Events in MathSys and Complexity Science
This is a calendar page detailing events within the MathSys CDT. It also acts as a booking diary for the Seminar Room D1.07. To book D1.07 please email Sheetal.Sharma@warwick.ac.uk
Please note that your event booking is for D1.07 only. The adjacent common room is a private area for the MathSys Centre that cannot used as part of your booking.
MathSys CDT events have priority for D1.07 room bookings.
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Complexity Forum - Jamie Luo
Title: Functionality and Speciation in Boolean Networks
Abstract:
Boolean Networks have been used to model Genetic Regulatory Networks since Stuart Kauffmann proposed them as a model in the 1960s. Early work focused on how the topology of a network influenced its dynamics. We investigate the inverse problem asking which network topologies satisfy a specified dynamic. In earlier work by A. Wagner et al [1, 2] a biological function or cell process was specified by an initial condition v(0) and an end point v ∞ in the expression state space. By so specifying a biological function one can then ask which networks perform this function. Our view is that in many cases a more appropriate means for defining a biological function would be by specifying the entire path {v(0), v(1), ..., v(T )}. We will report on how these two contrasting definitions of biological functionality lead to divergent results for their respective functional topologies, particularly regarding the implications for neutral evolution, multi-functionality and speciation.
References
[1] Ciliberti S, Martin OC, Wagner A (2007) Innovation and robustness in complex regulatory gene networks. Proc Natl Acad Sci USA 104:1359113596.
[2] Martin OC, Wagner A (2008) Multifunctionality and robustness trade-offs in model genetic circuits. Biophysical Journal, 94 (8), pp. 2927-2937.