.2 (CI,)-413.3 (1.00)-413.3 (to)]TJ T* (1.05];)Tj /T1_1 1 Tf 2.6937 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf (0.05\).)Tj -1.6936 -1.2201 Td [(In)-462.9 (men)-462.9 (and)-462.9 (women,)-462.9 (there)-462.9 (were)-462.9 (no)-462.9 (significant)-462.9 (linear)-462.9 (or)]TJ -1 -1.2201 Td [(nonlinear)-434.8 (trends)-434.8 (observed)-434.8 (with)-434.8 (any)-434.8 (of)-434.8 (the)-434.8 (models;)-434.8 (and)-434.8 (no)]TJ T* [(difference)-410.6 (in)-410.6 (levels)-410.6 (was)-410.6 (observed)-410.6 (in)-410.6 (short)-410.6 (or)-410.6 (long)-410.6 (sleepers)]TJ T* [(compared)-291.2 (with)-291.2 (those)-291.2 (sleeping)-291.2 (7)-291.2 (hours,)-291.3 (after)-291.3 (making)-291.2 (multiple)]TJ T* [(adjustments)-332.8 (\(Table)-332.8 (3\).)]TJ /T1_3 1 Tf 10.5 0 0 10.5 56.1648 107.8381 Tm [(Premenopausal)-332.8 (and)-332.8 (Postmenopausal)-332.8 (Women)]TJ /T1_0 1 Tf 9.5 0 0 9.5 56.1648 96.7472 Tm [(The)-447.6 (levels)-447.6 (of)-447.7 (each)-447.6 (of)-447.6 (the)-447.6 (hemostatic)-447.6 (markers)-447.6 (was)-447.6 (signifi-)]TJ T* [(cantly)-624.4 (higher)-624.4 (in)-624.4 (postmenopausal)-624.4 (women)-624.4 (compared)-624.4 (with)]TJ T* [(premenopausal)-618.4 (women)-618.4 (\(vWF:)-618.4 (105.6)-618.4 ([95%)-618.4 (CI,)-618.4 (103.2)-618.4 (to)]TJ T* [(108.1])-222.2 (IU/dL)-222.2 (versus)-222.2 (95.5)-222.2 ([95%)-222.1 (CI,)-222.2 (93.4)-222.2 (to)-222.2 (97.6])-222.2 (IU/dL;)-222.2 (factor)]TJ T* [(VII:)-323.9 (97.6)-323.8 ([95%)-323.8 (CI,)-323.8 (96.1)-323.8 (to)-323.8 (99.2])-323.8 (percentage)-323.8 (standard)-323.8 (versus)]TJ 27.1579 70.4737 Td [(83.6)-301.7 ([95%)-301.7 (CI,)-301.7 (82.0)-301.7 (to)-301.7 (85.2])-301.7 (percentage)-301.7 (standard;)-301.7 (fibrinogen:)]TJ 0 -1.2165 TD [(2.62)-268.2 ([95%)-268.2 (CI,)-268.2 (2.59)-268.2 (to)-268.2 (2.66])-268.2 (g/L)-268.2 (versus)-268.2 (2.38)-268.2 ([95%)-268.2 (CI,)-268.2 (2.35)-268.2 (to)]TJ T* [(2.42])-332.8 (g/L;)]TJ /T1_1 1 Tf 4.4155 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.001)-332.8 (for)-332.8 (each\).)]TJ -3.4154 -1.2165 Td [(With)-348.7 (the)-348.7 (fully)-348.7 (adjusted)-348.7 (employment)-348.7 (model,)-348.7 (the)-348.7 (increased)]TJ -1 -1.2165 Td [(level)-354.6 (of)-354.6 (vWF)-354.6 (was)-354.6 (observed)-354.6 (in)-354.6 (both)-354.6 (long)-354.6 (sleeping)-354.6 (premeno-)]TJ T* [(pausal)-336.1 (women)-336.1 (\(1.10)-336.1 ([95%)-336.1 (CI,)-336.1 (1.03)-336.1 (to)-336.1 (1.18]\))-336.1 (and)-336.1 (postmeno-)]TJ T* [(pausal)-289.8 (women)-289.7 (\(1.08)-289.7 ([95%)-289.7 (CI,)-289.8 (1.01)-289.8 (to)-289.7 (1.17]\))-289.8 (\()]TJ /T1_1 1 Tf 18.5923 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.05)-289.7 (versus)]TJ -18.5923 -1.2165 Td [(7)-285.3 (hours\).)