Events in MathSys and Complexity Science
This is a calendar page detailing events within the MathSys CDT. It also acts as a booking diary for the Seminar Room D1.07. To book D1.07 please email Sheetal.Sharma@warwick.ac.uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
MathSys CDT events have priority for D1.07 room bookings.
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Complexity Forum: Craig MacLean (Oxford)
Speaker:Craig MacLean (Department of Zoology, Univ. of Oxford)
Title: Experimental evolution of antibiotic resistance
Abstract:
The goal of microbial experimental evolution is to study the process of evolution by natural selection using experiments in which populations of microorganisms are challenged with adapting to novel laboratory environments. Microbes used in experimental evolution typically have large population sizes (millions to billions) and short generation times (minutes to hours) allowing for rapid evolution in response to defined conditions that can be easily manipulated and highly replicated. The response to selection can then be determined directly by determining the Darwinian fitness of evolved populations relative to their distant ancestors and the genetic basis of adaptation can be determined by targeted or whole genome sequencing. In my talk, I will show how experimental evolution can be used to gain insights into the fundamental processes that drive the evolution of antibiotic resistance in the pathogenic bacterium Pseudomonas aeruginosa. This bacterium rapidly evolves resistance to antibiotics in clinical settings and resistance in P.aeruginosa has emerged as an important clinical problem.