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Robb Lab

Publications/Outreach/Media

2026
  • dos Santos C, Li J, van Diemen PM, McMahon A, Mollett BC, Ramsay AM, Maina MM, James J, Everett HE, Daly JM, Robb NC. Isothermal detection of influenza D using RT-LAMP. BioRxiv.
2025
  • Deng A, Cunnison R, Carrique L, Gunl F, Paddon E, Staeyart J, Nguyen Duc D, Grimes J, Robb NC & Keown JR. Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA dependent RNA polymerase. BioRxiv.
  • Tasnim A, Murray LAM, Clayton RA, Uchechukwu CF, Zhao J, Liu SC, Cox Holanda de Barros Dias M, Liu N, Huang Y, Thompson CP, Alkhalaf LM, Challis GL & Robb NC. Bioinformatics-based stereochemical elucidation of MM 46115: an unusual antiviral spirotetronate that inhibits clathrin-mediated endocytosis. BioRxiv.
  • Stolle L, Bolton JS, Steventon R, Gregory R, Klim H, Di Genova C, Haddock L, Bhatta A, Carnell G, Brady C, Da Costa K, Edmans M, Calliss K, Simmonds P, Hill EM, Temperton N, Hill SC, Jarvis L, McInally C, James J, Banyard AC, Carroll M, Obolski U, Lambe T, Spencer A, Milicic A, Robb NC & Thompson CP. Divergent antibody-mediated population immunity to H5, H7 and H9 subtype potential pandemic influenza viruses. MedRxiv.
  • Uchechukwu CF & Robb NC. Implications of morphological variation in influenza viruses. Microbiology and Molecular Biology Reviews. 0:e00015-25.

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  • Groves D, Cunnison R, McMahon A, Fan H, Sharps J, Deng A, Keown JR, Fodor E & Robb NC. Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET. Nucleic Acids Research. 53(8).
  • Hepp C, Zhao Q, Robb NC, Fodor E & Kapanidis AN. High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity and flexibility during selective packaging in influenza. Nucleic Acids Research. 53(19)
2024
  • McMahon A, Vijayakrishnan S, El Sayyed H, Groves D, Conley MJ, Hutchinson E & Robb NC. Engineering stress as a motivation for filamentous virus morphology. Biophysical Reports. 4(4):100181.

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  • Nagorska A, Tomas RMF, Tasnim A, Robb NC & Gibson MI. Cryopreserved Kidney Epithelial (Vero) Cell Monolayers for Rapid Viral Quantification, Enabled by a Combination of Macromolecular Cryoprotectants. Biomacromolecules. 25(8):5352-5358. 10.1021/acs.biomac.4c00760Link opens in a new window
2023
  • McMahon A, Andrews R, Groves D, Ghani SV, Cordes T, Kapanidis AN & Robb NC. High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organisation. PLOS Pathogens. 19(6): e1011484.
  • Groves D, Hepp C, Kapanidis, AN & Robb NC. Single-molecule FRET for virology: 20 years of insight into protein structure and dynamics. Quarterly Reviews of Biophysics. 56:e3.
  • Agam G, Gebhardt C, et int., Cordes, T. Reliability and accuracy of single-molecule FRET studies for the characterization of structural dynamics and distances in proteins. Nature Methods. 20:523–535.
2022
  • Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C, Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N, Crook DW, Kapanidis AN & Robb NC. Virus detection and identification in minutes using single-particle imaging and deep learning. ACS Nano. 17(1):697–710.

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  • Robb NC. Virus morphology: Insights from super resolution fluorescence microscopy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1868(4):166347.
2021
  • McMahon A, Andrews R, Ghani SV, Cordes T, Kapanidis AN & Robb NC. High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organisation. BioRxiv.

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  • Lerner E, Barth A, et int. Weiss S. FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. eLife. 10:e60416.
  • Hepp C, Shiaelis N, Robb NC, Vaughan A, Matthews PC, Stoesser N, Crook D & Kapanidis AN. Viral detection and identification in 20 minutes by rapid single-particle fluorescence in-situ hybridization of viral RNA. Scientific Reports. 11(1):19579.