-285.3 (In)-285.3 (premenopausal,)-285.3 (but)-285.3 (not)-285.3 (postmenopausal,)-285.3 (women)]TJ T* [(\(as)-327.7 (for)-327.7 (the)-327.7 (men\),)-327.7 (a)-327.7 (significant)-327.7 (increase)-327.7 (was)-327.7 (also)-327.7 (observed)-327.7 (in)]TJ T* [(short)-345.1 (sleeping)-345.1 (women)-345.1 (\(1.07)-345.1 ([95%)-345.1 (CI,)-345.1 (1.00)-345.1 (to)-345.1 (1.15;)]TJ /T1_1 1 Tf 21.4369 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf (0.05)Tj -21.4368 -1.2165 Td [(versus)-604 (7)-604 (hours\).)-604 (The)-604 (nonlinear)-604 (trend)-604 (was)-604 (significant)-604.1 (in)]TJ T* [(premenopausal,)-521.5 (but)-521.5 (not)-521.5 (postmenopausal,)-521.5 (women)-521.5 (\()]TJ /T1_1 1 Tf 21.4377 0 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf (0.04)Tj -21.4376 -1.2165 Td (and)Tj /T1_1 1 Tf 1.7768 0 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf [(0.15,)-332.8 (respectively\).)]TJ -0.7767 -1.2165 Td [(For)-450 (factor)-450 (VII)-450 (and)-450 (fibrinogen,)-450 (as)-450 (for)-450 (the)-450 (total)-450 (group)-450 (of)]TJ -1 -1.2165 Td [(women,)-551.7 (in)-551.7 (the)-551.7 (adjusted)-551.7 (models,)-551.7 (there)-551.7 (were)-551.7 (no)-551.7 (observed)]TJ T* [(associations)-246.7 (between)-246.7 (these)-246.7 (factors)-246.7 (in)-246.7 (sleep)-246.7 (in)-246.7 (either)-246.7 (premeno-)]TJ T* [(pausal)-332.8 (or)-332.8 (postmenopausal)-332.8 (women)-332.8 (\(data)-332.8 (not)-332.8 (shown\).)]TJ /T1_3 1 Tf 11.5 0 0 11.5 405.2898 511.9177 Tm (Discussion)Tj /T1_0 1 Tf 9.5 0 0 9.5 314.1648 500.8608 Tm [(Our)-343.6 (findings)-343.6 (from)-343.6 (more)-343.6 (than)-343.6 (6400)-343.6 (British)-343.6 (white-collar)-343.6 (civil)]TJ T* [(servants)-350.5 (suggest)-350.5 (that)-350.5 (the)-350.5 (associations)-350.5 (of)-350.5 (sleep)-350.5 (duration)-350.4 (with)]TJ T* [(different)-399.5 (hemostatic)-399.5 (factors)-399.5 (are,)-399.5 (in)-399.5 (part,)-399.5 (sex)-399.5 (dependent)-399.5 (and)]TJ T* [(vary)-332.8 (according)-332.8 (to)-332.8 (the)-332.8 (marker)-332.8 (studied.)]TJ 1 -1.2165 Td [(In)-481.4 (the)-481.4 (simple)-481.4 (model,)-481.4 (there)-481.4 (were)-481.4 (no)-481.4 (linear)-481.4 (or)-481.4 (nonlinear)]TJ -1 -1.2165 Td [(trends)-336.7 (observed)-336.7 (between)-336.7 (sleep)-336.7 (and)-336.7 (the)-336.7 (measured)-336.7 (markers)-336.7 (in)]TJ T* [(men;)-401.3 (for)-401.3 (each)-401.3 (of)-401.3 (the)-401.3 (markers,)-401.3 (the)-401.3 (levels)-401.3 (were)-401.3 (significantly)]TJ T* [(higher)-240.4 (in)-240.4 (long)-240.4 (sleepers)-240.4 (compared)-240.4 (with)-240.4 (those)-240.4 (sleeping)-240.4 (7)-240.4 (hours.)]TJ T* [(However,)-336.7 (in)-336.7 (women,)-336.7 (there)-336.7 (was)-336.7 (a)-336.7 (significant)-336.7 (nonlinear)-336.7 (asso-)]TJ T* [(ciation)-410.3 (between)-410.3 (sleep)-410.3 (and)-410.3 (vWF)-410.3 (but)-410.3 (not)-410.3 (between)-410.3 (sleep)-410.3 (and)]TJ T* [(factor)-378 (VII)-378 (or)-378 (fibrinogen.)-378 (The)-378 (levels)-378 (of)-378 (vWF)-378 (and)-378 (factor)-378 (VII)]TJ T* [(were)-635.1 (also)-635.1 (significantly)-635.1 (increased)-635.1 (in)-635.1 (the)-635.1 (short)-635.2 (and)-635.1 (long)]TJ T* [(sleepers)-506.6 (compared)-506.6 (with)-506.6 (those)-506.6 (women)-506.5 (who)-506.5 (slept)-506.6 (7)-506.6 (hours.)]TJ T* [(After)-286.8 (multiple)-286.8 (adjustments)-286.8 (for)-286.8 (potential)-286.8 (confounding)-286.8 (factors,)]TJ T* [(the)-305.3 (significant)-305.3 (nonlinear)-305.3 (association)-305.3 (between)-305.3 (sleep)-305.3 (and)-305.3 (vWF)]TJ T* [(in)-413 (women)-413 (was)-413 (maintained.)-413 (However,)-413 (although)-413 (the)-413 (level)-413 (in)]TJ T* [(short)-336.1 (sleepers)-336.1 (was)-336.1 (no)-336.1 (longer)-336.1 (significantly)-336.1 (higher)-336.1 (than)-336.1 (in)-336.1 (the)]TJ T* [(reference)-494 (group)-494 (\(7)-494 (hours\),)-494 (the)-494 (level)-494 (in)-494 (long)-494 (sleepers)-494 (was)]TJ T* [(significantly)-511.6 (higher;)-511.7 (this)-511.6 (difference)-511.6 (was)-511.6 (observed)-511.6 (in)-511.6 (both)]TJ 0 -1.2153 TD [(premenopausal)-291.6 (and)-291.5 (postmenopausal)-291.5 (women)-291.5 (and)-291.5 (after)-291.5 (adjust-)]TJ T* [(ment)-345.7 (for)-345.7 (IL-6.)-345.7 (With)-345.7 (adjustment)-345.7 (for)-345.7 (marital)-345.7 (status)-345.7 (instead)-345.7 (of)]TJ T* [(employment)-499.7 (grade,)-499.7 (both)-499.7 (linear)-499.7 (and)-499.7 (nonlinear)-499.7 (trends)-499.7 (were)]TJ T* [(significant.)-453.6 (No)-453.6 (significant)-453.6 (linear)-453.6 (or)-453.6 (nonlinear)-453.6 (relationships)]TJ T* [(with)-262.2 (sleep)-262.2 (were)-262.2 (observed)-262.2 (with)-262.2 (the)-262.2 (other)-262.2 (hemostatic)-262.2 (factors)-262.2 (in)]TJ T* [(these)-332.8 (fully)-332.8 (adjusted)-332.8 (models.)]TJ 1 -1.2153 Td [(To)-481.1 (our)-481.1 (knowledge,)-481.1 (this)-481.1 (is)-481.1 (the)-481.1 (first)-481.1 (large-scale)-481.1 (study)-481.1 (to)]TJ -1 -1.2153 Td [(describe)-356.7 (the)-356.7 (associations)-356.7 (between)-356.7 (different)-356.7 (hemostatic)-356.7 (mea-)]TJ T* [(sures)-339.1 (and)-339.1 (sleep)-339.1 (duration)-339.1 (in)-339.1 (both)-339.1 (men)-339.1 (and)-339.1 (women.)-339.1 (Although)]TJ T* [(our)-238.6 (findings)-238.6 (are)-238.6 (restricted)-238.6 (to)-238.6 (a)-238.6 (white)-238.6 (population,)-238.6 (the)-238.6 (study)-238.6 (has)]TJ T* [(the)-364.5 (benefit)-364.5 (that)-364.5 (the)-364.5 (population)-364.5 (has)-364.5 (been)-364.5 (extensively)-364.5 (charac-)]TJ T* [(terized)-413 (and,)-413 (thus,)-413 (allows)-413 (for)-413 (the)-413 (adjustment)-413 (of)-413 (well-known)]TJ T* [(confounders,)-356.1 (including)-356.1 (measures)-356.1 (of)-356.1 (obesity,)-356.2 (glucose)-356.1 (metab-)]TJ T* [(olism,)-332.8 (blood)-332.8 (pressure,)-332.8 (and)-332.8 (measures)-332.8 (of)-332.8 (social)-332.8 (position.)]TJ 1 -1.2153 Td [(Hemostatic)-567.6 (markers)-567.6 (are)-567.6 (associated)-567.6 (with)-567.6 (CVD)-567.5 (and)-567.6 (are)]TJ -1 -1.2153 Td [(important)-353.8 (in)-353.7 (fibrinolysis)-353.7 (and)-353.7 (clotting.)