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2020
  • Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C , Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N , Crook D, Kapanidis AN & Robb NC. Virus detection and identification in minutes using single-particle imaging and deep learning. MedRxiv.  

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  • McMahon A & Robb NC. Reinfection with SARS-CoV-2: Discrete SIR (Susceptible, Infected, Recovered) Modeling Using Empirical Infection Data. JMIR Public Health Surveill. 6(4):e21168.
2019
  • Robb NC, Taylor JM, Kent A, Pambos O, Gilboa B, Kapanidis AN. Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction. Scientific Reports. 9(1):16219.

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  • Robb NC, te Velthuis AJW, Fodor E, Kapanidis AN. Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent differences in initiation dynamics. Nucleic Acids Research. 47(12):6466-6477.
2018
  • Hepp C & Robb NC. Coming together during viral assembly. Nature Reviews Microbiology. 16(12):721.
  • Hellenkamp B, Schmid S, et int., Hugel T. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature Methods. 15(9):669-676.
  • Duchi D, Gryte K, Robb NC, Morichaud Z, Sheppard C, Brodolin K, Wigneshweraraj S, Kapanidis AN. Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes. Nucleic Acids Research. 46(2):677-688.
2016
  • Robb NC, te Velthuis AJW, Wieneke R, Tamp猫 R, Cordes T, Fodor E, Kapanidis AN. Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA. Nucleic Acids Research. 44(21):10304-10315.
  • Duchi D, Bauer DLV, Fernandez L, Evans G, Robb NC, Hwang LC, Gryte K, Tomescu A, Zawadski P, Morichaud Z, Brodolin K, Kapanidis AN. RNA polymerase pausing during initial transcription. Molecular Cell. 63(6):939-50.
  • Te Velthuis AJW, Robb NC, Kapanidis AN, Fodor E. The role of the priming loop in Influenza A virus RNA synthesis. Nature Microbiology. 1:16029.
2014
  • Tomescu AI*, Robb NC*, Hengrung N, Fodor E, Kapanidis AN. Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter. PNAS. 111(32):E3335-42. (*Joint first authors)
2013
  • Robb NC*, Cordes T*, Hwang LC*, Gryte K, Duchi D, Craggs TD, Santoso Y, Weiss S, Ebright RH, Kapanidis AN. The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection. J Mol Biol. 425(5):875-85. (*Joint first authors)
2012
  • Wise HM, Hutchinson EC, Jagger BW, Stuart, AD, Kang ZH, Robb NC, Kash JC, Fodor, E, Firth AE, Gog JR, Taubenberger JK and Digard P. Identification of a novel splice variant form of the influenza a virus M2 ion channel. PLoS Pathogens. 8(11): e1002998.
  • Robb NC and Fodor E. The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein. J Gen Virol . 93(Pt 1):113-8.
2011
  • Robb NC, Chase G, Bier K, Vreede FT, Shaw P, Naffakh N, Schwemmle M, Fodor E. The influenza A NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes. J Virol. 85(10):5228-31.
2010
  • Wang Z, Robb NC, Lenz E, Wolff T, FodorE, Pleschka S. Reassortment of the NS segment of an H7-type HPAIV affects its propagation by altering the regulation of viral RNA production and the anti-viral host response. J. Virol . 84(21):11323-35.
  • Robb NC, Jackson D, Vreede FT and Fodor E. Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein. J Gen Virol. 91(Pt 9):2331-40.
  • Chan W, Ng A, Robb NC, Lam M, Chan P, Au S, Fodor E, Shaw P. Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J. Virol . 84(14):7337-45.
  • Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb NC, Vreede F, Barclay W, Fodor E, Reis e Sousa C. RIG-I detects viral genomic RNA during negative strand RNA virus infection. Cell. 140(3):397-408.
2009
  • Robb NC*, Smith M*, Vreede FT, Fodor E. (2009) The NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J Gen Virol. 90(Pt 6):139. (*Joint first authors).
Outreach Articles

Aartjan te Velthuis & Nicole Robb

The Conversation, 2016.

Aartjan te Velthuis & Nicole Robb

World Economic Forum, 2016.

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Nicole Robb

Oxplore, 2019.

  • - a virtual science outreach evening to discuss some of the science behind Covid-19

Nicole Robb

Selected Media Articles

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