-353.8 (Data)-353.7 (from)-353.7 (the)-353.7 (White-)]TJ T* [(hall)-244.9 (II)-244.9 (and)-244.9 (other)-244.9 (studies)-244.9 (have)-244.9 (indicated)-244.9 (a)-244.9 (role)-244.9 (for)-244.9 (these)-244.9 (factors)]TJ T* [(in)-503.6 (the)-503.6 (underlying)-503.6 (association)-503.6 (between)-503.6 (social)-503.6 (position)-503.6 (and)]TJ T* [(CHD.)-406.4 (There)-406.4 (is)-406.4 (a)-406.4 (grade)-406.4 (gradient)-406.4 (in)-406.4 (vWF,)-406.4 (and)-406.4 (the)-406.4 (levels)-406.4 (of)]TJ T* [(vWF)-238 (are)-238 (associated)-238 (with)-238 (other)-238 (confounding)-238 (factors,)-238 (including)]TJ T* [(alcohol)-269.4 (intake)-269.4 (and)-269.4 (fasting)-269.4 (glucose)-269.4 (level.)]TJ 6.5 0 0 5.5 467.5844 52.9148 Tm (17)Tj 9.5 0 0 9.5 476.6442 50.3835 Tm [(Data)-269.4 (from)-269.4 (this)-269.4 (and)]TJ /T1_3 1 Tf 10 0 0 10 324.9063 752.3835 Tm [(Miller)-332.9 (et)-332.9 (al)-2000 (Sleep)-332.9 (and)-332.9 (Hemostatic)-332.9 (Factors)]TJ /T1_4 1 Tf 21.8278 0 Td (5)Tj 0 g /RelativeColorimetric ri /GS1 gs /T1_5 1 Tf 9 0 0 9 272.50206 32 Tm ( at University of TV \(war\) / Eng on July 26, 2010 )Tj 0 0 1 rg /GS1 gs -8.16499 0 Td (atvb.ahajournals.org)Tj 0 g /GS1 gs -7.55399 0 Td (Downloaded from )Tj ET endstream endobj 41 0 obj <>stream JFIFddDucky<&Adobed E%u       h!"23 01#@P4AD!1AQaq" 0P2@BRrb!1AQaq 0P@ "`=2:t*&Dd$(tLN::@8t@*3).8XoIp`.(4*-8L2')& $H1£qa7 CIQ3IL H@H+,&Vt$A /,A"(/#h2 Np+, .D &pz fLfeCAXis9y3h*&gIYy^Ph4/18o$N:p 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(17)Tj 8.5 0 0 8.5 91.8345 237.0427 Tm [(The)-352.6 (coefficient)-352.6 (of)-352.6 (variation)-352.6 (was)-352.6 (16.1%.)-352.6 (A)-352.6 (spline)-352.6 (fit)-352.6 (was)]TJ -4.1964 -1.1257 Td [(applied)-493 (to)-493 (the)-493 (results)-493 (to)-493 (determine)-493 (the)-493 (effect)-493 (of)-493 (time)-493 (of)-493 (sample)]TJ T* [(collection)-329.2 (on)-329.2 (mean)-329.2 (level.)-329.2 (There)-329.2 (is)-329.2 (no)-329.2 (major)-329.2 (effect)-329.2 (of)-329.2 (time)-329.2 (on)-329.2 (these)]TJ T* [(levels)-322.8 (over)-322.9 (this)-322.8 (period.)-322.9 (The)-322.8 (proportion)-322.8 (of)-322.9 (the)-322.8 (variability)-322.8 (because)-322.8 (of)]TJ T* [(\223time)-332.9 (of)-332.9 (sampling\224)-332.9 (for)-332.9 (vWF)-332.9 (is)-332.9 (0.15%.)]TJ /T1_3 1 Tf 10.5 0 0 10.5 56.1648 178.2017 Tm [(Analysis)-332.8 (of)-332.8 (Factor)-332.8 (VII)]TJ /T1_0 1 Tf 8.5 0 0 8.5 56.1648 167.6336 Tm [(Factor)-479.3 (VII)-479.3 (activity)-479.3 (was)-479.3 (determined)-479.3 (according)-479.3 (to)-479.3 (the)-479.3 (method)-479.3 (de-)]TJ T* [(scribed)-277.1 (by)-277.1 (Brozovic)-277.1 (et)-277.1 (al,)]TJ 6 0 0 5 144.191 160.3296 Tm (18)Tj 8.5 0 0 8.5 152.5464 158.0654 Tm [(performed)-277.1 (without)-277.1 (automation.)-277.1 (A)-277.1 (single)]TJ -11.339 -1.1257 Td [(batch)-269.7 (of)-269.7 (factor)-269.7 (VII)-269.7 (reference)-269.7 (plasma,)-269.7 (stored)-269.7 (at)]TJ /T1_2 1 Tf 18.8443 0 Td (\003)Tj /T1_0 1 Tf [(70\260C,)-269.7 (was)-269.7 (obtained)]TJ -18.8443 -1.1257 Td [(from)-351.6 (a)-351.6 (pool)-351.6 (of)-351.6 (healthy)-351.6 (blood)-351.6 (donors)-351.6 (and)-351.6 (was)-351.6 (calibrated)-351.6 (against)-351.6 (an)]TJ T* [(NIBSC)-254.7 (standard.)-254.7 (The)-254.7 (within-batch)-254.7 (coefficient)-254.7 (of)-254.7 (variation)-254.7 (was)-254.7 (15%.)]TJ T* [(The)-414.4 (proportion)-414.4 (of)-414.4 (the)-414.4 (variability)-414.4 (because)-414.4 (of)-414.4 (time)-414.4 (of)-414.4 (sampling)-414.4 (for)]TJ T* [(factor)-332.9 (VII)-332.9 (is)-332.9 (0.57%.)]TJ /T1_3 1 Tf 10.5 0 0 10.5 56.1648 89.6563 Tm [(Analysis)-332.8 (of)-332.8 (Fibrinogen)]TJ /T1_0 1 Tf 8.5 0 0 8.5 56.1648 79.0881 Tm [(Fibrinogen)-293.8 (was)-293.8 (assayed)-293.8 (using)-293.8 (a)-293.8 (modification)-293.8 (of)-293.8 (the)-293.8 (clotting)-293.8 (method)]TJ T* [(of)-295.8 (Clauss.)-295.8 (However,)-295.8 (using)-295.8 (a)-295.8 (1:15)-295.8 (dilution)-295.8 (of)-295.8 (plasma)-295.8 (to)-295.8 (0.9%)-295.8 (saline,)]TJ T* [(fibrinogen)-275.4 (clotted)-275.4 (with)-275.4 (a)-275.4 (half)-275.4 (volume)-275.4 (of)-275.4 (bovine)-275.4 (thrombin,)-275.4 (50)-275.4 (U/mL,)]TJ T* [(in)-402.4 (an)-402.4 (MDA-180)-402.4 (coagulator)-402.4 (\(OrganonTeknika\))-402.4 (using)-402.4 (the)-402.4 (manufac-)]TJ 30.3529 78.8235 Td [(turer\222s)-543.4 (reagents)-543.4 (and)-543.4 (the)-543.4 (international)-543.4 (fibrinogen)-543.4 (standard.)]TJ 6 0 0 5 524.3449 722.6478 Tm (19)Tj 8.5 0 0 8.5 534.9646 720.3835 Tm (The)Tj -25.9764 -1.1337 Td [(within-batch)-315.8 (coefficient)-315.8 (of)-315.8 (variation)-315.8 (was)-315.8 (8%.)-315.8 (The)-315.8 (proportion)-315.8 (of)-315.8 (the)]TJ 0 -1.1337 TD [(variability)-332.9 (because)-332.9 (of)-332.9 (time)-332.9 (of)-332.9 (sampling)-332.9 (for)-332.9 (fibrinogen)-332.9 (is)-332.9 (0.39%.)]TJ /T1_3 1 Tf 10.5 0 0 10.5 314.1648 680.4745 Tm [(Ethics)-332.8 (Committee)-332.8 (Approval)-332.8 (and)]TJ 0 -1.1082 TD [(Statistical)-332.8 (Analysis)]TJ /T1_0 1 Tf 8.5 0 0 8.5 314.1648 658.2018 Tm [(Ethics)-330.9 (committee)-330.9 (approval)-330.9 (for)-330.9 (the)-330.9 (Whitehall)-330.9 (II)-330.9 (Study)-330.9 (was)-330.9 (obtained)]TJ 0 -1.1337 TD [(from)-607.9 (the)-607.9 (University)-607.9 (College)-607.9 (London)-607.9 (Medical)-607.9 (School,)-607.9 (London,)]TJ T* [(England,)-580.9 (committee)-580.9 (on)-580.9 (the)-580.9 (ethics)-580.9 (of)-580.9 (human)-580.9 (research.)-580.9 (Subjects)]TJ T* [(provided)-332.9 (written)-332.9 (informed)-332.9 (consent.)]TJ 1 -1.1337 Td [(In)-219.9 (the)-219.9 (univariate)-219.9 (analysis,)-219.9 (for)-219.9 (continuous)-219.9 (and)-219.9 (categorical)-219.9 (variables,)]TJ -1 -1.1337 Td [(Kruskal-Wallis)-239.6 (and)]TJ /T1_1 1 Tf 8.5 0 1.321 8.5 382.4458 610.0199 Tm (\003)Tj /T1_0 1 Tf 6.5 0 0 5.5 387.1717 613.5199 Tm (2)Tj 8.5 0 0 8.5 392.4587 610.0171 Tm [(tests,)-239.6 (respectively,)-239.6 (were)-239.6 (used)-239.6 (to)-239.6 (determine)-239.6 (the)]TJ -9.2111 -1.1334 Td [(statistical)-643.4 (significance)-643.4 (of)-643.4 (any)-643.4 (difference)-643.4 (in)-643.4 (the)-643.4 (distribution)-643.4 (of)]TJ T* [(baseline)-248.3 (variables)-248.3 (during)-248.3 (phase)-248.3 (3)-248.3 (across)-248.3 (categories)-248.3 (of)-248.3 (sleep)-248.3 (duration.)]TJ -0.0197 Tc 1 -1.1337 Td [(Skewed)-331.5 (variables)-331.5 (\(eg,)-331.5 (insulin,)-331.5 (glucose,)-331.5 (vWF,)-331.5 (fibrinogen,)-331.5 (and)-331.5 (factor)]TJ -1 -1.1337 Td [(VII\))-403.7 (were)-403.7 (natural-log)-403.7 (transformed)-403.7 (to)-403.7 (approach)-403.7 (a)-403.7 (normal)-403.7 (distribution,)]TJ T* [(and)-313.1 (results)-313.1 (are)-313.1 (presented)-313.1 (as)-313.1 (geometric)-313.1 (means)-313.1 (and)-313.1 (95%)-313.1 (CIs.)]TJ 0 Tc 1 -1.1337 Td [(The)-428.1 (statistical)-428.1 (significance)-428.1 (between)-428.1 (coagulation)-428.1 (at)-428.1 (phase)-428.1 (3)-428.1 (and)]TJ -1 -1.1337 Td [(categories)-414.4 (of)-414.4 (sleep)-414.4 (duration,)-414.4 (adjusted)-414.4 (for)-414.4 (other)-414.4 (baseline)-414.4 (variables,)]TJ T* [(was)-542.8 (tested)-542.8 (in)-542.8 (multivariate)-542.8 (linear)-542.8 (regression)-542.8 (models.)-542.8 (Results)-542.8 (are)]TJ T* [(expressed)-463.2 (as)-463.2 (geometric)-463.2 (means)-463.2 (ratios)-463.2 (separately)-463.2 (for)-463.2 (the)-463.2 (measured)]TJ T* [(hemostatic)-423.1 (factors)-423.1 (by)-423.1 (category)-423.1 (of)-423.1 (sleep)-423.1 (duration,)-423.1 (with)-423.1 (7)-423.1 (hours)-423.1 (of)]TJ T* [(sleep)-418.1 (as)-418.1 (the)-418.1 (reference)-418.1 (category)-418.1 (\(geometric)-418.1 (means)-418.1 (ratio,)-418.1 (1.00\))-418.1 (and)]TJ T* [(stratified)-591.2 (by)-591.2 (sex.)-591.2 (All)-591.2 (analyses)-591.2 (were)-591.2 (conducted)-591.2 (using)-591.2 (computer)]TJ T* [(software)-255 (\(STATA)-255 (10.0\).)-255 (A)-255 (spline)-255 (regression)-255 (analysis)-255 (was)-255 (performed)]TJ T* [(to)-436.8 (investigate)-436.8 (the)-436.8 (effect)-436.8 (of)-436.8 (time)-436.8 (\(using)-436.8 (restricted)-436.8 (cubic)-436.8 (spline\))-436.8 (of)]TJ T* [(blood)-453.9 (sampling)-453.9 (on)-453.9 (the)-453.9 (mean)-453.9 (levels)-453.9 (of)-453.9 (the)-453.9 (individual)-453.9 (coagulation)]TJ T* [(factors.)-352.6 (The)-352.6 (models)-352.6 (include)-352.6 (a)-352.6 (spline)-352.6 (time)-352.6 (adjustment.)]TJ /T1_4 1 Tf 22.4293 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.05)-352.6 (was)]TJ -22.4292 -1.1337 Td [(considered)-332.9 (statistically)-332.9 (significant.)]TJ /T1_3 1 Tf 11.5 0 0 11.5 413.2812 424.5654 Tm (Results)Tj 10.5 0 0 10.5 314.1648 408.929 Tm [(Characteristics)-332.8 (of)-332.8 (the)-332.8 (Population)-332.8 (by)-332.8 (Categories)-332.8 (of)]TJ 0 -1.1082 TD [(Sleep)-332.8 (Duration)]TJ /T1_0 1 Tf 9.5 0 0 9.5 314.1648 386.1563 Tm [(The)-508.9 (interaction)-508.9 (between)-508.9 (sleep)-508.9 (duration)-508.9 (and)-508.9 (sex)-508.9 (on)-508.9 (the)-509 (3)]TJ 0 -1.2249 TD [(coagulation)-328.9 (factors)-328.9 (was)-328.9 (significant)-328.9 (\()]TJ /T1_4 1 Tf 14.8121 0 Td (P)Tj /T1_2 1 Tf (\001)Tj /T1_0 1 Tf [(0.001\);)-328.9 (therefore,)-328.9 (all)]TJ -14.812 -1.2249 Td [(analyses)-278.1 (were)-278.1 (stratified)-278.1 (by)-278.1 (sex.)-278.1 (Characteristics)-278.1 (for)-278.1 (the)-278.1 (partic-)]TJ T* [(ipants)-312.2 (at)-312.2 (phase)-312.2 (3)-312.2 (in)-312.2 (men)-312.2 (and)-312.2 (women)-312.2 (are)-312.2 (reported)-312.2 (in)-312.2 (Table)-312.2 (1)]TJ T* [(by)-333.4 (categories)-333.4 (of)-333.4 (sleep)-333.4 (duration.)-333.4 (Variation)-333.4 (across)-333.4 (sleep)-333.4 (dura-)]TJ T* [(tion)-237.7 (groups)-237.7 (was)-237.7 (significant)-237.7 (for)-237.7 (a)-237.7 (number)-237.7 (of)-237.7 (the)-237.7 (characteristics)]TJ T* [(\(Table)-316.7 (1\).)-316.7 (Men)-316.7 (who)-316.7 (were)-316.7 (short)-316.7 (sleepers)-316.7 (were)-316.7 (more)-316.7 (likely)-316.7 (to)]TJ T* [(be)-290.1 (in)-290 (the)-290 (lowest)-290.1 (employment)-290.1 (grade)-290 (and)-290 (unmarried)-290 (\(Table)-290 (1\).)]TJ T* [(Women)-297.2 (who)-297.2 (were)-297.2 (short)-297.2 (sleepers)-297.2 (were)-297.2 (also)-297.2 (more)-297.2 (likely)-297.2 (to)-297.2 (be)]TJ T* [(unmarried)-332.8 (\(Table)-332.8 (1\).)]TJ -0.01981 Tc 1 -1.2249 Td [(No)-260.8 (significant)-260.8 (effect)-260.8 (of)-260.8 (time)-260.8 (of)-260.8 (blood)-260.8 (sampling)-260.8 (was)-260.8 (observed)]TJ -1 -1.2249 Td [(on)-390.3 (the)-390.3 (mean)-390.3 (level)-390.3 (of)-390.3 (each)-390.3 (of)-390.3 (the)-390.3 (coagulation)-390.3 (factors)-390.3 (\(supple-)]TJ T* [(mental)-262 (Figure;)]TJ 0 Tc 5.8781 0 Td [(available)-261.9 (online)-261.9 (at)-261.9 (http://atvb.ahajournals.org\).)]TJ -5.8781 -1.2249 Td [(In)-351.6 (men,)-351.7 (there)-351.7 (was)-351.7 (no)-351.7 (significant)-351.7 (variation)-351.7 (in)-351.7 (the)-351.7 (unadjusted)]TJ T* [(levels)-497 (of)-497 (vWF,)-497 (fibrinogen,)-497 (or)-497 (factor)-497 (VII)-497 (across)-497 (the)-497 (sleep)]TJ T* [(categories)-518.5 (\(Table)-518.5 (1\).)-518.5 (In)-518.5 (contrast,)-518.5 (in)-518.5 (women,)-518.5 (there)-518.5 (was)-518.5 (a)]TJ T* [(significant)-332.8 (variation)-332.8 (in)-332.8 (factor)-332.8 (VII)-332.8 (\(Table)-332.8 (1,)]TJ /T1_4 1 Tf 17.964 0 Td (P)Tj /T1_2 1 Tf (\002)Tj /T1_0 1 Tf (0.04\).)Tj /T1_3 1 Tf 10.5 0 0 10.5 314.1648 177.8381 Tm [(Multiple)-332.8 (Regression)-332.8 (Analysis)]TJ /T1_0 1 Tf 9.5 0 0 9.5 314.1648 166.7018 Tm [(Each)-385.7 (of)-385.7 (these)-385.7 (hemostatic)-385.7 (factors)-385.7 (is)-385.7 (known)-385.7 (to)-385.7 (be)-385.7 (associated)]TJ T* [(with)-290 (potential)-290.1 (cardiovascular)-290.1 (risk)-290 (factors.)-290.1 (Therefore,)-290.1 (a)-290 (corre-)]TJ T* [(lation)-234.7 (matrix)-234.7 (between)-234.7 (these)-234.7 (markers)-234.7 (and)-234.7 (risk)-234.7 (factors,)-234.7 (and)-234.7 (data)]TJ T* [(from)-459.9 (previously)-459.9 (published)-459.9 (studies,)-459.9 (helped)-459.9 (to)-459.9 (identify)-459.9 (con-)]TJ T* [(founders)-367.8 (that)-367.8 (were)-367.8 (used)-367.8 (in)-367.8 (the)-367.8 (multiple)-367.8 (regression)-367.8 (analysis.)]TJ T* [(The)-254.5 (level)-254.5 (of)-254.5 (the)]TJ -0.01981 Tc 6.5717 0 Td [(hemostatic)-254.5 (factors)-254.5 (at)-254.5 (7)-254.5 (hours)-254.5 (of)-254.5 (sleep)-254.5 (was)-254.5 (used)]TJ -6.5717 -1.2249 Td [(as)-318.8 (a)-318.8 (reference.)-318.8 (Results)-318.8 (are)-318.8 (shown)-318.8 (in)-318.8 (Table)-318.8 (2)-318.8 (and)-318.8 (Table)-318.8 (3.)-318.8 (A)-19.8 (g)-19.8 (e)]TJ 0 Tc 0 -1.2237 TD [(and)-515.5 (smoking,)-515.5 (which)-515.5 (vary)-515.5 (significantly)-515.5 (with)-515.5 (categories)-515.5 (of)]TJ T* [(sleep)-226.9 (in)-226.9 (both)-226.9 (men)-226.9 (and)-226.9 (women)-226.9 (\(Tables)-227 (1\),)-227 (along)-226.9 (with)-226.9 (BMI)-227 (and)]TJ T* [(sampling)-413.3 (time,)-413.3 (were)-413.3 (used)-413.2 (as)-413.3 (covariates)-413.3 (in)-413.3 (the)-413.3 (basic)-413.2 (model)]TJ T* [(\(model)-284.1 (1\))-284.1 (to)-284.1 (which)-284.1 (other)-284.1 (variables)-284.1 (were)-284.1 (added.)-284.1 (Models)-284.1 (were)]TJ /T1_5 1 Tf 10 0 0 10 56.1648 752.3835 Tm [(2)-2000 (Arterioscler)-332.9 (Thromb)-332.9 (Vasc)-332.9 (Biol)]TJ /T1_3 1 Tf 17.4441 0 Td [(October)-332.9 (2010)]TJ 0 g /RelativeColorimetric ri /GS1 gs /T1_6 1 Tf 9 0 0 9 272.50206 32 Tm ( at University of TV \(war\) / Eng on July 26, 2010 )Tj 0 0 1 rg /GS1 gs -8.16499 0 Td (atvb.ahajournals.org)Tj 0 g /GS1 gs -7.55399 0 Td (Downloaded from )Tj ET endstream endobj 53 0 obj <>stream JFIFddDucky<&Adobed E%u       h!"23 01#@P4AD!1AQaq" 0P2@BRrb!1AQaq 0P@ 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